Malt1 (MALT1 paracaspase) - Rat Genome Database

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Gene: Malt1 (MALT1 paracaspase) Rattus norvegicus
Analyze
Symbol: Malt1
Name: MALT1 paracaspase
RGD ID: 1309195
Description: Predicted to enable several functions, including identical protein binding activity; protease binding activity; and protein self-association. Predicted to contribute to kinase activator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including B-1 B cell differentiation; cellular response to lipopolysaccharide; and regulation of T cell receptor signaling pathway. Predicted to be located in cytosol and fibrillar center. Predicted to be part of CBM complex and polkadots. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC307366; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase 1; paracaspase-1; Pcasp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21858,942,282 - 58,996,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01861,108,712 - 61,162,446 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,305,085 - 60,358,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,708,388 - 61,760,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11861,720,756 - 61,832,919 (+)NCBI
Celera1857,070,977 - 57,125,050 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium silicate  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
metam  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
succimer  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Akagi T, etal., Oncogene. 1999 Oct 14;18(42):5785-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Sanchez-Izquierdo D, etal., Blood. 2003 Jun 1;101(11):4539-46. Epub 2003 Jan 30.
Additional References at PubMed
PMID:12761501   PMID:12819136   PMID:14576442   PMID:14614861   PMID:14695475   PMID:15125833   PMID:16123224   PMID:16495340   PMID:16751776   PMID:16831874   PMID:16862125   PMID:18223652  
PMID:22158899   PMID:22267217   PMID:25282160   PMID:25762782   PMID:26377317   PMID:28628108   PMID:31961340  


Genomics

Comparative Map Data
Malt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21858,942,282 - 58,996,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01861,108,712 - 61,162,446 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,305,085 - 60,358,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,708,388 - 61,760,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11861,720,756 - 61,832,919 (+)NCBI
Celera1857,070,977 - 57,125,050 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
MALT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,671,465 - 58,754,477 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1858,671,465 - 58,754,477 (+)EnsemblGRCh38hg38GRCh38
GRCh371856,338,697 - 56,421,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,489,598 - 54,568,350 (+)NCBINCBI36Build 36hg18NCBI36
Build 341854,489,597 - 54,568,350NCBI
Celera1853,055,193 - 53,133,688 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,046,774 - 53,125,499 (+)NCBIHuRef
CHM1_11856,333,855 - 56,412,584 (+)NCBICHM1_1
T2T-CHM13v2.01858,872,604 - 58,955,588 (+)NCBIT2T-CHM13v2.0
Malt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,564,010 - 65,611,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,564,009 - 65,612,138 (+)EnsemblGRCm39 Ensembl
GRCm381865,430,939 - 65,478,888 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,430,938 - 65,479,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,590,651 - 65,638,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,556,366 - 65,604,161 (+)NCBIMGSCv36mm8
Celera1866,699,207 - 66,748,598 (+)NCBICelera
Cytogenetic Map18E1NCBI
Malt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,911,649 - 42,972,429 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,919,480 - 42,968,873 (+)NCBIChiLan1.0ChiLan1.0
MALT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11855,395,462 - 55,473,574 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1855,395,462 - 55,473,574 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01852,060,878 - 52,141,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MALT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,351,458 - 17,412,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,354,926 - 17,403,927 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,335,003 - 18,396,343 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,231,245 - 17,291,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,232,316 - 17,291,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,292,714 - 17,350,173 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.1117,272,403 - 17,281,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,187,356 - 17,248,249 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,455,416 - 17,516,194 (-)NCBIUU_Cfam_GSD_1.0
Malt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,615,326 - 30,665,178 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,853,870 - 5,904,266 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364975,854,361 - 5,910,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MALT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,076,955 - 162,144,880 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,076,933 - 162,144,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,571,906 - 179,706,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MALT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,984,985 - 21,064,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,985,819 - 21,054,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660604,506,132 - 4,584,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Malt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,148,453 - 4,217,548 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247924,148,258 - 4,223,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Malt1
138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:134
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000023146, ENSRNOT00000068418
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 9 19 6 1 14 11
Low 1 23 48 41 41 8 11 68 34 27 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001060526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003751798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_225927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO556697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ607864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000068418   ⟹   ENSRNOP00000059281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)Ensembl
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094098   ⟹   ENSRNOP00000097032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)Ensembl
RefSeq Acc Id: XM_003751798   ⟹   XP_003751846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,942,283 - 58,996,318 (+)NCBI
Rnor_6.01861,108,712 - 61,162,446 (+)NCBI
Rnor_5.01860,305,085 - 60,358,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254888   ⟹   XP_006254950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,942,282 - 58,996,318 (+)NCBI
Rnor_6.01861,108,712 - 61,162,446 (+)NCBI
Rnor_5.01860,305,085 - 60,358,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097398   ⟹   XP_038953326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,967,394 - 58,996,318 (+)NCBI
RefSeq Acc Id: XM_039097399   ⟹   XP_038953327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,942,282 - 58,977,023 (+)NCBI
RefSeq Acc Id: XM_225927   ⟹   XP_225927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,942,283 - 58,996,318 (+)NCBI
Rnor_6.01861,108,712 - 61,162,446 (+)NCBI
Rnor_5.01860,305,085 - 60,358,786 (+)NCBI
RGSC_v3.41861,708,388 - 61,760,004 (+)RGD
Sequence:
RefSeq Acc Id: XR_005496483
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21858,942,282 - 58,987,441 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_225927   ⟸   XM_225927
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ARW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003751846   ⟸   XM_003751798
- Peptide Label: isoform X1
- UniProtKB: D4A980 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254950   ⟸   XM_006254888
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000059281   ⟸   ENSRNOT00000068418
RefSeq Acc Id: XP_038953327   ⟸   XM_039097399
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953326   ⟸   XM_039097398
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000097032   ⟸   ENSRNOT00000094098
Protein Domains
CASPASE_P20   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A980-F1-model_v2 AlphaFold D4A980 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309195 AgrOrtholog
BioCyc Gene G2FUF-7217 BioCyc
Ensembl Genes ENSRNOG00000017181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059281 ENTREZGENE
  ENSRNOP00000059281.3 UniProtKB/TrEMBL
  ENSRNOP00000097032 ENTREZGENE
  ENSRNOP00000097032.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068418 ENTREZGENE
  ENSRNOT00000068418.5 UniProtKB/TrEMBL
  ENSRNOT00000094098 ENTREZGENE
  ENSRNOT00000094098.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Caspase-like_dom UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  MALT1 UniProtKB/TrEMBL
  MALT1_Death UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
NCBI Gene 307366 ENTREZGENE
PANTHER PTHR22576:SF40 UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/TrEMBL
PhenoGen Malt1 PhenoGen
PROSITE CASPASE_P20 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A8I6ARW3 ENTREZGENE, UniProtKB/TrEMBL
  D4A980 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-03 Malt1  MALT1 paracaspase  Malt1  mucosa associated lymphoid tissue lymphoma translocation gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Malt1  mucosa associated lymphoid tissue lymphoma translocation gene 1   Malt1_predicted  mucosa associated lymphoid tissue lymphoma translocation gene 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Malt1_predicted  mucosa associated lymphoid tissue lymphoma translocation gene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED