EGR1 (early growth response 1) - Rat Genome Database

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Gene: EGR1 (early growth response 1) Homo sapiens
Analyze
Symbol: EGR1
Name: early growth response 1
RGD ID: 737111
HGNC Page HGNC:3238
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding activity; and histone acetyltransferase binding activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and regulation of protein sumoylation. Located in chromatin; cytoplasm; and nucleoplasm. Implicated in asthma. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; ZIF268; zinc finger gene 225; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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EGR1Humanadult respiratory distress syndrome  ISOEgr1 (Mus musculus)5131902protein:increased expression:lung (mouse)RGD 
EGR1HumanAlzheimer's disease  IEP 5131647protein:increased expression:temporal cortex and hippocampus (human)RGD 
EGR1HumanAlzheimer's disease treatmentISOEgr1 (Mus musculus)10395279 RGD 
EGR1HumanAlzheimer's disease treatmentISOEgr1 (Mus musculus)10395277 RGD 
EGR1Humanaortic valve stenosis  IEP 1626496protein:increased expression:aortic valve cuspRGD 
EGR1Humanarteriosclerosis  IEP 5131645mRNA more ...RGD 
EGR1Humanarteriosclerosis  ISOEgr1 (Mus musculus)5131874protein:increased expression:atherosclerotic lesions more ...RGD 
EGR1Humanarteriosclerosis  ISOEgr1 (Mus musculus)5131652 RGD 
EGR1Humanasthma  IAGP 5131993DNA:snp:5' utr:g.-4071A>G rs7729723 (human)RGD 
EGR1Humanasthma  ISOEgr1 (Mus musculus)5131985 RGD 
EGR1Humanasthma  IEP 5130915mRNA:increased expression:bronchoalveolar lavage cell (human)RGD 
EGR1HumanBrain Hypoxia-Ischemia  ISOEgr1 (Rattus norvegicus)2289081mRNA:increased expression:forebrain (rat)RGD 
EGR1Humanbreast cancer  ISOEgr1 (Rattus norvegicus)5131943protein:decreased expression:tumor (rat)RGD 
EGR1Humanbreast cancer  IEP 5131943protein:decreased expression:tumor (human)RGD 
EGR1Humanbronchiolo-alveolar adenocarcinoma  IEP 5131942mRNA:decreased expression:tumor (human)RGD 
EGR1Humanbronchitis  ISOEgr1 (Mus musculus)5132266 RGD 
EGR1Humancarcinoma disease_progressionISOEgr1 (Mus musculus)5131888 RGD 
EGR1HumanCardiomegaly  ISOEgr1 (Mus musculus)5131654 RGD 
EGR1Humanchronic obstructive pulmonary disease  ISOEgr1 (Mus musculus)5131878associated with Tobacco Use DisorderRGD 
EGR1Humanchronic obstructive pulmonary disease  IEP 5131854associated with Tobacco Use Disorder and mRNA:increased expression:lung (human)RGD 
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EGR1Humanautosomal dominant intellectual developmental disorder 31  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH NEONATAL RESPIRATORY INSUFFICIENCY more ...ClinVarPMID:28492532
EGR1Humanfamilial adenomatous polyposis 1  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
EGR1HumanHereditary Neoplastic Syndromes  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
EGR1HumanNeurodevelopmental Disorders  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
EGR1Humansquamous cell carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Squamous cell carcinomaClinVarPMID:27993330
EGR1HumanSTING-associated vasculopathy with onset in infancy  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: STING-associated vasculopathy with onset in infancyClinVarPMID:28492532
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EGR1Humanautoimmune disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
EGR1Humanbrain ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17394460
EGR1Humancholangitis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
EGR1Humancholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21224055
EGR1HumanCocaine-Related Disorders  EXP 11554173CTD more ...CTDPMID:16157275 more ...
EGR1Humanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560
EGR1Humanhydronephrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25015655
EGR1HumanHypoxia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12468449
EGR1HumanInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22094456
EGR1Humanintrahepatic cholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18364083 and PMID:22094456
EGR1Humanischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12468449
EGR1Humanjuvenile rheumatoid arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
EGR1HumanLung Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27935865
EGR1HumanMesothelioma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15878867
EGR1Humanpneumonia  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:29787794
EGR1HumanProstatic Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16552752
EGR1HumanReperfusion Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12468449
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EGR1Humanmyelodysplastic syndrome  ISSEgr1 (Mus musculus)13592920OMIM:614286MouseDO 

