EGR1 (early growth response 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: EGR1 (early growth response 1) Homo sapiens
Analyze
Symbol: EGR1
Name: early growth response 1
RGD ID: 737111
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding activity; and histone acetyltransferase binding activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and regulation of protein sumoylation. Located in cytoplasm and nucleoplasm. Is active in chromatin. Implicated in asthma. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; zinc finger gene 225; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (IEP,ISO)
aortic valve stenosis  (IEP)
arteriosclerosis  (IEP,ISO)
asthma  (IAGP,IEP,ISO)
autoimmune disease  (EXP)
autosomal dominant non-syndromic intellectual disability 31  (IAGP)
autosomal dominant nonsyndromic deafness 1  (IAGP)
brain ischemia  (EXP)
breast cancer  (IEP,ISO)
bronchiolo-alveolar adenocarcinoma  (IEP)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (EXP)
cholestasis  (EXP)
chronic obstructive pulmonary disease  (IEP,ISO)
Cocaine-Related Disorders  (EXP,ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Melanoma  (ISO)
familial adenomatous polyposis 1  (IAGP)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (EXP)
Hereditary Neoplastic Syndromes  (IAGP)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (EXP)
Hypoxia  (EXP)
Hypoxia-Ischemia, Brain  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (EXP)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (EXP)
ischemia  (EXP)
juvenile rheumatoid arthritis  (EXP)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (EXP)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISS)
myeloid neoplasm  (ISO)
Nasal Polyps  (IEP)
Neurodevelopmental Disorders  (IAGP)
osteoarthritis  (IEP)
osteosarcoma  (IEP)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (IAGP)
pneumonia  (EXP)
Prostatic Neoplasms  (EXP)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (IEP)
Reperfusion Injury  (EXP,ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (IEP)
T-Cell Lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20R)-protopanaxadiol  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
13-HPODE  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
22-Hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-cyanoalanine  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP,ISO)
aripiprazole  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
Aurin  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
bazedoxifene  (EXP)
benzalkonium chloride  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (ISO)
betamethasone  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butanal  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
camostat  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carbonyl sulfide  (ISO)
carrageenan  (EXP)
cefaloridine  (ISO)
chenodeoxycholic acid  (ISO)
chlornitrofen  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP,ISO)
DDT  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
desipramine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (EXP,ISO)
doramapimod  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enniatin  (EXP)
Enterolactone  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
eugenol  (ISO)
fenpyroximate  (EXP)
ferric oxide  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isobutanol  (EXP)
isoprenaline  (ISO)
juglone  (EXP)
kainic acid  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
manganese(II) chloride  (ISO)
MeIQx  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naltrexone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (ISO)
Norbinaltorphimine  (ISO)
NS-398  (EXP)
O-acetyl-L-carnitine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxazepam  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenanthrene  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
poly(I:C)  (ISO)
potassium atom  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propranolol  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinpirole  (ISO)
raloxifene  (EXP)
ranitidine  (ISO)
razoxane  (ISO)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rifampicin  (EXP,ISO)
risperidone  (ISO)
ropinirole  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
SKF 38393  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium tungstate  (ISO)
Soman  (ISO)
styrene  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (EXP)
sulprostone  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (ISO)
trans-caffeic acid  (EXP)
tranylcypromine  (ISO)
triacsin C  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
Triton X-100  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vancomycin  (ISO)
vecuronium bromide  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
xanomeline  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc molecular entity  (EXP)
zinc pyrithione  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISS)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IDA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISS)
cellular response to organic substance  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (ISS)
circadian rhythm  (ISO)
circadian temperature homeostasis  (ISS)
estrous cycle  (ISS)
glomerular mesangial cell proliferation  (ISS)
interleukin-1-mediated signaling pathway  (IMP)
learning or memory  (ISO)
locomotor rhythm  (ISS)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell death  (ISO)
positive regulation of chemokine production  (ISS)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISS)
positive regulation of hormone biosynthetic process  (ISS)
positive regulation of interleukin-1 beta production  (ISS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tau-protein kinase activity  (ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of progesterone biosynthetic process  (ISS)
regulation of protein sumoylation  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA,ISO)
regulation of transcription, DNA-templated  (ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (ISS)
response to insulin  (IEA)
response to ischemia  (ISS)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
wound healing  (ISO)

Cellular Component
chromatin  (IDA,ISA)
cytoplasm  (IDA,ISS)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bakalash S, etal., Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9033-46. doi: 10.1167/iovs.11-7498.
