Lmnb1 (lamin B1) - Rat Genome Database

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Gene: Lmnb1 (lamin B1) Rattus norvegicus
Analyze
Symbol: Lmnb1
Name: lamin B1
RGD ID: 620522
Description: Predicted to enable phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including cellular response to L-glutamate; cellular response to corticosterone stimulus; and response to xenobiotic stimulus. Located in nuclear lamina; nuclear matrix; and nuclear membrane. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamin-B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21850,175,861 - 50,215,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1852,214,944 - 52,253,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,922,869 - 52,961,415 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,720,824 - 50,759,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,785,111 - 51,822,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01850,979,862 - 51,018,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41852,470,605 - 52,508,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11852,516,112 - 52,553,517 (+)NCBI
Celera1848,320,757 - 48,358,598 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-ionone  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
cladribine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
mirex  (EXP)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
intermediate filament  (IEA)
lamin filament  (IEA,ISO)
nuclear envelope  (IBA,IDA,IEA,ISO)
nuclear inner membrane  (IEA,ISO)
nuclear lamina  (IBA,IDA,IEA,ISO)
nuclear matrix  (IDA,IEA,ISO)
nuclear membrane  (IDA,ISO)
nuclear periphery  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Barboro P, etal., Exp Cell Res. 2002 Oct 1;279(2):202-18.
2. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Chang KH, etal., Mol Biol Cell. 2011 May;22(9):1452-62. doi: 10.1091/mbc.E10-07-0654. Epub 2011 Mar 9.
3. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes. Chen QM, etal., Mol Pharmacol. 2005 Jun;67(6):1861-73. Epub 2005 Mar 8.
4. Calphostin C, a remarkable multimodal photodynamic killer of neoplastic cells by selective nuclear lamin B1 destruction and apoptogenesis (Review). Chiarini A, etal., Oncol Rep. 2010 Apr;23(4):887-92.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Perineuronal germinal cells in the rat cerebral cortex. Kataoka Y, etal., Med Mol Morphol. 2006 Mar;39(1):28-32.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Lamin B1 duplications cause autosomal dominant leukodystrophy. Padiath QS, etal., Nat Genet. 2006 Oct;38(10):1114-23. Epub 2006 Sep 3.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Transcriptomic analysis of nephrotoxicity induced by cephaloridine, a representative cephalosporin antibiotic. Rokushima M, etal., Chem Res Toxicol. 2008 Jun;21(6):1186-96. doi: 10.1021/tx800008e. Epub 2008 May 23.
16. Quantitative analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome alterations in 5L rat hepatoma cells using isotope-coded protein labels. Sarioglu H, etal., Proteomics. 2006 Apr;6(8):2407-21.
17. Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil. Shiraki A, etal., Toxicol Lett. 2014 Aug 4;228(3):225-34. doi: 10.1016/j.toxlet.2014.04.018. Epub 2014 Apr 26.
18. Characterization of inositol 1,4,5-trisphosphate (IP3) receptor subtypes at rat colonic epithelium. Siefjediers A, etal., Cell Calcium. 2007 Apr;41(4):303-15. Epub 2006 Sep 6.
19. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components. Strom A, etal., Eur J Cell Biol. 2011 May;90(5):414-9. doi: 10.1016/j.ejcb.2010.11.015. Epub 2011 Jan 28.
20. Differential expression of nuclear lamin, the major component of nuclear lamina, during neurogenesis in two germinal regions of adult rat brain. Takamori Y, etal., Eur J Neurosci. 2007 Mar;25(6):1653-62.
21. Knockdown of dystrophin Dp71 impairs PC12 cells cycle: localization in the spindle and cytokinesis structures implies a role for Dp71 in cell division. Villarreal-Silva M, etal., PLoS One. 2011;6(8):e23504. doi: 10.1371/journal.pone.0023504. Epub 2011 Aug 19.
22. Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina. Wakabayashi T, etal., Histochem Cell Biol. 2011 Oct;136(4):427-36. doi: 10.1007/s00418-011-0853-8. Epub 2011 Aug 14.
Additional References at PubMed
PMID:2023931   PMID:8032679   PMID:9053846   PMID:9305626   PMID:10791971   PMID:12714744   PMID:16128803   PMID:16283426   PMID:16364897   PMID:16641100   PMID:16791210   PMID:19028838  
PMID:19946888   PMID:20153721   PMID:20457914   PMID:21503901   PMID:21610090   PMID:21700703   PMID:21874024   PMID:22871113   PMID:23028340   PMID:23106098   PMID:23117660   PMID:23166514  
PMID:25123547   PMID:25931508   PMID:29476059   PMID:29484800   PMID:30924780   PMID:33300615   PMID:33450132  