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EGR1Human(+)-pilocarpine increases expressionISOEgr1 (Rattus norvegicus)6480464Pilocarpine results in increased expression of EGR1 mRNACTDPMID:7968354
EGR1Human(+)-pilocarpine multiple interactionsISOEgr1 (Rattus norvegicus)6480464Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] and Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]CTDPMID:7968354
EGR1Human(-)-alpha-phellandrene increases expressionEXP 6480464alpha phellandrene results in increased expression of EGR1 mRNACTDPMID:25075043
EGR1Human(-)-anisomycin multiple interactionsISOEgr1 (Mus musculus)6480464SB 203580 inhibits the reaction [Anisomycin results in increased expression of EGR1 mRNA]CTDPMID:9671412
EGR1Human(-)-anisomycin increases expressionISOEgr1 (Mus musculus)6480464Anisomycin results in increased expression of EGR1 mRNACTDPMID:9671412
EGR1Human(-)-citrinin increases expressionEXP 6480464Citrinin results in increased expression of EGR1 mRNA and Citrinin results in increased expression of EGR1 proteinCTDPMID:19361540
EGR1Human(-)-citrinin multiple interactionsEXP 6480464U 0126 inhibits the reaction [Citrinin results in increased expression of EGR1 protein]CTDPMID:19361540
EGR1Human(-)-demecolcine increases expressionEXP 6480464Demecolcine results in increased expression of EGR1 mRNACTDPMID:23649840
EGR1Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of EGR1 mRNA and epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in increased expression of EGR1 mRNA]CTDPMID:22079256
EGR1Human(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of EGR1 mRNACTDPMID:32512070
EGR1Human(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of EGR1 mRNACTDPMID:22079256
EGR1Human(1->4)-beta-D-glucan multiple interactionsISOEgr1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of EGR1 mRNACTDPMID:36331819
EGR1Human(20R)-protopanaxadiol multiple interactionsISOEgr1 (Mus musculus)6480464protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]CTDPMID:29133030
EGR1Human(R)-noradrenaline increases expressionISOEgr1 (Rattus norvegicus)6480464Norepinephrine results in increased expression of EGR1CTDPMID:7905536
EGR1Human(S)-amphetamine multiple interactionsISOEgr1 (Rattus norvegicus)6480464[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA more ...CTDPMID:1347779 and PMID:16771831
EGR1Human(S)-amphetamine affects expressionISOEgr1 (Rattus norvegicus)6480464Dextroamphetamine affects the expression of EGR1 mRNACTDPMID:17049170
EGR1Human(S)-amphetamine increases expressionISOEgr1 (Rattus norvegicus)6480464Dextroamphetamine results in increased expression of EGR1 mRNACTDPMID:11750902 and PMID:1347779
EGR1Human(S)-naringenin multiple interactionsEXP 6480464[naringenin co-treated with bisphenol A] results in increased expression of EGR1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGR1 mRNACTDPMID:36235125
EGR1Human(S)-nicotine increases expressionISOEgr1 (Mus musculus)6480464Nicotine results in increased expression of EGR1 mRNA and Nicotine results in increased expression of EGR1 proteinCTDPMID:17456735 and PMID:31622651
EGR1Human(S)-nicotine increases expressionISOEgr1 (Rattus norvegicus)6480464Nicotine results in increased expression of EGR1 mRNA and Nicotine results in increased expression of EGR1 proteinCTDPMID:29486207 and PMID:31622651

