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Gene: Megf10 (multiple EGF-like domains 10) Rattus norvegicus

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Symbol:

Megf10

Name:

multiple EGF-like domains 10

RGD ID:

735084

Description:

Predicted to enable Notch binding activity; complement component C1q complex binding activity; and scavenger receptor activity. Predicted to be involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Predicted to act upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and recognition of apoptotic cell. Predicted to be located in phagocytic cup. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

multiple epidermal growth factor-like domains protein 10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEGF10 (multiple EGF like domains 10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Megf10 (multiple EGF-like-domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Megf10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEGF10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEGF10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Megf10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEGF10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEGF10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Megf10 (multiple EGF like domains 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SCARA3 (scavenger receptor class A member 3)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Megf10 (multiple EGF-like-domains 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MEGF10 (multiple EGF like domains 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	megf10 (multiple EGF-like-domains 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ced-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	drpr	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	drpr	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	megf10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	52,803,292 - 52,953,431 (+)	NCBI		GRCr8
GRCr8 Ensembl	18	52,847,781 - 52,950,675 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	18	50,605,231 - 50,755,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	50,605,656 - 50,754,456 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	52,694,133 - 52,797,033 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	53,409,354 - 53,512,382 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	51,200,013 - 51,302,914 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	52,215,652 - 52,366,212 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	52,215,682 - 52,366,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	51,403,811 - 51,554,336 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	52,948,935 - 53,051,823 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	48,786,696 - 48,889,249 (+)	NCBI		Celera
RGSC_v3.1	18	53,052,380 - 53,072,113 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital myopathy 10B (ISO)

Deglutition Disorders (ISO)

early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

muscular disease (ISO)

Neurodevelopmental Disorders (ISO)

newborn respiratory distress syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

cocaine (EXP)

Cuprizon (EXP)

cytarabine (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fenvalerate (EXP)

fonofos (ISO)

FR900359 (ISO)

fulvestrant (ISO)

glyphosate (EXP)

GSK-J4 (ISO)

isoflurane (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methylmercury chloride (ISO)

monosodium L-glutamate (ISO)

nickel atom (ISO)

ozone (ISO)

palytoxin (ISO)

paracetamol (EXP)

parathion (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium lactate (ISO)

temozolomide (ISO)

terbufos (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic cell clearance (IBA)

apoptotic process involved in development (IEA,ISO)

cell adhesion (IEA)

cell development (IEA)

engulfment of apoptotic cell (IEA,ISO)

homotypic cell-cell adhesion (IEA,ISO)

muscle cell development (IEA,ISO)

muscle cell proliferation (IEA,ISO)

muscle organ development (IEA)

myelination (NAS)

myoblast development (IEA,ISO)

myoblast migration (IEA,ISO)

phagocytosis (IEA)

positive regulation of cell-cell adhesion (IEA,ISO)

positive regulation of myoblast proliferation (IEA,ISO)

recognition of apoptotic cell (IEA,ISO)

regulation of muscle cell differentiation (IEA,ISO)

regulation of skeletal muscle tissue development (IEA,ISO)

skeletal muscle satellite cell activation (IEA,ISO)

skeletal muscle satellite cell differentiation (IEA,ISO)

skeletal muscle satellite cell proliferation (IEA,ISO)

vesicle-mediated transport (IEA)

Cellular Component

cell projection (IEA)

membrane (IEA)

phagocytic cup (IEA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

complement component C1q complex binding (IEA,ISO)

Notch binding (IBA,IEA,ISO)

scavenger receptor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A monoclonal autoantibody which promotes central nervous system remyelination is highly polyreactive to multiple known and novel antigens.	Asakura K, etal., J Neuroimmunol 1996 Mar;65(1):11-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17205124	PMID:17643423	PMID:18056409	PMID:19915564	PMID:22101682	PMID:22407321	PMID:27170117	PMID:28498977

Genomics

Comparative Map Data

Megf10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	52,803,292 - 52,953,431 (+)	NCBI		GRCr8
GRCr8 Ensembl	18	52,847,781 - 52,950,675 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	18	50,605,231 - 50,755,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	50,605,656 - 50,754,456 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	52,694,133 - 52,797,033 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	53,409,354 - 53,512,382 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	51,200,013 - 51,302,914 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	52,215,652 - 52,366,212 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	52,215,682 - 52,366,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	51,403,811 - 51,554,336 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	52,948,935 - 53,051,823 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	48,786,696 - 48,889,249 (+)	NCBI		Celera
RGSC_v3.1	18	53,052,380 - 53,072,113 (+)	NCBI
Cytogenetic Map	18	q12.1	NCBI

MEGF10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	127,229,300 - 127,461,222 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	127,290,796 - 127,465,737 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	126,626,488 - 126,796,914 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	126,654,514 - 126,824,807 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	122,757,239 - 122,927,674 (+)	NCBI		Celera
Cytogenetic Map	5	q23.2	NCBI
HuRef	5	121,817,526 - 121,988,151 (+)	NCBI		HuRef
CHM1_1	5	126,059,059 - 126,229,496 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	127,749,142 - 127,981,009 (+)	NCBI		T2T-CHM13v2.0

