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Gene: Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) Mus musculus
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Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Description: Predicted to have several functions, including hydro-lyase activity; protein homodimerization activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Localizes to peroxisome. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-dexrazoxane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17[b]-HSD; 4; AW208803; D-bifunctional protein; DBP; MFE-2; Mfp-2; MFP2; MPF-2; multifunctional protein 2; perMFE-2; peroxisomal multifunctional enzyme type 2
Orthologs:
Homo sapiens (human) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Canis lupus familiaris (dog) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
Sus scrofa (pig) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Chlorocebus sabaeus (African green monkey) : HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4)
Heterocephalus glaber (naked mole-rat) : Hsd17b4 (hydroxysteroid 17-beta dehydrogenase 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBImm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hsd17b4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731285
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.