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Biological Process
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EGR1HumanBMP signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1Humancellular response to antibiotic  ISOEgr1 (Rattus norvegicus)9068941trichostatin ARGDPMID:21490970 and REF_RGD_ID:5131646
EGR1Humancellular response to cAMP  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:12021067 and REF_RGD_ID:729311
EGR1Humancellular response to follicle-stimulating hormone stimulus  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:12021067 and REF_RGD_ID:729311
EGR1Humancellular response to gamma radiation involved_inIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1Humancellular response to gonadotropin stimulus  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:12021067 and REF_RGD_ID:729311
EGR1Humancellular response to growth factor stimulus  ISOEgr1 (Rattus norvegicus)9068941nerve growth factorRGDPMID:21489990 and REF_RGD_ID:5131647
EGR1Humancellular response to heparin involved_inISSUniProtKB:P08154150520179 UniProtGO_REF:0000024
EGR1Humancellular response to hyperoxia  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:15734424 and REF_RGD_ID:5131935
EGR1Humancellular response to hypoxia  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:21220915 and REF_RGD_ID:5131857
EGR1Humancellular response to insulin stimulus  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:12970165 and REF_RGD_ID:1601014
EGR1Humancellular response to interleukin-8 involved_inIDA 150520179 PMID:20363028UniProtPMID:20363028
EGR1Humancellular response to isoquinoline alkaloid  ISOEgr1 (Rattus norvegicus)9068941berberineRGDPMID:16448624 and REF_RGD_ID:5131909
EGR1Humancellular response to mechanical stimulus  ISOEgr1 (Rattus norvegicus)9068941cyclic stretchRGDPMID:16998809 and REF_RGD_ID:5131896
EGR1Humancellular response to mycophenolic acid involved_inISSUniProtKB:P08154150520179 UniProtGO_REF:0000024
EGR1Humancellular response to steroid hormone stimulus  ISOEgr1 (Rattus norvegicus)9068941pregnenoloneRGDPMID:21257751 and REF_RGD_ID:5131851
EGR1Humancellular response to xenobiotic stimulus  ISOEgr1 (Rattus norvegicus)9068941imipramineRGDPMID:21354245 and REF_RGD_ID:5131879
EGR1Humancircadian regulation of gene expression involved_inIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1Humancircadian regulation of gene expression involved_inISSUniProtKB:P08046150520179 UniProtGO_REF:0000024
EGR1Humancircadian rhythm  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:21363938 and REF_RGD_ID:5131656
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Cellular Component
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EGR1Humanchromatin located_inIDA 150520179 PMID:19307576ARUK-UCLPMID:19307576
EGR1Humanchromatin located_inISAtfclass:2.3.1150520179 NTNU_SBGO_REF:0000113
EGR1Humancytoplasm located_inISSUniProtKB:P08154150520179 UniProtGO_REF:0000024
EGR1Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
EGR1Humancytoplasm located_inIDA 150520179 PMID:19057511 and PMID:20363028UniProtPMID:19057511 and PMID:20363028
EGR1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
EGR1Humannucleoplasm located_inIEAARBA:ARBA00026290150520179 UniProtGO_REF:0000117
EGR1Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
EGR1Humannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-1015702 more ...
EGR1Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
EGR1Humannucleus located_inISSUniProtKB:P08154150520179 UniProtGO_REF:0000024
EGR1Humannucleus located_inIDA 150520179 PMID:19057511 more ...BHF-UCLPMID:19057511 more ...
EGR1Humannucleus located_inIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
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Molecular Function
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EGR1HumanDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
EGR1HumanDNA binding enablesIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1HumanDNA binding enablesIDA 150520179 PMID:12560508UniProtPMID:12560508
EGR1HumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 150520179 PMID:19307576 and PMID:20018936BHF-UCLPMID:19307576 and PMID:20018936
EGR1HumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1HumanDNA-binding transcription activator activity, RNA polymerase II-specific  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:12021067 and REF_RGD_ID:729311
EGR1HumanDNA-binding transcription factor activity  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:16849326 and REF_RGD_ID:1626495
EGR1HumanDNA-binding transcription factor activity enablesIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1HumanDNA-binding transcription factor activity enablesIDA 150520179 PMID:12560508UniProtPMID:12560508
EGR1HumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesISAtfclass:2.3.1150520179 NTNU_SBGO_REF:0000113
EGR1HumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000233 more ...150520179 GO_CentralGO_REF:0000033
EGR1Humandouble-stranded DNA binding  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:10837920 and REF_RGD_ID:1626488
EGR1Humandouble-stranded methylated DNA binding enablesIDA 150520179 PMID:25258363UniProtPMID:25258363
EGR1Humanenzyme binding enablesIEAUniProtKB:P08046 and ensembl:ENSMUSP00000069616150520179 EnsemblGO_REF:0000107
EGR1Humanhemi-methylated DNA-binding enablesIDA 150520179 PMID:25258363UniProtPMID:25258363
EGR1Humanhistone acetyltransferase binding enablesIPIUniProtKB:Q09472150520179 PMID:20018936BHF-UCLPMID:20018936
EGR1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
EGR1Humanpromoter-specific chromatin binding  ISOEgr1 (Rattus norvegicus)9068941 RGDPMID:22292946 and REF_RGD_ID:10395298
EGR1Humanpromoter-specific chromatin binding enablesIDA 150520179 PMID:20363028UniProtPMID:20363028
EGR1Humanprotein binding enablesIPIUniProtKB:P35222150520179 PMID:21743491IntActPMID:21743491
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RGD Manual Annotations


