(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HBEGF mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1605733 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HBEGF mRNA, epigallocatechin gallate affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:22079256 , PMID:26800359 1,10-phenanthroline increases expression ISO RGD:1605733 6480464 1, 10-phenanthroline results in increased expression of HBEGF mRNA CTD PMID:26800359 1,2,4-trimethylbenzene increases expression EXP 6480464 pseudocumene results in increased expression of HBEGF protein CTD PMID:17337753 1,2-dimethylhydrazine increases expression ISO RGD:1552258 6480464 1, 2-Dimethylhydrazine results in increased expression of HBEGF mRNA CTD PMID:22206623 1-nitropyrene increases expression ISO RGD:1605733 6480464 1-nitropyrene results in increased expression of HBEGF mRNA CTD PMID:19041380 17beta-estradiol increases expression ISO RGD:1552258 6480464 Estradiol results in increased expression of HBEGF mRNA CTD PMID:25210133 17beta-estradiol increases expression ISO RGD:1605733 6480464 Estradiol results in increased expression of HBEGF mRNA CTD PMID:31614463 17beta-estradiol multiple interactions ISO RGD:1605733 6480464 [Estradiol co-treated with EGF protein] results in increased expression of HBEGF mRNA, [Estradiol results in increased abundance of Cadmium] which results in increased expression of HBEGF protein CTD PMID:24758408 , PMID:31468104 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of HBEGF mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552258 6480464 Tetrachlorodibenzodioxin affects the expression of HBEGF mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNA CTD PMID:23196670 , PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNA] CTD PMID:23196670 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1605733 6480464 Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1552258 6480464 Tetrachlorodibenzodioxin results in decreased expression of HBEGF mRNA CTD PMID:19770486 more ... 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:1552258 6480464 [Galactosamine co-treated with lipopolysaccharide more ... CTD PMID:28887131 2-butoxyethanol increases expression ISO RGD:1552258 6480464 n-butoxyethanol results in increased expression of HBEGF mRNA CTD PMID:19812364 2-hydroxypropanoic acid increases expression ISO RGD:1605733 6480464 Lactic Acid results in increased expression of HBEGF mRNA CTD PMID:30851411 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:1605733 6480464 3 more ... CTD PMID:23146750 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1552258 6480464 tetrabromobisphenol A results in increased expression of HBEGF mRNA CTD PMID:25172293 3,7-dihydropurine-6-thione decreases expression EXP 6480464 Mercaptopurine results in decreased expression of HBEGF mRNA CTD PMID:23358152 4,4'-sulfonyldiphenol increases expression ISO RGD:1552258 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of HBEGF mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1552258 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of HBEGF mRNA CTD PMID:30951980 4-hydroxynon-2-enal decreases expression ISO RGD:1605733 6480464 4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA CTD PMID:12419474 4-hydroxyphenyl retinamide increases expression ISO RGD:1552258 6480464 Fenretinide results in increased expression of HBEGF mRNA CTD PMID:28973697 4-nonylphenol increases secretion ISO RGD:1552258 6480464 4-nonylphenol results in increased secretion of HBEGF protein CTD PMID:28703301 4-nonylphenol multiple interactions ISO RGD:1552258 6480464 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2 more ... CTD PMID:28703301 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HBEGF mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases expression ISO RGD:1552258 6480464 9 more ... CTD PMID:32553695 9-cis-retinoic acid increases expression ISO RGD:1605733 6480464 Alitretinoin results in increased expression of HBEGF mRNA CTD PMID:15982314 acetamide increases expression EXP 6480464 acetamide results in increased expression of HBEGF mRNA CTD PMID:31881176 acetylsalicylic acid multiple interactions EXP 6480464 apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF mRNA], apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF protein] CTD PMID:18482463 acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of HBEGF mRNA, Aspirin results in increased expression of HBEGF protein CTD PMID:18482463 acrolein multiple interactions ISO RGD:1605733 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HBEGF mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HBEGF mRNA CTD PMID:32699268 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of HBEGF mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:1605733 6480464 Acrylamide results in increased expression of HBEGF mRNA CTD PMID:32763439 actinomycin D decreases expression ISO