EGR1 (early growth response 1) - Rat Genome Database

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Gene: EGR1 (early growth response 1) Canis lupus familiaris
Analyze
Symbol: EGR1
Name: early growth response 1
RGD ID: 12244446
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cellular response to antibiotic (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN long term potentiation; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Alzheimer's disease (ortholog); aortic valve stenosis (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); INTERACTS WITH enalapril; metoprolol; ranolazine
Type: protein-coding
RefSeq Status: MODEL
Previously known as: early growth response protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
autosomal dominant nonsyndromic deafness 1  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Melanoma  (ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hypoxia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Reperfusion Injury  (ISO)
Seizures, Cortical Blindness, and Microcephaly Syndrome  (ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (ISO)
T-Cell Lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
enalapril  (EXP)
metoprolol  (EXP)
ranolazine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IEA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISO)
cellular response to organic substance  (IEA,ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (ISO)
circadian temperature homeostasis  (IEA)
estrous cycle  (IEA)
glomerular mesangial cell proliferation  (ISO)
interleukin-1-mediated signaling pathway  (IEA)
learning or memory  (ISO)
locomotor rhythm  (IEA)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell death  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISO)
positive regulation of hormone biosynthetic process  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of post-translational protein modification  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of progesterone biosynthetic process  (IEA)
regulation of protein sumoylation  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA,ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (IEA)
response to insulin  (IEA)
response to ischemia  (IEA)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
wound healing  (ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19428450  


Genomics

Comparative Map Data
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)EnsemblGRCm39 Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBIMGSCv36mm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21826,463,333 - 26,465,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKY
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,625,892 - 7,629,749 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,140,065 - 41,142,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,247,516 - 31,252,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EGR1
22 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 21 6 6 6 6 1 12 9 3
Low 2 5 1 5 8 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001962   ⟹   ENSCAFP00000001811
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845038567   ⟹   ENSCAFP00845030190
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)Ensembl
RefSeq Acc Id: XM_038490231   ⟹   XP_038346159
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
RefSeq Acc Id: XM_038552314   ⟹   XP_038408242
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
RefSeq Acc Id: XM_038616179   ⟹   XP_038472107
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
RefSeq Acc Id: XM_038681672   ⟹   XP_038537600
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
RefSeq Acc Id: XM_846145   ⟹   XP_851238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,046,195 - 26,049,806 (+)NCBI
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038346159 (Get FASTA)   NCBI Sequence Viewer  
  XP_038408242 (Get FASTA)   NCBI Sequence Viewer  
  XP_038472107 (Get FASTA)   NCBI Sequence Viewer  
  XP_038537600 (Get FASTA)   NCBI Sequence Viewer  
  XP_851238 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_851238   ⟸   XM_846145
- UniProtKB: E2RBP5 (UniProtKB/TrEMBL),   A0A8C0SPV5 (UniProtKB/TrEMBL),   A0A8C0QYI3 (UniProtKB/TrEMBL),   A0A8I3PHY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001811   ⟸   ENSCAFT00000001962
RefSeq Acc Id: XP_038346159   ⟸   XM_038490231
RefSeq Acc Id: XP_038472107   ⟸   XM_038616179
RefSeq Acc Id: XP_038537600   ⟸   XM_038681672
- UniProtKB: A0A8C0SPV5 (UniProtKB/TrEMBL),   A0A8C0QYI3 (UniProtKB/TrEMBL),   A0A8I3PHY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408242   ⟸   XM_038552314
RefSeq Acc Id: ENSCAFP00845030190   ⟸   ENSCAFT00845038567
Protein Domains
C2H2-type

Promoters
RGD ID:13685191
Promoter ID:EPDNEW_C3258
Type:multiple initiation site
Name:EGR1_1
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,045,945 - 26,046,005EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001254 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004255 UniProtKB/TrEMBL
  ENSCAFG00040015140 UniProtKB/TrEMBL
  ENSCAFG00845021860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000001811.4 UniProtKB/TrEMBL
  ENSCAFP00030006854.1 UniProtKB/TrEMBL
  ENSCAFP00040024220 UniProtKB/TrEMBL
  ENSCAFP00845030190 ENTREZGENE
  ENSCAFP00845030190.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001962.6 UniProtKB/TrEMBL
  ENSCAFT00030007815.1 UniProtKB/TrEMBL
  ENSCAFT00040027890 UniProtKB/TrEMBL
  ENSCAFT00845038567 ENTREZGENE
  ENSCAFT00845038567.1 UniProtKB/TrEMBL
InterPro EGR1_C UniProtKB/TrEMBL
  EGR_N UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene EGR1 ENTREZGENE
Pfam DUF3432 UniProtKB/TrEMBL
  DUF3446 UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0QYI3 ENTREZGENE
  A0A8C0SPV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PHY4 ENTREZGENE, UniProtKB/TrEMBL
  E2RBP5 ENTREZGENE
VGNC ID VGNC:51711 ENTREZGENE