EGR1 (early growth response 1) - Rat Genome Database

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Gene: EGR1 (early growth response 1) Homo sapiens
Symbol: EGR1
Name: early growth response 1
RGD ID: 737111
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; double-stranded DNA binding activity; and histone acetyltransferase binding activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and regulation of protein sumoylation. Located in cytoplasm and nucleoplasm. Is active in chromatin. Implicated in asthma. Biomarker of several diseases, including Alzheimer's disease; artery disease (multiple); asthma; bone disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AT225; early growth response protein 1; EGR-1; G0S30; KROX-24; nerve growth factor-induced protein A; NGFI-A; TIS8; transcription factor ETR103; transcription factor Zif268; ZIF-268; zinc finger gene 225; zinc finger protein 225; zinc finger protein Krox-24; ZNF225
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (IEP,ISO)
aortic valve stenosis  (IEP)
arteriosclerosis  (IEP,ISO)
asthma  (IAGP,IEP,ISO)
autoimmune disease  (EXP)
autosomal dominant non-syndromic intellectual disability 31  (IAGP)
autosomal dominant nonsyndromic deafness 1  (IAGP)
brain ischemia  (EXP)
breast cancer  (IEP,ISO)
bronchiolo-alveolar adenocarcinoma  (IEP)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (EXP)
cholestasis  (EXP)
chronic obstructive pulmonary disease  (IEP,ISO)
Cocaine-Related Disorders  (EXP,ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Melanoma  (ISO)
familial adenomatous polyposis 1  (IAGP)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (EXP)
Hereditary Neoplastic Syndromes  (IAGP)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (EXP)
Hypoxia  (EXP)
Hypoxia-Ischemia, Brain  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (EXP)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (EXP)
ischemia  (EXP)
juvenile rheumatoid arthritis  (EXP)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (EXP)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISS)
myeloid neoplasm  (ISO)
Nasal Polyps  (IEP)
Neurodevelopmental Disorders  (IAGP)
osteoarthritis  (IEP)
osteosarcoma  (IEP)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (IAGP)
pneumonia  (EXP)
Prostatic Neoplasms  (EXP)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary sarcoidosis  (IEP)
Reperfusion Injury  (EXP,ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (IEP)
T-Cell Lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20R)-protopanaxadiol  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
22-Hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-cyanoalanine  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP,ISO)
aripiprazole  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
atropine  (ISO)
Aurin  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
bazedoxifene  (EXP)
benzalkonium chloride  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (ISO)
betamethasone  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butanal  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
camostat  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carbonyl sulfide  (ISO)
carrageenan  (EXP)
cefaloridine  (ISO)
chenodeoxycholic acid  (ISO)
chlornitrofen  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
desipramine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (EXP,ISO)
doramapimod  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enniatin  (EXP)
Enterolactone  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
Ethylenethiourea  (ISO)
eugenol  (ISO)
fenpyroximate  (EXP)
ferric oxide  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gemcitabine  (EXP)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isobutanol  (EXP)
isoprenaline  (ISO)
juglone  (EXP)
kainic acid  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
manganese(II) chloride  (ISO)
MeIQx  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naltrexone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitrofen  (ISO)
Norbinaltorphimine  (ISO)
NS-398  (EXP)
O-acetyl-L-carnitine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxazepam  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenanthrene  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
poly(I:C)  (ISO)
potassium atom  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propranolol  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinpirole  (ISO)
raloxifene  (EXP)
ranitidine  (ISO)
razoxane  (ISO)
reactive oxygen species  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rifampicin  (EXP,ISO)
risperidone  (ISO)
ropinirole  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sanguinarine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
SKF 38393  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium tungstate  (ISO)
Soman  (ISO)
styrene  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulindac sulfide  (EXP)
sulprostone  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
topotecan  (ISO)
trans-caffeic acid  (EXP)
tranylcypromine  (ISO)
triacsin C  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
Triton X-100  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vancomycin  (ISO)
vecuronium bromide  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
xanomeline  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc molecular entity  (EXP)
zinc pyrithione  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISS)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IDA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISS)
cellular response to organic substance  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (ISS)
circadian rhythm  (ISO)
circadian temperature homeostasis  (ISS)
estrous cycle  (ISS)
glomerular mesangial cell proliferation  (ISS)
interleukin-1-mediated signaling pathway  (IMP)
learning or memory  (ISO)
locomotor rhythm  (ISS)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell death  (ISO)
positive regulation of chemokine production  (ISS)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISS)
positive regulation of hormone biosynthetic process  (ISS)
positive regulation of interleukin-1 beta production  (ISS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tau-protein kinase activity  (ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of progesterone biosynthetic process  (ISS)
regulation of protein sumoylation  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA,ISO)
regulation of transcription, DNA-templated  (ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (ISS)
response to insulin  (IEA)
response to ischemia  (ISS)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
wound healing  (ISO)