Megf10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	57,266,162 - 57,430,539 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	57,266,162 - 57,430,539 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	57,133,090 - 57,297,467 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	57,133,090 - 57,297,467 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	57,292,744 - 57,457,121 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	57,258,844 - 57,422,835 (+)	NCBI		MGSCv36	mm8
Celera	18	58,443,454 - 58,608,465 (+)	NCBI		Celera
Cytogenetic Map	18	D3	NCBI
cM Map	18	31.5	NCBI

Megf10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	335,012 - 513,891 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	393,642 - 513,157 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEGF10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	122,534,832 - 122,770,730 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	120,674,719 - 120,910,289 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	122,639,155 - 122,877,324 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	128,466,095 - 128,657,845 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	128,466,095 - 128,641,043 (+)	Ensembl	panpan1.1		panPan2

MEGF10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	16,359,648 - 16,574,882 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	16,378,669 - 16,617,335 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	15,047,444 - 15,360,462 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	16,981,258 - 17,301,745 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	16,940,314 - 17,349,743 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	15,711,146 - 16,024,958 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	15,557,940 - 15,871,023 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	16,155,094 - 16,474,941 (+)	NCBI		UU_Cfam_GSD_1.0

Megf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	139,012,245 - 139,182,163 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	586,190 - 756,255 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	634,167 - 753,438 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEGF10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	130,189,556 - 130,401,077 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	130,226,222 - 130,403,960 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	135,524,848 - 135,686,689 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEGF10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	30,028,154 - 30,405,033 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	30,234,489 - 30,404,996 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	47,643,480 - 48,026,869 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Megf10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	14,153,687 - 14,355,406 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	14,147,412 - 14,354,886 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Megf10
1194 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	451
Count of miRNA genes:	255
Interacting mature miRNAs:	303
Transcripts:	ENSRNOT00000037901
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
1331736	Bp227	Blood pressure QTL 227	2.791		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	48917054	60064728	Rat
631834	Sach3	Saccharin preference QTL 3	3.9	0.01	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	18	38575919	83575919	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	45620306	86134022	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	48915737	86134022	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	48915737	86134022	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	45620306	86134022	Rat
61360	Eaey	Experimental allergic encephalomyelitis QTL y	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	18	49187226	62647720	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	40462383	85462383	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	50795212	86134022	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
1331806	Bp229	Blood pressure QTL 229	4.36484		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	48917054	60064728	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
1331780	Bp238	Blood pressure QTL 238	3.269		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	48917054	60064728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	36121626	81121626	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	48915737	86134022	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	50795212	86134022	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	52198059	68120379	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	49	113	65	64	33	25	33	6	179	97	11	93	32	60	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L41686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037901 ⟹ ENSRNOP00000036049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	52,847,781 - 52,950,675 (+)	Ensembl
mRatBN7.2 Ensembl	18	50,605,656 - 50,754,456 (+)	Ensembl
Rnor_6.0 Ensembl	18	52,215,682 - 52,366,238 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114483 ⟹ ENSRNOP00000076780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	52,847,781 - 52,950,675 (+)	Ensembl
mRatBN7.2 Ensembl	18	50,605,656 - 50,697,297 (+)	Ensembl

RefSeq Acc Id:

NM_001100657 ⟹ NP_001094127

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	52,847,781 - 52,950,675 (+)	NCBI
mRatBN7.2	18	50,649,725 - 50,752,618 (+)	NCBI
Rnor_6.0	18	52,260,507 - 52,363,389 (+)	NCBI
Rnor_5.0	18	51,403,811 - 51,554,336 (+)	NCBI
RGSC_v3.4	18	52,948,935 - 53,051,823 (+)	RGD
Celera	18	48,786,696 - 48,889,249 (+)	RGD

Sequence:

