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Gene: Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) Rattus norvegicus
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Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
RGD ID: 621806
Description: Exhibits 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; and identical protein binding activity. Involved in several processes, including aging; response to drug; and response to steroid hormone. Localizes to peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; MFP-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II
Orthologs:
Homo sapiens (human) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)  HGNC  Alliance
Mus musculus (house mouse) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Canis lupus familiaris (dog) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Sus scrofa (pig) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Chlorocebus sabaeus (African green monkey) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Heterocephalus glaber (naked mole-rat) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01844,810,462 - 44,897,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01844,032,347 - 44,119,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41845,157,435 - 45,251,606 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11845,194,975 - 45,281,963 (+)NCBI
Celera1841,553,644 - 41,635,741 (+)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hsd17b4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621806
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.