RGD:1605733 6480464 Dactinomycin results in decreased expression of HBEGF mRNA CTD PMID:26800359 actinomycin D multiple interactions ISO RGD:1605733 6480464 Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 aflatoxin B1 affects expression ISO RGD:1605733 6480464 Aflatoxin B1 affects the expression of HBEGF protein CTD PMID:20106945 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of HBEGF mRNA CTD PMID:33354967 aflatoxin B1 increases expression ISO RGD:1605733 6480464 Aflatoxin B1 results in increased expression of HBEGF mRNA CTD PMID:21641981 , PMID:22100608 aflatoxin B1 increases expression ISO RGD:1552258 6480464 Aflatoxin B1 results in increased expression of HBEGF mRNA CTD PMID:19770486 aldehydo-D-glucose increases expression ISO RGD:1552258 6480464 Glucose results in increased expression of HBEGF mRNA CTD PMID:17178593 all-trans-4-oxoretinoic acid increases expression ISO RGD:1605733 6480464 4-oxoretinoic acid results in increased expression of HBEGF mRNA CTD PMID:15982314 all-trans-retinal increases expression ISO RGD:1605733 6480464 Retinaldehyde results in increased expression of HBEGF mRNA CTD PMID:16470170 all-trans-retinoic acid multiple interactions ISO RGD:1552258 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of HBEGF mRNA more ... CTD PMID:16357442 , PMID:30951980 all-trans-retinoic acid increases expression ISO RGD:1605733 6480464 Tretinoin metabolite results in increased expression of HBEGF mRNA more ... CTD PMID:15894607 more ... all-trans-retinoic acid increases expression ISO RGD:1552258 6480464 Tretinoin results in increased expression of HBEGF mRNA, Tretinoin results in increased expression of HBEGF protein CTD PMID:10075925 more ... all-trans-retinol increases expression ISO RGD:1605733 6480464 Vitamin A results in increased expression of HBEGF mRNA CTD PMID:19648781 alpha-pinene multiple interactions ISO RGD:1605733 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HBEGF mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HBEGF mRNA CTD PMID:32699268 alprenolol multiple interactions ISO RGD:1605733 6480464 HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]] more ... CTD PMID:18787115 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HBEGF mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of HBEGF mRNA CTD PMID:30779732 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1605733 6480464 pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]], pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:19193634 , PMID:26800359 apigenin multiple interactions ISO RGD:1605733 6480464 Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 aripiprazole decreases expression EXP 6480464 Aripiprazole results in decreased expression of HBEGF mRNA CTD PMID:17868501 aristolochic acid A increases expression ISO RGD:1605733 6480464 aristolochic acid I results in increased expression of HBEGF mRNA CTD PMID:33212167 Aroclor 1254 increases expression ISO RGD:1552258 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of HBEGF mRNA CTD PMID:25270620 arsenite(3-) multiple interactions ISO RGD:1605733 6480464 [[sodium arsenite results in increased abundance of arsenite] which co-treated with HBEGF protein] results in increased expression of CCND1 mRNA more ... CTD PMID:31616959 arsenous acid increases expression ISO RGD:1605733 6480464 Arsenic Trioxide results in increased expression of HBEGF mRNA CTD PMID:25258189 , PMID:26705709 atorvastatin calcium decreases expression ISO RGD:1552258 6480464 Atorvastatin results in decreased expression of HBEGF protein CTD PMID:18360054 benzalkonium chloride increases expression ISO RGD:1552258 6480464 Benzalkonium Compounds results in increased expression of HBEGF mRNA CTD PMID:30171875 benzo[a]pyrene decreases expression ISO RGD:1552258 6480464 Benzo(a)pyrene results in decreased expression of HBEGF mRNA CTD PMID:19770486 , PMID:27195522 benzo[a]pyrene increases methylation ISO RGD:1605733 6480464 Benzo(a)pyrene results in increased methylation of HBEGF 3' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1605733 6480464 Benzo(a)pyrene results in increased expression of HBEGF mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO RGD:1552258 6480464 Benzo(a)pyrene metabolite results in increased expression of HBEGF mRNA, Benzo(a)pyrene results in increased expression of HBEGF mRNA CTD PMID:22228805 more ... benzo[a]pyrene diol epoxide I affects expression ISO RGD:1605733 6480464 7 more ... CTD PMID:20382639 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1605733 6480464 7 more ... CTD PMID:19150397 beraprost multiple interactions ISO RGD:1552258 6480464 beraprost inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HBEGF mRNA] CTD PMID:28887131 bis(2-chloroethyl) sulfide increases expression ISO RGD:1552258 6480464 Mustard Gas results in increased expression of HBEGF mRNA CTD PMID:15674843 bis(2-chloroethyl) sulfide increases