Egr1 (early growth response 1) - Rat Genome Database

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Gene: Egr1 (early growth response 1) Rattus norvegicus
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Symbol: Egr1
Name: early growth response 1
RGD ID: 2544
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of synaptic plasticity; and response to isoquinoline alkaloid. Located in cytoplasm and nucleus. Biomarker of several diseases, including cocaine dependence; lung disease (multiple); middle cerebral artery infarction; pancreatitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1); PARTICIPATES IN long term potentiation; prion disease pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: early growth response protein 1; EGR-1; Krox-24; Nerve growth factor-induced gene; nerve growth factor-induced protein A; Ngf1; Ngfi; NGFI-A; transcription factor Zif268; zif-268; zinc finger protein Krox-24
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
Brain Hypoxia-Ischemia  (IEP)
brain ischemia  (ISO)
breast cancer  (IEP,ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine dependence  (IEP)
Cocaine-Related Disorders  (IEP,ISO)
congenital hypothyroidism  (IEP)
Decompression Sickness  (IEP)
Drug-Induced Dyskinesia  (IEP)
duodenal ulcer  (ISO)
endometriosis  (IEP)
Experimental Melanoma  (ISO)
Experimental Seizures  (IEP,ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Hypoxia  (IDA)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (IMP)
Heart Block  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hypoxia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Intimal Hyperplasia  (IMP)
intrahepatic cholestasis  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (IEP)
lung disease  (IEP,ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP,IMP)
Memory Disorders  (IEP)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IEP)
morphine withdrawal syndrome  (IEP)
myelodysplastic syndrome  (ISS)
myeloid neoplasm  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
pancreatitis  (IEP)
Perennial Allergic Rhinitis  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (ISO)
Reperfusion Injury  (IEP,ISO)
silicosis  (IEP)
Spinal Cord Compression  (IEP)
squamous cell carcinoma  (ISO)
STING-associated vasculopathy with onset in infancy  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Tendon Injuries  (IDA)
Tissue Adhesions  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
13-HPODE  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-cyanoalanine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzhydrazide  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aripiprazole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
ATP  (EXP)
atrazine  (EXP)
atropine  (EXP)
Aurin  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
betamethasone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
carbachol  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (EXP)
carrageenan  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlornitrofen  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-cycloserine  (EXP)
D-glucose  (ISO)
D-penicillamine  (EXP,ISO)
DDT  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
digoxin  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
estriol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Ethylenethiourea  (EXP,ISO)
eticlopride(1+)  (EXP)
eugenol  (ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallium nitrate  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glycine betaine  (EXP,ISO)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
juglone  (ISO)
kainic acid  (EXP,ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lanthanum atom  (EXP)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP,ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
morphine  (EXP,ISO)
Muraglitazar  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naltrexone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orotic acid  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxazepam  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
potassium cyanide  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propiconazole  (ISO)
propranolol  (EXP)
propylparaben  (ISO)
protein kinase inhibitor  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinpirole  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
razoxane  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
risperidone  (EXP)
ropinirole  (EXP)
rotenone  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sanguinarine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SKF 38393  (EXP)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium azide  (EXP)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium tungstate  (EXP)
Soman  (EXP)
styrene  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triton X-100  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tungsten  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vancomycin  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
xanomeline  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc molecular entity  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to gamma radiation  (IEA,ISO)
cellular response to gonadotropin stimulus  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heparin  (IDA)
cellular response to hyperoxia  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-8  (IEA,ISO,ISS)
cellular response to isoquinoline alkaloid  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to mycophenolic acid  (IDA)
cellular response to steroid hormone stimulus  (IEP)
cellular response to xenobiotic stimulus  (IEP)
circadian regulation of gene expression  (IEA,ISO,ISS)
circadian rhythm  (IEP)
circadian temperature homeostasis  (IEA,ISO,ISS)
estrous cycle  (IEA,ISO,ISS)
glomerular mesangial cell proliferation  (IMP)
interleukin-1-mediated signaling pathway  (IEA,ISO)
learning or memory  (IEP,IMP)
locomotor rhythm  (IEA,ISO,ISS)
long-term memory  (IMP)
long-term synaptic potentiation  (IEP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (IEP)
positive regulation of chemokine production  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (IEA,ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (IMP)
positive regulation of hormone biosynthetic process  (IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of post-translational protein modification  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IC,IDA,IEA,IMP,ISO)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of neuron apoptotic process  (IGI)
regulation of progesterone biosynthetic process  (IEA,ISO,ISS)
regulation of protein sumoylation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to amphetamine  (IEP)
response to carbon monoxide  (IEP)
response to cocaine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEP)
response to follicle-stimulating hormone  (IEP)
response to glucose  (IEA,ISO)
response to gonadotropin  (IEP)
response to hypoxia  (IEA,ISO,ISS)
response to insulin  (IEA,ISO)
response to ischemia  (IDA,IEA,ISO)
response to morphine  (IEP)
response to norepinephrine  (IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (IEP)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IDA,IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
3. Egr1 expression is induced following glatiramer acetate immunotherapy in rodent models of glaucoma and Alzheimer's disease. Bakalash S, etal., Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9033-46. doi: 10.1167/iovs.11-7498.
4. Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. Berasi SP, etal., J Biol Chem. 2006 Sep 15;281(37):27167-77. Epub 2006 Jul 18.
5. Progressive pulmonary sarcoidosis--a fibroproliferative process potentially triggered by EGR-1 and IL-6. Bihl MP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar;23(1):38-50.
6. Carbon monoxide orchestrates a protective response through PPARgamma. Bilban M, etal., Immunity. 2006 May;24(5):601-10.
7. Elevated peritoneal fluid TNF-alpha incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis. Birt JA, etal., Reprod Sci. 2013 May;20(5):514-23. doi: 10.1177/1933719113477479. Epub 2013 Feb 20.
8. Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. Bisler S, etal., J Chem Neuroanat 2002 Mar;23(3):187-98.
9. Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion. Bonventre JV, etal., Cell Regul. 1991 Mar;2(3):251-60.
10. Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF). Boon K, etal., PLoS One. 2009;4(4):e5134. Epub 2009 Apr 6.
11. Expression of nuclear proto-oncogenes in isoproterenol-induced cardiac hypertrophy. Brand T, etal., J Mol Cell Cardiol. 1993 Nov;25(11):1325-37.
12. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Buitrago M, etal., Nat Med. 2005 Aug;11(8):837-44. Epub 2005 Jul 17.
13. Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice. Caso G, etal., J Hematol Oncol. 2009 Feb 7;2:7.
14. High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. Chan IH, etal., Clin Chim Acta. 2010 Jan;411(1-2):67-71. Epub 2009 Oct 12.
15. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children. Chan IH, etal., Pediatr Allergy Immunol. 2009 Mar;20(2):142-50. Epub 2008 May 28.
16. EGR-1 regulates Ho-1 expression induced by cigarette smoke. Chen H, etal., Biochem Biophys Res Commun. 2010 May 28;396(2):388-93. doi: 10.1016/j.bbrc.2010.04.102. Epub 2010 Apr 22.
17. Promoter methylation of Egr-1 site contributes to fetal hypoxia-mediated PKCepsilon gene repression in the developing heart. Chen M, etal., Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R683-9. doi: 10.1152/ajpregu.00461.2012. Epub 2013 Feb 20.
18. Dietary fructooligosaccharides and wheat bran elicit specific and dose-dependent gene expression profiles in the proximal colon epithelia of healthy Fischer 344 rats. Chen Q, etal., J Nutr. 2011 May;141(5):790-7. Epub 2011 Mar 23.
19. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. Chen ZH, etal., PLoS One. 2008 Oct 2;3(10):e3316.
20. Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory. Cheval H, etal., Hippocampus. 2011 Mar 18. doi: 10.1002/hipo.20926.
21. [Expression and role of early growth response gene-1 in experimental silicosis of rat]. Chu L, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):47-50.
22. Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells. Copland IB and Post M, J Cell Physiol. 2007 Jan;210(1):133-43.
23. Early changes in lung gene expression due to high tidal volume. Copland IB, etal., Am J Respir Crit Care Med. 2003 Nov 1;168(9):1051-9. Epub 2003 Jun 19.
24. Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation. Creed MC, etal., Eur Neuropsychopharmacol. 2012 Jul;22(7):506-17. doi: 10.1016/j.euroneu