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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b4increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of HSD17B4 mRNA; perfluorooctanoic acid results in increased expression of HSD17B4 proteinPMID:28511854 PMID:34958885
Hsd17b4increases expressionISOHSD17B4 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of HSD17B4 mRNAPMID:23567314
Hsd17b4increases expressionISOHsd17b4 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of HSD17B4 mRNAPMID:17681415 PMID:18467677 PMID:20118188 PMID:20936131
Hsd17b4multiple interactionsISOHsd17b4 (Mus musculus)6480464CTDPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of HSD17B4 mRNA]PMID:18467677 PMID:20936131
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