Egr1 (early growth response 1) - Rat Genome Database

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Gene: Egr1 (early growth response 1) Rattus norvegicus
Symbol: Egr1
Name: early growth response 1
RGD ID: 2544
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to organonitrogen compound; and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Biomarker of several diseases, including lung disease (multiple); middle cerebral artery infarction; pancreatitis; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1); PARTICIPATES IN long term potentiation; prion disease pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: early growth response protein 1; EGR-1; Krox-24; Nerve growth factor-induced gene; nerve growth factor-induced protein A; Ngf1; Ngfi; NGFI-A; transcription factor Zif268; zif-268; zinc finger protein Krox-24
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
Brain Hypoxia-Ischemia  (IEP)
brain ischemia  (ISO)
breast cancer  (IEP,ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine dependence  (IEP)
Cocaine-Related Disorders  (IEP,ISO)
congenital hypothyroidism  (IEP)
Decompression Sickness  (IEP)
Drug-Induced Dyskinesia  (IEP)
duodenal ulcer  (ISO)
endometriosis  (IEP)
epilepsy  (ISO)
Experimental Melanoma  (ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Hypoxia  (IDA)
fibrosarcoma  (ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (IMP)
Heart Block  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hypoxia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Intimal Hyperplasia  (IMP)
intrahepatic cholestasis  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (IEP)
lung disease  (IEP,ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP,IMP)
Memory Disorders  (IEP)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IEP)
morphine withdrawal syndrome  (IEP)
myelodysplastic syndrome  (ISS)
myeloid neoplasm  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
pancreatitis  (IEP)
Perennial Allergic Rhinitis  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (ISO)
Reperfusion Injury  (IEP,ISO)
silicosis  (IEP)
Spinal Cord Compression  (IEP)
squamous cell carcinoma  (ISO)
STING-associated vasculopathy with onset in infancy  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Tendon Injuries  (IDA)
Tissue Adhesions  (IEP)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-cyanoalanine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aripiprazole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
atropine  (EXP)
Aurin  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (EXP)
betamethasone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (EXP)
carrageenan  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlornitrofen  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-cycloserine  (EXP)
D-glucose  (ISO)
D-penicillamine  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
digoxin  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
estriol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Ethylenethiourea  (EXP,ISO)
eticlopride(1+)  (EXP)
eugenol  (ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glycine betaine  (EXP,ISO)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
juglone  (ISO)
kainic acid  (EXP,ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lanthanum atom  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP,ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
morphine  (EXP,ISO)
Muraglitazar  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naltrexone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxazepam  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
potassium cyanide  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propranolol  (EXP)
protein kinase inhibitor  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinpirole  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
razoxane  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
risperidone  (EXP)
ropinirole  (EXP)
rotenone  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sanguinarine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SKF 38393  (EXP)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium azide  (EXP)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium tungstate  (EXP)
Soman  (EXP)
styrene  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triton X-100  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vancomycin  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
xanomeline  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc molecular entity  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to gamma radiation  (IEA,ISO)
cellular response to gonadotropin stimulus  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heparin  (IDA)
cellular response to hyperoxia  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-8  (IEA,ISO,ISS)
cellular response to isoquinoline alkaloid  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to mycophenolic acid  (IDA)
cellular response to organic substance  (ISO)
cellular response to steroid hormone stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
circadian regulation of gene expression  (IEA,ISO,ISS)
circadian rhythm  (IEP)
circadian temperature homeostasis  (IEA,ISO,ISS)
estrous cycle  (IEA,ISO,ISS)
glomerular mesangial cell proliferation  (IMP)
interleukin-1-mediated signaling pathway  (IEA,ISO)
learning or memory  (IEP,IMP)
locomotor rhythm  (IEA,ISO,ISS)
long-term memory  (IMP)
long-term synaptic potentiation  (IEP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (IEP)
positive regulation of chemokine production  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (IEA,ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (IMP)
positive regulation of hormone biosynthetic process  (IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of post-translational protein modification  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IC,IDA,IEA,IMP,ISO)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of neuron apoptotic process  (IGI)
regulation of progesterone biosynthetic process  (IEA,ISO,ISS)
regulation of protein sumoylation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to amphetamine  (IEP)
response to carbon monoxide  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to follicle-stimulating hormone  (IEP)
response to glucose  (IEA,ISO)
response to gonadotropin  (IEP)
response to hypoxia  (IEA,ISO,ISS)
response to insulin  (IEA,ISO)
response to ischemia  (IDA,IEA,ISO)
response to morphine  (IEP)
response to norepinephrine  (IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (IEP)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IDA,IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
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110. Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling. Van Rheen Z, etal., Am J Respir Cell Mol Biol. 2011 Apr;44(4):500-8. Epub 2010 Jun 10.
111. Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage. Wang FL, etal., Osteoarthritis Cartilage. 2000 May;8(3):161-9.
112. Early levothyroxine treatment on maternal subclinical hypothyroidism improves spatial learning of offspring in rats. Wang S, etal., J Neuroendocrinol. 2012 May;24(5):841-8. doi: 10.1111/j.1365-2826.2011.02275.x.
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115. Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Williams JM, etal., Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.
116. Ischemic postconditioning downregulates Egr-1 expression and attenuates postischemic pulmonary inflammatory cytokine release and tissue injury in rats. Wu H, etal., J Surg Res. 2013 May;181(2):204-12. doi: 10.1016/j.jss.2012.07.031. Epub 2012 Jul 31.
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118. Egr-1 transactivates bim gene expression to promote neuronal apoptosis. Xie B, etal., J Neurosci. 2011 Mar 30;31(13):5032-44.
119. Impact of prolonged cold preservation on the graft function and gene expression levels in an experimental lung transplantation model. Yoshida O, etal., Surg Today. 2013 Jan;43(1):81-7. doi: 10.1007/s00595-012-0234-5. Epub 2012 Jun 27.
120. Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene. Yoshino M, etal., Biol Reprod 2002 Jun;66(6):1813-9.
121. Expression of Egr-1 in late stage emphysema. Zhang W, etal., Am J Pathol. 2000 Oct;157(4):1311-20.
122. N-n-butyl haloperidol iodide protects cardiac microvascular endothelial cells from hypoxia/reoxygenation injury by down-regulating Egr-1 expression. Zhou Y, etal., Cell Physiol Biochem. 2010;26(6):839-48. Epub 2011 Jan 4.
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PMID:16926376   PMID:17015857   PMID:17202132   PMID:17497096   PMID:17671844   PMID:17698419   PMID:17762190   PMID:17822405   PMID:17900634   PMID:17917080   PMID:17952413   PMID:18093743  
PMID:18247371   PMID:18281035   PMID:18323529   PMID:18364083   PMID:18385988   PMID:18485334   PMID:18550051   PMID:18555615   PMID:18571897   PMID:18587494   PMID:18606818   PMID:18612190  
PMID:18717731   PMID:18718911   PMID:19057511   PMID:19088446   PMID:19144181   PMID:19171159   PMID:19249349   PMID:19270309   PMID:19307576   PMID:19419424   PMID:19464153   PMID:19505043  
PMID:19681663   PMID:19710510   PMID:19721135   PMID:19723547   PMID:19769948   PMID:19835936   PMID:19847159   PMID:19910692   PMID:20018936   PMID:20025889   PMID:20363028   PMID:20417179  
PMID:20457228   PMID:20534729   PMID:20535567   PMID:20546710   PMID:20592749   PMID:20615913   PMID:20651841   PMID:20654701   PMID:20921194   PMID:21141532   PMID:21187408   PMID:21357543  
PMID:21368226   PMID:21507338   PMID:21559360   PMID:21624330   PMID:21737703   PMID:21777515   PMID:22056598   PMID:22143198   PMID:22147266   PMID:22390138   PMID:22431737   PMID:22488213  
PMID:22577133   PMID:22593050   PMID:22597533   PMID:22826348   PMID:23181383   PMID:23277542   PMID:23373701   PMID:23435960   PMID:23460384   PMID:23632436   PMID:23660497   PMID:23763269  
PMID:23873727   PMID:23973447   PMID:24028087   PMID:24244514   PMID:24365880   PMID:24534707   PMID:24613747   PMID:24704997   PMID:24976583   PMID:25028387   PMID:25139489   PMID:25201174  
PMID:25239865   PMID:25249385   PMID:25258363   PMID:25258388   PMID:26238574   PMID:26279418   PMID:26282370   PMID:26471974   PMID:26546817   PMID:26547966   PMID:26778782   PMID:26972614  
PMID:27057945   PMID:27078100   PMID:27190312   PMID:27233617   PMID:27576688   PMID:27697743   PMID:27816701   PMID:28076410   PMID:28105751   PMID:28125090   PMID:28187447   PMID:28266660  
PMID:28391399   PMID:28460186   PMID:28673338   PMID:28736133   PMID:28814471   PMID:28862251   PMID:28866293   PMID:29138967   PMID:29355377   PMID:29452227   PMID:29481791   PMID:30024615  
PMID:30050950   PMID:30346189   PMID:30887692   PMID:31131895   PMID:31539105   PMID:31605697   PMID:31719567   PMID:32172399   PMID:32705196   PMID:32731408   PMID:32879888   PMID:32971090  
PMID:33183026   PMID:33600884   PMID:35469366   PMID:36527644   PMID:36759943   PMID:38324049  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)EnsemblGRCm39 Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBIMGSCv36mm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24133,740,921 - 133,744,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,880,479 - 131,884,306 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,625,892 - 7,629,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,140,065 - 41,142,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474331,247,516 - 31,252,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Egr1
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:116
Interacting mature miRNAs:147
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report