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Gene: Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) Mus musculus
Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Description: Predicted to have several functions, including hydro-lyase activity; protein homodimerization activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Localizes to peroxisome. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-dexrazoxane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17[b]-HSD; 4; AW208803; D-bifunctional protein; DBP; MFE-2; Mfp-2; MFP2; MPF-2; multifunctional protein 2; perMFE-2; peroxisomal multifunctional enzyme type 2
Homo sapiens (human) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Canis lupus familiaris (dog) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Sus scrofa (pig) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Chlorocebus sabaeus (African green monkey) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Heterocephalus glaber (naked mole-rat) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBImm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hsd17b4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731285
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.