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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:91272
Term: 13-HPODE
Definition: An HPODE (hydroperoxyoctadecadienoic acid) in which the double bonds are at positions 9 and 11 (E and Z geometry, respectively) and the hydroperoxy group is at position 13.
Chemical ID: MESH:C038649
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1multiple interactionsEXP 6480464CTD[13-hydroperoxy-9, 11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA, [13-hydroperoxy-9, 11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein, [13-hydroperoxy-9, 11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA, [13-hydroperoxy-9, 11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein

PMID:22135674
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.