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Gene: Tcof1 (treacle ribosome biogenesis factor 1) Rattus norvegicus
Symbol: Tcof1
Name: treacle ribosome biogenesis factor 1
RGD ID: 1309850
Description: Predicted to have RNA polymerase I core binding activity; protein heterodimerization activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to localize to cytosol; fibrillar center; and nucleoplasm. Human ortholog(s) of this gene implicated in Treacher Collins syndrome. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; amphetamine.
Type: protein-coding
Also known as: LOC291571; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; Treacher Collins-Franceschetti syndrome 1 homolog (human); treacle protein
Homo sapiens (human) : TCOF1 (treacle ribosome biogenesis factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Tcof1 (treacle ribosome biogenesis factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcof1 (treacle ribosome biogenesis factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TCOF1 (treacle ribosome biogenesis factor 1)
Canis lupus familiaris (dog) : TCOF1 (treacle ribosome biogenesis factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcof1 (treacle ribosome biogenesis factor 1)
Sus scrofa (pig) : TCOF1 (treacle ribosome biogenesis factor 1)
Chlorocebus sabaeus (African green monkey) : TCOF1 (treacle ribosome biogenesis factor 1)
Heterocephalus glaber (naked mole-rat) : Tcof1 (treacle ribosome biogenesis factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01856,081,863 - 56,115,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,082,195 - 56,115,593 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,316,277 - 55,350,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,766,742 - 56,800,908 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11856,838,954 - 56,873,215 (-)NCBI
Celera1852,421,817 - 52,455,101 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tcof1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309850
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.