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Gene: EGR1 (early growth response 1) Homo sapiens
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Symbol: EGR1
Name: early growth response 1
RGD ID: 737111
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding activity; and histone acetyltransferase binding activity. Involved in cellular response to cytokine stimulus; positive regulation of pri-miRNA transcription by RNA polymerase II; and regulation of protein sumoylation. Localizes to cytoplasm; nuclear chromatin; and nucleoplasm. Implicated in asthma. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
Orthologs:
Mus musculus (house mouse) : Egr1 (early growth response 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egr1 (early growth response 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egr1 (early growth response 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGR1 (early growth response 1)
Canis lupus familiaris (dog) : EGR1 (early growth response 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egr1 (early growth response 1)
Sus scrofa (pig) : EGR1 (early growth response 1)
Chlorocebus sabaeus (African green monkey) : EGR1 (early growth response 1)
Heterocephalus glaber (naked mole-rat) : Egr1 (early growth response 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,181 - 137,805,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EGR1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737111
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.