Camk2a (calcium/calmodulin-dependent protein kinase II alpha) - Rat Genome Database

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Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Rattus norvegicus
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
RGD ID: 2261
Description: Enables GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of protein localization to cell periphery. Located in several cellular components, including dendrite cytoplasm; glutamatergic postsynaptic density; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
Previously known as: alpha CaM kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II, alpha; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; caM-kinase II alpha chain; caMK-II subunit alpha; PK2CDD; PKCCD
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21854,378,642 - 54,441,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,467,554 - 56,526,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,182,163 - 57,240,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,002,670 - 55,061,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Celera1852,533,226 - 52,592,130 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-chlorokynurenic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azamethiphos  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dizocilpine maleate  (EXP)
dopamine  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
flurotyl  (EXP)
FPL 64176  (EXP)
Glutathione ethyl ester  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
heptachlor  (EXP)
ibuprofen  (EXP)
ionomycin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
KN-93  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
losartan  (ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
memantine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (EXP)
N-nitrosodiethylamine  (ISO)
nicardipine  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nifedipine  (EXP,ISO)
ochratoxin A  (EXP)
olanzapine  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phencyclidine  (ISO)
phenylephrine  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (ISO)
S-allylcysteine  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
trifluoperazine  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
U-73122  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. Ashpole NM, etal., J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18.
2. Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Bingol B, etal., Cell. 2010 Feb 19;140(4):567-78. doi: 10.1016/j.cell.2010.01.024.
3. Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation. Carlton SM Brain Res. 2002 Aug 30;947(2):252-9.
4. Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. Chin D and Means AR, Biochemistry 2002 Nov 26;41(47):14001-9.
5. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Cho KO, etal., Neuron 1992 Nov;9(5):929-42.
6. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
7. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2.
8. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
9. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. Dupuis JP, etal., EMBO J. 2014 Apr 16;33(8):842-61. doi: 10.1002/embj.201386356. Epub 2014 Mar 3.
10. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Esteban JA, etal., Nat Neurosci. 2003 Feb;6(2):136-43.
11. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. Gardoni F, etal., J Biol Chem 2003 Nov 7;278(45):44745-52. Epub 2003 Aug 21.
12. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. Gardoni F, etal., J Biol Chem. 2001 Mar 9;276(10):7609-13. Epub 2000 Dec 4.
13. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. Gardoni F, etal., J Neurosci. 2001 Mar 1;21(5):1501-9.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
16. Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation. House SJ, etal., Am J Physiol Cell Physiol. 2007 Jun;292(6):C2276-87. Epub 2007 Jan 31.
17. Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Jiang X, etal., Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):341-6. Epub 2007 Dec 27.
18. Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Jones TL, etal., Anesth Analg. 2007 Dec;105(6):1650-6, table of contents.
19. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
20. Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. Lu W, etal., Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22266-71. doi: 10.1073/pnas.1016289107. Epub 2010 Dec 6.
21. Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion. Matsumoto S, etal., J Cereb Blood Flow Metab 2004 Jan;24(1):54-61.
22. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats. Meng F and Zhang G, Neurosci Lett 2002 Nov 15;333(1):59-63.
23. Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain. Mengesdorf T, etal., Neurochem Res. 2002 Jun;27(6):477-84.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Nair JS, etal., Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5971-6. doi: 10.1073/pnas.052159099. Epub 2002 Apr 23.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
28. Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain. Ochiishi T, etal., Brain Res. 1994 Oct 3;659(1-2):179-93.
29. CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin. Opazo P, etal., Neuron. 2010 Jul 29;67(2):239-52. doi: 10.1016/j.neuron.2010.06.007.
30. Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Petrini EM, etal., Nat Commun. 2014 Jun 4;5:3921. doi: 10.1038/ncomms4921.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons. Price TJ, etal., Neurosci Lett. 2005 Dec 2;389(2):94-8.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24.
38. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Shen K and Meyer T, Science. 1999 Apr 2;284(5411):162-6.
39. Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. Song B, etal., Neurosci Lett. 2003 Oct 9;349(3):183-6.
40. Structure and composition of the postsynaptic density during development. Swulius MT, etal., J Comp Neurol. 2010 Oct 15;518(20):4243-60. doi: 10.1002/cne.22451.
41. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
42. Changes in the distribution of calcium calmodulin-dependent protein kinase II at the presynaptic bouton after depolarization. Tao-Cheng JH, etal., Brain Cell Biol. 2006 Jun;35(2-3):117-24. doi: 10.1007/s11068-007-9012-5. Epub 2007 Sep 20.
43. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
44. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. Wang P, etal., Neurotoxicology. 2013 Jul;37:51-62. doi: 10.1016/j.neuro.2013.03.007. Epub 2013 Apr 1.
45. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Wang YJ, etal., Brain Res. 2005 Jan 7;1031(1):101-8. doi: 10.1016/j.brainres.2004.10.061.
46. Developmentally regulated expression of CaMKII and iGluRs in the rat retina. Xue J, etal., Brain Res Dev Brain Res 2002 Sep 20;138(1):61-70.
47. [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] Yamamoto H Tanpakushitsu Kakusan Koso 2002 Mar;47(3):241-7.
48. A 63 signature genes prediction system is effective for glioblastoma prognosis. Zhang Y, etal., Int J Mol Med. 2018 Apr;41(4):2070-2078. doi: 10.3892/ijmm.2018.3422. Epub 2018 Jan 25.
49. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Zhu JJ, etal., Cell. 2002 Aug 23;110(4):443-55.
Additional References at PubMed
PMID:1328883   PMID:2153289   PMID:2842767   PMID:2856087   PMID:3037704   PMID:3475713   PMID:8280084   PMID:8598227   PMID:10347170   PMID:11036263   PMID:11160423   PMID:11264466  
PMID:11403681   PMID:11427314   PMID:12218415   PMID:12218416   PMID:12629219   PMID:12660151   PMID:12823475   PMID:12873384   PMID:12873385   PMID:12896970   PMID:12954639   PMID:14499348  
PMID:15044062   PMID:15292517   PMID:15312654   PMID:15375008   PMID:15383398   PMID:15494036   PMID:15574738   PMID:15607978   PMID:15649892   PMID:15659234   PMID:15664178   PMID:15673434  
PMID:15714506   PMID:15775983   PMID:15964981   PMID:15994560   PMID:16214364   PMID:16277604   PMID:16436603   PMID:16501029   PMID:16627565   PMID:16632208   PMID:16648177   PMID:16709720  
PMID:16710293   PMID:16843447   PMID:16872923   PMID:17052756   PMID:17114649   PMID:17212683   PMID:17332063   PMID:17404223   PMID:17442679   PMID:17494705   PMID:17570344   PMID:17610578  
PMID:17652761   PMID:17660813   PMID:17898207   PMID:17948240   PMID:18046020   PMID:18053645   PMID:18094239   PMID:18271754   PMID:18278040   PMID:18305102   PMID:18408996   PMID:18436302  
PMID:18480293   PMID:18562151   PMID:18617607   PMID:18697934   PMID:19046383   PMID:19047462   PMID:19121366   PMID:19135986   PMID:19172997   PMID:19182667   PMID:19200342   PMID:19217373  
PMID:19235894   PMID:19292454   PMID:19332038   PMID:19409102   PMID:19555740   PMID:19591836   PMID:19638347   PMID:19735285   PMID:19735700   PMID:19858198   PMID:19860859   PMID:19882720  
PMID:19934217   PMID:20008273   PMID:20023119   PMID:20060004   PMID:20060891   PMID:20124353   PMID:20127074   PMID:20424167   PMID:20459031   PMID:20551968   PMID:20584908   PMID:20643921  
PMID:20654708   PMID:20660727   PMID:20668654   PMID:20807573   PMID:21041242   PMID:21059908   PMID:21143596   PMID:21491127   PMID:21593322   PMID:21610080   PMID:21630459   PMID:21697368  
PMID:21869818   PMID:21884935   PMID:21925648   PMID:21933187   PMID:22227452   PMID:22294157   PMID:22609102   PMID:22627922   PMID:22764246   PMID:22796763   PMID:22815963   PMID:22871113  
PMID:22906554   PMID:22929440   PMID:22952977   PMID:22960015   PMID:22965911   PMID:23051746   PMID:23160045   PMID:23267764   PMID:23297306   PMID:23408944   PMID:23426668   PMID:23549416  
PMID:23576750   PMID:23584669   PMID:23602566   PMID:23602989   PMID:23643989   PMID:23645665   PMID:23651084   PMID:23749614   PMID:23825405   PMID:23953174   PMID:23976956   PMID:24032403  
PMID:24560900   PMID:24755854   PMID:24872564   PMID:25034033   PMID:25054156   PMID:25067828   PMID:25073061   PMID:25266254   PMID:25297099   PMID:25457025   PMID:25515219   PMID:25568108  
PMID:25644714   PMID:25682687   PMID:25701274   PMID:25944900   PMID:26086939   PMID:26110816   PMID:26174594   PMID:26291163   PMID:26742808   PMID:26779588   PMID:26809094   PMID:26821292  
PMID:27477489   PMID:27611779   PMID:28130356   PMID:28230177   PMID:28236215   PMID:28536695   PMID:28553222   PMID:28573136   PMID:28638088   PMID:28717010   PMID:28730575   PMID:28754591  
PMID:28865231   PMID:28940879   PMID:28957669   PMID:29100089   PMID:29184507   PMID:29273596   PMID:29279520   PMID:29476059   PMID:29604406   PMID:29806529   PMID:30053369   PMID:30142538  
PMID:30177751   PMID:30299584   PMID:30520144   PMID:30526621   PMID:30919283   PMID:31100477   PMID:31874853   PMID:31935048   PMID:32005763   PMID:32238193   PMID:32303334   PMID:32357304  
PMID:32716967   PMID:32841609   PMID:32920522   PMID:33393454   PMID:34775982   PMID:36424866  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21854,378,642 - 54,441,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,467,554 - 56,526,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,182,163 - 57,240,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,002,670 - 55,061,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Celera1852,533,226 - 52,592,130 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385150,219,491 - 150,290,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,219,491 - 150,290,093 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,599,054 - 149,669,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,579,248 - 149,649,529 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,579,247 - 149,649,529NCBI
