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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2544
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1multiple interactionsISOEgr1 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EGR1 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EGR1 genePMID:20938992 PMID:22206623 PMID:33549593
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTD[Folic Acid co-treated with Arsenic] affects the expression of EGR1 mRNA; Folic Acid inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]PMID:35490796
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