Nme5 (NME/NM23 family member 5) - Rat Genome Database

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Gene: Nme5 (NME/NM23 family member 5) Rattus norvegicus
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Symbol: Nme5
Name: NME/NM23 family member 5
RGD ID: 1583004
Description: Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in cilium movement and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; spermatid development; and ventricular system development. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; cadmium dichloride; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688903; nucleoside diphosphate kinase homolog 5; similar to Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (nm23-M5)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,437,705 - 26,454,828 (-)NCBIGRCr8
mRatBN7.21826,163,558 - 26,180,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,163,555 - 26,180,794 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01827,357,460 - 27,374,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,357,413 - 27,374,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,071,170 - 27,087,990 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,033,366 - 27,049,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1825,901,876 - 25,918,575 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12788088   PMID:19303412   PMID:21746835  


Genomics

Comparative Map Data
Nme5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,437,705 - 26,454,828 (-)NCBIGRCr8
mRatBN7.21826,163,558 - 26,180,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,163,555 - 26,180,794 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01827,357,460 - 27,374,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,357,413 - 27,374,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,071,170 - 27,087,990 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,033,366 - 27,049,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1825,901,876 - 25,918,575 (-)NCBICelera
Cytogenetic Map18p12NCBI
NME5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,115,175 - 138,139,428 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,115,175 - 138,139,443 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,450,864 - 137,475,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,478,760 - 137,503,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,478,760 - 137,503,031NCBI
Celera5133,572,789 - 133,596,436 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,641,817 - 132,666,155 (-)NCBIHuRef
CHM1_15136,883,576 - 136,907,841 (-)NCBICHM1_1
T2T-CHM13v2.05138,641,496 - 138,665,760 (-)NCBIT2T-CHM13v2.0
Nme5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,695,687 - 34,712,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,695,687 - 34,712,168 (-)EnsemblGRCm39 Ensembl
GRCm381834,562,634 - 34,579,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,562,634 - 34,579,115 (-)EnsemblGRCm38mm10GRCm38
MGSCv371834,722,295 - 34,738,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,687,524 - 34,703,487 (-)NCBIMGSCv36mm8
Celera1835,015,665 - 35,031,668 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
Nme5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,282,574 - 2,302,106 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,282,721 - 2,301,997 (+)NCBIChiLan1.0ChiLan1.0
NME5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,388,554 - 133,412,673 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,525,350 - 131,552,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,493,930 - 133,517,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,628,678 - 139,651,789 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,628,678 - 139,651,372 (-)Ensemblpanpan1.1panPan2
NME5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,772,162 - 25,792,856 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,772,157 - 25,792,176 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,538,412 - 24,559,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,624,451 - 26,645,447 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,624,446 - 26,644,768 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,332,083 - 25,352,763 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,155,488 - 25,176,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,819,025 - 25,839,791 (-)NCBIUU_Cfam_GSD_1.0
Nme5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,292,830 - 154,314,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,296,556 - 7,318,682 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,296,565 - 7,318,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,131,991 - 140,167,934 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,132,871 - 140,168,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,830,949 - 145,866,364 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NME5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,785,234 - 40,808,391 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,785,255 - 40,807,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603437,081,967 - 37,105,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nme5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474330,925,445 - 30,950,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474330,925,210 - 30,950,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nme5
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000027244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 85 84 53 25 53 6 212 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027244   ⟹   ENSRNOP00000027244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1826,163,555 - 26,180,794 (-)Ensembl
Rnor_6.0 Ensembl1827,357,413 - 27,374,603 (-)Ensembl
RefSeq Acc Id: NM_001427396   ⟹   NP_001414325
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,437,781 - 26,454,828 (-)NCBI
RefSeq Acc Id: XM_039097262   ⟹   XP_038953190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,437,705 - 26,454,434 (-)NCBI
mRatBN7.21826,163,558 - 26,180,742 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414325 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953190 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027244.4
Ensembl Acc Id: ENSRNOP00000027244   ⟸   ENSRNOT00000027244
RefSeq Acc Id: XP_038953190   ⟸   XM_039097262
- Peptide Label: isoform X1
- UniProtKB: A6J2U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414325   ⟸   NM_001427396
- UniProtKB: D3ZH90 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH90-F1-model_v2 AlphaFold D3ZH90 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700705
Promoter ID:EPDNEW_R11218
Type:initiation region
Name:Nme5_1
Description:NME/NM23 family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01827,374,591 - 27,374,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583004 AgrOrtholog
BioCyc Gene G2FUF-7954 BioCyc
BioCyc Pathway PWY-7176 [UTP and CTP de novo biosynthesis] BioCyc
  PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7197 [pyrimidine deoxyribonucleotide phosphorylation] BioCyc
  PWY-7205 [CMP phosphorylation] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
  PWY-7224 [purine deoxyribonucleosides salvage] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7176 BioCyc
  PWY-7184 BioCyc
  PWY-7197 BioCyc
  PWY-7205 BioCyc
  PWY-7210 BioCyc
  PWY-7221 BioCyc
  PWY-7224 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000020118 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027244.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.141 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
InterPro Dpy-30_motif UniProtKB/TrEMBL
  NDK-like_dom UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/TrEMBL
  NDK_H5 UniProtKB/TrEMBL
  Nucleoside_diP_kinase UniProtKB/TrEMBL
NCBI Gene 688903 ENTREZGENE
PANTHER NUCLEOSIDE DIPHOSPHATE KINASE UniProtKB/TrEMBL
  NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5 UniProtKB/TrEMBL
Pfam Dpy-30 UniProtKB/TrEMBL
  NDK UniProtKB/TrEMBL
PhenoGen Nme5 PhenoGen
PIRSF NDK_H5 UniProtKB/TrEMBL
PRINTS NUCDPKINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020118 RatGTEx
SMART NDK UniProtKB/TrEMBL
Superfamily-SCOP SSF54919 UniProtKB/TrEMBL
UniProt A6J2U7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZH90 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Nme5  NME/NM23 family member 5  LOC688903  similar to Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (nm23-M5)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688903  similar to Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (nm23-M5)      Symbol and Name status set to provisional 70820 PROVISIONAL