EGR1 (early growth response 1) - Rat Genome Database

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Gene: EGR1 (early growth response 1) Homo sapiens
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Symbol: EGR1
Name: early growth response 1
RGD ID: 737111
HGNC Page HGNC:3238
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding activity; and histone acetyltransferase binding activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and regulation of protein sumoylation. Located in chromatin; cytoplasm; and nucleoplasm. Implicated in asthma. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; ZIF268; zinc finger gene 225; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (IEP,ISO)
aortic valve stenosis  (IEP)
arteriosclerosis  (IEP,ISO)
asthma  (IAGP,IEP,ISO)
autoimmune disease  (EXP)
autosomal dominant intellectual developmental disorder 31  (IAGP)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (EXP)
breast cancer  (IEP,ISO)
bronchiolo-alveolar adenocarcinoma  (IEP)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (EXP)
cholestasis  (EXP)
chronic obstructive pulmonary disease  (IEP,ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (EXP,ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Seizures  (ISO)
familial adenomatous polyposis 1  (IAGP)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (EXP)
Hereditary Neoplastic Syndromes  (IAGP)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (EXP)
Hypoxia  (EXP)
Immediate Hypersensitivity  (ISO)
Inflammation  (EXP)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (EXP)
ischemia  (EXP)
juvenile rheumatoid arthritis  (EXP)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (EXP)
middle cerebral artery infarction  (ISO)
morphine withdrawal syndrome  (ISO)
myelodysplastic syndrome  (ISS)
myeloid neoplasm  (ISO)
Nasal Polyps  (IEP)
Neurodevelopmental Disorders  (IAGP)
osteoarthritis  (IEP)
osteosarcoma  (IEP)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (IAGP)
pneumonia  (EXP)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (EXP)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (IEP)
Reperfusion Injury  (EXP,ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (IAGP,IEP)
STING-associated vasculopathy with onset in infancy  (IAGP)
T-cell non-Hodgkin lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-anisomycin  (ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
13-HPODE  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
22-Hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-cyanoalanine  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (EXP)
alpha-Zearalanol  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP,ISO)
aripiprazole  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
atropine  (ISO)
Aurin  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
bazedoxifene  (EXP)
benzalkonium chloride  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-lapachone  (EXP)
beta-naphthoflavone  (ISO)
betamethasone  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bromoacetate  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butanal  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
camostat  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbachol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carbonyl sulfide  (ISO)
carrageenan  (EXP)
cefaloridine  (ISO)
chenodeoxycholic acid  (ISO)
chlornitrofen  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP,ISO)
DDT  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
desipramine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
digoxin  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (EXP,ISO)
doramapimod  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enniatin  (EXP)
Enterolactone  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
eticlopride(1+)  (ISO)
eugenol  (ISO)
fenpyroximate  (EXP)
fentin chloride  (ISO)
ferric oxide  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallium nitrate  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
herbicide  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (EXP)
ibuprofen  (ISO)
imidazopyrazole  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
inulin  (ISO)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isobutanol  (EXP)
isoprenaline  (ISO)
juglone  (EXP)
kainic acid  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
maneb  (ISO)
manganese(II) chloride  (ISO)
MeIQx  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naltrexone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (ISO)
Norbinaltorphimine  (ISO)
NS-398  (EXP)
O-acetyl-L-carnitine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (EXP)
orotic acid  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxazepam  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pentanal  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenanthrene  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
poly(I:C)  (ISO)
potassium atom  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (EXP)
propiconazole  (ISO)
propranolol  (ISO)
propylparaben  (EXP)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinpirole  (ISO)
raloxifene  (EXP)
ranitidine  (ISO)
razoxane  (ISO)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rifampicin  (EXP,ISO)
