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Gene: Tcof1 (treacle ribosome biogenesis factor 1) Rattus norvegicus
Symbol: Tcof1
Name: treacle ribosome biogenesis factor 1
Description: Predicted to have RNA polymerase I core binding activity; protein heterodimerization activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to localize to the cytosol and fibrillar center. Human ortholog(s) of this gene implicated in Treacher Collins syndrome. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 2,4-dinitrotoluene.
Type: protein-coding
Also known as: LOC291571; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; Treacher Collins-Franceschetti syndrome 1 homolog (human); treacle protein
Homo sapiens (human) : TCOF1 (treacle ribosome biogenesis factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Tcof1 (treacle ribosome biogenesis factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcof1 (treacle ribosome biogenesis factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TCOF1 (treacle ribosome biogenesis factor 1)
Canis lupus familiaris (dog) : TCOF1 (treacle ribosome biogenesis factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcof1 (treacle ribosome biogenesis factor 1)
Sus scrofa (pig) : TCOF1 (treacle ribosome biogenesis factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01856,081,863 - 56,115,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01855,316,277 - 55,350,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,766,742 - 56,800,908 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11856,838,954 - 56,873,215 (-)NCBI
Celera1852,421,817 - 52,455,101 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tcof1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309850
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.