show sequence

ATTGTTCTTCAAAGAAAATGGCTATTTCTTCAAGCTCCTGCCTGGGCCTCATCTGCTCACTGCT
GTGCCACTGGCTGAGGGCAGCATCCTCACTGAACCTGGAAGACCCCAATGTATGCAGCCACTGG
GAAAGCTACTCAGTGACTGTGCAGGAGTCTTACCCACATCCCTTCGATCAGATTTACTACACAA
GCTGCACTGACATACTGAACTGGTTTAAATGCACTCGGCACAGAGTGAGCTACCGGACAGCCTA
CCGCCATGGGGAGAAAACCATGTACAGACGCAAATCCCAGTGTTGCCCCGGATTTTATGAAAGT
CGAGACGTGTGTGTCCCTCACTGCGCTGATAAATGCGTCCACGGTCGCTGCATCGCTCCAAACA
CCTGTCAGTGTGAGCCTGGCTGGGGTGGGACCAACTGTAGCAGTGCTTGTGACGGTGATCACTG
GGGACCTCACTGCAGCAGCCGGTGTCAGTGCAAAAACAGAGCTTTGTGTAACCCCATCACCGGA
GCTTGTCACTGCGCCGCGGGCTACCGGGGATGGCGCTGTGAGGACCGTTGTGAACAGGGCACCT
ACGGTAACGACTGTCATCAAAGGTGCCAGTGTCAGAATGGAGCGACCTGTGACCACATCACTGG
GGAATGTCGTTGTTCACCTGGATACACTGGAGCCTTCTGTGAGGATCTGTGTCCTCCTGGCAAA
CATGGCCCACAGTGTGAGCAGAGATGTCCCTGCCAAAATGGAGGCGTGTGCCATCATGTCACTG
GAGAGTGCTCCTGCCCTTCTGGCTGGATGGGCACAGTGTGTGGTCAGCCCTGCCCCGAGGGTCG
CTTTGGAAAGAACTGTTCCCAAGAATGTCAGTGCCACAATGGAGGAGCGTGTGATGCTGCCACA
GGCCAATGTCACTGCAGCCCAGGATACACAGGGGAACGGTGTCAGGATGAATGTCCTGTTGGAA
CCTATGGAGTTCGCTGTGCTGAGACCTGCAGGTGTGTTAATGGAGGGAAGTGTTACCATGTGAG
CGGCACATGCCTATGCGAAGCAGGTTTTTCAGGTGAATTTTGCGAGGCTCGTCTGTGCCCTGAG
GGGCTTTACGGCATCAAATGTGACAAGCGGTGCCCCTGCCACCTGGACAATACTCATAGCTGTC
ATCCCATGTCTGGAGAGTGTGGCTGCAAGCCGGGTTGGTCTGGACTGTACTGTAATGAAACATG
CTCTCCTGGATTCTACGGGGAAGCTTGCCAACAGATCTGCAGCTGCCAAAACGGGGCTGACTGT
GACAGTGTGAGTGGAAGGTGTGCCTGTGCTCCAGGATTCAAAGGAACTGACTGCTCTACTCCGT
GTCCTCTGGGACGCTATGGGATAAATTGTTCTTCTCGCTGTGGCTGTAAAAACGATGCTGTCTG
TTCTCCTGTGGATGGATCGTGCATCTGTAAGGCAGGCTGGCACGGGGTGGACTGTTCCATCAGC
TGCCCCAGTGGCACATGGGGCTTTGGCTGTAATCTAACCTGTCAGTGCCTCAATGGCGGTGCCT
GCAACACACTGGACGGCACCTGCACCTGTGCGCCGGGATGGCGAGGGGAGAAATGTGAATTTCC
CTGCCAGGATGGCACATATGGGCTGAACTGTGCTGAGCGCTGTGACTGCAGCCATGCAGACGGA
TGTCACCCCACTACCGGCCATTGCCGATGCCTCCCTGGATGGTCAGGTGTGCACTGTGACAGTG
TGTGTGCTGAGGGACGCTGGGGTCCTAACTGCTCGCTGCCCTGCTACTGTAAAAATGGGGCTTC
GTGTTCTCCCGATGATGGCATCTGTGAATGCGCACCCGGATTCCGAGGCACCACTTGCCAGAGA
ATCTGCTCCCCGGGCTTTTATGGACACCGCTGTAGCCAGACATGCCCACAGTGTGTGCACAGCA
GTGGACCATGCCACCACATCACAGGCCTGTGTGACTGCTTGCCTGGCTTCACTGGCGCCCTGTG
CAATGAAGTGTGTCCCAGTGGCAGATTTGGGAAGAACTGTGCAGGTGTTTGTACCTGCACCAAC