expression ISO RGD:1605733 6480464 Mustard Gas results in increased expression of HBEGF mRNA CTD PMID:16173061 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HBEGF mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HBEGF mRNA CTD PMID:34947998 bisphenol A decreases expression ISO RGD:1605733 6480464 bisphenol A results in decreased expression of HBEGF mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:1552258 6480464 bisphenol A results in increased expression of HBEGF mRNA CTD PMID:30951980 bisphenol A increases secretion ISO RGD:1552258 6480464 bisphenol A results in increased secretion of HBEGF protein CTD PMID:28703301 bisphenol A multiple interactions ISO RGD:1552258 6480464 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2 more ... CTD PMID:28703301 , PMID:30951980 bisphenol F increases expression ISO RGD:1552258 6480464 bisphenol F results in increased expression of HBEGF mRNA CTD PMID:30951980 bisphenol F multiple interactions ISO RGD:1552258 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of HBEGF mRNA CTD PMID:30951980 bleomycin A2 increases expression ISO RGD:1605733 6480464 Bleomycin results in increased expression of HBEGF mRNA CTD PMID:18684396 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of HBEGF mRNA CTD PMID:32479839 butan-1-ol multiple interactions ISO RGD:1605733 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of HBEGF mRNA CTD PMID:29432896 butanal increases expression ISO RGD:1605733 6480464 butyraldehyde results in increased expression of HBEGF mRNA CTD PMID:26079696 butane-2,3-dione increases secretion ISO RGD:1605733 6480464 Diacetyl results in increased secretion of HBEGF protein CTD PMID:30851105 cadmium atom multiple interactions ISO RGD:1605733 6480464 [1-(4-(6-bromobenzo(1 more ... CTD PMID:31468104 cadmium dichloride multiple interactions ISO RGD:1605733 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HBEGF protein CTD PMID:31468104 calcitriol multiple interactions ISO RGD:1605733 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HBEGF mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:1605733 6480464 Calcitriol results in increased expression of HBEGF mRNA CTD PMID:16002434 , PMID:21592394 cannabidiol increases expression ISO RGD:1605733 6480464 Cannabidiol results in increased expression of HBEGF mRNA CTD PMID:31518892 , PMID:33244087 capsaicin multiple interactions ISO RGD:1552258 6480464 [Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of HBEGF mRNA CTD PMID:20660715 carbamazepine affects expression ISO RGD:1605733 6480464 Carbamazepine affects the expression of HBEGF mRNA CTD PMID:24752500 carbon nanotube increases expression ISO RGD:1605733 6480464 Nanotubes, Carbon analog results in increased expression of HBEGF mRNA CTD PMID:25102311 carbon nanotube increases expression ISO RGD:1552258 6480464 Nanotubes more ... CTD PMID:25554681 carvedilol multiple interactions ISO RGD:1605733 6480464 HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]] more ... CTD PMID:18787115 CGP 52608 multiple interactions ISO RGD:1605733 6480464 CGP 52608 promotes the reaction [RORA protein binds to HBEGF gene] CTD PMID:28238834 chloropicrin increases expression ISO RGD:1605733 6480464 chloropicrin results in increased expression of HBEGF mRNA CTD PMID:26352163 cholesterol increases expression ISO RGD:1605733 6480464 Cholesterol results in increased expression of HBEGF mRNA CTD PMID:26296894 choline multiple interactions ISO RGD:1552258 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HBEGF mRNA CTD PMID:20938992 chondroitin sulfate affects binding ISO RGD:1605733 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein, Chondroitin Sulfates analog binds to HBEGF protein CTD PMID:12221095 , PMID:15385557 chromium(6+) affects expression ISO RGD:1605733 6480464 chromium hexavalent ion affects the expression of HBEGF mRNA CTD PMID:30690063 clobetasol decreases expression ISO RGD:1552258 6480464 Clobetasol results in decreased expression of HBEGF mRNA CTD PMID:27462272 clofibrate increases expression ISO RGD:1552258 6480464 Clofibrate results in increased expression of HBEGF mRNA CTD PMID:25270620 cobalt dichloride increases expression ISO RGD:1605733 6480464 cobaltous chloride results in increased expression of HBEGF mRNA CTD PMID:26800359 copper atom multiple interactions ISO RGD:1605733 6480464 [Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA, [NSC 689534 binds to Copper] which results in increased expression of HBEGF mRNA CTD PMID:20971185 , PMID:24690739 copper(0) multiple interactions ISO RGD:1605733 6480464 [Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA, [NSC 689534 binds to Copper] which results in increased expression of HBEGF mRNA CTD PMID:20971185 , PMID:24690739 copper(II) sulfate increases expression ISO RGD:1605733 6480464 Copper Sulfate results in increased expression of HBEGF mRNA CTD PMID:19549813 crizotinib multiple