EGR1 (early growth response 1) - Rat Genome Database

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Gene: EGR1 (early growth response 1) Sus scrofa
Analyze
Symbol: EGR1
Name: early growth response 1
RGD ID: 14163982
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN BMP signaling pathway (ortholog); cellular response to antibiotic (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN long term potentiation; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Alzheimer's disease (ortholog); aortic valve stenosis (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); nucleoplasm (inferred); INTERACTS WITH ammonia; bis(2-chloroethyl) sulfide; cadmium dichloride
Type: protein-coding
RefSeq Status: MODEL
Previously known as: early growth response protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
Alzheimer's disease  (ISO)
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchitis  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
congenital hypothyroidism  (ISO)
Decompression Sickness  (ISO)
Drug-Induced Dyskinesia  (ISO)
duodenal ulcer  (ISO)
endometriosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Seizures  (ISO)
familial adenomatous polyposis 1  (ISO)
Fetal Hypoxia  (ISO)
fibrosarcoma  (ISO)
Graft Occlusion, Vascular  (ISO)
Heart Block  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hypoxia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
Intimal Hyperplasia  (ISO)
intrahepatic cholestasis  (ISO)
ischemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Memory Disorders  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
morphine withdrawal syndrome  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
osteosarcoma  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Reperfusion Injury  (ISO)
silicosis  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (ISO)
STING-associated vasculopathy with onset in infancy  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Tendon Injuries  (ISO)
Tissue Adhesions  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IEA,ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to gonadotropin stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heparin  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-8  (IEA)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mycophenolic acid  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (ISO)
circadian temperature homeostasis  (IEA)
estrous cycle  (IEA)
glomerular mesangial cell proliferation  (ISO)
interleukin-1-mediated signaling pathway  (IEA)
learning or memory  (ISO)
locomotor rhythm  (IEA)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (IEA)
positive regulation of glomerular metanephric mesangial cell proliferation  (ISO)
positive regulation of hormone biosynthetic process  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of post-translational protein modification  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of progesterone biosynthetic process  (IEA)
regulation of protein sumoylation  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to amphetamine  (ISO)
response to carbon monoxide  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to glucose  (IEA)
response to gonadotropin  (ISO)
response to hypoxia  (IEA)
response to insulin  (IEA)
response to ischemia  (IEA)
response to morphine  (ISO)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
T cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA)
cytoplasm  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22344601   PMID:23902638   PMID:30032202  