AACGGCACCTGTAACCCCATCGACCGGTCCTGTCAGTGCTACCCAGGCTGGATTGGCAGTGACT
GCTCCCAGCCCTGTCCACCAGCCCACTGGGGTCCGAACTGCATCCATACATGCAACTGCCACAA
TGGAGCCTTTTGCAGCGCCTATGATGGGGAATGCAAATGCACTCCTGGCTGGACGGGGCTCTAC
TGCACTCAGAGATGCCCTCTGGGCTTCTATGGCAAGGACTGTGCACTGGTATGCCAATGTCAAA
ACGGAGCTGACTGCGACCACATCTCGGGGCAGTGTACCTGCCGCACGGGATTCATGGGACGGCA
CTGTGAACAGAAATGCCCTGCGGGAACATACGGCTATGGCTGTCGCCAGATCTGCGACTGTCTG
AACAACTCCACCTGTGACCACATCACCGGCACGTGTTACTGTAGCCCAGGGTGGAAAGGAGCAC
GATGTGACCAAGCTGGGGTCATCATCGTGGGCAATCTGAACAGCTTAAGCAGGACCAGCACCGC
CCTTCCTGCTGACTCCTATCAGATTGGGGCCATCGCGGGCATCGTGGTCCTTCTGCTTGTTGTG
CTCTTCCTGCTGGCGCTGTTCGTTATCTACAGACACAAGCAGAAGAGGAAGGAATCGAGCATGC
CGGCCGTGACCTACACCCCTGCCATGAGGGTTATCAATGCAGACTATACCATTGCAGAAACCCT
GCCTCACAGCAATGGCGGAAATGCCAACAGCCACTACTTCACCAATCCCAGTTATCACACACTT
AGCCAGTGTGCCGCGTCCCCTCATGTGAACAACAGGGACAGGATGACCATTGCAAAGTCAAAAA
ACAATCAACTGTTTGTGAATCTTAAAAATGTGAATCCAGGGAAGAGAGGCGCTTTGGTGGACTG
CACTGGGACGTTGCCAGCTGACTGGAAGCAAGGAGGCTACCTCAATGAACTTGGTGCTTTTGGG
CTGGACAGAAGCTACATGGGAAAGTCCTTAAAAGATCTGGGGAAGAATTCTGAGTACAATTCAA
GTACTTGTTCCCTAAGCAGCTCGGAGAACCCATATGCCACCATTAAAGACCCTCCTGCGCTCTT
GCCTAAAAGCTCCGAGTGTGGCTACGTGGAGATGAAGTCGCCAGCGCGAAGAGACTCCCCATAT
GCAGAGATCAATAACTCAACTTCAGCCAACAGGAATGTCTATGAAGTCGAACCTACAGTCAGTG
TGGTGCAAGGAGTATTCAGCAACAATGGTCATGTCACCCAAGACCCATATGACCTTCCAAAGAA
CAGTCACATCCCTTGCCATTATGACCTGCTGCCAGTAAGGGACAGTTCATCCTCCCCAAAGAGA
GAGGATGGTGGTGGCAGCAGCAGCAGCACCACCACCAGCAACAGCAGCAACAGCAGCGAATGAC
ATCAAAGGACTACTGGGTGACCATTGGTACTCTTTTCAAGCCTTCAGTTCATCTCCAGTTGGCA
CTGCAGATGACTGTGAATTACTCTAATAAGCAGTTGTTGGACATGTACCAGAAAGCTCCAAGCT
GAGGCTAACACCCATCGAGGTGTGTTGTGATCACAGGGCTTAGAAGGAGAGAGCTTCATGATTT
CTCCTTGCTGTTAGGTTAGGAATGGCACCAATGACTTGTTTTAAGATGTTGGCTGATAAGGTGA
ACTTCATGGGACCTTTAAGAGACAGAGACTGGAGGAGACATTGTATTGTCACCTGGAAAACTAA
AGTCTATTTGTTGTCTGTAACATCACAGAGCCACTCCTAGGATCGTGCAGGTCACCACATGTTT
ATCTAAGAAAAGTGAAAACTGCCAAACACATAGGAGACAAGGAATATTCTCCTGAGTCCTCCTT
GCATAATGGTTTTTTTTTTCCATTTGGACTCAAGATCAGAAGCATTCTGTCAGGTGGTAGGATT
GGATAGCAATGAGAGCAAATCGAAACATAAAACCTTTGTTTGTTTTTAGGATGAGAAATGTTCA
ATTAGAATTATTTTAGACATAG