interactions ISO RGD:1605733 6480464 EGFR protein promotes the reaction [HBEGF protein results in decreased susceptibility to crizotinib] more ... CTD PMID:22553343 crizotinib decreases response to substance ISO RGD:1605733 6480464 HBEGF protein results in decreased susceptibility to crizotinib CTD PMID:22553343 crocidolite asbestos increases expression ISO RGD:1605733 6480464 Asbestos, Crocidolite results in increased expression of HBEGF mRNA CTD PMID:18687144 cyanidin cation multiple interactions ISO RGD:1605733 6480464 cyanidin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 cycloheximide increases expression ISO RGD:1605733 6480464 Cycloheximide results in increased expression of HBEGF mRNA CTD PMID:15228094 cyclophosphamide multiple interactions EXP 6480464 O-1602 compound inhibits the reaction [Cyclophosphamide results in decreased expression of HBEGF protein] CTD PMID:32615180 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of HBEGF protein CTD PMID:32615180 cyclosporin A decreases expression ISO RGD:1605733 6480464 Cyclosporine results in decreased expression of HBEGF mRNA CTD PMID:22147139 , PMID:27989131 cyclosporin A increases expression ISO RGD:1605733 6480464 Cyclosporine results in increased expression of HBEGF mRNA CTD PMID:20106945 , PMID:25562108 cypermethrin multiple interactions EXP 6480464 cypermethrin results in decreased expression of and results in decreased secretion of HBEGF protein more ... CTD PMID:22048644 cypermethrin decreases response to substance EXP 6480464 HBEGF protein results in decreased susceptibility to cypermethrin CTD PMID:22048644 cypermethrin decreases expression EXP 6480464 cypermethrin results in decreased expression of HBEGF mRNA CTD PMID:22048644 D-glucose increases expression ISO RGD:1552258 6480464 Glucose results in increased expression of HBEGF mRNA CTD PMID:17178593 dermatan sulfate affects binding ISO RGD:1605733 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein CTD PMID:15385557 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of HBEGF mRNA CTD PMID:14618091 dexamethasone multiple interactions ISO RGD:1552258 6480464 apicidin inhibits the reaction [Dexamethasone results in decreased expression of HBEGF mRNA] more ... CTD PMID:27645313 dexamethasone decreases expression ISO RGD:1552258 6480464 Dexamethasone results in decreased expression of HBEGF mRNA CTD PMID:22733784 , PMID:27645313 diarsenic trioxide increases expression ISO RGD:1605733 6480464 Arsenic Trioxide results in increased expression of HBEGF mRNA CTD PMID:25258189 , PMID:26705709 diclofenac affects expression ISO RGD:1605733 6480464 Diclofenac affects the expression of HBEGF mRNA CTD PMID:24752500 diclofenac decreases expression ISO RGD:1552258 6480464 Diclofenac results in decreased expression of HBEGF mRNA CTD PMID:35537566 diclofenac increases expression ISO RGD:1552258 6480464 Diclofenac results in increased expression of HBEGF mRNA CTD PMID:26934552 dimethylarsinous acid decreases expression ISO RGD:1605733 6480464 dimethylarsinous acid results in decreased expression of HBEGF mRNA CTD PMID:16507463 dioxygen multiple interactions ISO RGD:1605733 6480464 Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein] more ... CTD PMID:19193634 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of HBEGF mRNA CTD PMID:33729688 dioxygen multiple interactions ISO RGD:1552258 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of HBEGF mRNA CTD PMID:30529165 diprotium oxide decreases expression ISO RGD:1605733 6480464 Water results in decreased expression of HBEGF mRNA CTD PMID:26800359 disulfiram multiple interactions ISO RGD:1605733 6480464 [Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA CTD PMID:24690739 divanadium pentaoxide multiple interactions ISO RGD:1605733 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA] more ... CTD PMID:11159045 , PMID:12676768 divanadium pentaoxide increases expression ISO RGD:1605733 6480464 vanadium pentoxide results in increased expression of HBEGF mRNA, vanadium pentoxide results in increased expression of HBEGF protein CTD PMID:11159045 more ... dobutamine multiple interactions ISO RGD:1605733 6480464 HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]] more ... CTD PMID:18787115 dorsomorphin multiple interactions ISO RGD:1605733 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HBEGF mRNA CTD PMID:27188386 doxorubicin affects response to substance ISO RGD:1605733 6480464 HBEGF protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin decreases expression ISO RGD:1605733 6480464 Doxorubicin results in decreased expression of HBEGF mRNA CTD PMID:29803840 doxorubicin decreases response to substance ISO RGD:1605733 6480464 HBEGF protein results in decreased susceptibility to Doxorubicin CTD PMID:29305325 doxorubicin decreases expression ISO RGD:1552258 6480464 Doxorubicin results in decreased expression of HBEGF mRNA CTD PMID:15033991 erlotinib hydrochloride multiple interactions ISO RGD:1605733 6480464 Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 ethanol multiple interactions ISO RGD:1605733 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of HBEGF mRNA more ... CTD PMID:19919524 , PMID:29432896 ethanol increases expression ISO RGD:1552258 6480464 Ethanol results in increased expression of HBEGF mRNA CTD PMID:30319688 etoposide increases expression ISO RGD:1605733 6480464 Etoposide results in increased expression of HBEGF mRNA CTD PMID:15228094 fenamidone increases expression ISO RGD:1552258 6480464 fenamidone results in increased expression of HBEGF mRNA CTD PMID:27029645 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of HBEGF mRNA CTD PMID:30307764 ferric oxide increases expression ISO RGD:1552258 6480464 ferric oxide analog results in increased expression of HBEGF mRNA CTD PMID:25086211 fluoranthene multiple interactions ISO RGD:1552258 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of HBEGF mRNA CTD PMID:28329830 folic acid multiple interactions ISO RGD:1552258 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HBEGF mRNA CTD PMID:20938992 formaldehyde increases expression ISO RGD:1605733 6480464 Formaldehyde results in increased expression of HBEGF mRNA CTD PMID:27664576 furan increases expression EXP 6480464 furan results in increased expression of HBEGF mRNA CTD PMID:27387713 gefitinib multiple interactions ISO RGD:1605733 6480464 gefitinib inhibits the reaction [irinotecan metabolite results in increased expression of HBEGF mRNA], gefitinib inhibits the reaction [irinotecan results in increased expression of HBEGF mRNA] CTD PMID:15723263 gefitinib multiple interactions EXP 6480464 gefitinib inhibits the reaction [HBEGF protein inhibits the reaction [sodium arsenite results in decreased expression of GFAP protein]] more ... CTD PMID:29228391 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HBEGF mRNA CTD PMID:33387578 glucose increases expression ISO RGD:1552258 6480464 Glucose results in increased expression of HBEGF mRNA CTD PMID:17178593 graphite affects expression EXP 6480464 Graphite affects the expression of HBEGF mRNA CTD PMID:29933104 Heptachlor epoxide increases expression ISO RGD:1552258 6480464 Heptachlor Epoxide results in increased expression of HBEGF mRNA CTD PMID:25270620 hydrogen cyanide increases expression ISO RGD:1552258 6480464 Hydrogen Cyanide results in increased expression of HBEGF mRNA CTD PMID:33914522 hydrogen peroxide increases expression ISO RGD:1605733 6480464 Hydrogen Peroxide results in increased expression of HBEGF mRNA CTD PMID:12676768 more ... hydrogen peroxide multiple interactions ISO RGD:1605733 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of HBEGF mRNA], SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of HBEGF mRNA] CTD PMID:12676768 hydroquinone increases expression ISO RGD:1605733 6480464 hydroquinone results in increased expression of HBEGF mRNA CTD PMID:31256213 irinotecan increases expression ISO RGD:1605733 6480464 Irinotecan metabolite results in increased expression of HBEGF mRNA, Irinotecan results in increased expression of HBEGF mRNA CTD PMID:15723263 irinotecan multiple interactions ISO RGD:1605733 6480464 Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of HBEGF mRNA], Gefitinib inhibits the reaction [Irinotecan results in increased expression of HBEGF mRNA] CTD PMID:15723263 isotretinoin increases expression ISO RGD:1605733 6480464 Isotretinoin results in increased expression of HBEGF mRNA CTD PMID:15982314 L-methionine multiple interactions ISO RGD:1552258 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HBEGF mRNA CTD PMID:20938992 lead(0) affects expression ISO RGD:1605733 6480464 Lead affects the expression of HBEGF mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1605733 6480464 Lead affects the expression of HBEGF mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:1605733 6480464 leflunomide results in increased expression of HBEGF mRNA CTD PMID:28988120 Licochalcone B increases expression ISO RGD:1605733 6480464 licochalcone B results in increased expression of HBEGF mRNA CTD PMID:33647349 lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of HBEGF mRNA CTD PMID:35283115 lipopolysaccharide increases expression ISO RGD:1605733 6480464 Lipopolysaccharides results in increased expression of HBEGF mRNA CTD PMID:18684396 lipopolysaccharide multiple interactions EXP 6480464 HBEGF protein inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] CTD PMID:16567187 luteolin multiple interactions ISO RGD:1605733 6480464 Luteolin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 medroxyprogesterone acetate decreases expression ISO RGD:1605733 6480464 Medroxyprogesterone Acetate results in decreased expression of HBEGF mRNA CTD PMID:20843944 mercaptopurine decreases expression EXP 6480464 Mercaptopurine results in decreased expression of HBEGF mRNA CTD PMID:23358152 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of HBEGF mRNA, Mercuric Chloride results in increased expression of HBEGF protein CTD PMID:10901180 , PMID:7635938 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of HBEGF gene CTD PMID:23303685 methylisothiazolinone increases expression ISO RGD:1605733 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of HBEGF mRNA CTD PMID:31629900 methylmercury chloride increases expression ISO RGD:1605733 6480464 methylmercuric chloride results in increased expression of HBEGF mRNA CTD PMID:28001369 mifepristone decreases expression EXP 6480464 Mifepristone results in decreased expression of HBEGF mRNA CTD PMID:18591650 Muraglitazar decreases expression EXP 6480464 muraglitazar results in decreased expression of HBEGF mRNA CTD PMID:21515302 myricetin multiple interactions ISO RGD:1605733 6480464 myricetin affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 N-acetyl-L-cysteine multiple interactions ISO RGD:1605733 6480464 Acetylcysteine inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA] CTD PMID:12676768 N-Nitrosopyrrolidine increases expression ISO RGD:1605733 6480464 N-Nitrosopyrrolidine results in increased expression of HBEGF mRNA CTD PMID:32234424 naphthalenes increases expression EXP 6480464 Naphthalenes results in increased expression of HBEGF protein CTD PMID:17337753 nickel atom increases expression ISO RGD:1605733 6480464 Nickel results in increased expression of HBEGF mRNA CTD PMID:25583101 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of HBEGF mRNA CTD PMID:33484710 ozone increases expression EXP 6480464 Ozone results in increased expression of DTR mRNA CTD PMID:16716893 ozone multiple interactions ISO RGD:1552258 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of HBEGF mRNA, [Air Pollutants results in increased abundance of Ozone] which results in increased expression of HBEGF mRNA CTD PMID:34911549 ozone multiple interactions ISO RGD:1605733 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HBEGF mRNA more ... CTD PMID:32699268 paracetamol affects expression ISO RGD:1552258 6480464 Acetaminophen affects the expression of HBEGF mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HBEGF mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:1605733 6480464 Acetaminophen results in increased expression of HBEGF mRNA CTD PMID:21420995 , PMID:29067470 paraquat increases expression EXP 6480464 Paraquat results in increased expression of HBEGF mRNA CTD PMID:32680482 PCB138 increases expression EXP 6480464 2 more ... CTD PMID:23829299 pentanal increases expression ISO RGD:1605733 6480464 pentanal results in increased expression of HBEGF mRNA CTD PMID:26079696 pentane-2,3-dione increases expression EXP 6480464 2, 3-pentanedione results in increased expression of HBEGF mRNA CTD PMID:25710175 perfluoroundecanoic acid decreases expression ISO RGD:1605733 6480464 perfluoroundecanoic acid results in decreased expression of HBEGF protein CTD PMID:32916415 phenobarbital affects expression ISO RGD:1605733 6480464 Phenobarbital affects the expression of HBEGF mRNA CTD PMID:19159669 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of DTR mRNA CTD PMID:18158353 phenylmercury acetate increases expression ISO RGD:1605733 6480464 Phenylmercuric Acetate results in increased expression of HBEGF mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1605733 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HBEGF mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1605733 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of HBEGF mRNA CTD PMID:16979875 phorbol 13-acetate 12-myristate increases secretion ISO RGD:1552258 6480464 Tetradecanoylphorbol Acetate results in increased secretion of HBEGF protein CTD PMID:28703301 phorbol 13-acetate 12-myristate increases expression ISO RGD:1605733 6480464 Tetradecanoylphorbol Acetate results in increased expression of HBEGF mRNA CTD PMID:10910055 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1552258 6480464 [Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of HBEGF mRNA more ... CTD PMID:20660715 , PMID:28703301 pirinixic acid multiple interactions ISO RGD:1552258 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HBEGF mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:1552258 6480464 pirinixic acid results in increased expression of HBEGF mRNA CTD PMID:16985257 pirinixic acid decreases expression ISO RGD:1552258 6480464 pirinixic acid results in decreased expression of HBEGF mRNA CTD PMID:17426115 potassium chromate increases expression ISO RGD:1605733 6480464 potassium chromate(VI) results in increased expression of HBEGF mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1605733 6480464 potassium chromate(VI) results in decreased expression of HBEGF mRNA CTD PMID:22714537 potassium chromate multiple interactions