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Strain Registration

Strain: SS/JrHsdMcwi

Symbol: SS/JrHsdMcwi
Strain: SS
Substrain: JrHsdMcwi
RGD ID: 61499
Citation ID: RRID:RGD_61499
Ontology ID: RS:0000811
Also Known As: MDC-03-09; SS/1JrHsdMcwi
Type: inbred
Available Source: RGD HRDP, contact HRDP
Origination: PhysGen
Description: Inbred from a congenic control group of Dahl S rats (SS/Ren) obtained from Dr. Theodore Kurtz (UCSF, CA) which were originally derived from the Harlan SS/Jr colony. Maintained at the Medical College of Wisconsin since 1991, this strain has undergone considerable marker-selected breeding to eliminate residual heterozygosity and genetic contamination. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley etal. 2000, Physiol. Genomics. 2:107-115).
Coat Color: Albino
Inbred Generations: at MCW since 1991
Last Known Status: Live Animals; Cryorecovery





Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood glucose level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
body length, nose to rump
kidney weight
right kidney wet weight
left kidney wet weight
liver weight
lung weight
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
blood B lymphocyte count
plasma renin activity level
urine creatinine level
urine sodium level
minute ventilation
spleen weight
lung weight to body weight ratio
spleen wet weight
cardiac output
arterial blood flow rate
tidal volume
stroke volume
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
left atrium weight
right atrium weight
mammary tumor number
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
tibia length
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
heart left ventricle weight to body weight ratio
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
plasma triglyceride level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
urine total protein level
liver weight to body weight ratio
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
urine creatinine excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle weight
heart right ventricle weight
heart left ventricle end-diastolic diameter
heart left ventricle fractional shortening
middle cerebral artery inner diameter
kidney glomerulus diameter
resting tone of middle cerebral artery
blood mononuclear cell count
urine fractional sodium excretion
ratio of change in renal blood flow rate to kidney weight
timed urine volume to body weight ratio
serum globulin level
heart left ventricle end-diastolic anterior wall thickness
heart left ventricle end-diastolic posterior wall thickness
heart left ventricle weight to tibia length ratio
urine podocalyxin excretion rate
tibialis anterior muscle weight to body weight ratio
extensor digitorum longus muscle weight to body weight ratio
liver weight to tibia length ratio
lung weight to tibia length ratio
single kidney weight to tibia length ratio
kidney total CD3 positive T cell count
kidney total CD45 positive leukocyte count
heart right ventricle weight to tibia length ratio
heart right atrium weight to tibia length ratio
heart left atrium weight to tibia length ratio
heart right ventricle weight to left ventricle plus septum weight ratio

References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
2. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
3. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Cowley AW Jr, etal., Physiol Genomics 2000 Apr 27;2(3):107-15.
4. Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation. de Resende MM, etal., Physiol Genomics. 2008 Jan 15;.
5. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
6. 20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. Frisbee JC, etal., Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1066-74.
7. Female-specific hypertension loci on rat chromosome 13. Hoffman MJ, etal., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1.
8. Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross. Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
9. Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
10. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
11. Dietary Protein Source Determines the Degree of Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat. Mattson DL, etal., Hypertension 2005 Feb 7;.
12. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
13. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.
14. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Moreno C, etal., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. doi: 10.1152/ajpheart.01026.2010. Epub 2011 Jan 21.
15. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
16. High Perfusion Pressure Accelerates Renal Injury in Salt-Sensitive Hypertension. Mori T, etal., J Am Soc Nephrol. 2008 Apr 16;.
17. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
18. PhysGen Strains PhysGen strains
19. RGD Strain RSO annotation pipeline RGD Automated Pipelines
20. Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Roman RJ, etal., Am J Physiol Renal Physiol. 2006 Jan 5;.
21. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
22. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.
23. Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Spires D, etal., Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097. doi: 10.1152/ajprenal.00155.2018. Epub 2018 Jun 20.
24. Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels. Stadnicka A, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):727-35. Epub 2009 Jun 18.
25. Differences in cardiovascular sensitivity to propofol in a chromosome substitution rat model. Stekiel TA, etal., Croat Med J. 2007 Jun;48(3):312-8.
26. A genomic-systems biology map for cardiovascular function. Stoll M, etal., Science 2001 Nov 23;294(5547):1723-6.
27. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Wiessner JH, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F301-6. Epub 2009 Jun 3.

Region

Strain QTL Data
Symbol Name Trait
Bp170 Blood pressure QTL 170 arterial blood pressure trait   (VT:2000000)    
Bp171 Blood pressure QTL 171 arterial blood pressure trait   (VT:2000000)    
Bp172 Blood pressure QTL 172 arterial blood pressure trait   (VT:2000000)    
Bp173 Blood pressure QTL 173 arterial blood pressure trait   (VT:2000000)    
Bp174 Blood pressure QTL 174 arterial blood pressure trait   (VT:2000000)    
Bp175 Blood pressure QTL 175 arterial blood pressure trait   (VT:2000000)    
Bp176 Blood pressure QTL 176 arterial blood pressure trait   (VT:2000000)    
Bp177 Blood pressure QTL 177 arterial blood pressure trait   (VT:2000000)    
Bp178 Blood pressure QTL 178 arterial blood pressure trait   (VT:2000000)    
Bp179 Blood pressure QTL 179 arterial blood pressure trait   (VT:2000000)    
Bp180 Blood pressure QTL 180 arterial blood pressure trait   (VT:2000000)    
Bp181 Blood pressure QTL 181 arterial blood pressure trait   (VT:2000000)    
Bp182 Blood pressure QTL 182 arterial blood pressure trait   (VT:2000000)    
Bp183 Blood pressure QTL 183 arterial blood pressure trait   (VT:2000000)    
Bp184 Blood pressure QTL 184 arterial blood pressure trait   (VT:2000000)    
Bp185 Blood pressure QTL 185 arterial blood pressure trait   (VT:2000000)    
Bp186 Blood pressure QTL 186 arterial blood pressure trait   (VT:2000000)    
Bp187 Blood pressure QTL 187 arterial blood pressure trait   (VT:2000000)    
Bp188 Blood pressure QTL 188 arterial blood pressure trait   (VT:2000000)    
Bp189 Blood pressure QTL 189 arterial blood pressure trait   (VT:2000000)    
Bp190 Blood pressure QTL 190 arterial blood pressure trait   (VT:2000000)    
Bp191 Blood pressure QTL 191 arterial blood pressure trait   (VT:2000000)    
Bp192 Blood pressure QTL 192 arterial blood pressure trait   (VT:2000000)    
Bp193 Blood pressure QTL 193 arterial blood pressure trait   (VT:2000000)    
Bp194 Blood pressure QTL 194 arterial blood pressure trait   (VT:2000000)    
Bp195 Blood pressure QTL 195 arterial blood pressure trait   (VT:2000000)    
Bp199 Blood pressure QTL 199 arterial blood pressure trait   (VT:2000000)    
Bp200 Blood pressure QTL 200 arterial blood pressure trait   (VT:2000000)    
Bp201 Blood pressure QTL 201 arterial blood pressure trait   (VT:2000000)    
Bp202 Blood pressure QTL 202 arterial blood pressure trait   (VT:2000000)    
Bp203 Blood pressure QTL 203 arterial blood pressure trait   (VT:2000000)    
Bp204 Blood pressure QTL 204 arterial blood pressure trait   (VT:2000000)    
Bp205 Blood pressure QTL 205 arterial blood pressure trait   (VT:2000000)    
Bp206 Blood pressure QTL 206 arterial blood pressure trait   (VT:2000000)    