Celera5145,680,447 - 145,750,799 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,747,170 - 144,817,356 (-)NCBIHuRef
CHM1_15149,031,647 - 149,101,993 (-)NCBICHM1_1
T2T-CHM13v2.05150,756,093 - 150,826,669 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391861,058,704 - 61,121,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,058,690 - 61,121,224 (+)EnsemblGRCm39 Ensembl
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBIMGSCv36mm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554154,247,014 - 4,307,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,247,307 - 4,307,402 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan15143,588,026 - 143,658,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,644,164 - 145,714,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,649,062 - 151,719,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,649,062 - 151,719,373 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1458,800,818 - 58,865,830 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,800,813 - 58,865,830 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,567,052 - 58,631,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,281,664 - 59,346,612 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,281,703 - 59,346,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,070,398 - 59,135,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,184,686 - 59,249,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,715,947 - 59,780,872 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213143,064,159 - 143,126,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,638,176 - 4,700,984 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365044,636,863 - 4,700,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2151,248,358 - 151,308,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,248,356 - 151,353,907 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,335,771 - 158,396,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12352,829,438 - 52,899,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,829,350 - 52,899,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,817,181 - 24,887,318 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247749,526,323 - 9,585,649 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,526,323 - 9,585,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Camk2a
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:118
Interacting mature miRNAs:133
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,401,652 - 54,401,849 (+)MAPPERmRatBN7.2
Rnor_6.01856,216,839 - 56,217,035NCBIRnor6.0
Rnor_5.01855,451,263 - 55,451,459UniSTSRnor5.0
Celera1852,556,111 - 52,556,307UniSTS
RH 3.4 Map18530.2RGD
RH 3.4 Map18530.2UniSTS
RH 2.0 Map18383.9RGD
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,382 - 54,424,523 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,221 - 56,282,361NCBIRnor6.0
Rnor_5.01855,515,397 - 55,515,537UniSTSRnor5.0
RGSC_v3.41856,934,889 - 56,935,029UniSTSRGSC3.4
Celera1852,578,482 - 52,578,622UniSTS
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,403,634 - 54,403,764 (+)MAPPERmRatBN7.2
Rnor_6.01856,218,821 - 56,218,950NCBIRnor6.0
Rnor_5.01855,453,245 - 55,453,374UniSTSRnor5.0
Celera1852,558,093 - 52,558,222UniSTS
RH 3.4 Map18534.5UniSTS
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,283 - 54,424,453 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,122 - 56,282,291NCBIRnor6.0
Rnor_5.01855,515,298 - 55,515,467UniSTSRnor5.0
RGSC_v3.41856,934,790 - 56,934,959UniSTSRGSC3.4
Celera1852,578,383 - 52,578,552UniSTS
RH 3.4 Map18530.3UniSTS
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,381 - 54,424,523 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,220 - 56,282,361NCBIRnor6.0
Rnor_5.01855,515,396 - 55,515,537UniSTSRnor5.0
RGSC_v3.41856,934,888 - 56,935,029UniSTSRGSC3.4
Celera1852,578,481 - 52,578,622UniSTS
RH 3.4 Map18530.3UniSTS
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,423,405 - 54,423,556 (+)MAPPERmRatBN7.2
Rnor_6.01856,281,244 - 56,281,394NCBIRnor6.0
Rnor_5.01855,514,420 - 55,514,570UniSTSRnor5.0
RGSC_v3.41856,933,193 - 56,933,343UniSTSRGSC3.4
Celera1852,577,505 - 52,577,655UniSTS
RH 3.4 Map18530.1UniSTS
Cytogenetic Map18q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,440,499 - 54,440,654 (+)MAPPERmRatBN7.2
Rnor_6.01856,298,335 - 56,298,489NCBIRnor6.0
Rnor_5.01855,531,511 - 55,531,665UniSTSRnor5.0
RGSC_v3.41856,951,003 - 56,951,157UniSTSRGSC3.4
