Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) - Rat Genome Database

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Gene: Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) Mus musculus
Analyze
Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
RGD ID: 731285
MGI Page MGI
Description: Predicted to enable hydro-lyase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Acts upstream of or within Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17[b]-HS; 17[b]-HSD; 4; AW208803; D-bifunctional protein; DBP; MFE-2; MFP; Mfp-; Mfp-2; MFP2; MPF-2; multifunctional protein 2; perMFE; perMFE-2; peroxisomal multifunctional enzyme type 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391850,261,268 - 50,329,337 (+)NCBIGRCm39mm39
GRCm39 Ensembl1850,261,268 - 50,329,336 (+)Ensembl
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBImm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trichlorophenol  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dibromophenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-bromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydrocoumarin  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitro-m-cresol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
aniline  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzbromarone  (ISO)
benzofurans  (ISO)
betamethasone  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (ISO)
calcidiol  (ISO)
carbamazepine  (ISO)
carboplatin  (ISO)
chlorothalonil  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
entacapone  (ISO)
estrone  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
gallic acid  (ISO)
gemfibrozil  (ISO)
glafenine  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-ethionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
Propiverine  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
sulfasalazine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
Tesaglitazar  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
tolcapone  (ISO)
trichloroethene  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (HDA)
peroxisomal matrix  (TAS)
peroxisome  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal bile salt level  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal gait  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal intestinal absorption  (IAGP)
abnormal iris morphology  (IEA)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal peroxisome morphology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen morphology  (IEA)
abnormal sternum morphology  (IEA)
abnormal suckling behavior  (IAGP)
abnormal testis morphology  (IAGP)
abnormal tooth morphology  (IEA)
astrocytosis  (IAGP)
ataxia  (IAGP)
axon degeneration  (IAGP)
cataract  (IAGP)
cerebellum atrophy  (IAGP)
decreased body weight  (IAGP)
decreased circulating aspartate transaminase level  (IEA)
decreased eosinophil cell number  (IEA)
decreased fatty acids level  (IAGP)
decreased litter size  (IAGP)
demyelination  (IAGP)
enlarged adrenal glands  (IEA)
enlarged heart  (IEA)
enlarged urinary bladder  (IEA)
hypoactivity  (IAGP)
hypotonia  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased fatty acids level  (IAGP)
increased grip strength  (IEA)
irregularly shaped pupil  (IEA)
lethargy  (IAGP)
limb grasping  (IEA)
male infertility  (IAGP)
microgliosis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
Purkinje cell degeneration  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
seminiferous tubule degeneration  (IAGP)
short stride length  (IAGP)
small testis  (IAGP)
small uterus  (IEA)
tremors  (IAGP)
References

Additional References at PubMed
PMID:8547180   PMID:8547181   PMID:8943781   PMID:9224647   PMID:10349636   PMID:10627506   PMID:10671535   PMID:10748062   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11171065  
PMID:11939592   PMID:12409309   PMID:12477932   PMID:12520002   PMID:12897163   PMID:14500732   PMID:14681479   PMID:15489334   PMID:15769750   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:16452087   PMID:16484321   PMID:16565505   PMID:16766224   PMID:16916647   PMID:17062636   PMID:17442273   PMID:17967808   PMID:18614015   PMID:18773970   PMID:20202875   PMID:21267068  
PMID:21873635   PMID:23777740   PMID:24457600   PMID:25846981   PMID:27353294   PMID:27746211   PMID:28286294   PMID:28470148   PMID:29459677   PMID:29892213   PMID:30540494   PMID:30550785  
PMID:30866963   PMID:31040226   PMID:31176039   PMID:32325033   PMID:32814053  


