Gene: Sh3rf2 (SH3 domain containing ring finger 2) Rattus norvegicus
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Symbol: Sh3rf2
Name: SH3 domain containing ring finger 2
Description: ENCODES a protein that exhibits phosphatase binding (ortholog); protein phosphatase 1 binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of apoptotic process; negative regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide
AGR Description: Predicted to have protein phosphatase 1 binding activity and ubiquitin protein ligase activity; involved in negative regulation of JNK cascade, negative regulation of apoptotic process, and positive regulation of proteasomal ubiquitin-dependent protein catabolic process; predicted to localize to the nucleoplasm; orthologous to human SH3RF2 (SH3 domain containing ring finger 2).
Merged Description: Predicted to have protein phosphatase 1 binding activity and ubiquitin protein ligase activity; involved in negative regulation of JNK cascade, negative regulation of apoptotic process, and positive regulation of proteasomal ubiquitin-dependent protein catabolic process; predicted to localize to the nucleoplasm; orthologous to human SH3RF2 (SH3 domain containing ring finger 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase SH3RF2; LOC307472; MGC114566; Posh2; Ppp1r39; protein phosphatase 1 regulatory subunit 39; protein phosphatase 1, regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2
Orthologs:
Homo sapiens (human) : SH3RF2 (SH3 domain containing ring finger 2)  HGNC  Alliance
Mus musculus (house mouse) : Sh3rf2 (SH3 domain containing ring finger 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3rf2 (SH3 domain containing ring finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3RF2 (SH3 domain containing ring finger 2)
Canis lupus familiaris (dog) : SH3RF2 (SH3 domain containing ring finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3rf2 (SH3 domain containing ring finger 2)
Sus scrofa (pig) : SH3RF2 (SH3 domain containing ring finger 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01836,371,041 - 36,471,020 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01836,038,469 - 36,138,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41835,242,898 - 35,344,485 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11835,278,198 - 35,379,745 (+)NCBI
Celera1833,643,909 - 33,743,873 (+)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Sh3rf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308415
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.