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Gene: Onecut2 (one cut homeobox 2) Rattus norvegicus

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Symbol:

Onecut2

Name:

one cut homeobox 2

RGD ID:

1564677

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; peripheral nervous system neuron development; and positive regulation of mesenchymal stem cell migration. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ONECUT2 (one cut homeobox 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC307376; one cut domain family member 2; RGD1564677; similar to transcription factor ONECUT2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ONECUT2 (one cut homeobox 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Onecut2 (one cut domain, family member 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Onecut2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ONECUT2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ONECUT2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Onecut2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ONECUT2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ONECUT2 (one cut homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ONECUT2 (one cut homeobox 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Onecut2 (one cut domain, family member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	onecut2 (one cut homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	onecut	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-48	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	onecut3	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	60,101,967 - 60,161,095 (+)	NCBI		GRCr8
mRatBN7.2	18	57,831,647 - 57,890,884 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	57,832,111 - 57,879,629 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	59,913,751 - 59,972,932 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	60,625,609 - 60,684,747 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	58,455,463 - 58,514,601 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	59,830,375 - 59,882,490 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	59,830,363 - 59,875,127 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	59,041,278 - 59,094,065 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	60,547,891 - 60,594,526 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	55,970,012 - 56,030,948 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

polycystic liver disease (ISO)

polycystic liver disease 1 (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clobetasol (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

dichloromethane (ISO)

dorsomorphin (ISO)

entinostat (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

inulin (ISO)

L-methionine (ISO)

leflunomide (ISO)

maneb (ISO)

mercury dibromide (ISO)

methidathion (ISO)

methimazole (EXP)

miconazole (ISO)

nefazodone (EXP)

panobinostat (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propiconazole (ISO)

Ptaquiloside (ISO)

quercetin (ISO)

SB 431542 (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure morphogenesis (IEA,ISO)

cell fate commitment (IEA,ISO)

cell migration (IEA,ISO)

cilium assembly (IEA,ISO)

endocrine pancreas development (IEA,ISO)

epithelial cell development (IEA,ISO)

liver development (IEA,ISO)

mesenchymal stem cell migration (IEA,ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA,ISO)

pancreas development (IEA,ISO)

peripheral nervous system neuron development (IEA,ISO)

positive regulation of mesenchymal stem cell migration (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of cell-matrix adhesion (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA)

transforming growth factor beta receptor signaling pathway (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11478782	PMID:11944891	PMID:16103213	PMID:16472605	PMID:17400205	PMID:17698011	PMID:17936262

Genomics

Comparative Map Data

Onecut2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	60,101,967 - 60,161,095 (+)	NCBI		GRCr8
mRatBN7.2	18	57,831,647 - 57,890,884 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	57,832,111 - 57,879,629 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	59,913,751 - 59,972,932 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	60,625,609 - 60,684,747 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	58,455,463 - 58,514,601 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	59,830,375 - 59,882,490 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	59,830,363 - 59,875,127 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	59,041,278 - 59,094,065 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	60,547,891 - 60,594,526 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	55,970,012 - 56,030,948 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

ONECUT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	57,435,374 - 57,491,298 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	57,435,374 - 57,491,298 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	55,102,606 - 55,158,530 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	53,253,915 - 53,309,528 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	53,253,914 - 53,295,062	NCBI
Celera	18	51,819,929 - 51,875,634 (+)	NCBI		Celera
Cytogenetic Map	18	q21.31	NCBI
HuRef	18	51,813,575 - 51,869,027 (+)	NCBI		HuRef
CHM1_1	18	55,098,361 - 55,153,854 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	57,636,246 - 57,692,260 (+)	NCBI		T2T-CHM13v2.0

Onecut2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	64,473,098 - 64,531,559 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	64,473,091 - 64,534,058 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	64,340,032 - 64,398,488 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	64,340,020 - 64,400,987 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	64,500,018 - 64,558,142 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	64,465,733 - 64,512,126 (+)	NCBI		MGSCv36	mm8
Celera	18	65,606,684 - 65,664,663 (+)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	37.33	NCBI

Onecut2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	41,782,281 - 41,839,782 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	41,782,281 - 41,839,782 (+)	NCBI	ChiLan1.0	ChiLan1.0

ONECUT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	74,975,774 - 75,031,798 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	60,668,386 - 60,724,415 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	50,826,110 - 50,882,127 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	54,161,765 - 54,205,185 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ONECUT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	18,428,112 - 18,486,047 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	18,440,172 - 18,486,048 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	19,409,022 - 19,470,180 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	18,306,646 - 18,368,530 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	18,321,367 - 18,368,530 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	18,363,216 - 18,424,955 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	18,261,022 - 18,322,552 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	18,529,774 - 18,591,518 (-)	NCBI		UU_Cfam_GSD_1.0