Genomics

Comparative Map Data
Hsd17b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391850,261,268 - 50,329,337 (+)NCBIGRCm39mm39
GRCm39 Ensembl1850,261,268 - 50,329,336 (+)Ensembl
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBImm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
HSD17B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5119,452,465 - 119,637,199 (+)EnsemblGRCh38hg38GRCh38
GRCh385119,452,497 - 119,542,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375118,788,192 - 118,878,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365118,816,122 - 118,905,923 (+)NCBINCBI36hg18NCBI36
Build 345118,816,123 - 118,905,923NCBI
Celera5114,741,869 - 114,831,759 (+)NCBI
Cytogenetic Map5q23.1NCBI
HuRef5113,983,371 - 114,073,268 (+)NCBIHuRef
CHM1_15118,221,090 - 118,311,127 (+)NCBICHM1_1
Hsd17b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21843,328,903 - 43,417,950 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1843,328,824 - 43,417,952 (+)Ensembl
Rnor_6.01844,810,462 - 44,897,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01844,032,347 - 44,119,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41845,157,435 - 45,251,606 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11845,194,975 - 45,281,963 (+)NCBI
Celera1841,553,644 - 41,635,741 (+)NCBICelera
Cytogenetic Map18q11NCBI
Hsd17b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540839,040,840 - 39,138,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540839,041,028 - 39,136,867 (+)NCBIChiLan1.0ChiLan1.0
HSD17B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15120,628,605 - 120,713,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5120,628,605 - 120,713,860 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05114,842,892 - 114,928,559 (+)NCBIMhudiblu_PPA_v0panPan3
HSD17B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,717,182 - 8,810,716 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,717,349 - 8,824,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,845,728 - 9,939,173 (+)NCBI
ROS_Cfam_1.0118,803,421 - 8,896,940 (+)NCBI
UMICH_Zoey_3.1118,674,773 - 8,768,177 (+)NCBI
UNSW_CanFamBas_1.0118,731,175 - 8,824,571 (+)NCBI
UU_Cfam_GSD_1.0118,988,828 - 9,082,305 (+)NCBI
Hsd17b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213131,797,848 - 131,887,229 (+)NCBI
SpeTri2.0NW_0049367152,357,215 - 2,446,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2123,313,448 - 123,402,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12123,313,445 - 123,401,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22128,752,284 - 128,841,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12322,674,059 - 22,761,270 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2322,674,072 - 22,762,056 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603455,546,291 - 55,636,123 (-)NCBIVero_WHO_p1.0
Hsd17b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247332,126,124 - 2,204,966 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126796  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381850,135,373 - 50,135,577UniSTSGRCm38
GRCm3810128,912,449 - 128,912,806UniSTSGRCm38
MGSCv3710128,349,505 - 128,349,862UniSTSGRCm37
MGSCv371850,295,027 - 50,295,231UniSTSGRCm37
Celera1851,467,805 - 51,468,009UniSTS
Celera10131,305,131 - 131,305,488UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map10D3UniSTS
cM Map1827.24UniSTS
cM Map1072.0UniSTS
AW208803  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381850,195,947 - 50,196,053UniSTSGRCm38
MGSCv371850,355,601 - 50,355,707UniSTSGRCm37
Celera1851,528,372 - 51,528,478UniSTS
Cytogenetic Map18D1UniSTS
Whitehead/MRC_RH18721.39UniSTS
RH125938  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381850,135,308 - 50,135,556UniSTSGRCm38
GRCm3810128,912,248 - 128,912,785UniSTSGRCm38
MGSCv3710128,349,304 - 128,349,841UniSTSGRCm37
MGSCv371850,294,962 - 50,295,210UniSTSGRCm37
Celera1851,467,740 - 51,467,988UniSTS
Celera10131,304,930 - 131,305,467UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map10D3UniSTS
cM Map1827.24UniSTS
cM Map1072.0UniSTS
Whitehead/MRC_RH18720.85UniSTS
RH139213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,911,507 - 128,911,831UniSTSGRCm38
MGSCv3710128,348,563 - 128,348,887UniSTSGRCm37
Celera1851,467,130 - 51,467,518UniSTS
Celera10131,304,190 - 131,304,514UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map10D3UniSTS
cM Map1827.24UniSTS
cM Map1072.0UniSTS
UniSTS:224400  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381850,196,028 - 50,196,136UniSTSGRCm38
MGSCv371850,355,682 - 50,355,790UniSTSGRCm37
Celera1851,528,453 - 51,528,561UniSTS
Cytogenetic Map18D1UniSTS
Hsd17b4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18D1UniSTS
cM Map1827.24UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181800665152006806Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181888582152885939Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181888582152885939Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182082063757457636Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182108452755084674Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182248686156487074Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182248686156487074Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182248686156487074Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182248686156487074Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182248686156487074Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182398250757982677Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182592381059923810Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182710806258694005Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182710806258694005Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182710806258694005Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182797631361976451Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2799753761997672Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183295797666958154Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183552556069525779Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183615795070158108Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183807349772073497Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183807349772073497Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183807349772073497Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183807349772073497Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183897060572970721Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184317804877178271Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184499753768645706Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184629021680290216Mouse
10412184Sstapa1_mSuseptibility to Staphylococus aureus infection 1 (mouse)Not determined184640847957457636Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184674183280741971Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184674183280741971Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:295
Interacting mature miRNAs:328
Transcripts:ENSMUST00000025385, ENSMUST00000127325, ENSMUST00000139502, ENSMUST00000152388
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025385   ⟹   ENSMUSP00000025385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1850,261,268 - 50,329,336 (+)Ensembl
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1850,324,391 - 50,329,039 (+)Ensembl
GRCm38.p6 Ensembl1850,191,324 - 50,195,972 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1850,275,436 - 50,279,636 (+)Ensembl
GRCm38.p6 Ensembl1850,142,369 - 50,146,569 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152388
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1850,261,561 - 50,275,679 (+)Ensembl
GRCm38.p6 Ensembl1850,128,494 - 50,142,612 (+)Ensembl
RefSeq Acc Id: NM_008292   ⟹   NP_032318
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391850,261,268 - 50,329,337 (+)NCBI
GRCm381850,128,201 - 50,196,270 (+)ENTREZGENE
MGSCv371850,287,986 - 50,355,920 (+)RGD
Celera1851,460,428 - 51,528,695 (+)ENTREZGENE
cM Map18 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032318   ⟸   NM_008292
- UniProtKB: P51660 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025385   ⟸   ENSMUST00000025385
Protein Domains
MaoC-like   SCP2

Promoters
RGD ID:13677782
Promoter ID:EPDNEW_M23040
Type:initiation region
Name:Hsd17b4_1
Description:Mus musculus hydroxysteroid (17-beta) dehydrogenase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381850,128,227 - 50,128,287EPDNEW
RGD ID:6829304
Promoter ID:MM_KWN:25269
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008292,   OTTMUST00000050011,   OTTMUST00000050098
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361850,287,769 - 50,288,269 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105089 AgrOrtholog
Ensembl Genes ENSMUSG00000024507 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025385 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025385 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HotDog_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MaoC-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2_sterol-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2_sterol-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15488 UniProtKB/Swiss-Prot
MGD MGI:105089 ENTREZGENE
NCBI Gene 15488 ENTREZGENE
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MaoC_dehydratas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b4 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55718 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DHB4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TT11_MOUSE UniProtKB/TrEMBL
  Q3UHW2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9DBM3 UniProtKB/Swiss-Prot