Celera1852,594,596 - 52,594,750UniSTS
Cytogenetic Map18q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 27 8 11 57 8
Low 3 16 14 5 19 5 10 8 38 11
Below cutoff 41 35 35 25 3


RefSeq Acc Id: ENSRNOT00000041533   ⟹   ENSRNOP00000041940
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,378,784 - 54,438,030 (+)Ensembl
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080177   ⟹   ENSRNOP00000069249
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,378,784 - 54,437,755 (+)Ensembl
Rnor_6.0 Ensembl1856,194,019 - 56,295,594 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098023   ⟹   ENSRNOP00000094280
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,378,784 - 54,437,755 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101374   ⟹   ENSRNOP00000093893
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)Ensembl
RefSeq Acc Id: NM_012920   ⟹   NP_037052
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,378,784 - 54,438,030 (+)NCBI
Rnor_6.01856,193,978 - 56,295,869 (+)NCBI
Rnor_5.01855,428,487 - 55,463,016 (+)NCBI
Rnor_5.01855,514,559 - 55,529,045 (+)NCBI
RGSC_v3.41856,879,247 - 56,948,537 (+)RGD
Celera1852,533,226 - 52,592,130 (+)RGD
RefSeq Acc Id: XM_039096592   ⟹   XP_038952520
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,378,642 - 54,441,120 (+)NCBI
RefSeq Acc Id: XM_039096593   ⟹   XP_038952521
Rat AssemblyChrPosition (strand)Source
mRatBN7.21854,378,642 - 54,437,755 (+)NCBI
RefSeq Acc Id: NP_037052   ⟸   NM_012920
- UniProtKB: P11275 (UniProtKB/Swiss-Prot),   A6IXE8 (UniProtKB/TrEMBL),   A0A8I6AHE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069249   ⟸   ENSRNOT00000080177
RefSeq Acc Id: ENSRNOP00000041940   ⟸   ENSRNOT00000041533
RefSeq Acc Id: XP_038952520   ⟸   XM_039096592
- Peptide Label: isoform X1
- UniProtKB: F1LZG4 (UniProtKB/TrEMBL),   A0A0G2JUV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952521   ⟸   XM_039096593
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094280   ⟸   ENSRNOT00000098023
RefSeq Acc Id: ENSRNOP00000093893   ⟸   ENSRNOT00000101374
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11275-F1-model_v2 AlphaFold P11275 1-478 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2261 AgrOrtholog
BioCyc Gene G2FUF-7351 BioCyc
Ensembl Genes ENSRNOG00000018712 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041940 ENTREZGENE
  ENSRNOP00000041940.6 UniProtKB/TrEMBL
  ENSRNOP00000069249.2 UniProtKB/TrEMBL
  ENSRNOP00000093893.1 UniProtKB/TrEMBL
  ENSRNOP00000094280.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041533 ENTREZGENE
  ENSRNOT00000041533.6 UniProtKB/TrEMBL
  ENSRNOT00000080177.2 UniProtKB/TrEMBL
  ENSRNOT00000098023.1 UniProtKB/TrEMBL
  ENSRNOT00000101374.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ca/CaM-dep_prot_kinase-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF2-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25400 UniProtKB/Swiss-Prot
Pfam CaMKII_AD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Camk2a PhenoGen
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228753
  Q924T0_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Camk2a  calcium/calmodulin-dependent protein kinase II alpha  Camk2a  calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Camk2a  calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha  Camk2a  calcium/calmodulin-dependent protein kinase II, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Camk2a  calcium/calmodulin-dependent protein kinase II, alpha    calcium/calmodulin-dependent protein kinase II alpha subunit  Name updated 1299863 APPROVED
2002-11-06 Camk2a  calcium/calmodulin-dependent protein kinase II alpha subunit    Ca2+/calmodulin-dependent protein kinase II alpha  Name updated 625702 APPROVED
2002-06-10 Camk2a  Ca2+/calmodulin-dependent protein kinase II alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression in hippocampal cells strongly induced upon ischemic insult 634689
gene_expression expressed at high levels in neurons 1299829
gene_function kinase subunit 634689
gene_function phosphorylates N-methyl-D-aspartate receptor subunit 2B on serine 634689
gene_function autophosphorylates on threonine (T286) 1299829
gene_physical_interaction binds to and is activated by calcium/calmodulin 1299829
gene_process may play a role in the development of the retina 634688
gene_process may regulate channel properties of N-methyl-D-aspartate receptor subunit 2B during ischemia via phosphorylation 634689
gene_process transduces cellular signals corresponding to fluctuations in intracellular calcium levels in conjuction with calmodulin 1299829
gene_process important in learning and memory 1299829
gene_regulation activity is regulated by calcium/calmodulin binding and autophosphorylation 1299829