MIR183 (microRNA 183) - Rat Genome Database
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Gene: MIR183 (microRNA 183) Homo sapiens
Analyze
Symbol: MIR183
Name: microRNA 183
RGD ID: 1342756
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; retinal cone cell development; and sensory perception of sound.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: miR-183; MIRN183; miRNA183
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7129,774,905 - 129,775,014 (-)EnsemblGRCh38hg38GRCh38
GRCh387129,774,905 - 129,775,014 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377129,414,745 - 129,414,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,201,980 - 129,202,089 (-)NCBINCBI36hg18NCBI36
Celera7124,210,490 - 124,210,599 (-)NCBI
Cytogenetic Map7q32.2NCBI
HuRef7123,776,030 - 123,776,139 (-)NCBIHuRef
CHM1_17129,348,136 - 129,348,245 (-)NCBICHM1_1
CRA_TCAGchr7v27128,799,021 - 128,799,130 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12554860   PMID:12624257   PMID:16381832   PMID:17597072   PMID:17604727   PMID:17616659   PMID:18840437   PMID:19940135   PMID:20186779   PMID:20858276   PMID:21037258   PMID:21118966  
PMID:21176563   PMID:21920043   PMID:22045813   PMID:22525461   PMID:22922800   PMID:23007659   PMID:23263745   PMID:23417028   PMID:23538390   PMID:23791657   PMID:23823476   PMID:23906647  
PMID:24150523   PMID:24173391   PMID:24277930   PMID:24289859   PMID:24352761   PMID:24586048   PMID:24631480   PMID:24805982   PMID:25109303   PMID:25211657   PMID:25274328   PMID:25277099  
PMID:25337200   PMID:25394902   PMID:25518924   PMID:25556023   PMID:25629978   PMID:25695717   PMID:25720086   PMID:25755759   PMID:25776494   PMID:25798833   PMID:25856466   PMID:25873390  
PMID:25963660   PMID:25983004   PMID:26063221   PMID:26091793   PMID:26170125   PMID:26357653   PMID:26646931   PMID:26717041   PMID:26873866   PMID:26935154   PMID:26951513   PMID:26961483  
PMID:27071841   PMID:27081087   PMID:27116545   PMID:27155522   PMID:27215622   PMID:27239679   PMID:27283384   PMID:27431799   PMID:27476679   PMID:27593936   PMID:27738758   PMID:27768748  
PMID:27966454   PMID:28017617   PMID:28115792   PMID:28184912   PMID:28224282   PMID:28273643   PMID:28281960   PMID:28321157   PMID:28412207   PMID:28506766   PMID:28631568   PMID:28783105  
PMID:28794468   PMID:29132136   PMID:29331391   PMID:29373811   PMID:29402412   PMID:29437554   PMID:29587281   PMID:29703573   PMID:29749535   PMID:29793318   PMID:29845278   PMID:29952976  
PMID:29955039   PMID:30070321   PMID:30201436   PMID:30221685   PMID:30226564   PMID:30256056   PMID:30293085   PMID:30380528   PMID:30395908   PMID:30522116   PMID:30528264   PMID:30688676  
PMID:30689558   PMID:30720057   PMID:30841423   PMID:30856381   PMID:30896885   PMID:30910587   PMID:30982999   PMID:31210063   PMID:31314587   PMID:31352788   PMID:31433201   PMID:31538425  
PMID:31558304   PMID:31605132   PMID:31605468   PMID:31638242   PMID:31646550   PMID:31694919   PMID:31699956   PMID:31727599   PMID:31786540   PMID:31894433   PMID:32396572   PMID:32571464  