  
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EGR1Humanlong term potentiation  ISOEgr1 (Rattus norvegicus)1626499 RGD 

Imported Annotations - KEGG (archival)

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EGR1Humanprion disease pathway  IEA 6907045 KEGGhsa:05020
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EGR1HumanSquamous cell carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Squamous cell carcinomaClinVarPMID:27993330

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Reference Title
Reference Citation
1. Egr1 expression is induced following glatiramer acetate immunotherapy in rodent models of glaucoma and Alzheimer's disease. Bakalash S, etal., Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9033-46. doi: 10.1167/iovs.11-7498.
2. Progressive pulmonary sarcoidosis--a fibroproliferative process potentially triggered by EGR-1 and IL-6. Bihl MP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar;23(1):38-50.
3. Carbon monoxide orchestrates a protective response through PPARgamma. Bilban M, etal., Immunity. 2006 May;24(5):601-10.
4. Elevated peritoneal fluid TNF-alpha incites ovarian early growth response factor 1 expression and downstream protease mediators: a correlation with ovulatory dysfunction in endometriosis. Birt JA, etal., Reprod Sci. 2013 May;20(5):514-23. doi: 10.1177/1933719113477479. Epub 2013 Feb 20.
5. Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF). Boon K, etal., PLoS One. 2009;4(4):e5134. Epub 2009 Apr 6.
6. The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Buitrago M, etal., Nat Med. 2005 Aug;11(8):837-44. Epub 2005 Jul 17.
7. Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice. Caso G, etal., J Hematol Oncol. 2009 Feb 7;2:7.
8. High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. Chan IH, etal., Clin Chim Acta. 2010 Jan;411(1-2):67-71. Epub 2009 Oct 12.
9. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children. Chan IH, etal., Pediatr Allergy Immunol. 2009 Mar;20(2):142-50. Epub 2008 May 28.
10. EGR-1 regulates Ho-1 expression induced by cigarette smoke. Chen H, etal., Biochem Biophys Res Commun. 2010 May 28;396(2):388-93. doi: 10.1016/j.bbrc.2010.04.102. Epub 2010 Apr 22.
11. Promoter methylation of Egr-1 site contributes to fetal hypoxia-mediated PKCepsilon gene repression in the developing heart. Chen M, etal., Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R683-9. doi: 10.1152/ajpregu.00461.2012. Epub 2013 Feb 20.
12. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. Chen ZH, etal., PLoS One. 2008 Oct 2;3(10):e3316.
13. [Expression and role of early growth response gene-1 in experimental silicosis of rat]. Chu L, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):47-50.
14. Early changes in lung gene expression due to high tidal volume. Copland IB, etal., Am J Respir Crit Care Med. 2003 Nov 1;168(9):1051-9. Epub 2003 Jun 19.
15. Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation. Creed MC, etal., Eur Neuropsychopharmacol. 2012 Jul;22(7):506-17. doi: 10.1016/j.euroneuro.2011.11.004. Epub 2011 Dec 7.
16. Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Densmore VS, etal., Pain. 2010 Oct;151(1):184-93. Epub 2010 Aug 1.
17. Early growth response-1 transcription factor promotes hepatic fibrosis and steatosis in long-term ethanol-fed Long-Evans rats. Derdak Z, etal., Liver Int. 2012 May;32(5):761-70. doi: 10.1111/j.1478-3231.2012.02752.x. Epub 2012 Jan 31.
18. Egr-1 expression during neointimal development in flow-associated pulmonary hypertension. Dickinson MG, etal., Am J Pathol. 2011 Nov;179(5):2199-209. doi: 10.1016/j.ajpath.2011.07.030. Epub 2011 Sep 13.
19. Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Ding BS, etal., Am J Respir Crit Care Med. 2009 Aug 1;180(3):247-56. Epub 2009 Apr 2.
20. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
1 to 20 of 78 rows
1 to 10 of 46 rows
PMID:1090709   PMID:1383501   PMID:1411083   PMID:1569051   PMID:1662794   PMID:1702972   PMID:2109185   PMID:2110381   PMID:2377485   PMID:3127059   PMID:3839394   PMID:7624335  
PMID:8662759   PMID:8668170   PMID:9806899   PMID:10049687   PMID:10051405   PMID:10079243   PMID:10082522   PMID:10409428   PMID:10575214   PMID:10671503   PMID:10849212   PMID:11124866  
PMID:11251186   PMID:11278640   PMID:11795984   PMID:11819815   PMID:11830539   PMID:11909874   PMID:11925592   PMID:11956220   PMID:11978801   PMID:12011097   PMID:12065847   PMID:12165491  
PMID:12235180   PMID:12379479   PMID:12384223   PMID:12393577   PMID:12433834   PMID:12439908   PMID:12456801   PMID:12457461   PMID:12470865   PMID:12477932   PMID:12507899   PMID:12517959  
PMID:12543866   PMID:12553019   PMID:12553721   PMID:12560487   PMID:12560508   PMID:12566441   PMID:12569082   PMID:12571843   PMID:12618431   PMID:12637574   PMID:12690110   PMID:12706485  
PMID:12729460   PMID:12840049   PMID:12872165   PMID:12890669   PMID:12947119   PMID:12958075   PMID:14522979   PMID:14662774   PMID:14744935   PMID:14966901   PMID:14979875   PMID:14985468  
PMID:15003938   PMID:15023995   PMID:15155664   PMID:15211096   PMID:15225550   PMID:15231681   PMID:15449318   PMID:15486985   PMID:15489334   PMID:15517593   PMID:15523672   PMID:15545275  
PMID:15611055   PMID:15616591   PMID:15640148   PMID:15689620   PMID:15709168   PMID:15875316   PMID:15910736   PMID:15923644   PMID:15999367   PMID:16007175   PMID:16079301   PMID:16091742  
PMID:16093249   PMID:16260776   PMID:16382041   PMID:16393964   PMID:16464174   PMID:16552541   PMID:16702209   PMID:16741963   PMID:16831524   PMID:16858414   PMID:16995904   PMID:17099140  
PMID:17257596   PMID:17448597   PMID:17494953   PMID:17502875   PMID:17516844   PMID:17559061   PMID:17581316   PMID:17599039   PMID:17631285   PMID:17631291   PMID:17671831   PMID:17932312  
1 to 10 of 46 rows



EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)EnsemblGRCm39 Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBIMGSCv36mm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,740,921 - 133,744,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,880,479 - 131,884,306 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,625,892 - 7,629,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,140,065 - 41,142,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,247,516 - 31,252,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in EGR1
19 total Variants

1 to 10 of 41 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3		 pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3		 pathogenic
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
Chr5:5q31.2		 uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
1 to 10 of 41 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118966
MIR183hsa-miR-183-5pOncomiRDBexternal_infoNANA21118966

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:419
Interacting mature miRNAs:451
Transcripts:ENST00000239938
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597190154GWAS1286228_Htestosterone measurement QTL GWAS1286228 (human)4e-14testosterone measurementserum testosterone level (CMO:0000568)5138466715138466716Human
597098610GWAS1194684_Hsex hormone-binding globulin measurement QTL GWAS1194684 (human)4e-16sex hormone-binding globulin measurement5138466715138466716Human
1357314AASTH54_HAllergic/atopic asthma related QTL 54 (human)3.560.0003Reversible airflow obstructiontotal serum IgE5135892246150155845Human
597097968GWAS1194042_Hsex hormone-binding globulin measurement QTL GWAS1194042 (human)2e-12sex hormone-binding globulin measurement5138466715138466716Human
597189794GWAS1285868_Hsex hormone-binding globulin measurement QTL GWAS1285868 (human)1e-12sex hormone-binding globulin measurement5138466715138466716Human
597099932GWAS1196006_Hsex hormone-binding globulin measurement QTL GWAS1196006 (human)5e-15sex hormone-binding globulin measurement5138466715138466716Human
597097626GWAS1193700_Hsex hormone-binding globulin measurement QTL GWAS1193700 (human)4e-11sex hormone-binding globulin measurement5138466715138466716Human

WI-12096  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,909 - 137,804,058UniSTSGRCh37
Build 365137,831,808 - 137,831,957RGDNCBI36
Celera5133,924,757 - 133,924,906RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,474 - 132,994,623UniSTS
GeneMap99-GB4 RH Map5524.46UniSTS
Whitehead-RH Map5432.2UniSTS
PMC321436P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,801,723 - 137,802,491UniSTSGRCh37
Build 365137,829,622 - 137,830,390RGDNCBI36
Celera5133,922,571 - 133,923,339RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,992,288 - 132,993,056UniSTS
PMC64850P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,566 - 137,803,742UniSTSGRCh37
Build 365137,831,465 - 137,831,641RGDNCBI36
Celera5133,924,414 - 133,924,590RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,131 - 132,994,307UniSTS
PMC98754P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,802,530 - 137,803,031UniSTSGRCh37
Build 365137,830,429 - 137,830,930RGDNCBI36
Celera5133,923,378 - 133,923,879RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,993,095 - 132,993,596UniSTS
EGR1_437  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,310 - 137,805,095UniSTSGRCh37
Build 365137,832,209 - 137,832,994RGDNCBI36
Celera5133,925,158 - 133,925,943RGD
HuRef5132,994,875 - 132,995,660UniSTS
D5S2415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,772 - 137,804,998UniSTSGRCh37
Build 365137,832,671 - 137,832,897RGDNCBI36
Celera5133,925,620 - 133,925,846RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,995,337 - 132,995,563UniSTS
Whitehead-YAC Contig Map5 UniSTS
SHGC-11945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,843 - 137,803,981UniSTSGRCh37
Build 365137,831,742 - 137,831,880RGDNCBI36
Celera5133,924,691 - 133,924,829RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,408 - 132,994,546UniSTS
Stanford-G3 RH Map55185.0UniSTS
GeneMap99-G3 RH Map55273.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 171


1 to 18 of 18 rows
RefSeq Transcripts NG_021374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS691417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENST00000239938   ⟹   ENSP00000239938
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)Ensembl
RefSeq Acc Id: NM_001964   ⟹   NP_001955
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,479 - 138,469,303 (+)NCBI
GRCh375137,801,181 - 137,805,004 (+)ENTREZGENE
Build 365137,829,080 - 137,832,903 (+)NCBI Archive
HuRef5132,991,746 - 132,995,569 (+)ENTREZGENE
CHM1_15137,233,931 - 137,237,754 (+)NCBI
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001955   ⟸   NM_001964
- UniProtKB: P18146 (UniProtKB/Swiss-Prot),   Q546S1 (UniProtKB/TrEMBL),   A0A089VKS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000239938   ⟸   ENST00000239938
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-P18146-F1-model_v2 AlphaFold P18146 1-543 view protein structure

RGD ID:6803024
Promoter ID:HG_KWN:51209
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000251274
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,828,156 - 137,829,572 (+)MPROMDB
RGD ID:6812702
Promoter ID:HG_ACW:65455
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:EGR1.BAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,829,756 - 137,830,582 (+)MPROMDB
RGD ID:6815550
Promoter ID:HG_MRA:12992
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:M24019
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,831,951 - 137,832,602 (+)MPROMDB
RGD ID:6870708
Promoter ID:EPDNEW_H8519
Type:initiation region
Name:EGR1_1
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,480 - 138,465,540EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
COSMIC EGR1 COSMIC
Ensembl Genes ENSG00000120738 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239938 ENTREZGENE
  ENST00000239938.5 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000120738 GTEx
HGNC ID HGNC:3238 ENTREZGENE
Human Proteome Map EGR1 Human Proteome Map
InterPro EGR1_C UniProtKB/Swiss-Prot
  EGR_N UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:1958 UniProtKB/Swiss-Prot
NCBI Gene 1958 ENTREZGENE
OMIM 128990 OMIM
PANTHER C2H2-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER AND BTB DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam DUF3432 UniProtKB/Swiss-Prot
  DUF3446 UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA27673 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A089VKS7 ENTREZGENE, UniProtKB/TrEMBL
  EGR1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q546S1 ENTREZGENE, UniProtKB/TrEMBL
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