Genomics

Comparative Map Data
Lmnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21850,175,861 - 50,215,210 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1852,214,944 - 52,253,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01852,922,869 - 52,961,415 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01850,720,824 - 50,759,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01851,785,111 - 51,822,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01850,979,862 - 51,018,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41852,470,605 - 52,508,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11852,516,112 - 52,553,517 (+)NCBI
Celera1848,320,757 - 48,358,598 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
LMNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385126,776,623 - 126,837,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5126,776,623 - 126,837,020 (+)EnsemblGRCh38hg38GRCh38
GRCh375126,112,315 - 126,172,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365126,140,732 - 126,200,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345126,140,731 - 126,200,608NCBI
Celera5122,068,688 - 122,128,577 (+)NCBICelera
Cytogenetic Map5q23.2NCBI
HuRef5121,304,338 - 121,364,498 (+)NCBIHuRef
CHM1_15125,544,889 - 125,605,473 (+)NCBICHM1_1
T2T-CHM13v2.05127,296,579 - 127,357,028 (+)NCBIT2T-CHM13v2.0
Lmnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391856,840,885 - 56,886,496 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1856,840,885 - 56,886,496 (+)EnsemblGRCm39 Ensembl
GRCm381856,707,813 - 56,753,424 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1856,707,813 - 56,753,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv371856,867,467 - 56,913,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361856,833,242 - 56,878,791 (+)NCBIMGSCv36mm8
Celera1858,016,751 - 58,063,869 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1830.84NCBI
Lmnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555214,583,671 - 4,612,271 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555214,583,691 - 4,612,271 (+)NCBIChiLan1.0ChiLan1.0
LMNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15120,228,131 - 120,289,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05122,179,513 - 122,240,848 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15127,949,457 - 128,010,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5127,949,457 - 128,010,721 (+)Ensemblpanpan1.1panPan2
LMNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11115,996,627 - 16,052,719 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1115,930,436 - 16,052,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1114,788,442 - 14,844,580 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01116,721,688 - 16,778,072 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1116,721,265 - 16,778,626 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11115,451,725 - 15,508,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01115,298,132 - 15,354,432 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,895,575 - 15,951,943 (+)NCBIUU_Cfam_GSD_1.0
Lmnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213138,583,486 - 138,637,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936504157,453 - 211,967 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936504157,459 - 211,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2129,807,318 - 129,872,270 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12129,807,228 - 129,862,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22135,104,017 - 135,158,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12329,759,133 - 29,814,332 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2329,759,514 - 29,814,314 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603448,254,893 - 48,313,748 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477414,805,465 - 14,863,241 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477414,806,585 - 14,863,543 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lmnb1
190 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:70
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000019351
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 38 28 19 28 1 1 64 22 40 10 1
Low 14 19 13 13 7 10 10 13 1 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019351   ⟹   ENSRNOP00000019351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1850,175,874 - 50,214,502 (+)Ensembl
Rnor_6.0 Ensembl1851,785,111 - 51,822,264 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104660   ⟹   ENSRNOP00000089957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1850,175,874 - 50,206,806 (+)Ensembl
RefSeq Acc Id: NM_053905   ⟹   NP_446357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21850,175,861 - 50,215,210 (+)NCBI
Rnor_6.01851,785,111 - 51,822,264 (+)NCBI
Rnor_5.01850,979,862 - 51,018,232 (+)NCBI
RGSC_v3.41852,470,605 - 52,508,022 (+)RGD
Celera1848,320,757 - 48,358,598 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446357 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB09600 (Get FASTA)   NCBI Sequence Viewer  
  P70615 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446357   ⟸   NM_053905
- UniProtKB: P70615 (UniProtKB/Swiss-Prot),   G3V7U4 (UniProtKB/TrEMBL),   A6IX67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019351   ⟸   ENSRNOT00000019351
RefSeq Acc Id: ENSRNOP00000089957   ⟸   ENSRNOT00000104660
Protein Domains
IF rod   LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70615-F1-model_v2 AlphaFold P70615 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620522 AgrOrtholog
BioCyc Gene G2FUF-7440 BioCyc
Ensembl Genes ENSRNOG00000013774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019351 ENTREZGENE
  ENSRNOP00000019351.3 UniProtKB/TrEMBL
  ENSRNOP00000089957.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019351 ENTREZGENE
  ENSRNOT00000019351.6 UniProtKB/TrEMBL
  ENSRNOT00000104660.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116685 UniProtKB/Swiss-Prot
NCBI Gene 116685 ENTREZGENE
PANTHER LAMIN DM0-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMIN-B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lmnb1 PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ACW5_RAT UniProtKB/TrEMBL
  A6IX67 ENTREZGENE, UniProtKB/TrEMBL
  G3V7U4 ENTREZGENE, UniProtKB/TrEMBL
  LMNB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Lmnb1  lamin B1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lmnb1  lamin B1      Symbol and Name status set to provisional 70820 PROVISIONAL