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Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Rattus norvegicus
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Description: Exhibits GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; protein phosphorylation; and regulation of protein localization to cell periphery. Localizes to several cellular components, including glutamatergic postsynaptic density; postsynaptic cytosol; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
Also known as: alpha CaM kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II, alpha; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; caM-kinase II alpha chain; caMK-II subunit alpha; PK2CDD; PKCCD
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Celera1852,533,226 - 52,592,130 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Camk2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2261
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.