Genomics

Comparative Map Data
MIR183
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7129,774,905 - 129,775,014 (-)EnsemblGRCh38hg38GRCh38
GRCh387129,774,905 - 129,775,014 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377129,414,745 - 129,414,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,201,980 - 129,202,089 (-)NCBINCBI36hg18NCBI36
Celera7124,210,490 - 124,210,599 (-)NCBI
Cytogenetic Map7q32.2NCBI
HuRef7123,776,030 - 123,776,139 (-)NCBIHuRef
CHM1_17129,348,136 - 129,348,245 (-)NCBICHM1_1
CRA_TCAGchr7v27128,799,021 - 128,799,130 (-)NCBI
Mir183
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,169,667 - 30,169,736 (-)NCBIGRCm39mm39
GRCm38630,169,668 - 30,169,737 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,169,668 - 30,169,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv37630,119,668 - 30,119,737 (-)NCBIGRCm37mm9NCBIm37
Celera630,176,496 - 30,176,565 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
Mir183
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0457,463,569 - 57,463,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,463,569 - 57,463,678 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,225,370 - 57,225,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera453,888,185 - 53,888,294 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR183
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl147,068,519 - 7,068,625 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1147,068,542 - 7,068,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR183
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,982,269 - 18,982,338 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,982,269 - 18,982,338 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,030,651 - 20,030,720 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
EGR1hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118966
FOXO1hsa-miR-183-5pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
ITGB1hsa-miR-183-5pMirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI19940135
EZRhsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18840437
BTRChsa-miR-183-5pMirtarbaseexternal_info5'RACE//qRT-PCR//Western blotFunctional MTI19647520
SRSF2hsa-miR-183-5pMirtarbaseexternal_infoImmunoblot//Microarray//qRT-PCRFunctional MTI (Weak)19711202
SRSF2hsa-miR-183-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
PDCD4hsa-miR-183-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20602797
PDCD6hsa-miR-183-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)20602797
AKAP12hsa-miR-183-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//MFunctional MTI20979053
IDH2hsa-miR-183-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//qRFunctional MTI23263745
TTF2hsa-miR-183-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ITGB1hsa-miR-183-5pTarbaseexternal_infoReporter GenePOSITIVE
RTN4hsa-miR-183-5pTarbaseexternal_infoSequencingPOSITIVE
EZRhsa-miR-183-5pMirecordsexternal_info{unchanged}NA18840437
CLIC1hsa-miR-183-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
KRTAP3-2hsa-miR-183-5pMirecordsexternal_info{changed}NA18840437
FOXO1hsa-miR-183-5pMirecordsexternal_infoNANA20028871
EZRhsa-miR-183-5pOncomiRDBexternal_infoNANA22922800
EZRhsa-miR-183-5pOncomiRDBexternal_infoNANA22525461
EGR1hsa-miR-183-5pOncomiRDBexternal_infoNANA21118966
PDCD4hsa-miR-183-5pOncomiRDBexternal_infoNANA20602797
ITGB1hsa-miR-183-5pOncomiRDBexternal_infoNANA19940135
BMI1hsa-miR-183-5pOncomiRDBexternal_infoNANA19935649
EZRhsa-miR-183-5pOncomiRDBexternal_infoNANA18840437

Predicted Targets
Summary Value
Count of predictions:27891
Count of gene targets:11207
Count of transcripts:21438
Interacting mature miRNAs:hsa-miR-183-3p, hsa-miR-183-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 7 1 5 15 10 1 4 1 12 16 3
Below cutoff 17 7 7 2 12 2 30 18 16 5 13 9 2 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384958
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7129,774,905 - 129,775,014 (-)Ensembl
RefSeq Acc Id: NR_029615
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387129,774,905 - 129,775,014 (-)NCBI
GRCh377129,414,745 - 129,414,854 (-)RGD
Celera7124,210,490 - 124,210,599 (-)RGD
HuRef7123,776,030 - 123,776,139 (-)ENTREZGENE
CHM1_17129,348,136 - 129,348,245 (-)NCBI
CRA_TCAGchr7v27128,799,021 - 128,799,130 (-)ENTREZGENE
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3		 pathogenic
GRCh38/hg38 7q32.1-33(chr7:128747478-134018250)x3 copy number gain See cases [RCV000051072] Chr7:128747478..134018250 [GRCh38]
Chr7:128387532..133703003 [GRCh37]
Chr7:128174768..133353543 [NCBI36]
Chr7:7q32.1-33		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q31.33-32.3(chr7:126859732-132750936)x1 copy number loss See cases [RCV000054171] Chr7:126859732..132750936 [GRCh38]
Chr7:126499786..132435696 [GRCh37]
Chr7:126287022..132086236 [NCBI36]
Chr7:7q31.33-32.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33		 pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3		 pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3		 pathogenic
GRCh38/hg38 7q31.33-33(chr7:124170657-134163594)x1 copy number loss See cases [RCV000142552] Chr7:124170657..134163594 [GRCh38]
Chr7:123810711..133848346 [GRCh37]
Chr7:123597947..133498886 [NCBI36]
Chr7:7q31.33-33		 pathogenic
NR_029615.1(MIR183):n.51G>T single nucleotide variant not specified [RCV000151019] Chr7:129774964 [GRCh38]
Chr7:129414804 [GRCh37]
Chr7:7q32.2		 likely benign
NR_029615.1(MIR183):n.105C>A single nucleotide variant not specified [RCV000151021] Chr7:129774910 [GRCh38]
Chr7:129414750 [GRCh37]
Chr7:7q32.2		 not provided
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34		 pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele complex Renal transitional cell carcinoma [RCV000754611] Chr7:129367205..140482957 [GRCh37]
Chr7:7q32.2-34		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31554 AgrOrtholog
COSMIC MIR183 COSMIC
Ensembl Genes ENSG00000207691 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384958 ENTREZGENE
GTEx ENSG00000207691 GTEx
HGNC ID HGNC:31554 ENTREZGENE
Human Proteome Map MIR183 Human Proteome Map
miRBase MI0000273 ENTREZGENE
NCBI Gene 406959 ENTREZGENE
OMIM 611608 OMIM
PharmGKB PA164722531 PharmGKB
RNAcentral URS0000345DEB RNACentral
  URS0000528CBC RNACentral
  URS00005BBC98 RNACentral