2. Bihl MP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar;23(1):38-50.
3. Bilban M, etal., Immunity. 2006 May;24(5):601-10.
4. Birt JA, etal., Reprod Sci. 2013 May;20(5):514-23. doi: 10.1177/1933719113477479. Epub 2013 Feb 20.
5. Boon K, etal., PLoS One. 2009;4(4):e5134. Epub 2009 Apr 6.
6. Buitrago M, etal., Nat Med. 2005 Aug;11(8):837-44. Epub 2005 Jul 17.
7. Caso G, etal., J Hematol Oncol. 2009 Feb 7;2:7.
8. Chan IH, etal., Clin Chim Acta. 2010 Jan;411(1-2):67-71. Epub 2009 Oct 12.
9. Chan IH, etal., Pediatr Allergy Immunol. 2009 Mar;20(2):142-50. Epub 2008 May 28.
10. Chen H, etal., Biochem Biophys Res Commun. 2010 May 28;396(2):388-93. doi: 10.1016/j.bbrc.2010.04.102. Epub 2010 Apr 22.
11. Chen M, etal., Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R683-9. doi: 10.1152/ajpregu.00461.2012. Epub 2013 Feb 20.
12. Chen ZH, etal., PLoS One. 2008 Oct 2;3(10):e3316.
13. Chu L, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):47-50.
14. Copland IB, etal., Am J Respir Crit Care Med. 2003 Nov 1;168(9):1051-9. Epub 2003 Jun 19.
15. Creed MC, etal., Eur Neuropsychopharmacol. 2012 Jul;22(7):506-17. doi: 10.1016/j.euroneuro.2011.11.004. Epub 2011 Dec 7.
16. Densmore VS, etal., Pain. 2010 Oct;151(1):184-93. Epub 2010 Aug 1.
17. Derdak Z, etal., Liver Int. 2012 May;32(5):761-70. doi: 10.1111/j.1478-3231.2012.02752.x. Epub 2012 Jan 31.
18. Dickinson MG, etal., Am J Pathol. 2011 Nov;179(5):2199-209. doi: 10.1016/j.ajpath.2011.07.030. Epub 2011 Sep 13.
19. Ding BS, etal., Am J Respir Crit Care Med. 2009 Aug 1;180(3):247-56. Epub 2009 Apr 2.
20. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
21. Farivar AS, etal., Ann Thorac Surg. 2006 Mar;81(3):1061-7.
22. Ferraro B, etal., J Clin Oncol. 2005 Mar 20;23(9):1921-6.
23. Fritz M, etal., Addict Biol. 2011 Apr;16(2):273-84. doi: 10.1111/j.1369-1600.2010.00285.x. Epub 2011 Feb 11.
24. Gangarossa G, etal., PLoS One. 2011 May 3;6(5):e19415.
25. Gao K, etal., PLoS One. 2009 Jun 11;4(6):e5875.
26. Ghazvini-Boroujerdi M, etal., J Heart Valve Dis. 2004 Nov;13(6):894-903.
27. Gine E, etal., Mol Cell Endocrinol. 2013 Jan 5;365(1):119-28. doi: 10.1016/j.mce.2012.10.004. Epub 2012 Oct 16.
28. GOA_HUMAN data from the GO Consortium
29. Goleva E, etal., J Allergy Clin Immunol. 2008 Sep;122(3):550-9.e3.
30. Gong LB, etal., World J Gastroenterol. 2005 Aug 28;11(32):5022-4.
31. Gubits RM, etal., Brain Res Mol Brain Res. 1993 May;18(3):228-38.
32. Hamada N, etal., J Atheroscler Thromb. 2011 Mar 28;18(3):209-16. Epub 2010 Nov 19.
33. Harada C, etal., Am J Respir Crit Care Med. 2011 Mar 15;183(6):743-51. Epub 2010 Oct 8.
34. Harada H, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L124-30. Epub 2007 Mar 23.
35. Harja E, etal., Circ Res. 2004 Feb 20;94(3):333-9. Epub 2003 Dec 11.
36. Hoetzel A, etal., Am J Respir Crit Care Med. 2008 Jun 1;177(11):1223-32. Epub 2008 Mar 20.
37. Huang RP, etal., Cancer Res. 1995 Nov 1;55(21):5054-62.
38. Huang RP, etal., Int J Cancer. 1997 Jul 3;72(1):102-9.
39. Joslin JM, etal., Blood. 2007 Jul 15;110(2):719-26. Epub 2007 Apr 9.
40. Khomenko T, etal., Dig Dis Sci. 2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
41. Kramer EL, etal., Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25. Epub 2009 Feb 2.
42. Lacoste B, etal., J Neuroinflammation. 2013 May 4;10:57. doi: 10.1186/1742-2094-10-57.
43. Lee SJ, etal., Am J Respir Crit Care Med. 2011 Mar 1;183(5):649-58. Epub 2010 Oct 1.
44. Li CW, etal., Thorax. 2009 Apr;64(4):306-12. Epub 2009 Jan 21.
45. Liu C, etal., Biomed Res Int. 2013;2013:310406. doi: 10.1155/2013/310406. Epub 2013 Mar 17.
46. Lu Y, etal., J Biol Chem. 2011 Apr 13.
47. Matsunoshita Y, etal., PLoS One. 2011 Jan 20;6(1):e16234.
48. McCaffrey TA, etal., J Clin Invest. 2000 Mar;105(5):653-62.
49. McDoniels-Silvers AL, etal., Clin Cancer Res. 2002 Apr;8(4):1127-38.
50. Mengozzi M, etal., Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22. doi: 10.1073/pnas.1200554109. Epub 2012 May 29.
51. Mishra S, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5191-6. Epub 2006 Mar 21.
52. Montcalm-Smith E, etal., Aviat Space Environ Med. 2007 Feb;78(2):87-93.
53. Moreno JL, etal., J Neurosci. 2011 Feb 2;31(5):1863-72.
54. Ngiam N, etal., Am J Respir Crit Care Med. 2010 May 1;181(9):947-56. Epub 2010 Jan 28.
55. Ning W, etal., Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14895-900. Epub 2004 Oct 5.
56. Nozik-Grayck E, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L422-30. Epub 2008 Jul 3.
57. Pipeline to import KEGG annotations from KEGG into RGD
58. Prast JM, etal., Front Behav Neurosci. 2014 Sep 24;8:317. doi: 10.3389/fnbeh.2014.00317. eCollection 2014.
59. Reynolds PR, etal., Am J Respir Cell Mol Biol. 2006 Sep;35(3):314-9. Epub 2006 Apr 6.
60. RGD automated import pipeline for gene-chemical interactions
61. Roy S, etal., World J Surg. 2004 Mar;28(3):316-20. Epub 2004 Feb 17.
62. Royer A, etal., Circulation. 2005 Apr 12;111(14):1738-46. Epub 2005 Apr 4.
63. Rygh LJ, etal., Eur J Neurosci. 2006 Aug;24(3):761-72.
64. Silverman ES, etal., Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):778-85.
65. Spektor BS, etal., Brain Res Mol Brain Res. 2002 Jun 15;102(1-2):118-28.
66. Szyndler J, etal., Pharmacol Rep. 2013;65(2):368-78.
67. van Albada ME, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L483-91. Epub 2009 Dec 18.
68. Van Rheen Z, etal., Am J Respir Cell Mol Biol. 2011 Apr;44(4):500-8. Epub 2010 Jun 10.
69. Wang FL, etal., Osteoarthritis Cartilage. 2000 May;8(3):161-9.
70. Wang S, etal., J Neuroendocrinol. 2012 May;24(5):841-8. doi: 10.1111/j.1365-2826.2011.02275.x.
71. Wang TR, etal., Cardiology. 2013;125(3):192-200. doi: 10.1159/000350364. Epub 2013 Jun 15.
72. Wu H, etal., J Surg Res. 2013 May;181(2):204-12. doi: 10.1016/j.jss.2012.07.031. Epub 2012 Jul 31.
73. Wu M, etal., Am J Pathol. 2009 Sep;175(3):1041-55. Epub 2009 Aug 13.
74. Yoshida O, etal., Surg Today. 2013 Jan;43(1):81-7. doi: 10.1007/s00595-012-0234-5. Epub 2012 Jun 27.
75. Zhang W, etal., Am J Pathol. 2000 Oct;157(4):1311-20.
Additional References at PubMed
PMID:1090709   PMID:1383501   PMID:1411083   PMID:1569051   PMID:1662794   PMID:1702972   PMID:2109185   PMID:2110381   PMID:2377485   PMID:3127059   PMID:3839394   PMID:7624335  
PMID:8662759   PMID:8668170   PMID:9806899   PMID:10049687   PMID:10051405   PMID:10079243   PMID:10082522   PMID:10409428   PMID:10575214   PMID:10671503   PMID:10849212   PMID:11124866  
PMID:11251186   PMID:11278640   PMID:11795984   PMID:11819815   PMID:11830539   PMID:11909874   PMID:11925592   PMID:11956220   PMID:11978801   PMID:12011097   PMID:12065847   PMID:12165491  
PMID:12235180   PMID:12379479   PMID:12384223   PMID:12393577   PMID:12433834   PMID:12439908   PMID:12456801   PMID:12457461   PMID:12470865   PMID:12477932   PMID:12507899   PMID:12517959  
PMID:12543866   PMID:12553019   PMID:12553721   PMID:12560487   PMID:12560508   PMID:12566441   PMID:12569082   PMID:12571843   PMID:12618431   PMID:12637574   PMID:12690110   PMID:12706485  
PMID:12729460   PMID:12840049   PMID:12872165   PMID:12890669   PMID:12947119   PMID:12958075   PMID:14522979   PMID:14662774   PMID:14744935   PMID:14966901   PMID:14979875   PMID:14985468  
PMID:15003938   PMID:15023995   PMID:15155664   PMID:15211096   PMID:15225550   PMID:15231681   PMID:15449318   PMID:15486985   PMID:15489334   PMID:15517593   PMID:15523672   PMID:15545275  
PMID:15611055   PMID:15616591   PMID:15640148   PMID:15689620   PMID:15709168   PMID:15875316   PMID:15910736   PMID:15923644   PMID:15999367   PMID:16007175   PMID:16079301   PMID:16091742  
PMID:16093249   PMID:16260776   PMID:16382041   PMID:16393964   PMID:16464174   PMID:16552541   PMID:16702209   PMID:16741963   PMID:16831524   PMID:16858414   PMID:16995904   PMID:17099140  
PMID:17257596   PMID:17448597   PMID:17494953   PMID:17502875   PMID:17516844   PMID:17559061   PMID:17581316   PMID:17599039   PMID:17631285   PMID:17631291   PMID:17671831   PMID:17932312  
PMID:17967787   PMID:17975260   PMID:17986608   PMID:18027854   PMID:18067864   PMID:18068676   PMID:18088351   PMID:18171299   PMID:18174470   PMID:18204200   PMID:18215136   PMID:18247371  
PMID:18281035   PMID:18281687   PMID:18303024   PMID:18316600   PMID:18324520   PMID:18378044   PMID:18434015   PMID:18434089   PMID:18435749   PMID:18460021   PMID:18469860   PMID:18489490  
PMID:18515748   PMID:18525291   PMID:18583706   PMID:18604866   PMID:18636116   PMID:18675783   PMID:18682391   PMID:18704310   PMID:18711316   PMID:18718911   PMID:18772333   PMID:18780286  
PMID:18989526   PMID:19032775   PMID:19050264   PMID:19057511   PMID:19067769   PMID:19074480   PMID:19074849   PMID:19112164   PMID:19115247   PMID:19131339   PMID:19152168   PMID:19245972  
PMID:19261809   PMID:19274049   PMID:19276347   PMID:19307156   PMID:19307576   PMID:19374776   PMID:19426596   PMID:19432968   PMID:19435811   PMID:19446747   PMID:19467232   PMID:19526316  
