Map3k2 (mitogen activated protein kinase kinase kinase 2)

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Gene: Map3k2 (mitogen activated protein kinase kinase kinase 2) Rattus norvegicus

Analyze

Symbol:

Map3k2

Name:

mitogen activated protein kinase kinase kinase 2

RGD ID:

620967

Description:

Exhibits MAP kinase kinase kinase activity. Involved in protein phosphorylation. Localizes to cytosol and nucleus. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

Mekk2; mitogen-activated protein kinase kinase kinase 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	23,807,218 - 23,879,722 (+)	NCBI
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	18	24,680,069 - 24,682,550 (+)	NCBI
Celera	18	23,559,225 - 23,623,916 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

fluoranthene (ISO)

formaldehyde (ISO)

hydrogen peroxide (ISO)

metformin (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

nickel sulfate (ISO)

paclitaxel (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

torcetrapib (ISO)

troglitazone (ISO)

valproic acid (EXP,ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of MAPK activity (NAS)

activation of MAPKK activity (IEA)

cell population proliferation (NAS)

cellular response to mechanical stimulus (ISO)

MAPK cascade (IEA)

positive regulation of transcription, DNA-templated (ISO)

protein phosphorylation (IDA)

Cellular Component

cytosol (IDA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IDA)

Molecular Function

ATP binding (IEA)

MAP kinase kinase kinase activity (IDA)

protein binding (ISO)

protein kinase activity (ISO)

protein kinase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

Erk5 MAPK signaling pathway (ISO)

gonadotropin-releasing hormone signaling pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

the extracellular signal-regulated Raf/Mek/Erk signaling pathway (NAS)

References

References - curated


1.	Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
4.	Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
5.	Lenz G, etal., J Neurochem 2001 May;77(4):1001-9.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Pipeline to import KEGG annotations from KEGG into RGD
9.	Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.

Additional References at PubMed

PMID:14515274	PMID:15001576	PMID:17003042	PMID:17906693	PMID:19593445

Genomics

Comparative Map Data

Map3k2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	23,807,218 - 23,879,722 (+)	NCBI
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	18	24,680,069 - 24,682,550 (+)	NCBI
Celera	18	23,559,225 - 23,623,916 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

MAP3K2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	127,298,730 - 127,388,465 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	2	127,298,668 - 127,388,465 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	127,298,668 - 127,388,465 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	128,056,244 - 128,146,041 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	127,778,609 - 127,817,240 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	127,780,007 - 127,817,035	NCBI
Celera	2	121,373,314 - 121,412,005 (-)	NCBI
Cytogenetic Map	2	q14.3	NCBI
HuRef	2	120,363,448 - 120,407,794 (-)	NCBI		HuRef
CHM1_1	2	128,060,819 - 128,105,372 (-)	NCBI		CHM1_1

Map3k2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	32,296,142 - 32,369,804 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	18	32,296,142 - 32,369,804 (+)	Ensembl
GRCm38	18	32,163,089 - 32,236,751 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	32,163,089 - 32,236,751 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	32,322,743 - 32,396,405 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	18	32,306,212 - 32,371,521 (+)	NCBI			mm8
Celera	18	32,644,790 - 32,718,516 (+)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI

Map3k2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	3,136,010 - 3,196,971 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	3,135,959 - 3,196,971 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	127,963,999 - 128,008,773 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	127,972,900 - 128,008,766 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	32,889,499 - 32,979,077 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MAP3K2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	23,210,106 - 23,303,426 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	23,210,714 - 23,294,586 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	23,457,614 - 23,550,900 (+)	NCBI
ROS_Cfam_1.0	19	24,536,705 - 24,630,042 (+)	NCBI
UMICH_Zoey_3.1	19	23,240,311 - 23,333,600 (+)	NCBI
UNSW_CanFamBas_1.0	19	23,434,707 - 23,529,263 (+)	NCBI
UU_Cfam_GSD_1.0	19	24,567,169 - 24,660,474 (+)	NCBI

Map3k2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	97,654,640 - 97,736,974 (-)	NCBI
SpeTri2.0	NW_004936469	43,880,816 - 43,958,556 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	25,087,738 - 25,178,060 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	25,087,479 - 25,184,106 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	28,766,719 - 28,864,185 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	2,831,265 - 2,921,782 (+)	NCBI
ChlSab1.1 Ensembl	10	2,831,270 - 2,912,897 (+)	Ensembl

Map3k2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624732	13,790,088 - 13,877,641 (-)	NCBI

