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High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults.

Authors: Chan, IH  Lee, DL  Ho, OY  Wong, EW  Lam, YY  Tang, NL  Chan, MH  Abdullah, VJ  Wong, CK  Lam, CW 
Citation: Chan IH, etal., Clin Chim Acta. 2010 Jan;411(1-2):67-71. Epub 2009 Oct 12.
Pubmed: (View Article at PubMed) PMID:19833116
DOI: Full-text: DOI:10.1016/j.cca.2009.10.005

BACKGROUND: Early growth response-1 (Egr-1) is expressed in human airways and its polymorphisms have been associated with total IgE and atopy in asthmatic patients. We investigated the effects of Chinese-tagging single nucleotide polymorphism (SNP) of Egr-1 and its mRNA expression on allergic rhinitis (AR) traits. METHODS: Among 214 Chinese AR adults and 259 controls, tag SNP -4071 A-->G was genotyped and mRNA expression in peripheral blood was quantified by real-time PCR. RESULTS: Egr-1 mRNA expression was significantly higher in patients than controls (median of 0.23 vs 0.15 fold GAPDH expression; p<0.001). Its expression was not associated with -4071 polymorphism. However, significant correlations were found between -4071 A-->G with increased plasma total IgE (p=0.028) and atopy (p=0.030) in patients. Logistic regression confirmed the association (p=0.034) with age and gender adjusted. Patients homozygous for the A allele had a 2.3-fold and 1.9-fold risks, respectively of having increased plasma total IgE and atopy than those G allele carriers. CONCLUSIONS: We showed high levels of Egr-1 mRNA expression and demonstrated a significant association of polymorphism with increased plasma total IgE and atopy in AR patients. It may be useful to explore the pharmacogenetics of Egr-1 inhibitors.


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RGD Object Information
RGD ID: 5131984
Created: 2011-05-17
Species: All species
Last Modified: 2011-05-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.