PMID:19724854   PMID:19747485   PMID:19765320   PMID:19781349   PMID:19786090   PMID:19822898   PMID:19837667   PMID:19837979   PMID:19878561   PMID:19885607   PMID:19888474   PMID:19913601  
PMID:19915002   PMID:20009530   PMID:20016208   PMID:20018936   PMID:20053757   PMID:20087343   PMID:20121949   PMID:20144677   PMID:20190820   PMID:20204305   PMID:20348948   PMID:20363028  
PMID:20372793   PMID:20398657   PMID:20403028   PMID:20414733   PMID:20448047   PMID:20489156   PMID:20506119   PMID:20507991   PMID:20578042   PMID:20585888   PMID:20621662   PMID:20690147  
PMID:20811575   PMID:20862322   PMID:20864524   PMID:20936779   PMID:20945384   PMID:21118966   PMID:21160498   PMID:21189327   PMID:21212994   PMID:21224049   PMID:21297666   PMID:21321112  
PMID:21325822   PMID:21336263   PMID:21354100   PMID:21354147   PMID:21365018   PMID:21368226   PMID:21419860   PMID:21436631   PMID:21479245   PMID:21506108   PMID:21551235   PMID:21596316  
PMID:21617851   PMID:21688838   PMID:21725089   PMID:21743491   PMID:21743958   PMID:21791614   PMID:21873635   PMID:21931594   PMID:21968973   PMID:21995436   PMID:21998680   PMID:22053691  
PMID:22095683   PMID:22115966   PMID:22127986   PMID:22140445   PMID:22198386   PMID:22199357   PMID:22260630   PMID:22316125   PMID:22344601   PMID:22354777   PMID:22428032   PMID:22431919  
PMID:22433566   PMID:22455954   PMID:22508482   PMID:22531302   PMID:22634339   PMID:22659570   PMID:22713211   PMID:22721276   PMID:22832523   PMID:22912725   PMID:22918686   PMID:23029358  
PMID:23103837   PMID:23121767   PMID:23127556   PMID:23142458   PMID:23152075   PMID:23178451   PMID:23363221   PMID:23373701   PMID:23409769   PMID:23416169   PMID:23433111   PMID:23468057  
PMID:23478574   PMID:23592216   PMID:23632636   PMID:23696025   PMID:23715767   PMID:23717422   PMID:23718776   PMID:23755764   PMID:23802749   PMID:23857582   PMID:23874821   PMID:23945289  
PMID:24001789   PMID:24011795   PMID:24012056   PMID:24076422   PMID:24077187   PMID:24098051   PMID:24106272   PMID:24190424   PMID:24244514   PMID:24297681   PMID:24337575   PMID:24376510  
PMID:24384380   PMID:24410631   PMID:24436125   PMID:24451137   PMID:24603130   PMID:24619556   PMID:24657079   PMID:24704156   PMID:24742676   PMID:24787739   PMID:24819335   PMID:24841508  
PMID:24925061   PMID:24952347   PMID:24990820   PMID:25028509   PMID:25029911   PMID:25031707   PMID:25056061   PMID:25108236   PMID:25192965   PMID:25224321   PMID:25256120   PMID:25258363  
PMID:25486203   PMID:25502753   PMID:25613134   PMID:25613138   PMID:25637490   PMID:25638726   PMID:25645941   PMID:25658856   PMID:25673149   PMID:25710185   PMID:25724735   PMID:25725290  
PMID:25737480   PMID:25740602   PMID:25753664   PMID:25997867   PMID:26011708   PMID:26089202   PMID:26109509   PMID:26113112   PMID:26115646   PMID:26120956   PMID:26134032   PMID:26206332  
PMID:26324943   PMID:26496610   PMID:26498686   PMID:26502071   PMID:26519755   PMID:26538827   PMID:26573109   PMID:26692143   PMID:26720342   PMID:26774383   PMID:26792551   PMID:26917778  
PMID:26922429   PMID:26936374   PMID:26975996   PMID:26984843   PMID:26988763   PMID:27002148   PMID:27072400   PMID:27099350   PMID:27173006   PMID:27244890   PMID:27251707   PMID:27442508  
PMID:27452907   PMID:27569005   PMID:27637333   PMID:27677186   PMID:27834104   PMID:27835650   PMID:27878298   PMID:27933778   PMID:27980400   PMID:28072411   PMID:28077323   PMID:28180113  
PMID:28187447   PMID:28269757   PMID:28411025   PMID:28473536   PMID:28514442   PMID:28594407   PMID:28602698   PMID:28803237   PMID:28991232   PMID:29036495   PMID:29197151   PMID:29246166  
