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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Rattus norvegicus
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Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Description: Exhibits several functions, including DNA binding activity; heat shock protein binding activity; and transcription coactivator activity. Involved in several processes, including positive regulation of cell development; positive regulation of transcription, DNA-templated; and response to glucocorticoid. Localizes to several cellular components, including dendritic spine; glutamatergic synapse; and postsynaptic density, intracellular component. Used to study several diseases, including asthma; congestive heart failure; hypertension; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal failure; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,4-dithiothreitol; 1-bromopropane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gcr; glucocorticoid receptor; GR; Grl; nuclear receptor subfamily 3 group C member 1
Orthologs:
Homo sapiens (human) : NR3C1 (nuclear receptor subfamily 3 group C member 1)  HGNC  Alliance
Mus musculus (house mouse) : Nr3c1 (nuclear receptor subfamily 3, group C, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Canis lupus familiaris (dog) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Sus scrofa (pig) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Chlorocebus sabaeus (African green monkey) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Heterocephalus glaber (naked mole-rat) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
more info ...
Is Marker For: QTLs:   Bp46   Bp47   Scl22   Sprol1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
Celera1830,905,394 - 30,993,522 (-)NCBICelera
Cytogenetic Map18p11NCBI
RH 3.4 Map18442.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr3c1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2741
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.