Bp207 Blood pressure QTL 207 arterial blood pressure trait   (VT:2000000)    
Bp208 Blood pressure QTL 208 arterial blood pressure trait   (VT:2000000)    
Bp209 Blood pressure QTL 209 arterial blood pressure trait   (VT:2000000)    
Bp210 Blood pressure QTL 210 arterial blood pressure trait   (VT:2000000)    
Bp211 Blood pressure QTL 211 arterial blood pressure trait   (VT:2000000)    
Bp212 Blood pressure QTL 212 arterial blood pressure trait   (VT:2000000)    
Bp213 Blood pressure QTL 213 arterial blood pressure trait   (VT:2000000)    
Bp214 Blood pressure QTL 214 arterial blood pressure trait   (VT:2000000)    
Bp215 Blood pressure QTL 215 arterial blood pressure trait   (VT:2000000)    
Bp216 Blood pressure QTL 216 arterial blood pressure trait   (VT:2000000)    
Bp217 Blood pressure QTL 217 arterial blood pressure trait   (VT:2000000)    
Bp218 Blood pressure QTL 218 arterial blood pressure trait   (VT:2000000)    
Bp219 Blood pressure QTL 219 arterial blood pressure trait   (VT:2000000)    
Bp220 Blood pressure QTL 220 arterial blood pressure trait   (VT:2000000)    
Bp221 Blood pressure QTL 221 arterial blood pressure trait   (VT:2000000)    
Bp222 Blood pressure QTL 222 arterial blood pressure trait   (VT:2000000)    
Bp223 Blood pressure QTL 223 arterial blood pressure trait   (VT:2000000)    
Bp224 Blood pressure QTL 224 arterial blood pressure trait   (VT:2000000)    
Bp225 Blood pressure QTL 225 arterial blood pressure trait   (VT:2000000)    
Bp226 Blood pressure QTL 226 arterial blood pressure trait   (VT:2000000)    
Bp227 Blood pressure QTL 227 arterial blood pressure trait   (VT:2000000)    
Bp228 Blood pressure QTL 228 arterial blood pressure trait   (VT:2000000)    
Bp229 Blood pressure QTL 229 arterial blood pressure trait   (VT:2000000)    
Bp230 Blood pressure QTL 230 arterial blood pressure trait   (VT:2000000)    
Bp231 Blood pressure QTL 231 arterial blood pressure trait   (VT:2000000)    
Bp232 Blood pressure QTL 232 arterial blood pressure trait   (VT:2000000)    
Bp233 Blood pressure QTL 233 arterial blood pressure trait   (VT:2000000)    
Bp234 Blood pressure QTL 234 arterial blood pressure trait   (VT:2000000)    
Bp235 Blood pressure QTL 235 arterial blood pressure trait   (VT:2000000)    
Bp236 Blood pressure QTL 236 arterial blood pressure trait   (VT:2000000)    
Bp237 Blood pressure QTL 237 arterial blood pressure trait   (VT:2000000)    
Bp238 Blood pressure QTL 238 arterial blood pressure trait   (VT:2000000)    
Bp349 Blood pressure QTL 349 arterial blood pressure trait   (VT:2000000)    
Bp350 Blood pressure QTL 350 arterial blood pressure trait   (VT:2000000)    
Bp351 Blood pressure QTL 351 arterial blood pressure trait   (VT:2000000)    
Bp352 Blood pressure QTL 352 arterial blood pressure trait   (VT:2000000)    
Bp353 Blood pressure QTL 353 arterial blood pressure trait   (VT:2000000)    
Bp354 Blood pressure QTL 354 arterial blood pressure trait   (VT:2000000)    
Bp355 Blood pressure QTL 355 arterial blood pressure trait   (VT:2000000)    
Bw14 Body weight QTL 14 body mass   (VT:0001259)    
Bw15 Body weight QTL 15 body mass   (VT:0001259)    
Bw24 Body weight QTL 24 body mass   (VT:0001259)    
