Map3k2 (mitogen activated protein kinase kinase kinase 2) - Rat Genome Database

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Gene: Map3k2 (mitogen activated protein kinase kinase kinase 2) Rattus norvegicus
Analyze
Symbol: Map3k2
Name: mitogen activated protein kinase kinase kinase 2
RGD ID: 620967
Description: Enables MAP kinase kinase kinase activity. Predicted to be involved in cellular response to mechanical stimulus and intracellular signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mekk2; mitogen-activated protein kinase kinase kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,081,444 - 24,153,940 (+)NCBIGRCr8
mRatBN7.21823,807,218 - 23,879,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,807,218 - 23,871,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,935,311 - 23,999,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,692,639 - 24,757,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,030,296 - 24,094,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,961,250 - 25,025,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,961,245 - 25,025,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,676,280 - 24,740,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,606,219 - 24,672,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,680,069 - 24,682,550 (+)NCBI
Celera1823,559,225 - 23,623,916 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
4. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
5. Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures. Lenz G, etal., J Neurochem 2001 May;77(4):1001-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
Additional References at PubMed
PMID:14515274   PMID:15001576   PMID:17003042   PMID:17906693   PMID:19593445   PMID:33506923  


Genomics

Comparative Map Data
Map3k2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,081,444 - 24,153,940 (+)NCBIGRCr8
mRatBN7.21823,807,218 - 23,879,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,807,218 - 23,871,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,935,311 - 23,999,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,692,639 - 24,757,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,030,296 - 24,094,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,961,250 - 25,025,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,961,245 - 25,025,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,676,280 - 24,740,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,606,219 - 24,672,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,680,069 - 24,682,550 (+)NCBI
Celera1823,559,225 - 23,623,916 (+)NCBICelera
Cytogenetic Map18p12NCBI
MAP3K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,298,668 - 127,388,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,298,668 - 127,388,465 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,056,244 - 128,146,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,778,609 - 127,817,240 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,780,007 - 127,817,035NCBI
Celera2121,373,314 - 121,412,005 (-)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,363,448 - 120,407,794 (-)NCBIHuRef
CHM1_12128,060,819 - 128,105,372 (-)NCBICHM1_1
T2T-CHM13v2.02127,733,893 - 127,823,745 (-)NCBIT2T-CHM13v2.0
Map3k2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,296,142 - 32,369,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,296,142 - 32,369,804 (+)EnsemblGRCm39 Ensembl
GRCm381832,163,089 - 32,236,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,163,089 - 32,236,751 (+)EnsemblGRCm38mm10GRCm38
MGSCv371832,322,743 - 32,396,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,306,212 - 32,371,521 (+)NCBIMGSCv36mm8
Celera1832,644,790 - 32,718,516 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.95NCBI
Map3k2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,136,010 - 3,196,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,135,959 - 3,196,971 (+)NCBIChiLan1.0ChiLan1.0
MAP3K2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,257,665 - 48,347,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,272,647 - 48,362,285 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,889,499 - 32,979,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B127,963,999 - 128,008,773 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B127,972,900 - 128,008,766 (-)Ensemblpanpan1.1panPan2
MAP3K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,210,106 - 23,303,426 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,210,714 - 23,294,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,457,614 - 23,550,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,536,705 - 24,630,042 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,519,123 - 24,622,032 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,240,311 - 23,333,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,434,707 - 23,529,263 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,567,169 - 24,660,474 (+)NCBIUU_Cfam_GSD_1.0
Map3k2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,654,640 - 97,736,974 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,880,468 - 43,958,556 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,880,816 - 43,958,556 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,087,738 - 25,178,060 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,087,479 - 25,184,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,766,719 - 28,864,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,831,265 - 2,921,782 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,831,270 - 2,912,897 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606119,831,765 - 19,921,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,790,080 - 13,877,598 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,790,088 - 13,877,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k2
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:84
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000060996
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat

Markers in Region
RH138636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21823,859,604 - 23,859,745 (+)MAPPERmRatBN7.2
Rnor_6.01825,013,660 - 25,013,800NCBIRnor6.0
Rnor_5.01824,728,903 - 24,729,043UniSTSRnor5.0
RGSC_v3.41824,660,910 - 24,661,050UniSTSRGSC3.4
Celera1823,612,079 - 23,612,219UniSTS
RH 3.4 Map18302.3UniSTS
Cytogenetic Map18p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 8 16 8 1 1 33 14 12 8 1
Low 3 42 33 33 3 33 7 9 41 21 29 3 7
Below cutoff 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000060996   ⟹   ENSRNOP00000057715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1823,807,218 - 23,871,433 (+)Ensembl
Rnor_6.0 Ensembl1824,961,245 - 25,025,897 (+)Ensembl
RefSeq Acc Id: NM_138503   ⟹   NP_612512
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,081,444 - 24,145,651 (+)NCBI
mRatBN7.21823,807,218 - 23,871,433 (+)NCBI
Rnor_6.01824,961,250 - 25,025,488 (+)NCBI
Rnor_5.01824,676,280 - 24,740,723 (+)NCBI
RGSC_v3.41824,606,219 - 24,672,732 (+)RGD
Celera1823,559,225 - 23,623,916 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096559   ⟹   XP_038952487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,122,980 - 24,153,940 (+)NCBI
mRatBN7.21823,848,760 - 23,879,722 (+)NCBI
Protein Sequences
Protein RefSeqs NP_612512 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL93245 (Get FASTA)   NCBI Sequence Viewer  
  EDL76185 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057715
  ENSRNOP00000057715.2
RefSeq Acc Id: NP_612512   ⟸   NM_138503
- UniProtKB: F1M9D0 (UniProtKB/TrEMBL),   A6J2Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057715   ⟸   ENSRNOT00000060996
RefSeq Acc Id: XP_038952487   ⟸   XM_039096559
- Peptide Label: isoform X1
Protein Domains
PB1   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9D0-F1-model_v2 AlphaFold F1M9D0 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700683
Promoter ID:EPDNEW_R11207
Type:initiation region
Name:Map3k2_1
Description:mitogen activated protein kinase kinase kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01824,961,250 - 24,961,310EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620967 AgrOrtholog
BioCyc Gene G2FUF-8039 BioCyc
Ensembl Genes ENSRNOG00000014089 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060996 ENTREZGENE
  ENSRNOT00000060996.4 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  OPR_PB1 UniProtKB/TrEMBL
  PB1_MEKK2/3 UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report rno:171492 UniProtKB/TrEMBL
NCBI Gene 171492 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k2 PhenoGen
PROSITE PB1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014089 RatGTEx
SMART PB1 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A6J2Q3 ENTREZGENE, UniProtKB/TrEMBL
  F1M9D0 ENTREZGENE, UniProtKB/TrEMBL
  Q8R4A9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Map3k2  mitogen activated protein kinase kinase kinase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Map3k2  mitogen activated protein kinase kinase kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation may be induced by FGF-2 724475