Position Markers

RH138636

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	23,859,604 - 23,859,745 (+)	MAPPER
Rnor_6.0	18	25,013,660 - 25,013,800	NCBI	Rnor6.0
Rnor_5.0	18	24,728,903 - 24,729,043	UniSTS	Rnor5.0
RGSC_v3.4	18	24,660,910 - 24,661,050	UniSTS	RGSC3.4
Celera	18	23,612,079 - 23,612,219	UniSTS
RH 3.4 Map	18	302.3	UniSTS
Cytogenetic Map	18	p12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25999214	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25999214	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35097280	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	38195967	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	38195967	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	38753381	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3719547	32487870	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4407513	62570466	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5430134	41781619	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14678852	59678852	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	15532963	32704022	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	15532963	32704022	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	15539427	25961165	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15539427	32670473	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	15539427	53861431	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	15539427	61499684	Rat
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15539551	27743236	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	15539551	27743236	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	15539551	27743236	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	15539551	27743236	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	15539551	27743236	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	15539551	27743236	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	15539551	27743236	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	15539671	29530300	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	15539671	61985648	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	15695872	68524999	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	15695872	87080053	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	15695872	87080053	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	19031030	68436105	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	19251717	32670473	Rat
1331735	Rf44	Renal function QTL 44	2.981		total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	19251717	32670473	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	20285758	87080053	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	21639491	66639491	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	22603736	87074531	Rat
6903353	Bp353	Blood pressure QTL 353	2.8		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	22604764	61985648	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	23184227	53861431	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	84
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000060996
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			24	8	16	8	1	1	33	14	12	8	1
Low	3	42	33	33	3	33	7	9	41	21	29	3	7
Below cutoff		1						1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC126902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF487544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000060996 ⟹ ENSRNOP00000057715

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl

RefSeq Acc Id:

NM_138503 ⟹ NP_612512

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	23,807,218 - 23,871,433 (+)	NCBI
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	RGD
Celera	18	23,559,225 - 23,623,916 (+)	RGD

Sequence:

show sequence

AGACATCACGGGTCTGTGTGTAGTGGCGGCCCGGCTGTCCTCAGCCGCATCGCCTGGCGAGGGT
GGCGCGGCGTTCCTGGGTTGCGGGACCGGCGACAAAGAGGACCGACAGAGAACGATCTGGTCGC
AGAGTCGCCGCTTCCGCTTAGCTGCTTCTCCGGTCACCCGCGACGCGGGCCCGGGGCTTCCTCC
TCGTCGGCCCAGTTTACTCGGCGGGCCCCGGGGCTGCATCTACCCAGAAGCAGCGAAGAGGCCC
CGGGCTGCGCGCCCGCTGTCCCATGTGAAGCAGGTTGGGCCTGGTTTCTGCTGCGGCCCTTCAG
GCCTCGGGGACCCCGCGAGGCGCTGCTCCTGGGGGGCGCGGTGACAGGCCGTGCGGGGGCGGAG
GGGTCAGCTCCGTGGCCTCCTCTCGGCCCTCCGCTCCACGATCCCCGCCCAGAGGCCGGGCAAT
AAAGAATGTTGATGGGAGAACTGTTTTCCTAATTTTAAAATTATTGAGCTGGACGCCATAATGG
ATGATCAGCAAGCTTTGAATTCAATCATGCAAGATTTGGCTGTCCTTCATAAGGCCAGTCGGCC
AGCATTATCTTTACAAGAAACCAGAAAAGCAAAACCCTCTTCACCAAAAAAACAGAATGATGTC
CGAGTCAAATTTGAACATAGAGGAGAAAAAAGAATCTTGCAGGTTACTAGACCAGTTAAACTAG
AAGATCTGAGGTCTAAGTCTAAAATTGCCTTTGGACAGTCTATGGATCTACACTATACCAACAA
CGAGTTGGTAATTCCGTTAACTACCCAAGATGACTTGGACAAAGCTGTGGAACTGCTGGATCGC
AGTATCCACATGAAGAGTCTCAAGATATTACTTGTTCTAAATGGGAGTACACAGGCTACTAATT
TAGAGCCGTCACCATCACCAGACGATCTGAATAATACACCACTCGGTGCGGAGAGGAAAAAGCG
GCTATCTGTAGTAGGTCCCCCTAATAGGGATAGAAGTTCTCCACCCCCAGGATACATTCCAGAT
GAACTGCACCAGATTGCCCGGAACGGGTCTTTCACCAGCATCAACAGTGAAGGAGAGTTCATCC
CAGAGAGCATGGACCAAATGCTGGATCCACTGTCTTTAAGCAGCCCTGAAAACTCTGGCTCAGG
AAGCTGCCCGTCACTGGATAGTCCTTTGGATGGAGAAAGCTACCCAAAATCACGGATGCCTAGG
GCACAGAGCTACCCAGATAATCATCAGGAGTTTTCAGACTATGATAACCCCATTTTTGAGAAAT
TTGGAAAAGGAGGAACATATCCAAGAAGGTATCATGTTTCATACCATCATCAAGAGTATAATGA
TGGTCGGAAGACTTTTCCAAGAGCCAGAAGGACCCAGGGCACCAGTTTCCGGTCTCCTGTGAGT
TTCAGTCCTACTGATCACTCCTTAAGCACTAGTAGTGGGAGCAGCATCTTTACCCCAGAGTATG
AAGACAGTCGGATAAGAAGACGGGGGAGTGACATAGACAATCCTACTTTGACTGTCACAGACAT
CAGCCCACCCAGCCGTTCACCTCGAGCTCCAACCAACTGGAGATTGGGCAAACTGCTTGGCCAA
GGAGCTTTTGGAAGGGTCTACCTCTGTTATGATGTTGATACCGGACGAGAACTGGCTGTTAAAC
AAGTTCAGTTTAACCCTGACAGCCCCGAGACCAGCAAGGAAGTAAATGCACTTGAGTGTGAAAT
TCAGTTGTTGAAAAACTTGTTGCATGAGCGAATTGTTCAGTATTATGGCTGTCTGAGGGATCCT
CAGGAGAAAACACTTTCCATCTTTATGGAGTACATGCCAGGGGGCTCAATTAAGGACCAACTCA
AAGCATATGGAGCCCTTACTGAGAATGTGACGAGGAAATACACCCGTCAGATTCTGGAGGGGGT
CCATTACCTGCATAGTAATATGATTGTCCATAGAGACATCAAAGGAGCGAATATCTTAAGGGAT
TCCACGGGCAATATCAAGCTAGGAGACTTTGGAGCTAGCAAACGACTTCAGACCATCTGTCTCT
CAGGCACAGGGATGAAGTCTGTCACAGGCACGCCATATTGGATGAGTCCTGAGGTCATTAGTGG
AGAAGGCTATGGCAGAAAAGCAGATATCTGGAGCGTAGCATGTACGGTGGTGGAGATGCTAACT
GAAAAGCCACCTTGGGCTGAATTTGAAGCAATGGCTGCCATCTTTAAGATCGCCACTCAGCCAA
CAAACCCAAAGCTGCCACCTCATGTCTCAGACTATACTCGGGACTTTCTCAAACGGATTTTTGT
AGAGGCCAAACTCCGACCTTCAGCCGAGGAGCTCCTGCGGCACCTGTTCGTGCATTGCCACTAG
CAGCCAGCGTCCTCCACCCGCCCGCCGCCACCGCCACCTTCTCTCTTACTGCACTTTCCTTTTT
TATAAAAAGAGAGATGGGGAGAAAAAGACAAGAGGGAAAAATATTTCTCTTGATTCTTGGTTAA
ATTTGTTTAATAATAATAGTAAACTAAA

