RGD Reference Report - Stress biomarkers in a rat model of decompression sickness. - Rat Genome Database

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Stress biomarkers in a rat model of decompression sickness.

Authors: Montcalm-Smith, E  Caviness, J  Chen, Y  McCarron, RM 
Citation: Montcalm-Smith E, etal., Aviat Space Environ Med. 2007 Feb;78(2):87-93.
RGD ID: 5131894
Pubmed: PMID:17310878   (View Abstract at PubMed)

INTRODUCTION: Immune reactivity, stress responses, and inflammatory reactions may all contribute to pathogenic mechanisms associated with decompression sickness (DCS). Currently, there are no biomarkers for DCS. This research examined if DCS is associated with increased levels of biomarkers associated with vascular function, early/non-specific stress responses, and hypothalamic-pituitary-adrenal (HPA) axis stress responses. METHODS: Rats undergoing a test dive to 175 ft of seawater (fsw) (6.2 ATA) for 60 min with a rapid decompression were observed for DCS (ambulatory deficit). Animals exercised on a rotating cage (approximately 3 m x min(-1)) throughout the dive and subsequent 30-min observation period. All animals were euthanized and blood and tissue samples (brain, liver, lung) were collected for analysis of CRP and ET-1 by ELISA and stress markers by PCR. RESULTS: HO-1 and HSP-70 increased in the brain, and HO-1, Egr-1, and iNOS increased in the lungs of animals with DCS. There was no difference in any stress marker in the liver, or in serum levels of CRP or ET-1. CONCLUSIONS: The results demonstrate that < 30 min after surfacing, there are genomic changes in animals with DCS compared with animals not showing signs of DCS. Identification of specific markers of DCS may permit use of such biomarkers as predictors of DCS susceptibility and/or occurrence.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Decompression Sickness  ISOEgr1 (Rattus norvegicus)5131894; 5131894mRNA:increased expression:lungs (rat)RGD 
Decompression Sickness  IEP 5131894mRNA:increased expression:lungs (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egr1  (early growth response 1)

Genes (Mus musculus)
Egr1  (early growth response 1)

Genes (Homo sapiens)
EGR1  (early growth response 1)


Additional Information