PMID:29253225   PMID:29307595   PMID:29309750   PMID:29393474   PMID:29399809   PMID:29427323   PMID:29437554   PMID:29656893   PMID:29787794   PMID:30015900   PMID:30024615   PMID:30185552  
PMID:30290239   PMID:30333255   PMID:30365040   PMID:30372829   PMID:30385546   PMID:30503931   PMID:30514177   PMID:30548663   PMID:30557604   PMID:30593723   PMID:30627917   PMID:30674949  
PMID:30711473   PMID:30767098   PMID:30815865   PMID:30816527   PMID:30887692   PMID:30925677   PMID:30929558   PMID:31013265   PMID:31122130   PMID:31201921   PMID:31237749   PMID:31253870  
PMID:31291448   PMID:31312026   PMID:31371485   PMID:31387910   PMID:31399076   PMID:31466866   PMID:31515938   PMID:31521893   PMID:31536138   PMID:31661546   PMID:31681626   PMID:31692087  
PMID:31748910   PMID:31752873   PMID:31786685   PMID:31857113   PMID:32204913   PMID:32317080   PMID:32319557   PMID:32347987   PMID:32518380   PMID:32531042   PMID:32635983   PMID:32705506  
PMID:32737769   PMID:33009487   PMID:33114612   PMID:33145887   PMID:33167868   PMID:33276948   PMID:33346749   PMID:33436746   PMID:33449301   PMID:33656268   PMID:33961781   PMID:33990633  
PMID:34239022   PMID:34287043   PMID:34294125   PMID:34562454  


Genomics

Comparative Map Data
EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBImm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21826,463,333 - 26,465,531 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)Ensembl
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0panPan3
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBI
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
WI-12096  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,909 - 137,804,058UniSTSGRCh37
Build 365137,831,808 - 137,831,957RGDNCBI36
Celera5133,924,757 - 133,924,906RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,474 - 132,994,623UniSTS
GeneMap99-GB4 RH Map5524.46UniSTS
Whitehead-RH Map5432.2UniSTS
PMC321436P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,801,723 - 137,802,491UniSTSGRCh37
Build 365137,829,622 - 137,830,390RGDNCBI36
Celera5133,922,571 - 133,923,339RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,992,288 - 132,993,056UniSTS
PMC64850P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,566 - 137,803,742UniSTSGRCh37
Build 365137,831,465 - 137,831,641RGDNCBI36
Celera5133,924,414 - 133,924,590RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,131 - 132,994,307UniSTS
PMC98754P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,802,530 - 137,803,031UniSTSGRCh37
Build 365137,830,429 - 137,830,930RGDNCBI36
Celera5133,923,378 - 133,923,879RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,993,095 - 132,993,596UniSTS
EGR1_437  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,310 - 137,805,095UniSTSGRCh37
Build 365137,832,209 - 137,832,994RGDNCBI36
Celera5133,925,158 - 133,925,943RGD
HuRef5132,994,875 - 132,995,660UniSTS
D5S2415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,772 - 137,804,998UniSTSGRCh37
Build 365137,832,671 - 137,832,897RGDNCBI36
Celera5133,925,620 - 133,925,846RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,995,337 - 132,995,563UniSTS
Whitehead-YAC Contig Map5 UniSTS
SHGC-11945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,843 - 137,803,981UniSTSGRCh37
Build 365137,831,742 - 137,831,880RGDNCBI36
Celera5133,924,691 - 133,924,829RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,408 - 132,994,546UniSTS
Stanford-G3 RH Map55185.0UniSTS
GeneMap99-G3 RH Map55273.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118966
MIR183hsa-miR-183-5pOncomiRDBexternal_infoNANA21118966

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:419
Interacting mature miRNAs:451