Onecut2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	31,600,534 - 31,656,619 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	6,854,238 - 6,895,660 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	6,853,739 - 6,896,408 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ONECUT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	106,751,738 - 106,799,607 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	106,751,346 - 106,812,484 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ONECUT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	22,248,353 - 22,296,290 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	22,252,123 - 22,296,166 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666060	3,272,876 - 3,329,598 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Onecut2
213 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	30
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000024631, ENSRNOT00000071309
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331730	Scl27	Serum cholesterol level QTL 27	3.826		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	52292875	59796643	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	54709769	83828827	Rat
1331736	Bp227	Blood pressure QTL 227	2.791		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	46718763	59796643	Rat
1300125	Rf26	Renal function QTL 26	3.2		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	18	52539863	65844950	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	61698465	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
61360	Eaey	Experimental allergic encephalomyelitis QTL y	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	18	46988939	60377753	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	52539763	76104388	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
2293658	Bmd23	Bone mineral density QTL 23	7.3	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	18	51464733	63636873	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	52292875	73997283	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1331752	Bw27	Body weight QTL 27	2.963		body mass (VT:0001259)	body weight (CMO:0000012)	18	52292875	65845095	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	52539763	76104388	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	52539763	76104388	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	52539763	76104388	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31271681	60377755	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	52539763	76104388	Rat
1331806	Bp229	Blood pressure QTL 229	4.36484		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718763	57867167	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	52539763	76104388	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	52539763	76104388	Rat
1331780	Bp238	Blood pressure QTL 238	3.269		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718763	59796643	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31359408	59796643	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359530	59796478	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	52539763	69140759	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
1600375	Mcs22	Mammary carcinoma susceptibility QTL 22	3.3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	52539763	63933058	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31359408	70263868	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	49999958	65845095	Rat

Markers in Region

RH134340

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	57,838,887 - 57,839,079 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	59,837,373 - 59,837,564	NCBI	Rnor6.0
Rnor_5.0	18	59,048,948 - 59,049,139	UniSTS	Rnor5.0
RGSC_v3.4	18	60,554,465 - 60,554,656	UniSTS	RGSC3.4
Celera	18	55,976,598 - 55,976,789	UniSTS
RH 3.4 Map	18	569.2	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Onecut2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	57,832,488 - 57,832,565 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	59,830,737 - 59,830,813	NCBI	Rnor6.0
Rnor_5.0	18	59,042,312 - 59,042,388	UniSTS	Rnor5.0
RGSC_v3.4	18	60,548,044 - 60,548,120	UniSTS	RGSC3.4
Celera	18	55,970,231 - 55,970,307	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	2	18	109	79	76	59	8	59	6	128	42	93	18	49	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001400633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002725360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078378 ⟹ ENSRNOP00000075225

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	57,832,111 - 57,879,629 (+)	Ensembl
Rnor_6.0 Ensembl	18	59,830,422 - 59,875,127 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082650 ⟹ ENSRNOP00000072120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	59,830,363 - 59,875,124 (+)	Ensembl

RefSeq Acc Id:

NM_001400633 ⟹ NP_001387562

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	60,101,973 - 60,161,095 (+)	NCBI
mRatBN7.2	18	57,831,759 - 57,890,884 (+)	NCBI

RefSeq Acc Id:

XM_039097412 ⟹ XP_038953340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	60,101,967 - 60,109,392 (+)	NCBI
mRatBN7.2	18	57,831,647 - 57,839,179 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001387562	(Get FASTA)	NCBI Sequence Viewer
	XP_038953340	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075225
	ENSRNOP00000075225.2

Ensembl Acc Id:

ENSRNOP00000072120 ⟸ ENSRNOT00000082650

Ensembl Acc Id:

ENSRNOP00000075225 ⟸ ENSRNOT00000078378

RefSeq Acc Id:	XP_038953340 ⟸ XM_039097412
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001387562 ⟸ NM_001400633
- UniProtKB:	A0A0G2KA21 (UniProtKB/TrEMBL)

Protein Domains

CUT Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K263-F1-model_v2	AlphaFold	A0A0G2K263	1-502	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700831

Promoter ID:

EPDNEW_R11355

Type:

single initiation site

Name:

Onecut2_1

Description:

One cut domain family member 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	59,830,470 - 59,830,530	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564677	AgrOrtholog
BioCyc Gene	G2FUF-7256	BioCyc
Ensembl Genes	ENSRNOG00000052665	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078378	ENTREZGENE
	ENSRNOT00000078378.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.260.40	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
InterPro	CUT_dom	UniProtKB/TrEMBL
	CUT_Homeobox	UniProtKB/TrEMBL
	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Lambda_DNA-bd_dom_sf	UniProtKB/TrEMBL
NCBI Gene	307376	ENTREZGENE
PANTHER	ONE CUT DOMAIN FAMILY MEMBER 2	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR ONECUT	UniProtKB/TrEMBL
Pfam	CUT	UniProtKB/TrEMBL
	Homeodomain	UniProtKB/TrEMBL
PhenoGen	Onecut2	PhenoGen
PROSITE	CUT	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000052665	RatGTEx
SMART	CUT	UniProtKB/TrEMBL
	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
	SSF47413	UniProtKB/TrEMBL
UniProt	A0A0G2KA21	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-12	Onecut2	one cut homeobox 2	RGD1564677	similar to transcription factor ONECUT2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564677	similar to transcription factor ONECUT2	RGD1564677_predicted	similar to transcription factor ONECUT2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564677_predicted	similar to transcription factor ONECUT2 (predicted)	LOC307376	similar to transcription factor ONECUT2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC307376	similar to transcription factor ONECUT2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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