hide sequence

RefSeq Acc Id:

XM_006254747 ⟹ XP_006254809

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	52,803,293 - 52,953,431 (+)	NCBI
mRatBN7.2	18	50,605,231 - 50,755,441 (+)	NCBI
Rnor_6.0	18	52,215,652 - 52,366,212 (+)	NCBI
Rnor_5.0	18	51,403,811 - 51,554,336 (+)	NCBI

Sequence:

show sequence

TCCCTCCTCCCTCCCCACTTTCCCAGTCACTTAGCTGCCGCTCGGTTCCTGGTGACCTGGCCTG
GTCCCCATCCCTTCTCCGTCCCACTTTTGCGCTCCCTCAGTCTGGGGACGCGCTGTCCTGTCCG
CTTGGCGGATGCTGGCCCTGTCCCCCAAATCCTTGTAGAGGGCCTAGACTCTTCTCCTGGGGTA
CTTTGAGGAGGGGTTAGCACTGGTACTGTGGAGCACAGCACTCTGTTATCACTCTCTCAAGCCC
CGTGGTGAGTCTTAAGTTTGCCAACTTCTTGACTCAGTCACTGACTGGGGTCCCAGGAGTCCGG
CCGGAAGGAGATTGCAGGTTTGGAGGGACCGCAAGCGAGCGACATCGCTCCCCCTCCCCAAACC
TCCCCCCCACCGGCCACTGTCCCGGAGGCAGCAGCTGCAGCAGAGGCAACTGCTCGCATCCCAG
CCGGGCTCGGGTTACCGCCTTCTTCCTCCAGCATCTCCTGCCAGACAGGGAAAAGCTTGATCAA
GTTTGCAGCAGGACTCGGTCCCTGTGCAAAACTGGGGCTCCGGGACGGGCCTGCTTCCCCGCGT
CCGCATCTCCAGAGCTTAAGCAAGACTAGCATACATTGCTTTCTCCTGGGACTCTGCTTGGAAG
CCAGCAGCCGCGGTTGGGAAAAGATTTTGAATCTCGGCTGGAGTGGGTGAAGACCAGGGGAAAA
CAGGTTGCACTGCCAATCACAGCATTTCAGGACCGGATTGTTCTTCAAAGAAAATGGCTATTTC
TTCAAGCTCCTGCCTGGGCCTCATCTGCTCACTGCTGTGCCACTGGCTGAGGGCAGCATCCTCA
CTGAACCTGGAAGACCCCAATGTATGCAGCCACTGGGAAAGCTACTCAGTGACTGTGCAGGAGT
CTTACCCACATCCCTTCGATCAGATTTACTACACAAGCTGCACTGACATACTGAACTGGTTTAA
ATGCACTCGGCACAGAGTGAGCTACCGGACAGCCTACCGCCATGGGGAGAAAACCATGTACAGA
CGCAAATCCCAGTGTTGCCCCGGATTTTATGAAAGTCGAGACGTGTGTGTCCCTCACTGCGCTG
ATAAATGCGTCCACGGTCGCTGCATCGCTCCAAACACCTGTCAGTGTGAGCCTGGCTGGGGTGG
GACCAACTGTAGCAGTGCTTGTGACGGTGATCACTGGGGACCTCACTGCAGCAGCCGGTGTCAG
TGCAAAAACAGAGCTTTGTGTAACCCCATCACCGGAGCTTGTCACTGCGCCGCGGGCTACCGGG
GATGGCGCTGTGAGGACCGTTGTGAACAGGGCACCTACGGTAACGACTGTCATCAAAGGTGCCA
GTGTCAGAATGGAGCGACCTGTGACCACATCACTGGGGAATGTCGTTGTTCACCTGGATACACT
GGAGCCTTCTGTGAGGATCTGTGTCCTCCTGGCAAACATGGCCCACAGTGTGAGCAGAGATGTC
CCTGCCAAAATGGAGGCGTGTGCCATCATGTCACTGGAGAGTGCTCCTGCCCTTCTGGCTGGAT
GGGCACAGTGTGTGGTCAGCCCTGCCCCGAGGGTCGCTTTGGAAAGAACTGTTCCCAAGAATGT
CAGTGCCACAATGGAGGAGCGTGTGATGCTGCCACAGGCCAATGTCACTGCAGCCCAGGATACA
CAGGGGAACGGTGTCAGGATGAATGTCCTGTTGGAACCTATGGAGTTCGCTGTGCTGAGACCTG
CAGGTGTGTTAATGGAGGGAAGTGTTACCATGTGAGCGGCACATGCCTATGCGAAGCAGGTTTT
TCAGGTGAATTTTGCGAGGCTCGTCTGTGCCCTGAGGGGCTTTACGGCATCAAATGTGACAAGC
GGTGCCCCTGCCACCTGGACAATACTCATAGCTGTCATCCCATGTCTGGAGAGTGTGGCTGCAA
GCCGGGTTGGTCTGGACTGTACTGTAATGAAACATGCTCTCCTGGATTCTACGGGGAAGCTTGC
CAACAGATCTGCAGCTGCCAAAACGGGGCTGACTGTGACAGTGTGAGTGGAAGGTGTGCCTGTG
CTCCAGGATTCAAAGGAACTGACTGCTCTACTCCGTGTCCTCTGGGACGCTATGGGATAAATTG
TTCTTCTCGCTGTGGCTGTAAAAACGATGCTGTCTGTTCTCCTGTGGATGGATCGTGCATCTGT
AAGGCAGGCTGGCACGGGGTGGACTGTTCCATCAGCTGCCCCAGTGGCACATGGGGCTTTGGCT
GTAATCTAACCTGTCAGTGCCTCAATGGCGGTGCCTGCAACACACTGGACGGCACCTGCACCTG
TGCGCCGGGATGGCGAGGGGAGAAATGTGAATTTCCCTGCCAGGATGGCACATATGGGCTGAAC
