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Gene: HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) Homo sapiens
Symbol: HSD17B4
Name: hydroxysteroid 17-beta dehydrogenase 4
Description: Exhibits hydro-lyase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in cellular hormone metabolic process; fatty acid beta-oxidation; and fatty-acyl-CoA metabolic process. Localizes to peroxisome. Implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein, peroxisomal; DBP; hydroxysteroid (17-beta) dehydrogenase 4; hydroxysteroid dehydrogenase 4; MFE-2; MFP-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type ii; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; short chain dehydrogenase/reductase family 8C member 1; short chain dehydrogenase/reductase family 8C, member 1
Mus musculus (house mouse) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Canis lupus familiaris (dog) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Sus scrofa (pig) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Chlorocebus sabaeus (African green monkey) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Heterocephalus glaber (naked mole-rat) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
more info ...
Related Pseudogenes: AC018992.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5119,452,473 - 119,637,199 (+)EnsemblGRCh38hg38GRCh38
GRCh385119,452,497 - 119,542,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375118,788,138 - 118,878,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365118,816,122 - 118,905,923 (+)NCBINCBI36hg18NCBI36
Build 345118,816,123 - 118,905,923NCBI
Celera5114,741,869 - 114,831,759 (+)NCBI
Cytogenetic Map5q23.1NCBI
HuRef5113,983,371 - 114,073,268 (+)NCBIHuRef
CHM1_15118,221,090 - 118,311,127 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSD17B4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731284
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.