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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1increases expressionEXP 6480464CTDGenistein results in increased expression of EGR1 mRNAPMID:12075121
Egr1decreases expressionISOEGR1 (Homo sapiens)6480464CTDGenistein results in decreased expression of EGR1 mRNAPMID:22228119
Egr1increases expressionISOEGR1 (Homo sapiens)6480464CTDGenistein results in increased expression of EGR1 mRNAPMID:15257099 PMID:23019147 PMID:26865667
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