Bw25 Body weight QTL 25 body mass   (VT:0001259)    
Bw26 Body weight QTL 26 body mass   (VT:0001259)    
Bw27 Body weight QTL 27 body mass   (VT:0001259)    
Cardf1 Cardiac cell morphology QTL 1 aorta morphology trait   (VT:0000272)    
Cm2 Cardiac mass QTL 2 heart mass   (VT:0007028)    
Cm29 Cardiac mass QTL 29 heart mass   (VT:0007028)    
Cm3 Cardiac mass QTL 3 heart mass   (VT:0007028)    
Cm30 Cardiac mass QTL 30 heart mass   (VT:0007028)    
Cm31 Cardiac mass QTL 31 heart mass   (VT:0007028)    
Cm4 Cardiac mass QTL 4 heart mass   (VT:0007028)    
Cm5 Cardiac mass QTL 5 heart mass   (VT:0007028)    
Cm6 Cardiac mass QTL 6 heart mass   (VT:0007028)    
Hrtrt1 Heart rate QTL 1 heart pumping trait   (VT:2000009)    
Hrtrt10 Heart rate QTL 10 heart pumping trait   (VT:2000009)    
Hrtrt11 Heart rate QTL 11 heart pumping trait   (VT:2000009)    
Hrtrt12 Heart rate QTL 12 heart pumping trait   (VT:2000009)    
Hrtrt13 Heart rate QTL 13 heart pumping trait   (VT:2000009)    
Hrtrt14 Heart rate QTL 14 heart pumping trait   (VT:2000009)    
Hrtrt15 Heart rate QTL 15 heart pumping trait   (VT:2000009)    
Hrtrt16 Heart rate QTL 16 heart pumping trait   (VT:2000009)    
Hrtrt2 Heart rate QTL 2 heart pumping trait   (VT:2000009)    
Hrtrt3 Heart rate QTL 3 heart pumping trait   (VT:2000009)    
Hrtrt4 Heart rate QTL 4 heart pumping trait   (VT:2000009)    
Hrtrt5 Heart rate QTL 5 heart pumping trait   (VT:2000009)    
Hrtrt6 Heart rate QTL 6 heart pumping trait   (VT:2000009)    
Hrtrt7 Heart rate QTL 7 heart pumping trait   (VT:2000009)    
Hrtrt8 Heart rate QTL 8 heart pumping trait   (VT:2000009)    
Hrtrt9 Heart rate QTL 9 heart pumping trait   (VT:2000009)    
Kidm10 Kidney mass QTL 10 kidney mass   (VT:0002707)    
Kidm11 Kidney mass QTL 11 kidney mass   (VT:0002707)    
Kidm4 Kidney mass QTL 4 kidney mass   (VT:0002707)    
Kidm5 Kidney mass QTL 5 kidney mass   (VT:0002707)    
Kidm6 Kidney mass QTL 6 kidney mass   (VT:0002707)    
Kidm7 Kidney mass QTL 7 kidney mass   (VT:0002707)    
Kidm9 Kidney mass QTL 9 kidney mass   (VT:0002707)    
Rf10 Renal function QTL 10 renal blood flow trait   (VT:2000006)    
Rf11 Renal function QTL 11 renal blood flow trait   (VT:2000006)    
Rf12 Renal function QTL 12 renal blood flow trait   (VT:2000006)    
Rf13 Renal function QTL 13 renal blood flow trait   (VT:2000006)    
Rf14 Renal function QTL 14 renal blood flow trait   (VT:2000006)    
Rf15 Renal function QTL 15 renal blood flow trait   (VT:2000006)    
Rf16 Renal function QTL 16 renal blood flow trait   (VT:2000006)    
Rf17 Renal function QTL 17 renal blood flow trait   (VT:2000006)    
Rf18 Renal function QTL 18 urine output   (VT:0003620)    
Rf19 Renal function QTL 19 blood creatinine amount   (VT:0005328)    
Rf20 Renal function QTL 20 kidney glomerulus integrity trait   (VT:0010546)    
Rf21 Renal function QTL 21 renal blood flow trait   (VT:2000006)    
Rf22 Renal function QTL 22 renal blood flow trait   (VT:2000006)    
Rf23 Renal function QTL 23 renal blood flow trait   (VT:2000006)    
Rf24 Renal function QTL 24 blood creatinine amount   (VT:0005328)    
Rf25 Renal function QTL 25 blood creatinine amount   (VT:0005328)    
Rf26 Renal function QTL 26 urine potassium amount   (VT:0010539)    
