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Gene: Hbegf (heparin-binding EGF-like growth factor) Rattus norvegicus
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
RGD ID: 2526
Description: Exhibits epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to localize to cell surface; extracellular space; and integral component of plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); Dtr; GFHB; Hb-egf; Hegfl; heparin binding epidermal growth factor-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
Homo sapiens (human) : HBEGF (heparin binding EGF like growth factor)  HGNC  Alliance
Mus musculus (house mouse) : Hbegf (heparin-binding EGF-like growth factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hbegf (heparin binding EGF like growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : HBEGF (heparin binding EGF like growth factor)
Canis lupus familiaris (dog) : HBEGF (heparin binding EGF like growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hbegf (heparin binding EGF like growth factor)
Sus scrofa (pig) : HBEGF (heparin binding EGF like growth factor)
Chlorocebus sabaeus (African green monkey) : HBEGF (heparin binding EGF like growth factor)
Heterocephalus glaber (naked mole-rat) : Hbegf (heparin binding EGF like growth factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hbegf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2526
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.