Hbegf (heparin-binding EGF-like growth factor) - Rat Genome Database

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Gene: Hbegf (heparin-binding EGF-like growth factor) Rattus norvegicus
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
RGD ID: 2526
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space and plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Previously known as: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); Dtr; GFHB; Hb-egf; Hegfl; heparin binding epidermal growth factor-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21828,106,284 - 28,116,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,233,442 - 28,243,328 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01828,995,528 - 29,005,411 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01828,330,776 - 28,340,662 (-)NCBIRnor_WKY
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beraprost  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gefitinib  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
graphite  (EXP)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Muraglitazar  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluoroundecanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
Rebamipide  (EXP)
rifampicin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
Tetramethylthiourea  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
versicolorin A  (ISO)
water  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues. Abraham JA, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):125-33.
2. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. Dvorak B, etal., J Pediatr Gastroenterol Nutr. 2008 Jul;47(1):11-8. doi: 10.1097/MPG.0b013e3181788618.
3. Heparin-binding epidermal-growth-factor-like growth factor gene expression is induced by scrape-wounding epithelial cell monolayers: involvement of mitogen-activated protein kinase cascades. Ellis PD, etal., Biochem J 2001 Feb 15;354(Pt 1):99-106.
4. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons. Farkas LM and Krieglstein K, J Neural Transm 2002 Mar;109(3):267-77.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
7. Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts. Liu J, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1106-15. Epub 2003 Jul 25.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
15. A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction. Tanaka N, etal., Biochem Biophys Res Commun 2002 Sep 20;297(2):375-81.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium. Uesaka T, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G840-7.
18. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. Wharram BL, etal., J Am Soc Nephrol 2005 Oct;16(10):2941-52. Epub 2005 Aug 17.
19. Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Zhang H, etal., Circ Res. 2004 Nov 12;95(10):989-97. Epub 2004 Oct 14.
Additional References at PubMed
PMID:1840698   PMID:8300582   PMID:8702723   PMID:9857183   PMID:11882602   PMID:12070119   PMID:12621152   PMID:12743035   PMID:12746188   PMID:15490481   PMID:15923649   PMID:16364500  
PMID:16737974   PMID:16753836   PMID:16806064   PMID:17655843   PMID:17855771   PMID:18299347   PMID:18929421   PMID:19193634   PMID:19225541   PMID:19237431   PMID:19389413   PMID:20696782  
PMID:21244855   PMID:23534509   PMID:24008408   PMID:24303948   PMID:24703506   PMID:25759388   PMID:31882563   PMID:35281434  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21828,106,284 - 28,116,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,233,442 - 28,243,328 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01828,995,528 - 29,005,411 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01828,330,776 - 28,340,662 (-)NCBIRnor_WKY
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385140,332,843 - 140,346,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5140,332,843 - 140,346,603 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,712,428 - 139,726,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,692,612 - 139,706,358 (-)NCBINCBI36Build 36hg18NCBI36
Celera5135,789,059 - 135,802,819 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5134,857,589 - 134,871,349 (-)NCBIHuRef
CHM1_15139,145,572 - 139,159,324 (-)NCBICHM1_1
T2T-CHM13v2.05140,858,275 - 140,872,035 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391836,637,980 - 36,648,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,637,980 - 36,648,858 (-)EnsemblGRCm39 Ensembl
GRCm381836,504,927 - 36,515,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,504,927 - 36,515,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,664,581 - 36,675,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,630,906 - 36,641,748 (-)NCBIMGSCv36mm8
Celera1836,954,561 - 36,965,476 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955418309,096 - 321,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955418259,860 - 321,340 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.15141,816,402 - 141,830,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5141,816,402 - 141,830,531 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05135,699,553 - 135,713,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1235,551,248 - 35,563,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,551,250 - 35,563,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,590,448 - 32,601,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,006,883 - 36,018,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,006,888 - 36,018,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,058,605 - 33,070,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,926,053 - 33,938,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,678,980 - 34,691,039 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213152,266,443 - 152,278,566 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,332,898 - 9,345,067 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365319,332,939 - 9,345,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2142,102,458 - 142,115,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,102,455 - 142,115,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,047,629 - 148,058,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12342,981,640 - 42,995,116 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,981,640 - 42,994,995 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,887,898 - 34,902,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474333,112,036 - 33,124,169 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,112,105 - 33,124,145 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hbegf
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:721
Count of miRNA genes:298
Interacting mature miRNAs:373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,105,863 - 28,106,082 (+)MAPPERmRatBN7.2
Rnor_6.01829,329,882 - 29,330,100NCBIRnor6.0
Rnor_5.01829,036,443 - 29,036,661UniSTSRnor5.0
RGSC_v3.41829,143,147 - 29,143,365UniSTSRGSC3.4
Celera1827,834,117 - 27,834,335UniSTS
RH 3.4 Map18416.8UniSTS
Cytogenetic Map18p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 2 1 3 31 2 2 3 1
Low 2 41 36 20 19 20 7 8 43 33 37 8 7
Below cutoff 21 21 21 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025157   ⟹   ENSRNOP00000025157
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)Ensembl
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)Ensembl
RefSeq Acc Id: NM_012945   ⟹   NP_037077
Rat AssemblyChrPosition (strand)Source
mRatBN7.21828,106,284 - 28,116,167 (-)NCBI
Rnor_6.01829,330,302 - 29,340,185 (-)NCBI
Rnor_5.01829,036,863 - 29,046,746 (-)NCBI
RGSC_v3.41829,143,567 - 29,153,944 (-)RGD
Celera1827,834,537 - 27,844,179 (-)RGD
Protein Sequences
Protein RefSeqs NP_037077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA81780 (Get FASTA)   NCBI Sequence Viewer  
  EDL76294 (Get FASTA)   NCBI Sequence Viewer  
  Q06175 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037077   ⟸   NM_012945
- Peptide Label: precursor
- UniProtKB: Q06175 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025157   ⟸   ENSRNOT00000025157
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06175-F1-model_v2 AlphaFold Q06175 1-208 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700720
Promoter ID:EPDNEW_R11243
Type:multiple initiation site
Description:heparin-binding EGF-like growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01829,340,413 - 29,340,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2526 AgrOrtholog
BioCyc Gene G2FUF-7875 BioCyc
Ensembl Genes ENSRNOG00000018646 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025157 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025157 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  EGF_rcpt_ligand UniProtKB/Swiss-Prot
KEGG Report rno:25433 UniProtKB/Swiss-Prot
PANTHER PTHR10740 UniProtKB/Swiss-Prot
PhenoGen Hbegf PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
TIGR TC230854

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hbegf  heparin-binding EGF-like growth factor  Dtr  diphtheria toxin receptor  Symbol and Name updated 1299863 APPROVED
2004-02-26 Dtr  diphtheria toxin receptor      Symbol and Name status set to approved 625702 APPROVED
2003-05-08 Dtr  diphtheria toxin receptor  Hb-egf  heparin-binding epidermal -growth factor  Data Merged 628472 PROVISIONAL
2003-04-09 Dtr  diphtheria toxin receptor  Hegfl  heparin binding epidermal growth factor-like growth factor  Symbol and Name updated 629477 APPROVED
2002-11-06 Hegfl  heparin binding epidermal growth factor-like growth factor  Dtr  Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)  Symbol and Name updated 625702 APPROVED
2002-06-10 Dtr  Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Hb-egf  heparin-binding epidermal -growth factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in cardiac fibroblast proliferation and remodeling after myocardial infarction 728765