Rf27 Renal function QTL 27 urine sodium amount   (VT:0006274)    
Rf28 Renal function QTL 28 urine potassium amount   (VT:0010539)    
Rf29 Renal function QTL 29 urine potassium amount   (VT:0010539)    
Rf30 Renal function QTL 30 urine potassium amount   (VT:0010539)    
Rf31 Renal function QTL 31 urine potassium amount   (VT:0010539)    
Rf32 Renal function QTL 32 kidney blood vessel physiology trait   (VT:0100012)    
Rf33 Renal function QTL 33 kidney blood vessel physiology trait   (VT:0100012)    
Rf34 Renal function QTL 34 kidney blood vessel physiology trait   (VT:0100012)    
Rf35 Renal function QTL 35 kidney blood vessel physiology trait   (VT:0100012)    
Rf36 Renal function QTL 36 kidney blood vessel physiology trait   (VT:0100012)    
Rf37 Renal function QTL 37 kidney blood vessel physiology trait   (VT:0100012)    
Rf38 Renal function QTL 38 kidney blood vessel physiology trait   (VT:0100012)    
Rf39 Renal function QTL 39 urine output   (VT:0003620)    
Rf40 Renal function QTL 40 kidney blood vessel physiology trait   (VT:0100012)    
Rf41 Renal function QTL 41 kidney blood vessel physiology trait   (VT:0100012)    
Rf42 Renal function QTL 42 kidney blood vessel physiology trait   (VT:0100012)    
Rf43 Renal function QTL 43 kidney blood vessel physiology trait   (VT:0100012)    
Rf44 Renal function QTL 44 urine total protein amount   (VT:0000032)    
Rf45 Renal function QTL 45 kidney blood vessel physiology trait   (VT:0100012)    
Rf6 Renal function QTL 6 renal blood flow trait   (VT:2000006)    
Rf7 Renal function QTL 7 urine creatinine amount   (VT:0010540)    
Rf8 Renal function QTL 8 renal blood flow trait   (VT:2000006)    
Rf9 Renal function QTL 9 kidney glomerulus integrity trait   (VT:0010546)    
Scl25 Serum cholesterol level QTL 25 blood cholesterol amount   (VT:0000180)    
Scl26 Serum cholesterol level QTL 26 blood cholesterol amount   (VT:0000180)    
Scl27 Serum cholesterol level QTL 27 blood HDL cholesterol amount   (VT:0000184)    
Scl28 Serum cholesterol level QTL 28 blood HDL cholesterol amount   (VT:0000184)    
Srn1 Serum renin concentration QTL 1 blood renin amount   (VT:0003349)    
Srn2 Serum renin concentration QTL 2 blood renin amount   (VT:0003349)    
Srn3 Serum renin concentration QTL 3 blood renin amount   (VT:0003349)    
Srn4 Serum renin concentration QTL 4 renin activity   (VT:0005581)    
Srn5 Serum renin concentration QTL 5 renin activity   (VT:0005581)    
Stl7 Serum triglyceride level QTL 7 blood triglyceride amount   (VT:0002644)    
Wbc1 White blood cell count QTL 1 leukocyte quantity   (VT:0000217)    
Wbc2 White blood cell count QTL 2 leukocyte quantity   (VT:0000217)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 SS/JrHsdMcwi (MDC) View Damaging Variants
RGSC_v3.4 SS/JrHsdMcwi (MCW) View Damaging Variants
RGSC_v3.4 SS/JrHsdMcwi (ICL) View Damaging Variants
Rnor_5.0 SS/JrHsdMcwi (MCW) View Damaging Variants
Rnor_5.0 SS/JrHsdMcwi (KNAW) View Damaging Variants
Rnor_6.0 SS/JrHsdMcwi (MCW) View Damaging Variants
Rnor_6.0 SS/JrHsdMcwi (RGD) View Damaging Variants
Rnor_6.0 SS/JrHsdMcwi (2019) View Damaging Variants
mRatBN7.2 SS/JrHsdMcwi (2019) View Damaging Variants