TGTGCTGAGCGCTGTGACTGCAGCCATGCAGACGGATGTCACCCCACTACCGGCCATTGCCGAT
GCCTCCCTGGATGGTCAGGTGTGCACTGTGACAGTGTGTGTGCTGAGGGACGCTGGGGTCCTAA
CTGCTCGCTGCCCTGCTACTGTAAAAATGGGGCTTCGTGTTCTCCCGATGATGGCATCTGTGAA
TGCGCACCCGGATTCCGAGGCACCACTTGCCAGAGAATCTGCTCCCCGGGCTTTTATGGACACC
GCTGTAGCCAGACATGCCCACAGTGTGTGCACAGCAGTGGACCATGCCACCACATCACAGGCCT
GTGTGACTGCTTGCCTGGCTTCACTGGCGCCCTGTGCAATGAAGTGTGTCCCAGTGGCAGATTT
GGGAAGAACTGTGCAGGTGTTTGTACCTGCACCAACAACGGCACCTGTAACCCCATCGACCGGT
CCTGTCAGTGCTACCCAGGCTGGATTGGCAGTGACTGCTCCCAGCCCTGTCCACCAGCCCACTG
GGGTCCGAACTGCATCCATACATGCAACTGCCACAATGGAGCCTTTTGCAGCGCCTATGATGGG
GAATGCAAATGCACTCCTGGCTGGACGGGGCTCTACTGCACTCAGAGATGCCCTCTGGGCTTCT
ATGGCAAGGACTGTGCACTGGTATGCCAATGTCAAAACGGAGCTGACTGCGACCACATCTCGGG
GCAGTGTACCTGCCGCACGGGATTCATGGGACGGCACTGTGAACAGAAATGCCCTGCGGGAACA
TACGGCTATGGCTGTCGCCAGATCTGCGACTGTCTGAACAACTCCACCTGTGACCACATCACCG
GCACGTGTTACTGTAGCCCAGGGTGGAAAGGAGCACGATGTGACCAAGCTGGGGTCATCATCGT
GGGCAATCTGAACAGCTTAAGCAGGACCAGCACCGCCCTTCCTGCTGACTCCTATCAGATTGGG
GCCATCGCGGGCATCGTGGTCCTTCTGCTTGTTGTGCTCTTCCTGCTGGCGCTGTTCGTTATCT
ACAGACACAAGCAGAAGAGGAAGGAATCGAGCATGCCGGCCGTGACCTACACCCCTGCCATGAG
GGTTATCAATGCAGACTATACCATTGCAGAAACCCTGCCTCACAGCAATGGCGGAAATGCCAAC
AGCCACTACTTCACCAATCCCAGTTATCACACACTTAGCCAGTGTGCCGCGTCCCCTCATGTGA
ACAACAGGGACAGGATGACCATTGCAAAGTCAAAAAACAATCAACTGTTTGTGAATCTTAAAAA
TGTGAATCCAGGGAAGAGAGGCGCTTTGGTGGACTGCACTGGGACGTTGCCAGCTGACTGGAAG
CAAGGAGGCTACCTCAATGAACTTGGTGCTTTTGGGCTGGACAGAAGCTACATGGGAAAGTCCT
TAAAAGATCTGGGGAAGAATTCTGAGTACAATTCAAGTACTTGTTCCCTAAGCAGCTCGGAGAA
CCCATATGCCACCATTAAAGACCCTCCTGCGCTCTTGCCTAAAAGCTCCGAGTGTGGCTACGTG
GAGATGAAGTCGCCAGCGCGAAGAGACTCCCCATATGCAGAGATCAATAACTCAACTTCAGCCA
ACAGGAATGTCTATGAAGTCGAACCTACAGTCAGTGTGGTGCAAGGAGTATTCAGCAACAATGG
TCATGTCACCCAAGACCCATATGACCTTCCAAAGAACAGTCACATCCCTTGCCATTATGACCTG
CTGCCAGTAAGGGACAGTTCATCCTCCCCAAAGAGAGAGGATGGTGGTGGCAGCAGCAGCAGCA
CCACCACCAGCAACAGCAGCAACAGCAGCGAATGACATCAAAGGACTACTGGGTGACCATTGGT
ACTCTTTTCAAGCCTTCAGTTCATCTCCAGTTGGCACTGCAGATGACTGTGAATTACTCTAATA
AGCAGTTGTTGGACATGTACCAGAAAGCTCCAAGCTGAGGCTAACACCCATCGAGGTGTGTTGT
GATCACAGGGCTTAGAAGGAGAGAGCTTCATGATTTCTCCTTGCTGTTAGGTTAGGAATGGCAC
CAATGACTTGTTTTAAGATGTTGGCTGATAAGGTGAACTTCATGGGACCTTTAAGAGACAGAGA
CTGGAGGAGACATTGTATTGTCACCTGGAAAACTAAAGTCTATTTGTTGTCTGTAACATCACAG
AGCCACTCCTAGGATCGTGCAGGTCACCACATGTTTATCTAAGAAAAGTGAAAACTGCCAAACA
CATAGGAGACAAGGAATATTCTCCTGAGTCCTCCTTGCATAATGGTTTTTTTTTTCCATTTGGA
CTCAAGATCAGAAGCATTCTGTCAGGTGGTAGGATTGGATAGCAATGAGAGCAAATCGAAACAT
AAAACCTTTGTTTGTTTTTAGGATGAGAAATGTTCAATTAGAATTATTTTAGACATAGTATATG
AGTATCGCAGAAATCAATACATAAATGTGGCATTTCCATTTGACCTTCGGCCCATGTTAGATTT
GTGACGTCATTCTAATTGCTGTCCCACCATGCATATTTACCACTTGAGGTTCATAACTTATCAG
TTATCCATATATACAAAGATGCAATCGTTTTATTGTTTGATTGAGTGAGTGTCTGGTGAGCAGC