Cellular Component
chromatin  (IDA,ISA)
cytoplasm  (IDA,ISS)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
1. Bakalash S, etal., Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9033-46. doi: 10.1167/iovs.11-7498.
2. Bihl MP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2006 Mar;23(1):38-50.
3. Bilban M, etal., Immunity. 2006 May;24(5):601-10.
4. Birt JA, etal., Reprod Sci. 2013 May;20(5):514-23. doi: 10.1177/1933719113477479. Epub 2013 Feb 20.
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Additional References at PubMed
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Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBImm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21826,463,333 - 26,465,531 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)Ensembl
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBI
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,909 - 137,804,058UniSTSGRCh37
Build 365137,831,808 - 137,831,957RGDNCBI36
Celera5133,924,757 - 133,924,906RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,474 - 132,994,623UniSTS
GeneMap99-GB4 RH Map5524.46UniSTS
Whitehead-RH Map5432.2UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,801,723 - 137,802,491UniSTSGRCh37
Build 365137,829,622 - 137,830,390RGDNCBI36
Celera5133,922,571 - 133,923,339RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,992,288 - 132,993,056UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,566 - 137,803,742UniSTSGRCh37
Build 365137,831,465 - 137,831,641RGDNCBI36
Celera5133,924,414 - 133,924,590RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,131 - 132,994,307UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,802,530 - 137,803,031UniSTSGRCh37
Build 365137,830,429 - 137,830,930RGDNCBI36
Celera5133,923,378 - 133,923,879RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,993,095 - 132,993,596UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,310 - 137,805,095UniSTSGRCh37
Build 365137,832,209 - 137,832,994RGDNCBI36
Celera5133,925,158 - 133,925,943RGD
HuRef5132,994,875 - 132,995,660UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,804,772 - 137,804,998UniSTSGRCh37
Build 365137,832,671 - 137,832,897RGDNCBI36
Celera5133,925,620 - 133,925,846RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,995,337 - 132,995,563UniSTS
Whitehead-YAC Contig Map5 UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,803,843 - 137,803,981UniSTSGRCh37
Build 365137,831,742 - 137,831,880RGDNCBI36
Celera5133,924,691 - 133,924,829RGD
Cytogenetic Map5q31.1UniSTS
HuRef5132,994,408 - 132,994,546UniSTS
Stanford-G3 RH Map55185.0UniSTS
GeneMap99-G3 RH Map55273.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118966

Predicted Target Of
Summary Value
Count of predictions:508
Count of miRNA genes:419
Interacting mature miRNAs:451
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 154 226 179 5 1 228 33 63 17 78 209 224 89
Medium 2243 2035 1499 581 1125 423 3905 1819 2920 372 1312 1312 170 973 2498 3
Low 35 684 45 41 768 40 222 341 725 29 58 87 1 7 201 1
Below cutoff 39 50


Reference Sequences
RefSeq Acc Id: ENST00000239938   ⟹   ENSP00000239938
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)Ensembl
RefSeq Acc Id: NM_001964   ⟹   NP_001955
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh385138,465,479 - 138,469,303 (+)NCBI
GRCh375137,801,181 - 137,805,004 (+)ENTREZGENE
Build 365137,829,080 - 137,832,903 (+)NCBI Archive
HuRef5132,991,746 - 132,995,569 (+)ENTREZGENE
CHM1_15137,233,931 - 137,237,754 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001955   ⟸   NM_001964
- UniProtKB: P18146 (UniProtKB/Swiss-Prot),   Q546S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000239938   ⟸   ENST00000239938
Protein Domains

RGD ID:6803024
Promoter ID:HG_KWN:51209
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Human AssemblyChrPosition (strand)Source
Build 365137,828,156 - 137,829,572 (+)MPROMDB
RGD ID:6812702
Promoter ID:HG_ACW:65455
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Human AssemblyChrPosition (strand)Source
Build 365137,829,756 - 137,830,582 (+)MPROMDB
RGD ID:6815550
Promoter ID:HG_MRA:12992
SO ACC ID:SO:0000170
Tissues & Cell Lines:K562
Human AssemblyChrPosition (strand)Source
Build 365137,831,951 - 137,832,602 (+)MPROMDB
RGD ID:6870708
Promoter ID:EPDNEW_H8519
Type:initiation region
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh385138,465,480 - 138,465,540EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
GRCh37/hg19 5q31.2(chr5:137717265-137802404)x3 copy number gain not provided [RCV000745191] Chr5:137717265..137802404 [GRCh37]
NM_001964.3(EGR1):c.184AGC[5] (p.Ser67del) microsatellite not provided [RCV000961140] Chr5:138465944..138465946 [GRCh38]
Chr5:137801633..137801635 [GRCh37]
likely benign
NM_001964.3(EGR1):c.513G>C (p.Ser171=) single nucleotide variant not provided [RCV000946876] Chr5:138466962 [GRCh38]
Chr5:137802651 [GRCh37]
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
uncertain significance
NM_001964.3(EGR1):c.1017T>G (p.Ala339=) single nucleotide variant not provided [RCV000953788] Chr5:138467466 [GRCh38]
Chr5:137803155 [GRCh37]
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication Deafness, autosomal dominant 1 [RCV001319817]|Mental retardation, autosomal dominant 31 [RCV001339088] Chr5:136633338..140998481 [GRCh37]
uncertain significance
GRCh37/hg19 5q31.2(chr5:137754277-138994590)x1 copy number loss not provided [RCV001270645] Chr5:137754277..138994590 [GRCh37]
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3238 AgrOrtholog
Ensembl Genes ENSG00000120738 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000239938 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000239938 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000120738 GTEx
Human Proteome Map EGR1 Human Proteome Map
InterPro EGR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1958 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
OMIM 128990 OMIM
Pfam DUF3432 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27673 PharmGKB
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL