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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of EGR1 mRNAPMID:29223816
Egr1affects expressionISOEGR1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of EGR1 mRNAPMID:12749819
Egr1affects methylationISOEGR1 (Homo sapiens)6480464CTDArsenic Trioxide affects the methylation of EGR1 promoterPMID:26046465
Egr1decreases expressionISOEGR1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of EGR1 mRNAPMID:20458559 PMID:22521957 PMID:22535156
Egr1increases expressionISOEgr1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of EGR1 mRNAPMID:15073043 PMID:15688020
Egr1increases expressionISOEGR1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of EGR1 mRNAPMID:25258189
Egr1multiple interactionsISOEgr1 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of EGR1 mRNA]; Tretinoin promotes the reaction [Arsenic Trioxide results in increased expression of EGR1 mRNA]PMID:15688020
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTD[Zidovudine co-treated with Arsenic Trioxide] results in increased expression of EGR1 mRNAPMID:29910624
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