AAAGGGTGTACATTTTACATGTAAGATGCTTGGGTTAGAGGAACCATTAGTAATACTTGTTGTA
ATATAGTCTTAGGGGGATGTTTTCCTTAATTTTTCCCTACAAGTGACTGAGATATTTTTTGTGC
ATATTTGGGAAAGGGGCACTTTTCTTATTAACTATTGATTTAGAGAAACCATGCTTAAGCTGGC
CTTTTGCATTGCTAATGTGACATGCACTCGTTTCTTTTTAGTTTGTATTTTCATTAAGTCGTGT
ATTCTGTTTTATAGTGTTTGGGTTGTTAATGCAGAATTATGATATGTCCATCGTTTCCTGAATC
ATTGCCATTCATCTTCTGCTCAAAAGGAACACGTTATTTTTCTTTTGGAGGAAGGAAATGAAAA
TATACAAATTGAACCTATTAAAATTGATCATTGCTAAAATAGTATAGTAGCCATAGGTGTGTAG
CTGATCACTGGAATGGAACTTTCTAATAGTCCACAGTGGAGATCTCTTTGGGGATGTTGGTTCC
CTGAGTCTTGGTTAAGCTCGGGAAGAAGGAGCGATGAGAATTACCAGTGATTTTGCTAAAGACT
TTCATCATGGTCATCAATAACTGAGCATATAAACTGGGCCACTTTTAATAGTAAATGAGGGCAT
TACTAATAGCCATCAGGCATTGGGTTTAAATATAGACTATTCTCAGCAGACCAGAACAAATGCT
TGCCTGATGTACACTCTAGCAGACACAGCTTTACCCCAAGGCTTTTGTCACATGAGAATGCCAA
TGTGATGCAACAAAGCATTGCTATATCTGAGCACACAGAAGAGAGGAAAGGGTGTGAGCATGTG
TAACATCAGAGCAGAATGACACGAAGACCCATGTGACAGTCTGTTGGAGTCTATTAATAATTGA
CTACTACACTCACCTAATAGCGGCAGCTATAAAGTGTTATCCCAGTCTGCCTCTGAGGCGGAAT
GTAGTCATTTTGCATTGCCCACCTGTGCCTATCATGATGGATTAATTTGGTCAGGTGAATAGTT
CTGCAAATGCACTTAGGGAAATTGCTCTTACATTATCTGGAACATTCTTTAGAAACAATCGAAT
TTTTTTCCAGCACTGGCTGATCCCTAGGGAGCAAACATCAAGCGGACACATGGTTTAGCAGCCA
TAGGAGCCCTTCCTGCTATGAGAAGGTTGAACACTTTCCCTTTTTCTCCTTAAATACCATCTCT
TTTACGCATAACGGTAAGATTGAGGTCCCTGTGACTCTATAGAGATTGTTTGTTTATTAAAGCT
GTCTTTCCCCATTGTACCATTTGGGAAAAAGAATTTGTGTGCAACAGTGAGAGGATCTTACTGG
AAAAATCTACAGAGAAGGTTCCAAACAGATGTCTTATGAGGTGGTAATGACACGCCCACAAGCT
ACCCTGTAGAATCCATTGATACCCATATCCTAACACAAGCTGATCTTCTGAACCTGTGTCCAAG
GCAGAGTTTACCTAGAAGTTTCCTCAAGACTTTCCCAAAGTCAGAACATTTCATATTTCAGACA
CTGTAAAAATCCCACACTGTCTCTGGAGACAAAGCATAATTTTCTAGATATTTTGCTATAATTT
CTCTCTGGTACCCTGCAGAAGAAAGCACTGGATAGGTTTGATAATTCCTTGTATGGGACATCCA
GATGCAAATGTGGTCCTAGCCATTATTTTTCCTTAGAAATTGAACCATTTTACCATTTACCATT
TGTACAGCAGTATATCAGAACTTGCCCAGATGATAATTCATATACTTGTTTTTATTAGGAGACC
ATGATATTTGTGGTTAATTCTGTGACATGGGAATTGTCATAATTACTCACAGTGCTAGATAGCC
CCTCCTCATAGAGTACTAGTAGTGGACAGAATTTAATGTGTTTAGCAATGTTTTTGTGGGTGTT
GGCCAAGTACAGAAAAACTGACCTTAGAAGTTTACAACAGAGCAGCATAGGGTGTTATGGCCAA
ATCCATTAGCATAATACCTCCTGATTGTGAGAAATGCAGGCAACTTTATGAAAATATGGTTATC
TTGATGTCAGTAGGCCATAATGGTGATCAGCCCTAGGGAACTTTTCTACCAAATACAACTCAAA
CTCAAACAAAAACAGCATATATCATCAATGTGATATTAGAAGACTACAATTCAAGTAAGACAAA
GATCATAAAAATCAAATCTTAGGATTATGGTTTTTAAAAAATGAATTTTCCATCTCTGGGTAAT
ATGTCCTTATTATTACAAGGAAACACTGAAGGGCTATTTTTATTTTAAAGGCTTAGTGCCATGG
ACATGTACAGAGGCTTGTGTGGAGTGGTTGCTTGTGAAGCAGGGGCTACACACAGCAAACTGTC
CTGTAGAGTCCTGTTCACCATTTTTGTCTCACCTTTGTTTTGATATGACCAAATTGCAGTATTT
CTCTCTATATTTTTACGAAGAAAAACTCATAATGCAGTATGGTTTACTTGGTGATTGCAAACAA
AATTAATGCTTTAAGTGTTACGCTCTCTCTTTCCCAAAGACAATAAACCTCCCTCAGAATTAGT
TTCATTGTCATTTATACCGTCAAATAGTCAATAGATGAGTGCAGTAAACTTTCTGATTAAAAAC
A