Genomics

Comparative Map Data
EGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,156,073 - 146,159,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,465,479 - 138,469,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,465,479 - 138,469,303 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,801,168 - 137,804,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,829,080 - 137,832,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,829,079 - 137,832,903NCBI
Celera5133,922,029 - 133,925,852 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,991,746 - 132,995,569 (+)NCBIHuRef
CHM1_15137,233,931 - 137,237,754 (+)NCBICHM1_1
T2T-CHM13v2.05138,991,707 - 138,995,531 (+)NCBIT2T-CHM13v2.0
Egr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,994,260 - 34,998,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,992,876 - 34,998,037 (+)EnsemblGRCm39 Ensembl
GRCm381834,861,207 - 34,864,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,859,823 - 34,864,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371835,020,861 - 35,024,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,987,181 - 34,990,930 (+)NCBIMGSCv36mm8
Celera1835,315,402 - 35,319,152 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.76NCBI
Egr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,737,078 - 26,740,877 (+)NCBIGRCr8
mRatBN7.21826,462,967 - 26,466,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,462,981 - 26,466,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,590,700 - 26,592,898 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018586,183 - 588,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,689,223 - 26,691,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,657,903 - 27,660,101 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,657,628 - 27,661,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,369,518 - 27,371,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,343,919 - 27,346,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,370,212 - 27,373,998 (+)NCBI
Celera1826,200,028 - 26,202,226 (+)NCBICelera
RH 3.4 Map18367.2RGD
Cytogenetic Map18p12NCBI
Egr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,002,699 - 2,005,007 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,001,509 - 2,005,269 (-)NCBIChiLan1.0ChiLan1.0
EGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,740,921 - 133,744,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,880,479 - 131,884,306 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,845,305 - 133,849,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,975,635 - 139,979,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,975,635 - 139,979,260 (+)Ensemblpanpan1.1panPan2
EGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,046,195 - 26,049,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,046,228 - 26,048,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,815,187 - 24,819,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,902,196 - 26,906,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,902,175 - 26,906,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,609,123 - 25,612,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,431,916 - 25,435,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,096,153 - 26,099,996 (+)NCBIUU_Cfam_GSD_1.0
Egr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,981,761 - 153,985,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,625,892 - 7,629,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,625,956 - 7,629,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,139,636 - 41,143,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,140,065 - 41,142,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,743,898 - 36,747,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,247,516 - 31,252,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,247,855 - 31,251,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EGR1
87 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000015660   ⟹   ENSSSCP00000015247
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2140,441,421 - 140,445,296 (+)Ensembl
RefSeq Acc Id: XM_003123974   ⟹   XP_003124022
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12140,440,829 - 140,445,302 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003124022   ⟸   XM_003123974
- UniProtKB: F1RH73 (UniProtKB/TrEMBL),   A0A8D0NAP9 (UniProtKB/TrEMBL),   A0A0B8RTR2 (UniProtKB/TrEMBL),   A0A8D0I2K9 (UniProtKB/TrEMBL),   A0A8D0LED0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000015247   ⟸   ENSSSCT00000015660
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005002689 UniProtKB/TrEMBL
  ENSSSCG00015027344 UniProtKB/TrEMBL
  ENSSSCG00025058298 UniProtKB/TrEMBL
  ENSSSCG00030037189 UniProtKB/TrEMBL
  ENSSSCG00035047326 UniProtKB/TrEMBL
  ENSSSCG00040073145 UniProtKB/TrEMBL
  ENSSSCG00045036926 UniProtKB/TrEMBL
  ENSSSCG00050041133 UniProtKB/TrEMBL
  ENSSSCG00055004704 UniProtKB/TrEMBL
  ENSSSCG00060013896 UniProtKB/TrEMBL
  ENSSSCG00065061571 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015660 ENTREZGENE
  ENSSSCT00000015660.5 UniProtKB/TrEMBL
  ENSSSCT00005004088.1 UniProtKB/TrEMBL
  ENSSSCT00005004094.1 UniProtKB/TrEMBL
  ENSSSCT00015036331.1 UniProtKB/TrEMBL
  ENSSSCT00025079770.1 UniProtKB/TrEMBL
  ENSSSCT00030051715.1 UniProtKB/TrEMBL
  ENSSSCT00035063011.1 UniProtKB/TrEMBL
  ENSSSCT00040100851.1 UniProtKB/TrEMBL
  ENSSSCT00045063600.1 UniProtKB/TrEMBL
  ENSSSCT00050055768.1 UniProtKB/TrEMBL
  ENSSSCT00055009285.1 UniProtKB/TrEMBL
  ENSSSCT00060018335.1 UniProtKB/TrEMBL
  ENSSSCT00065084380.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro EGR1_C UniProtKB/TrEMBL
  EGR_N UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report ssc:100520726 UniProtKB/TrEMBL
NCBI Gene EGR1 ENTREZGENE
PANTHER EARLY GROWTH RESPONSE PROTEIN 1 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam DUF3432 UniProtKB/TrEMBL
  DUF3446 UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0B8RTR2 ENTREZGENE
  A0A8D0I2K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LED0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NAP9 ENTREZGENE, UniProtKB/TrEMBL
  F1RH73 ENTREZGENE
UniProt Secondary F1RH73 UniProtKB/TrEMBL
VGNC ID VGNC:87590 ENTREZGENE