Transcripts:ENST00000239938
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 154 226 179 5 1 228 33 63 17 78 209 224 89
Medium 2243 2035 1499 581 1125 423 3905 1819 2920 372 1312 1312 170 973 2498 3
Low 35 684 45 41 768 40 222 341 725 29 58 87 1 7 201 1
Below cutoff 39 50

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000239938   ⟹   ENSP00000239938
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)Ensembl
RefSeq Acc Id: NM_001964   ⟹   NP_001955
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,479 - 138,469,303 (+)NCBI
GRCh375137,801,181 - 137,805,004 (+)ENTREZGENE
Build 365137,829,080 - 137,832,903 (+)NCBI Archive
HuRef5132,991,746 - 132,995,569 (+)ENTREZGENE
CHM1_15137,233,931 - 137,237,754 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001955   ⟸   NM_001964
- UniProtKB: P18146 (UniProtKB/Swiss-Prot),   Q546S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000239938   ⟸   ENST00000239938
Protein Domains
C2H2-type

Promoters
RGD ID:6803024
Promoter ID:HG_KWN:51209
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000251274
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,828,156 - 137,829,572 (+)MPROMDB
RGD ID:6812702
Promoter ID:HG_ACW:65455
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:EGR1.BAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,829,756 - 137,830,582 (+)MPROMDB
RGD ID:6815550
Promoter ID:HG_MRA:12992
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:M24019
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,831,951 - 137,832,602 (+)MPROMDB
RGD ID:6870708
Promoter ID:EPDNEW_H8519
Type:initiation region
Name:EGR1_1
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,480 - 138,465,540EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3
pathogenic
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
Chr5:5q31.2
uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q31.2(chr5:137717265-137802404)x3 copy number gain not provided [RCV000745191] Chr5:137717265..137802404 [GRCh37]
Chr5:5q31.2
benign
NM_001964.3(EGR1):c.184AGC[5] (p.Ser67del) microsatellite not provided [RCV000961140] Chr5:138465944..138465946 [GRCh38]
Chr5:137801633..137801635 [GRCh37]
Chr5:5q31.2
likely benign
NM_001964.3(EGR1):c.513G>C (p.Ser171=) single nucleotide variant not provided [RCV000946876] Chr5:138466962 [GRCh38]
Chr5:137802651 [GRCh37]
Chr5:5q31.2
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_001964.3(EGR1):c.1017T>G (p.Ala339=) single nucleotide variant not provided [RCV000953788] Chr5:138467466 [GRCh38]
Chr5:137803155 [GRCh37]
Chr5:5q31.2
benign
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication Deafness, autosomal dominant 1 [RCV001319817]|Mental retardation, autosomal dominant 31 [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q31.2(chr5:137754277-138994590)x1 copy number loss not provided [RCV001270645] Chr5:137754277..138994590 [GRCh37]
Chr5:5q31.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3238 AgrOrtholog
COSMIC EGR1 COSMIC
Ensembl Genes ENSG00000120738 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000239938 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239938 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000120738 GTEx
HGNC ID HGNC:3238 ENTREZGENE
Human Proteome Map EGR1 Human Proteome Map
InterPro EGR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1958 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1958 ENTREZGENE
OMIM 128990 OMIM
Pfam DUF3432 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27673 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EGR1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q546S1 ENTREZGENE, UniProtKB/TrEMBL