hide sequence

RefSeq Acc Id:

XM_039096646 ⟹ XP_038952574

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	52,803,292 - 52,953,431 (+)	NCBI
mRatBN7.2	18	50,605,231 - 50,755,441 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094127	(Get FASTA)	NCBI Sequence Viewer
	XP_006254809	(Get FASTA)	NCBI Sequence Viewer
	XP_038952574	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB05844	(Get FASTA)	NCBI Sequence Viewer
	EDM14505	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036049
	ENSRNOP00000036049.4
	ENSRNOP00000076780.1

RefSeq Acc Id:	NP_001094127 ⟸ NM_001100657
- Peptide Label:	precursor
- UniProtKB:	F1MAP4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAISSSSCLGLICSLLCHWLRAASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDIL NWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESRDVCVPHCADKCVHGRCIAPNTCQCEP GWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCH QRCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCP SGWMGTVCGQPCPEGRFGKNCSQECQCHNGGACDAATGQCHCSPGYTGERCQDECPVGTYGVRC AETCRCVNGGKCYHVSGTCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGE CGCKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPCPLGRY GINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACNTLDG TCTCAPGWRGEKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGR WGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHH ITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCP PAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALVCQCQNGADCD HISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAG VIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLLLVVLFLLALFVIYRHKQKRKESSMPAVTYT PAMRVINADYTIAETLPHSNGGNANSHYFTNPSYHTLSQCAASPHVNNRDRMTIAKSKNNQLFV NLKNVNPGKRGALVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSTCSLS SSENPYATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVF SNNGHVTQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGSSSSTTTSNSSNSSE hide sequence

RefSeq Acc Id:	XP_006254809 ⟸ XM_006254747
- Peptide Label:	isoform X1
- UniProtKB:	F1MAP4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAISSSSCLGLICSLLCHWLRAASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDIL NWFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYESRDVCVPHCADKCVHGRCIAPNTCQCEP GWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCH QRCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCP SGWMGTVCGQPCPEGRFGKNCSQECQCHNGGACDAATGQCHCSPGYTGERCQDECPVGTYGVRC AETCRCVNGGKCYHVSGTCLCEAGFSGEFCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGE CGCKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVSGRCACAPGFKGTDCSTPCPLGRY GINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSISCPSGTWGFGCNLTCQCLNGGACNTLDG TCTCAPGWRGEKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGR WGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHH ITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCP PAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALVCQCQNGADCD HISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAG VIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLLLVVLFLLALFVIYRHKQKRKESSMPAVTYT PAMRVINADYTIAETLPHSNGGNANSHYFTNPSYHTLSQCAASPHVNNRDRMTIAKSKNNQLFV NLKNVNPGKRGALVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSTCSLS SSENPYATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTSANRNVYEVEPTVSVVQGVF SNNGHVTQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGSSSSTTTSNSSNSSE hide sequence

Ensembl Acc Id:

ENSRNOP00000036049 ⟸ ENSRNOT00000037901

RefSeq Acc Id:	XP_038952574 ⟸ XM_039096646
- Peptide Label:	isoform X1
- UniProtKB:	F1MAP4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000076780 ⟸ ENSRNOT00000114483

Protein Domains

EGF-like EMI

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1MAP4-F1-model_v2	AlphaFold	F1MAP4	1-1145	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735084	AgrOrtholog
BioCyc Gene	G2FUF-7425	BioCyc
Ensembl Genes	ENSRNOG00000013674	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037901	ENTREZGENE
	ENSRNOT00000037901.7	UniProtKB/TrEMBL
	ENSRNOT00000114483.1	UniProtKB/TrEMBL
Gene3D-CATH	Laminin	UniProtKB/TrEMBL
	Tie2 ligand-binding domain superfamily	UniProtKB/TrEMBL
InterPro	EGF-like_reg_CS	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_laminin	UniProtKB/TrEMBL
	EMI_domain	UniProtKB/TrEMBL
	MEGF_diff_regulators	UniProtKB/TrEMBL
KEGG Report	rno:291445	UniProtKB/TrEMBL
NCBI Gene	291445	ENTREZGENE
PANTHER	DELTA-RELATED	UniProtKB/TrEMBL
	MULTIPLE EGF LIKE DOMAINS 11	UniProtKB/TrEMBL
	NIMROD A, ISOFORM E	UniProtKB/TrEMBL
	PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1	UniProtKB/TrEMBL
Pfam	EGF_PEAR1L	UniProtKB/TrEMBL
	EMI	UniProtKB/TrEMBL
	hEGF	UniProtKB/TrEMBL
	Laminin_EGF	UniProtKB/TrEMBL
PhenoGen	Megf10	PhenoGen
PRINTS	EGFLAMININ	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EMI	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013674	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	EGF_Lam	UniProtKB/TrEMBL
UniProt	A0A8I5Y0D5_RAT	UniProtKB/TrEMBL
	A6IX74_RAT	UniProtKB/TrEMBL
	F1MAP4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Megf10	multiple EGF-like domains 10	Megf10	Megf10 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Megf10	Megf10 protein			Symbol and Name status set to approved	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_other	a partial cDNA clone was isolated by screening a library with a mouse monoclonal antibody which was raised against a spinal cord extract and which had been determined to stimulate remyelination when injected into Theiler's virus-infected mice	1299635

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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