risperidone  (ISO)
ropinirole  (ISO)
rotenone  (EXP,ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
SKF 38393  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium tungstate  (ISO)
Soman  (ISO)
styrene  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (EXP)
sulprostone  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (ISO)
trans-caffeic acid  (EXP)
tranylcypromine  (ISO)
triacsin C  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (EXP,ISO)
Triton X-100  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vancomycin  (ISO)
vecuronium bromide  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
xanomeline  (ISO)
zearalenone  (EXP)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc molecular entity  (EXP)
zinc pyrithione  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISS)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IDA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISS)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (IEA,ISS)
circadian rhythm  (ISO)
circadian temperature homeostasis  (IEA,ISS)
estrous cycle  (IEA,ISS)
glomerular mesangial cell proliferation  (ISS)
interleukin-1-mediated signaling pathway  (IMP)
learning or memory  (ISO)
locomotor rhythm  (IEA,ISS)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of chemokine production  (IEA,ISS)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (IEA,ISS)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISS)
positive regulation of hormone biosynthetic process  (IEA,ISS)
positive regulation of interleukin-1 beta production  (IEA,ISS)
positive regulation of miRNA transcription  (IDA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of post-translational protein modification  (IMP)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IGI,IMP,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of neuron apoptotic process  (IEA,ISS)
regulation of progesterone biosynthetic process  (IEA,ISS)
regulation of protein sumoylation  (IDA)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (IEA,ISS)
response to insulin  (IEA)
response to ischemia  (IEA,ISS)
response to morphine  (ISO)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IDA,ISA)
cytoplasm  (IDA,IEA,ISS)
nucleoplasm  (IDA,IEA,TAS)
nucleus  (IDA,IEA,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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Additional References at PubMed
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PMID:25737480   PMID:25740602   PMID:25753664   PMID:25997867   PMID:26011708   PMID:26089202   PMID:26109509   PMID:26113112   PMID:26115646   PMID:26120956   PMID:26134032   PMID:26206332  
PMID:26324943   PMID:26496610   PMID:26498686   PMID:26502071   PMID:26519755   PMID:26538827   PMID:26573109   PMID:26692143   PMID:26720342   PMID:26774383   PMID:26792551   PMID:26917778  
PMID:26922429   PMID:26936374   PMID:26975996   PMID:26984843   PMID:26988763   PMID:27002148   PMID:27072400   PMID:27099350   PMID:27173006   PMID:27244890   PMID:27251707   PMID:27442508  
PMID:27452907   PMID:27569005   PMID:27637333   PMID:27677186   PMID:27834104   PMID:27835650   PMID:27878298   PMID:27933778   PMID:27980400   PMID:28072411   PMID:28077323   PMID:28180113  
PMID:28187447   PMID:28269757   PMID:28411025   PMID:28473536   PMID:28514442   PMID:28594407   PMID:28602698   PMID:28803237   PMID:28991232   PMID:29036495   PMID:29197151   PMID:29246166  
PMID:29253225   PMID:29307595   PMID:29309750   PMID:29393474   PMID:29399809   PMID:29427323   PMID:29437554   PMID:29656893   PMID:29787794   PMID:30015900   PMID:30024615   PMID:30185552  
PMID:30290239   PMID:30333255   PMID:30365040   PMID:30372829   PMID:30385546   PMID:30503931   PMID:30514177   PMID:30548663   PMID:30557604   PMID:30593723   PMID:30627917   PMID:30674949  
PMID:30711473   PMID:30767098   PMID:30815865   PMID:30816527   PMID:30887692   PMID:30925677   PMID:30929558   PMID:31013265   PMID:31122130   PMID:31201921   PMID:31237749   PMID:31253870  
PMID:31291448   PMID:31312026   PMID:31371485   PMID:31387910   PMID:31399076   PMID:31466866   PMID:31467272   PMID:31515938   PMID:31521893   PMID:31536138   PMID:31661546   PMID:31681626  
PMID:31692087   PMID:31748910   PMID:31752873   PMID:31786685   PMID:31857113   PMID:32204913   PMID:32317080   PMID:32319557   PMID:32347987   PMID:32518380   PMID:32531042   PMID:32635983  
PMID:32705506   PMID:32737769   PMID:33009487   PMID:33114612   PMID:33145887   PMID:33167868   PMID:33211275   PMID:33276948   PMID:33297605   PMID:33346749   PMID:33436746   PMID:33449301  
PMID:33523892   PMID:33656268   PMID:33687657   PMID:33961781   PMID:33973090   PMID:33980611   PMID:33990633   PMID:34163030   PMID:34165179   PMID:34189442   PMID:34239022   PMID:34287043  
PMID:34294125   PMID:34409922   PMID:34469714   PMID:34488929   PMID:34499269   PMID:34562454   PMID:34606618   PMID:34608841   PMID:34615546   PMID:34681812   PMID:34902339   PMID:35041980  
PMID:35044719   PMID:35103892   PMID:35169855   PMID:35184918   PMID:35398375   PMID:35438597   PMID:35679138   PMID:35746681   PMID:35787980   PMID:35788362   PMID:35910788   PMID:35997641  
PMID:36207572   PMID:36217030   PMID:36240645   PMID:36484839   PMID:36608994   PMID:36688959   PMID:36765275   PMID:36888606   PMID:37012388   PMID:37287279   PMID:37401387   PMID:37616343  
