Slc26a2 (solute carrier family 26 member 2) - Rat Genome Database

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Gene: Slc26a2 (solute carrier family 26 member 2) Rattus norvegicus
Analyze
Symbol: Slc26a2
Name: solute carrier family 26 member 2
RGD ID: 620622
Description: Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Involved in sulfate transmembrane transport. Located in apical plasma membrane and microvillus membrane. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: diastrophic dysplasia protein homolog; Dtdst; solute carrier family 26 (anion exchanger), member 2; solute carrier family 26 (sulfate transporter), member 2; sulfate transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,918,662 - 56,937,032 (-)NCBIGRCr8
mRatBN7.21854,648,276 - 54,666,627 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,652,951 - 54,666,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,741,163 - 56,754,830 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,455,767 - 57,469,434 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,276,830 - 55,290,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,518,999 - 56,534,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,520,740 - 56,534,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,751,800 - 55,765,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,170,814 - 57,184,489 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,243,045 - 57,256,721 (-)NCBI
Celera1852,805,316 - 52,818,991 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead diacetate  (ISO)
lidocaine  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
nickel dichloride  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Clinical and molecular characterization of Diastrophic Dysplasia in the Portuguese population. Barbosa M, etal., Clin Genet. 2011 Dec;80(6):550-7. doi: 10.1111/j.1399-0004.2010.01595.x. Epub 2010 Dec 13.
2. Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. Cai T, etal., Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8064-9. doi: 10.1073/pnas.1502454112. Epub 2015 Jun 15.
3. Protein localization of SLC26A2 (DTDST) in rat kidney. Chapman JM and Karniski LP, Histochem Cell Biol. 2010 May;133(5):541-7. doi: 10.1007/s00418-010-0694-x. Epub 2010 Apr 6.
4. A diastrophic dysplasia sulfate transporter (SLC26A2) mutant mouse: morphological and biochemical characterization of the resulting chondrodysplasia phenotype. Forlino A, etal., Hum Mol Genet. 2005 Mar 15;14(6):859-71. Epub 2005 Feb 9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias. Hastbacka J, etal., Am J Hum Genet. 1996 Feb;58(2):255-62.
8. Identification of the Finnish founder mutation for diastrophic dysplasia (DTD). Hästbacka J, etal., Eur J Hum Genet. 1999 Sep;7(6):664-70.
9. Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis. Ikeda T, etal., J Hum Genet. 2001;46(9):538-43.
10. Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. Lamb R, etal., Arthritis Rheum. 2007 Apr;56(4):1286-91.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. SLC26A2 disease spectrum in Sweden - high frequency of recessive multiple epiphyseal dysplasia (rMED). Mäkitie O, etal., Clin Genet. 2015 Mar;87(3):273-8. doi: 10.1111/cge.12371. Epub 2014 Apr 1.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans. Satoh H, etal., J Biol Chem 1998 May 15;273(20):12307-15.
20. Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene. Superti-Furga A, etal., Nat Genet. 1996 Jan;12(1):100-2.
Additional References at PubMed
PMID:7923357   PMID:23533145  