mRatBN7.2 SS/JrHsdMcwi (2019NG) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Normotensive rats were fed 0.4% NaCl and hypertensive rats were fed 4.0%NaCl for 4 weeks. Gracilis arteries had strong endothelium-independent myogenic activation in both the groups. 629526
strain_characteristics Normotensive rats were fed 0.4% Nacl and hypertensive rats were fed 4.0%Nacl for 4 weeks. Gracilis arteries had strong endothelium-independent myogenic activation in both the groups. 629526
strain_characteristics Other dietary components except sodium plays an important role in the development of hypertension and renal disease: carbohydrate in the diet did not affect body weight, arterial pressure or renal disease, substitution of casein with wheat gluten reduced body weight, mean arterial pressure and albumin secretion, replacement of fat increased arteral pressure without affecting body weight or albumin secretion. 1354517
strain_drgs_chems 20-hydroxyeicosatetraenoic acid (20-HETE) produced by omega-hydroxylation of arachidonoic acid via cytochrome P-450 was able to regulate myogenic activation of skeletal muscle resistance arteries. 629526
strain_drgs_chems 20-hydroxyeicosatetraenoic acid (20-HETE) produced by omega-hydroxylation of arachidonoic acid via cytochrome P-450 was abnormal 629526
strain_drgs_chems 20-hydroxyeicosatetraenoic acid (20-HETE) produced by omega-hydroxylation of arachidonoic acid via cytochrome P-450 was ab 629526
strain_drgs_chems exhibits greater cardiovascular sensitivity to anesthetic propofol than BN/NHsdMcwi 1626639
strain_life_disease These show similar resistance to myocardial ischemia as DA/OlaHsd strain but 2.5 times greater than BN/NHsdMcwi with LEW and WIST/Hsd intermediate in response. 1342469
strain_life_disease The blood pressure of females is 128 mmHg and of males is 126 mmHg. 629526
strain_life_disease Recovery of cortonary flow rate was more than 60% of its ischemic value which is similar to WIST/Hsd and LEW but less than DA/OlaHsd and BN/NHsdMcwi. 1342469
strain_other The average weight of females is 203g and of males 301g. 629526
strain_phys_biochem Cowley etal. reported the following arterial blood pressure measurements for this strain maintained for nearly 4 wk on 8% NaCl rat chow: Systolic arterial pressure (SAP) averaged 206 +/- 6 mmHg, and diastolic arterial pressure (DAP) averaged 167 +/- 4 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 35) averaged 185 +/- 5 mmHg and ranged from 127to 230 mmHg. Active MAP of rats on day 2 of recording averaged 172 +/- 7 mmHg, Inactive MAP on the same day averaged 173 +/- 7 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 45 +/- 4 mmHg, the average MAP following sodium depletion was 141 +/- 5 mmHg. 629526
strain_phys_biochem Cowley etal. reported the following arterial blood pressu 629526
strain_reproduction Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impaired fertility. The average litter size is 5.9 and the average generation time is 56 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 SS/JrHsdMcwi    SS/JrHsdMcwi    Name updated 68913 APPROVED
2013-08-12 SS/JrHsdMcwi    SS/JrHsdMcwi    Name updated 68913 APPROVED
2011-11-22 SS/JrHsdMcwi    SS/JrHsdMcwi    Name updated 68913 APPROVED
2011-11-22 SS/JrHsdMcwi    SS/JrHsdMcwi    Name updated 68913 APPROVED