calcium/calmodulin-dependent protein kinase II alpha
RGD ID:
2261
Description:
Enables GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of protein localization to cell periphery. Located in several cellular components, including dendrite cytoplasm; glutamatergic postsynaptic density; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
alpha CaM kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II, alpha; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; caM-kinase II alpha chain; caMK-II subunit alpha; PK2CDD; PKCCD
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein], Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]
2-aminoethoxydiphenyl borate inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein] more ...
Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein, Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]
7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] more ...
decabromobiphenyl ether metabolite results in increased expression of CAMK2A protein, decabromobiphenyl ether results in increased expression of CAMK2A protein
decabromobiphenyl ether results in decreased expression of CAMK2A protein, decabromobiphenyl ether results in decreased expression of CAMK2A protein modified form
[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]
FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein], Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]
Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA], Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]
[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]] more ...
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein], KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
[lead acetate results in increased abundance of Lead] which results in increased expression of and results in decreased phosphorylation of CAMK2A protein
[lead acetate results in increased abundance of Lead] which results in increased expression of and results in decreased phosphorylation of CAMK2A protein
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein], Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA], Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]
Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein], Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]
1-((3-benzyl-3-methyl-2, 3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of CAMK2A protein]
perfluorooctane sulfonic acid results in increased expression of CAMK2A mRNA, perfluorooctane sulfonic acid results in increased expression of CAMK2A protein
resveratrol inhibits the reaction [Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein]
myristoylated autocamtide-2-related inhibitory peptide inhibits the reaction [Streptozocin results in increased phosphorylation of CAMK2A protein] more ...
Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein], Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor.
Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion.
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.
Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