ISO RGD:1605733 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HBEGF mRNA CTD PMID:22079256 potassium cyanide increases expression ISO RGD:1552258 6480464 Potassium Cyanide results in increased expression of HBEGF mRNA CTD PMID:33914522 propanal increases expression ISO RGD:1605733 6480464 propionaldehyde results in increased expression of HBEGF mRNA CTD PMID:26079696 purine-6-thiol decreases expression EXP 6480464 Mercaptopurine results in decreased expression of HBEGF mRNA CTD PMID:23358152 quercetin multiple interactions ISO RGD:1605733 6480464 Quercetin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 quercetin increases expression ISO RGD:1605733 6480464 Quercetin results in increased expression of HBEGF mRNA CTD PMID:21632981 rac-lactic acid increases expression ISO RGD:1605733 6480464 Lactic Acid results in increased expression of HBEGF mRNA CTD PMID:30851411 raloxifene multiple interactions ISO RGD:1605733 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA CTD PMID:19059307 reactive oxygen species increases abundance ISO RGD:1605733 6480464 HBEGF protein mutant form results in increased abundance of Reactive Oxygen Species CTD PMID:19193634 reactive oxygen species multiple interactions EXP 6480464 1 more ... CTD PMID:7635938 reactive oxygen species increases expression EXP 6480464 Reactive Oxygen Species results in increased expression of HBEGF mRNA CTD PMID:7635938 Rebamipide increases expression EXP 6480464 rebamipide results in increased expression of HBEGF mRNA CTD PMID:15104358 rifampicin multiple interactions ISO RGD:1605733 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of HBEGF mRNA CTD PMID:21127053 SB 203580 multiple interactions ISO RGD:1605733 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of HBEGF mRNA] more ... CTD PMID:11159045 more ... SB 431542 multiple interactions ISO RGD:1605733 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HBEGF mRNA CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1605733 6480464 Silicon Dioxide analog results in increased expression of HBEGF mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1552258 6480464 Silicon Dioxide results in increased expression of HBEGF mRNA CTD PMID:19073995 , PMID:33720480 silver atom increases expression ISO RGD:1605733 6480464 Silver results in increased expression of HBEGF mRNA CTD PMID:26014281 silver(0) increases expression ISO RGD:1605733 6480464 Silver results in increased expression of HBEGF mRNA CTD PMID:26014281 sodium arsenite increases expression ISO RGD:1605733 6480464 sodium arsenite results in increased expression of HBEGF mRNA, sodium arsenite results in increased expression of HBEGF protein CTD PMID:10910055 more ... sodium arsenite decreases expression ISO RGD:1605733 6480464 sodium arsenite results in decreased expression of HBEGF mRNA CTD PMID:34032870 sodium arsenite multiple interactions ISO RGD:1605733 6480464 [[sodium arsenite results in increased abundance of arsenite] which co-treated with HBEGF protein] results in increased expression of CCND1 mRNA more ... CTD PMID:31616959 , PMID:32695675 sodium arsenite multiple interactions EXP 6480464 Gefitinib inhibits the reaction [HBEGF protein inhibits the reaction [sodium arsenite results in decreased expression of GFAP protein]] more ... CTD PMID:29228391 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of HBEGF mRNA, sodium arsenite results in decreased expression of HBEGF protein CTD PMID:29228391 sodium arsenite decreases secretion EXP 6480464 sodium arsenite results in decreased secretion of HBEGF protein CTD PMID:29228391 sodium chloride multiple interactions ISO RGD:1605733 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] more ... CTD PMID:26800359 sodium chloride increases expression ISO RGD:1605733 6480464 Sodium Chloride results in increased expression of HBEGF mRNA CTD PMID:26800359 sodium dichromate increases expression ISO RGD:1552258 6480464 sodium bichromate results in increased expression of HBEGF mRNA CTD PMID:27859739 Soman increases expression EXP 6480464 Soman results in increased expression of HBEGF mRNA CTD PMID:19281266 sotorasib multiple interactions ISO RGD:1605733 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HBEGF mRNA CTD PMID:36139627 succimer multiple interactions ISO RGD:1552258 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of HBEGF mRNA CTD PMID:21641980 sucrose increases expression ISO RGD:1605733 6480464 Sucrose results in increased expression of HBEGF mRNA CTD PMID:26800359 sunitinib decreases expression ISO RGD:1605733 6480464 Sunitinib results in decreased expression of HBEGF mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:1605733 6480464 [Tamoxifen co-treated with ESR2 protein] results in increased expression of HBEGF mRNA, Tamoxifen inhibits the reaction [EGF protein results in increased expression of HBEGF mRNA] CTD PMID:19059307 , PMID:24758408 