EGR1 (early growth response 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: EGR1 (early growth response 1) Canis lupus familiaris
Analyze
Symbol: EGR1
Name: early growth response 1
RGD ID: 12244446
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cellular response to antibiotic (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN long term potentiation; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Alzheimer's disease (ortholog); aortic valve stenosis (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); INTERACTS WITH enalapril; metoprolol; ranolazine
Type: protein-coding
RefSeq Status: MODEL
Also known as: early growth response protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant non-syndromic intellectual disability 31  (ISO)
autosomal dominant nonsyndromic deafness 1  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cocaine-Related Disorders  (ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Melanoma  (ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
myeloid neoplasm  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Reperfusion Injury  (ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (ISO)
T-Cell Lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
enalapril  (EXP)
metoprolol  (EXP)
ranolazine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IEA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISO)
cellular response to organic substance  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (ISO)
circadian temperature homeostasis  (IEA)
estrous cycle  (IEA)
glomerular mesangial cell proliferation  (ISO)
interleukin-1-mediated signaling pathway  (IEA)
learning or memory  (ISO)
locomotor rhythm  (IEA)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell death  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISO)
positive regulation of hormone biosynthetic process  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of progesterone biosynthetic process  (IEA)
regulation of protein sumoylation  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA,ISO)
regulation of transcription, DNA-templated  (ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (ISO)
response to insulin  (IEA)
response to ischemia  (IEA)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)
wound healing  (ISO)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19428450  


Genomics

Comparative Map Data
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBImm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21826,463,333 - 26,465,531 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)Ensembl
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0panPan3
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBI
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 21 6 6 6 6 1 12 9 3
Low 2 5 1 5 8 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001962   ⟹   ENSCAFP00000001811
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)Ensembl
RefSeq Acc Id: XM_038490231   ⟹   XP_038346159
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBI
RefSeq Acc Id: XM_038552314   ⟹   XP_038408242
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBI
RefSeq Acc Id: XM_038616179   ⟹   XP_038472107
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBI
RefSeq Acc Id: XM_038681672   ⟹   XP_038537600
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBI
RefSeq Acc Id: XM_846145   ⟹   XP_851238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,046,195 - 26,049,806 (+)NCBI
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038346159 (Get FASTA)   NCBI Sequence Viewer  
  XP_038408242 (Get FASTA)   NCBI Sequence Viewer  
  XP_038472107 (Get FASTA)   NCBI Sequence Viewer  
  XP_038537600 (Get FASTA)   NCBI Sequence Viewer  
  XP_851238 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_851238   ⟸   XM_846145
- UniProtKB: E2RBP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001811   ⟸   ENSCAFT00000001962
RefSeq Acc Id: XP_038346159   ⟸   XM_038490231
RefSeq Acc Id: XP_038472107   ⟸   XM_038616179
RefSeq Acc Id: XP_038537600   ⟸   XM_038681672
RefSeq Acc Id: XP_038408242   ⟸   XM_038552314

Promoters
RGD ID:13685191
Promoter ID:EPDNEW_C3258
Type:multiple initiation site
Name:EGR1_1
Description:early growth response 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11126,045,945 - 26,046,005EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001254 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000001811 ENTREZGENE
NCBI Gene EGR1 ENTREZGENE
UniProt E2RBP5 ENTREZGENE
VGNC ID VGNC:51711 ENTREZGENE