Genomics

Comparative Map Data
Slc26a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,918,662 - 56,937,032 (-)NCBIGRCr8
mRatBN7.21854,648,276 - 54,666,627 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,652,951 - 54,666,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,741,163 - 56,754,830 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,455,767 - 57,469,434 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,276,830 - 55,290,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,518,999 - 56,534,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,520,740 - 56,534,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,751,800 - 55,765,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,170,814 - 57,184,489 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,243,045 - 57,256,721 (-)NCBI
Celera1852,805,316 - 52,818,991 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
SLC26A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,960,758 - 149,987,400 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,960,758 - 149,993,455 (+)EnsemblGRCh38hg38GRCh38
GRCh375149,340,321 - 149,366,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,320,493 - 149,347,156 (+)NCBINCBI36Build 36hg18NCBI36
Build 345149,320,638 - 149,347,155NCBI
Celera5145,421,686 - 145,448,348 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,488,253 - 144,514,927 (+)NCBIHuRef
CHM1_15148,772,975 - 148,799,655 (+)NCBICHM1_1
T2T-CHM13v2.05150,497,305 - 150,523,943 (+)NCBIT2T-CHM13v2.0
Slc26a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,329,926 - 61,344,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,325,991 - 61,344,684 (-)EnsemblGRCm39 Ensembl
GRCm381861,196,854 - 61,211,596 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,192,919 - 61,211,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,356,508 - 61,371,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,322,223 - 61,336,851 (-)NCBIMGSCv36mm8
Celera1862,483,343 - 62,498,119 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Slc26a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,540,302 - 4,556,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,540,302 - 4,556,360 (-)NCBIChiLan1.0ChiLan1.0
SLC26A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,189,200 - 145,216,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,328,748 - 143,355,987 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,385,433 - 145,412,180 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,391,842 - 151,418,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,391,842 - 151,412,676 (+)Ensemblpanpan1.1panPan2
SLC26A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,068,601 - 59,090,803 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,074,008 - 59,078,892 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,834,366 - 58,856,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,548,901 - 59,571,050 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,552,321 - 59,571,008 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,337,914 - 59,360,071 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,452,291 - 59,474,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,983,542 - 60,005,748 (-)NCBIUU_Cfam_GSD_1.0
Slc26a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,417,023 - 143,431,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,991,080 - 5,005,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,990,996 - 5,005,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,996,686 - 151,022,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,996,868 - 151,027,483 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,937,743 - 157,942,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC26A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,565,322 - 52,598,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,565,409 - 52,592,657 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603425,118,641 - 25,151,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc26a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,257,682 - 9,269,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,258,057 - 9,273,722 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc26a2
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000024374
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
BE105826  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,657,315 - 54,657,477 (+)MAPPERmRatBN7.2
Rnor_6.01856,525,105 - 56,525,266NCBIRnor6.0
Rnor_5.01855,756,165 - 55,756,326UniSTSRnor5.0
RGSC_v3.41857,175,179 - 57,175,340UniSTSRGSC3.4
Celera1852,809,681 - 52,809,842UniSTS
RH 3.4 Map18535.5UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024374   ⟹   ENSRNOP00000024374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,652,951 - 54,666,626 (-)Ensembl
Rnor_6.0 Ensembl1856,520,740 - 56,534,415 (-)Ensembl
RefSeq Acc Id: NM_057127   ⟹   NP_476468
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,923,337 - 56,937,012 (-)NCBI
mRatBN7.21854,652,951 - 54,666,626 (-)NCBI
Rnor_6.01856,520,740 - 56,534,415 (-)NCBI
Rnor_5.01855,751,800 - 55,765,925 (-)NCBI
RGSC_v3.41857,170,814 - 57,184,489 (-)RGD
Celera1852,805,316 - 52,818,991 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254787   ⟹   XP_006254849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,918,662 - 56,937,013 (-)NCBI
mRatBN7.21854,648,276 - 54,666,627 (-)NCBI
Rnor_6.01856,518,999 - 56,534,539 (-)NCBI
Rnor_5.01855,751,800 - 55,765,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254788   ⟹   XP_006254850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,918,662 - 56,937,032 (-)NCBI
mRatBN7.21854,648,276 - 54,666,627 (-)NCBI
Rnor_6.01856,518,999 - 56,534,539 (-)NCBI
Rnor_5.01855,751,800 - 55,765,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096557   ⟹   XP_038952485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,918,662 - 56,937,013 (-)NCBI
mRatBN7.21854,648,276 - 54,666,627 (-)NCBI
RefSeq Acc Id: XM_039096558   ⟹   XP_038952486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,918,662 - 56,937,013 (-)NCBI
mRatBN7.21854,648,276 - 54,666,627 (-)NCBI
RefSeq Acc Id: XM_063277079   ⟹   XP_063133149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,918,662 - 56,937,013 (-)NCBI
RefSeq Acc Id: NP_476468   ⟸   NM_057127
- UniProtKB: O70531 (UniProtKB/Swiss-Prot),   A6IXG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254850   ⟸   XM_006254788
- Peptide Label: isoform X1
- UniProtKB: O70531 (UniProtKB/Swiss-Prot),   A6IXG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254849   ⟸   XM_006254787
- Peptide Label: isoform X1
- UniProtKB: O70531 (UniProtKB/Swiss-Prot),   A6IXG4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024374   ⟸   ENSRNOT00000024374
RefSeq Acc Id: XP_038952486   ⟸   XM_039096558
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952485   ⟸   XM_039096557
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133149   ⟸   XM_063277079
- Peptide Label: isoform X1
- UniProtKB: O70531 (UniProtKB/Swiss-Prot),   A6IXG4 (UniProtKB/TrEMBL)
Protein Domains
STAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70531-F1-model_v2 AlphaFold O70531 1-739 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700814
Promoter ID:EPDNEW_R11338
Type:single initiation site
Name:Slc26a2_1
Description:solute carrier family 26 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01856,534,285 - 56,534,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620622 AgrOrtholog
BioCyc Gene G2FUF-7339 BioCyc
Ensembl Genes ENSRNOG00000018082 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055013647 UniProtKB/Swiss-Prot
  ENSRNOG00060024801 UniProtKB/Swiss-Prot
  ENSRNOG00065021437 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024374.3 UniProtKB/Swiss-Prot
  ENSRNOT00055023419 UniProtKB/Swiss-Prot
  ENSRNOT00060042897 UniProtKB/Swiss-Prot
  ENSRNOT00065036443 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.750.24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro S04_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117267 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot
  PTHR11814:SF16 UniProtKB/Swiss-Prot
  SULFATE TRANSPORTER UniProtKB/TrEMBL
  SULFATE TRANSPORTER UniProtKB/TrEMBL
Pfam STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfate_transp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc26a2 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018082 RatGTEx
  ENSRNOG00055013647 RatGTEx
  ENSRNOG00060024801 RatGTEx
  ENSRNOG00065021437 RatGTEx
Superfamily-SCOP SpoIIaa-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IXG4 ENTREZGENE, UniProtKB/TrEMBL
  O70531 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc26a2  solute carrier family 26 member 2  Slc26a2  solute carrier family 26 (anion exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc26a2  solute carrier family 26 (anion exchanger), member 2  Slc26a2  solute carrier family 26 (sulfate transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc26a2  solute carrier family 26 (sulfate transporter), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc26a2  solute carrier family 26 (sulfate transporter), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in cartilage and intestine 730044
gene_function Na+-independent sulfate transport activity 730044