PMID:37650708   PMID:37689310   PMID:37737125   PMID:37738652   PMID:37762678   PMID:37772822   PMID:37862152   PMID:37880426   PMID:37989866   PMID:38218401   PMID:38233877   PMID:38287371  
PMID:38385088   PMID:38409611   PMID:38642782   PMID:38912889   PMID:38926457   PMID:39126833   PMID:39197193  


Genomics

Comparative Map Data
EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)EnsemblGRCm39 Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBIMGSCv36mm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,740,921 - 133,744,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,880,479 - 131,884,306 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,625,892 - 7,629,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,140,065 - 41,142,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,247,516 - 31,252,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EGR1
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3		 pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3		 pathogenic
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
Chr5:5q31.2		 uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q31.2(chr5:137717265-137802404)x3 copy number gain not provided [RCV000745191] Chr5:137717265..137802404 [GRCh37]
Chr5:5q31.2		 benign
NM_001964.3(EGR1):c.184AGC[5] (p.Ser67del) microsatellite not provided [RCV000961140] Chr5:138465944..138465946 [GRCh38]
Chr5:137801633..137801635 [GRCh37]
Chr5:5q31.2		 likely benign
NM_001964.3(EGR1):c.513G>C (p.Ser171=) single nucleotide variant not provided [RCV000946876] Chr5:138466962 [GRCh38]
Chr5:137802651 [GRCh37]
Chr5:5q31.2		 benign
NM_001964.3(EGR1):c.1478C>G (p.Pro493Arg) single nucleotide variant not specified [RCV004311891] Chr5:138467927 [GRCh38]
Chr5:137803616 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.1535G>T (p.Ser512Ile) single nucleotide variant not specified [RCV004284472] Chr5:138467984 [GRCh38]
Chr5:137803673 [GRCh37]
Chr5:5q31.2		 uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
NM_001964.3(EGR1):c.1017T>G (p.Ala339=) single nucleotide variant not provided [RCV000953788] Chr5:138467466 [GRCh38]
Chr5:137803155 [GRCh37]
Chr5:5q31.2		 benign
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3		 uncertain significance
GRCh37/hg19 5q31.2(chr5:137754277-138994590)x1 copy number loss not provided [RCV001270645] Chr5:137754277..138994590 [GRCh37]
Chr5:5q31.2		 likely pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NC_000005.9:g.(?_136957787)_(140078137_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV003116437] Chr5:136957787..140078137 [GRCh37]
Chr5:5q31.2-31.3		 uncertain significance
NC_000005.9:g.(?_136957787)_(138861289_?)del deletion STING-associated vasculopathy with onset in infancy [RCV003113978] Chr5:136957787..138861289 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.631A>C (p.Thr211Pro) single nucleotide variant not specified [RCV004099229] Chr5:138467080 [GRCh38]
Chr5:137802769 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.1072C>T (p.His358Tyr) single nucleotide variant not specified [RCV004140850] Chr5:138467521 [GRCh38]
Chr5:137803210 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.149G>A (p.Gly50Asp) single nucleotide variant not specified [RCV004146482] Chr5:138465910 [GRCh38]
Chr5:137801599 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.1570G>A (p.Ala524Thr) single nucleotide variant not specified [RCV004193177] Chr5:138468019 [GRCh38]
Chr5:137803708 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.142T>C (p.Phe48Leu) single nucleotide variant not specified [RCV004218164] Chr5:138465903 [GRCh38]
Chr5:137801592 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.-205G>A single nucleotide variant Squamous cell carcinoma [RCV003129701] Chr5:138465557 [GRCh38]
Chr5:137801246 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.514T>G (p.Ser172Ala) single nucleotide variant not specified [RCV004248370] Chr5:138466963 [GRCh38]
Chr5:137802652 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.1056C>T (p.Ser352=) single nucleotide variant not provided [RCV003429779] Chr5:138467505 [GRCh38]
Chr5:137803194 [GRCh37]
Chr5:5q31.2		 likely benign
NM_001964.3(EGR1):c.1445A>G (p.Tyr482Cys) single nucleotide variant not specified [RCV004377513] Chr5:138467894 [GRCh38]
Chr5:137803583 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.782A>G (p.Gln261Arg) single nucleotide variant not specified [RCV004377514] Chr5:138467231 [GRCh38]
Chr5:137802920 [GRCh37]
Chr5:5q31.2		 uncertain significance
NM_001964.3(EGR1):c.155C>T (p.Ala52Val) single nucleotide variant not specified [RCV004622460] Chr5:138465916 [GRCh38]
Chr5:137801605 [GRCh37]
Chr5:5q31.2		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118966
MIR183hsa-miR-183-5pOncomiRDBexternal_infoNANA21118966

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:419
Interacting mature miRNAs:451
Transcripts:ENST00000239938
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407028067GWAS677043_Hsex hormone-binding globulin measurement QTL GWAS677043 (human)1e-12sex hormone-binding globulin measurement5138466715138466716Human
407027889GWAS676865_Htestosterone measurement QTL GWAS676865 (human)4e-14testosterone measurementserum testosterone level (CMO:0000568)5138466715138466716Human
407006903GWAS655879_Hsex hormone-binding globulin measurement QTL GWAS655879 (human)5e-15sex hormone-binding globulin measurement5138466715138466716Human
1357314AASTH54_HAllergic/atopic asthma related QTL 54 (human)3.560.0003Reversible airflow obstructiontotal serum IgE5135892246150155845Human
406990452GWAS639428_Hsex hormone-binding globulin measurement QTL GWAS639428 (human)2e-12sex hormone-binding globulin measurement5138466715138466716Human
406994398GWAS643374_Hsex hormone-binding globulin measurement QTL GWAS643374 (human)4e-11sex hormone-binding globulin measurement5138466715138466716Human
407011485GWAS660461_Hsex hormone-binding globulin measurement QTL GWAS660461 (human)4e-16sex hormone-binding globulin measurement5138466715138466716Human

Markers in Region
WI-12096  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,909 - 137,804,058UniSTSGRCh37
Build 365137,831,808 - 137,831,957RGDNCBI36
Celera5133,924,757 - 133,924,906RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,474 - 132,994,623UniSTS
GeneMap99-GB4 RH Map5524.46UniSTS
Whitehead-RH Map5432.2UniSTS
PMC321436P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,801,723 - 137,802,491UniSTSGRCh37
Build 365137,829,622 - 137,830,390RGDNCBI36
Celera5133,922,571 - 133,923,339RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,992,288 - 132,993,056UniSTS
PMC64850P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,566 - 137,803,742UniSTSGRCh37
Build 365137,831,465 - 137,831,641RGDNCBI36
Celera5133,924,414 - 133,924,590RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,131 - 132,994,307UniSTS
PMC98754P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,802,530 - 137,803,031UniSTSGRCh37
Build 365137,830,429 - 137,830,930RGDNCBI36
Celera5133,923,378 - 133,923,879RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,993,095 - 132,993,596UniSTS
EGR1_437  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,310 - 137,805,095UniSTSGRCh37
Build 365137,832,209 - 137,832,994RGDNCBI36
Celera5133,925,158 - 133,925,943RGD
HuRef5132,994,875 - 132,995,660UniSTS
D5S2415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,772 - 137,804,998UniSTSGRCh37
Build 365137,832,671 - 137,832,897RGDNCBI36
Celera5133,925,620 - 133,925,846RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,995,337 - 132,995,563UniSTS
Whitehead-YAC Contig Map5 UniSTS
SHGC-11945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,843 - 137,803,981UniSTSGRCh37
Build 365137,831,742 - 137,831,880RGDNCBI36
Celera5133,924,691 - 133,924,829RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,408 - 132,994,546UniSTS
Stanford-G3 RH Map55185.0UniSTS
GeneMap99-G3 RH Map55273.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_021374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS691417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000239938   ⟹   ENSP00000239938
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)Ensembl
RefSeq Acc Id: NM_001964   ⟹   NP_001955
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,479 - 138,469,303 (+)NCBI
GRCh375137,801,181 - 137,805,004 (+)ENTREZGENE
Build 365137,829,080 - 137,832,903 (+)NCBI Archive
HuRef5132,991,746 - 132,995,569 (+)ENTREZGENE
CHM1_15137,233,931 - 137,237,754 (+)NCBI
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001955   ⟸   NM_001964
- UniProtKB: P18146 (UniProtKB/Swiss-Prot),   Q546S1 (UniProtKB/TrEMBL),   A0A089VKS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000239938   ⟸   ENST00000239938
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18146-F1-model_v2 AlphaFold P18146 1-543 view protein structure

Promoters
RGD ID:6803024
Promoter ID:HG_KWN:51209
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000251274
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,828,156 - 137,829,572 (+)MPROMDB
RGD ID:6812702
Promoter ID:HG_ACW:65455
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:EGR1.BAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,829,756 - 137,830,582 (+)MPROMDB
RGD ID:6815550
Promoter ID:HG_MRA:12992
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:M24019
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,831,951 - 137,832,602 (+)MPROMDB
RGD ID:6870708
Promoter ID:EPDNEW_H8519
Type:initiation region
Name:EGR1_1
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,465,480 - 138,465,540EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3238 AgrOrtholog
COSMIC EGR1 COSMIC
Ensembl Genes ENSG00000120738 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239938 ENTREZGENE
  ENST00000239938.5 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000120738 GTEx
HGNC ID HGNC:3238 ENTREZGENE
Human Proteome Map EGR1 Human Proteome Map
InterPro EGR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1958 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1958 ENTREZGENE
OMIM 128990 OMIM
PANTHER EARLY GROWTH RESPONSE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3432 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27673 PharmGKB
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A089VKS7 ENTREZGENE, UniProtKB/TrEMBL
  EGR1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q546S1 ENTREZGENE, UniProtKB/TrEMBL