Fgf1 (fibroblast growth factor 1) - Rat Genome Database

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Gene: Fgf1 (fibroblast growth factor 1) Rattus norvegicus
Analyze
Symbol: Fgf1
Name: fibroblast growth factor 1
RGD ID: 2605
Description: Enables Hsp70 protein binding activity and growth factor activity. Involved in positive regulation of hepatocyte proliferation. Predicted to be located in several cellular components, including cytosol; extracellular matrix; and nucleoplasm. Predicted to be active in cytoplasm; extracellular space; and nucleus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acidic fibroblast growth factor; aFGF; FGF-1; Fgf2b; fibroblast growth factor 1 (acidic); Fibroblast growth factor 1 (heparin binding); fibroblast growth factor 2b; HBGF-1; HBGF1; heparin-binding growth factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Fgf1em2Mcwi  
Genetic Models: SS-Fgf1em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21830,686,555 - 30,772,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,686,581 - 30,772,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1830,793,473 - 30,814,440 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01831,554,441 - 31,575,416 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01830,888,710 - 30,909,676 (-)NCBIRnor_WKY
Rnor_6.01832,273,830 - 32,359,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,273,770 - 32,359,824 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01831,951,411 - 32,037,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,785,480 - 31,806,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11831,815,644 - 31,836,615 (-)NCBI
Celera1830,325,334 - 30,346,306 (-)NCBICelera
RH 3.4 Map18442.3RGD
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
Calcimycin  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbachol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorogenic acid  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethanolamine  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folpet  (ISO)
fucoxanthin  (ISO)
fumaraldehyde  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-tocopherol  (ISO)
genistein  (ISO)
glucose  (ISO)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
histamine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (EXP)
indole-3-methanol  (EXP)
isobutyl nitrite  (ISO)
isotretinoin  (ISO)
KT 5720  (EXP)
kynurenic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
Osajin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
PD-166866  (EXP)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
propranolol  (EXP)
puerarin  (ISO)
quercetin  (EXP)
quinolinic acid  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
serotonin  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP,ISO)
XAV939  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell cortex  (IEA)
cytoplasm  (IBA)
cytosol  (ISO,ISS)
extracellular matrix  (ISO)
extracellular region  (ISO,ISS)
extracellular space  (IBA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation. Antoine M, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):224-33. Epub 2006 May 26.
2. Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function. Cheng H, etal., Science. 1996 Jul 26;273(5274):510-3.
3. Increased immunodetection of acidic fibroblast growth factor in bladder cancer, detectable in urine. Chopin DK, etal., J Urol. 1993 Oct;150(4):1126-30.
4. Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway. Choung PH, etal., Biochem Biophys Res Commun 2002 Jul 26;295(4):898-902.
5. Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration. Formiga FR, etal., J Control Release. 2014 Jan 10;173:132-9. doi: 10.1016/j.jconrel.2013.10.034. Epub 2013 Nov 5.
6. Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers. Fujimoto J, etal., Tumour Biol. 1996;17(4):226-33.
7. Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene. Fujita M, etal., Mol Cell Biochem. 2004 Mar;258(1-2):183-9.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. The nucleotide sequence of rat heparin binding growth factor 1 (HBGF-1). Goodrich SP, etal., Nucleic Acids Res 1989 Apr 11;17(7):2867.
11. Molecular profiling of cervical cancer progression. Hagemann T, etal., Br J Cancer. 2007 Jan 29;96(2):321-8.
12. Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. Hashimoto M, etal., J Biol Chem 2002 Sep 6;277(36):32985-91.
13. Sensory and motor recovery after repairing transected cervical roots. Huang MC, etal., Surg Neurol. 2007;68 Suppl 1:S17-24; discussion S24. Epub 2007 Feb 15.
14. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. Jungerius BJ, etal., Mol Psychiatry. 2008 Nov;13(11):1060-8. Epub 2007 Sep 25.
15. Expression of acidic fibroblast growth factor and basic fibroblast growth factor in nasal polyps. Kim HJ, etal., Acta Otolaryngol. 2006 Jun;126(6):600-5.
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Improvement of gait patterns in step-trained, complete spinal cord-transected rats treated with a peripheral nerve graft and acidic fibroblast growth factor. Lee YS, etal., Exp Neurol. 2010 Aug;224(2):429-37. Epub 2010 May 19.
18. NBT-II carcinoma behaviour is not dependent on cell-cell communication through gap junctions. Lesueur F, etal., Biochem Biophys Res Commun 2002 May 31;294(1):108-15.
19. Increased acidic fibroblast growth factor concentrations in the serum and cerebrospinal fluid of patients with Alzheimer's disease. Mashayekhi F, etal., J Clin Neurosci. 2010 Mar;17(3):357-9. Epub 2010 Jan 15.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. Mizukoshi E, etal., Biochem J. 1999 Oct 15;343 Pt 2:461-6.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Investigation of FGF1 and FGFR gene polymorphisms in a group of Iranian patients with nonsyndromic cleft lip with or without cleft palate. Rafiqdoost Z, etal., Int J Pediatr Otorhinolaryngol. 2014 May;78(5):731-6. doi: 10.1016/j.ijporl.2014.01.024. Epub 2014 Jan 27.
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Assessment of the VEGF, bFGF, aFGF and IL8 angiogenic activity in urinary bladder carcinoma, using the mice cutaneous angiogenesis test. Rogala E, etal., Anticancer Res. 2001 Nov-Dec;21(6B):4259-63.
30. Transgenic expression of human FGF-1 protects against hypoxic-ischemic injury in perinatal brain by intervening at caspase-XIAP signaling cascades. Russell JC, etal., Neurobiol Dis. 2006 Jun;22(3):677-90. Epub 2006 Apr 24.
31. Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs. Song S, etal., Proc Natl Acad Sci U S A 2000 Jul 18;97(15):8658-63.
32. Culture-induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells. Speir E, etal., J Cell Physiol. 1991 May;147(2):362-73.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach. Tsai MC, etal., Mol Cell Proteomics. 2008 Sep;7(9):1668-87. Epub 2008 May 14.
35. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. White KE, etal., Am J Hum Genet. 2005 Feb;76(2):361-7. Epub 2004 Dec 28.
36. Fibroblast growth factors (FGF) in human myometrium and uterine leiomyomas in various stages of tumour growth. Wolanska M and Bankowski E, Biochimie. 2006 Feb;88(2):141-6. Epub 2005 Aug 22.
37. Acidic fibroblast growth factor for repair of human spinal cord injury: a clinical trial. Wu JC, etal., J Neurosurg Spine. 2011 Sep;15(3):216-27. Epub 2011 Jun 10.
38. Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats. Xu H, etal., Injury. 2009 Sep;40(9):963-7. Epub 2009 Jun 3.
39. [Expression of aFGF and bFGF in ovarian cancer and their effect on ovarian cancer cell proliferation]. Zhang Y, etal., Ai Zheng. 2003 Nov;22(11):1162-5.
Additional References at PubMed
PMID:8663044   PMID:8898217   PMID:10830168   PMID:11432880   PMID:11731227   PMID:12746488   PMID:12815063   PMID:12851419   PMID:15264218   PMID:15381701   PMID:15576401   PMID:15627653  
PMID:15800000   PMID:16519964   PMID:17187775   PMID:17548887   PMID:17701912   PMID:18086466   PMID:18187602   PMID:18189245   PMID:18400376   PMID:18441324   PMID:19229075   PMID:19233122  
PMID:19555698   PMID:19765618   PMID:19819303   PMID:20145243   PMID:20175207   PMID:20674996   PMID:23469107   PMID:23716589   PMID:23775125   PMID:25589163   PMID:26420862   PMID:26844696  
PMID:27425145   PMID:28298517   PMID:28795363   PMID:28813681   PMID:32360543   PMID:35477223  