hide sequence

RefSeq Acc Id:

XM_039096559 ⟹ XP_038952487

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	23,848,760 - 23,879,722 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_612512	(Get FASTA)	NCBI Sequence Viewer
	XP_038952487	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL93245	(Get FASTA)	NCBI Sequence Viewer
	EDL76185	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_612512 ⟸ NM_138503

- UniProtKB:

F1M9D0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVK
LEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVLNGSTQAT
NLEPSPSPDDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEF
IPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFE
KFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPE
YEDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAV
KQVQFNPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQ
LKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTIC
LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ
PTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH

hide sequence

RefSeq Acc Id:

ENSRNOP00000057715 ⟸ ENSRNOT00000060996

RefSeq Acc Id:	XP_038952487 ⟸ XM_039096559
- Peptide Label:	isoform X1

Protein Domains

PB1 Protein kinase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700683

Promoter ID:

EPDNEW_R11207

Type:

initiation region

Name:

Map3k2_1

Description:

mitogen activated protein kinase kinase kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	24,961,250 - 24,961,310	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
18	24714219	24714220	C	G	snv	BUF/MNa (KyushuU)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620967	AgrOrtholog
Ensembl Genes	ENSRNOG00000014089	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000057715	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060996	ENTREZGENE, UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	OPR_PB1	UniProtKB/TrEMBL
	PB1_MEKK2/3	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
KEGG Report	rno:171492	UniProtKB/TrEMBL
NCBI Gene	171492	ENTREZGENE
Pfam	PB1	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PhenoGen	Map3k2	PhenoGen
PROSITE	PB1	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
SMART	PB1	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	F1M9D0	ENTREZGENE, UniProtKB/TrEMBL
	Q8R4A9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Map3k2	mitogen activated protein kinase kinase kinase 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Map3k2	mitogen activated protein kinase kinase kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	may be induced by FGF-2	724475

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)