tebuconazole decreases expression ISO RGD:1605733 6480464 tebuconazole results in decreased expression of HBEGF mRNA CTD PMID:26852204 tert-butyl hydroperoxide decreases expression ISO RGD:1605733 6480464 tert-Butylhydroperoxide results in decreased expression of HBEGF mRNA CTD PMID:12419474 testosterone multiple interactions ISO RGD:1605733 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HBEGF mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1605733 6480464 Testosterone results in increased expression of HBEGF mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HBEGF mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HBEGF mRNA] CTD PMID:31150632 Tetramethylthiourea multiple interactions EXP 6480464 tetramethylthiourea inhibits the reaction [Reactive Oxygen Species results in increased expression of HBEGF mRNA] CTD PMID:7635938 thapsigargin increases expression ISO RGD:1605733 6480464 Thapsigargin results in increased expression of HBEGF mRNA CTD PMID:29453283 thimerosal increases expression ISO RGD:1605733 6480464 Thimerosal results in increased expression of HBEGF mRNA CTD PMID:16870260 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HBEGF mRNA, Thioacetamide results in increased expression of HBEGF protein CTD PMID:10634158 , PMID:34492290 titanium dioxide increases expression ISO RGD:1552258 6480464 titanium dioxide results in increased expression of HBEGF mRNA CTD PMID:23557971 , PMID:27760801 titanium dioxide decreases methylation ISO RGD:1605733 6480464 titanium dioxide results in decreased methylation of HBEGF gene CTD PMID:34973136 trametinib multiple interactions ISO RGD:1605733 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HBEGF mRNA CTD PMID:36139627 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of HBEGF mRNA CTD PMID:33387578 trichostatin A increases expression ISO RGD:1605733 6480464 trichostatin A results in increased expression of HBEGF mRNA CTD PMID:26705709 triptonide increases expression ISO RGD:1552258 6480464 triptonide results in increased expression of HBEGF mRNA CTD PMID:33045310 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of HBEGF mRNA CTD PMID:21515302 trovafloxacin increases expression ISO RGD:1552258 6480464 trovafloxacin results in increased expression of HBEGF mRNA CTD PMID:35537566 tyrphostin AG 1478 increases expression ISO RGD:1605733 6480464 RTKI cpd results in increased expression of HBEGF mRNA CTD PMID:26800359 tyrphostin AG 1478 decreases expression EXP 6480464 RTKI cpd results in decreased expression of HBEGF mRNA, RTKI cpd results in decreased expression of HBEGF protein CTD PMID:22048644 tyrphostin AG 1478 multiple interactions ISO RGD:1605733 6480464 RTKI cpd inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA] CTD PMID:11159045 undecane increases expression EXP 6480464 undecane results in increased expression of HBEGF protein CTD PMID:17337753 urethane increases expression ISO RGD:1605733 6480464 Urethane results in increased expression of HBEGF mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:1605733 6480464 Valproic Acid results in increased expression of HBEGF mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:1605733 6480464 Valproic Acid affects the expression of HBEGF mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1552258 6480464 Valproic Acid results in increased expression of HBEGF mRNA CTD PMID:27645313 valproic acid multiple interactions ISO RGD:1552258 6480464 KDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HBEGF mRNA]], Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HBEGF mRNA] CTD PMID:27645313 valsartan multiple interactions ISO RGD:1605733 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA] CTD PMID:19225232 vanadyl sulfate increases expression ISO RGD:1605733 6480464 vanadyl sulfate results in increased expression of HBEGF mRNA CTD PMID:18684396 versicolorin A increases expression ISO RGD:1605733 6480464 versicolorin A results in increased expression of HBEGF mRNA CTD PMID:32106047 water decreases expression ISO RGD:1605733 6480464 Water results in decreased expression of HBEGF mRNA CTD PMID:26800359 zinc atom multiple interactions ISO RGD:1605733 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of HBEGF mRNA more ... CTD PMID:12972402 more ... zinc atom increases secretion ISO RGD:1605733 6480464 Zinc results in increased secretion of HBEGF protein CTD PMID:12972402 zinc atom increases expression ISO RGD:1605733 6480464 Zinc results in increased expression of HBEGF mRNA CTD PMID:12972402 zinc(0) multiple interactions ISO RGD:1605733 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of HBEGF mRNA more ... CTD PMID:12972402 more ... zinc(0) increases expression ISO RGD:1605733 6480464 Zinc results in increased expression of HBEGF mRNA CTD PMID:12972402 zinc(0) increases secretion ISO RGD:1605733 6480464 Zinc results in increased secretion of HBEGF protein CTD PMID:12972402