Genomics

Comparative Map Data
Fgf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21830,686,555 - 30,772,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,686,581 - 30,772,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1830,793,473 - 30,814,440 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01831,554,441 - 31,575,416 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01830,888,710 - 30,909,676 (-)NCBIRnor_WKY
Rnor_6.01832,273,830 - 32,359,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1832,273,770 - 32,359,824 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01831,951,411 - 32,037,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41831,785,480 - 31,806,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11831,815,644 - 31,836,615 (-)NCBI
Celera1830,325,334 - 30,346,306 (-)NCBICelera
RH 3.4 Map18442.3RGD
Cytogenetic Map18p11NCBI
FGF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385142,592,178 - 142,698,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5142,592,178 - 142,698,070 (-)EnsemblGRCh38hg38GRCh38
GRCh375141,971,743 - 142,077,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365141,953,306 - 142,045,812 (-)NCBINCBI36Build 36hg18NCBI36
Build 345141,953,306 - 142,045,812NCBI
Celera5138,053,068 - 138,158,948 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,119,474 - 137,224,982 (-)NCBIHuRef
CHM1_15141,405,414 - 141,511,305 (-)NCBICHM1_1
T2T-CHM13v2.05143,123,428 - 143,229,306 (-)NCBIT2T-CHM13v2.0
Fgf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,971,725 - 39,062,532 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,971,726 - 39,062,525 (-)EnsemblGRCm39 Ensembl
GRCm381838,838,672 - 38,929,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1838,838,673 - 38,929,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv371838,998,327 - 39,078,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361838,965,154 - 39,044,673 (-)NCBIMGSCv36mm8
Celera1840,186,840 - 40,265,902 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1820.74NCBI
Fgf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541511,151,266 - 11,247,344 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541511,151,330 - 11,245,554 (+)NCBIChiLan1.0ChiLan1.0
FGF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15135,976,573 - 136,069,372 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05137,949,100 - 138,054,553 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15144,056,387 - 144,161,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,056,387 - 144,078,001 (-)Ensemblpanpan1.1panPan2
FGF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,467,431 - 37,554,770 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,470,985 - 37,554,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha234,520,400 - 34,607,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,924,029 - 38,010,951 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl237,924,031 - 38,011,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,002,929 - 35,089,106 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0235,815,172 - 35,902,044 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0236,617,132 - 36,703,569 (-)NCBIUU_Cfam_GSD_1.0
Fgf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,016,744 - 150,111,186 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650411,590,637 - 11,685,194 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650411,590,687 - 11,684,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,133,392 - 144,241,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12144,133,846 - 144,241,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22150,317,372 - 150,435,039 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12345,220,827 - 45,328,387 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,220,800 - 45,328,328 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603432,516,959 - 32,624,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247741,779,170 - 1,867,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247741,779,168 - 1,867,321 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf1
392 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:169
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000018577
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat

Markers in Region
RH94587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,689,351 - 30,689,504 (-)MAPPERmRatBN7.2
Rnor_6.01832,356,876 - 32,357,028NCBIRnor6.0
Rnor_5.01832,034,477 - 32,034,629UniSTSRnor5.0
RGSC_v3.41831,785,526 - 31,785,678UniSTSRGSC3.4
Celera1830,325,380 - 30,325,532UniSTS
RH 3.4 Map18442.3UniSTS
Cytogenetic Map18p11UniSTS
PMC26870P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,689,460 - 30,689,742 (-)MAPPERmRatBN7.2
Rnor_6.01832,356,638 - 32,356,919NCBIRnor6.0
Rnor_5.01832,034,239 - 32,034,520UniSTSRnor5.0
RGSC_v3.41831,785,635 - 31,785,916UniSTSRGSC3.4
Celera1830,325,489 - 30,325,770UniSTS
Cytogenetic Map18p11UniSTS


Genetic Models
This gene Fgf1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 5 5 19 5 11
Low 1 10 37 21 14 21 8 11 45 16 30 8
Below cutoff 20 20 20 20 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018577   ⟹   ENSRNOP00000018577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1832,336,102 - 32,357,072 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087408   ⟹   ENSRNOP00000070685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1830,686,581 - 30,772,357 (-)Ensembl
Rnor_6.0 Ensembl1832,273,770 - 32,359,824 (+)Ensembl
RefSeq Acc Id: NM_012846   ⟹   NP_036978
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21830,689,306 - 30,710,281 (-)NCBI
Rnor_6.01832,336,102 - 32,357,074 (+)NCBI
Rnor_5.01831,951,411 - 32,037,426 (+)NCBI
RGSC_v3.41831,785,480 - 31,806,452 (-)RGD
Celera1830,325,334 - 30,346,306 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254650   ⟹   XP_006254712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21830,686,555 - 30,772,667 (-)NCBI
Rnor_6.01832,273,830 - 32,359,831 (+)NCBI
Rnor_5.01831,951,411 - 32,037,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254651   ⟹   XP_006254713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21830,686,555 - 30,710,787 (-)NCBI
Rnor_6.01832,335,567 - 32,359,831 (+)NCBI
Rnor_5.01831,951,411 - 32,037,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254652   ⟹   XP_006254714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21830,686,555 - 30,713,802 (-)NCBI
Rnor_6.01832,332,601 - 32,359,831 (+)NCBI
Rnor_5.01831,951,411 - 32,037,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096591   ⟹   XP_038952519
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21830,686,555 - 30,772,667 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036978   ⟸   NM_012846
- UniProtKB: P61149 (UniProtKB/Swiss-Prot),   A0A7U3JW64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254712   ⟸   XM_006254650
- Peptide Label: isoform X1
- UniProtKB: P61149 (UniProtKB/Swiss-Prot),   A0A7U3JW64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254714   ⟸   XM_006254652
- Peptide Label: isoform X1
- UniProtKB: P61149 (UniProtKB/Swiss-Prot),   A0A7U3JW64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254713   ⟸   XM_006254651
- Peptide Label: isoform X1
- UniProtKB: P61149 (UniProtKB/Swiss-Prot),   A0A7U3JW64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018577   ⟸   ENSRNOT00000018577
RefSeq Acc Id: ENSRNOP00000070685   ⟸   ENSRNOT00000087408
RefSeq Acc Id: XP_038952519   ⟸   XM_039096591
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61149-F1-model_v2 AlphaFold P61149 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700744
Promoter ID:EPDNEW_R11266
Type:initiation region
Name:Fgf1_1
Description:fibroblast growth factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01832,336,091 - 32,336,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2605 AgrOrtholog
BioCyc Gene G2FUF-7750 BioCyc
Ensembl Genes ENSRNOG00000013867 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000070685 ENTREZGENE
  ENSRNOP00000070685.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087408 ENTREZGENE
  ENSRNOT00000087408.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25317 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf1 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234571
UniProt A0A7U3JW64 ENTREZGENE, UniProtKB/TrEMBL
  FGF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P10935 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf1  fibroblast growth factor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process functions in epigenetic chemoresistance mechanism 69831
gene_process functions in epigenetic chemoresistance mechanism 70306
gene_process has a role in chemoresistance 69831
gene_process has a role in chemoresistance 70306
gene_protein consist of aFGF(acidic) and bFGF(basic) forms 69831
gene_protein consist of aFGF(acidic) and bFGF(basic) forms 70306