RGD Reference Report - Unlocking the presequence import pathway. - Rat Genome Database

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Unlocking the presequence import pathway.

Authors: Schulz, C  Schendzielorz, A  Rehling, P 
Citation: Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
RGD ID: 10412659
Pubmed: (View Article at PubMed) PMID:25542066
DOI: Full-text: DOI:10.1016/j.tcb.2014.12.001

Translocation of presequence-containing precursor proteins into the inner mitochondrial membrane and matrix is an essential process that is facilitated by the translocase of the outer membrane (TOM) together with the presequence translocase of the inner membrane (TIM23). After initial recognition by receptors of the TOM complex followed by transport across the outer membrane, the precursor emerges into the intermembrane space (IMS). Recognition of the presequence by Tim50 triggers rearrangements of the presequence translocase, priming it for inner membrane translocation. Subsequently, the precursor can be released into the membrane or translocated into the mitochondrial matrix aided by the import motor. This heat-shock protein 70 (Hsp70)-based motor drives precursor unfolding and translocation and is subject to dynamic remodelling. Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway.

Annotation

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Dnajc19  (DnaJ heat shock protein family (Hsp40) member C19)
Grpel1  (GrpE-like 1, mitochondrial)
Grpel2  (GrpE-like 2, mitochondrial)
Hspa9  (heat shock protein family A (Hsp70) member 9)
Pam16  (presequence translocase associated motor 16)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17A)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm44  (translocase of inner mitochondrial membrane 44)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70  (translocase of outer mitochondrial membrane 70)

Genes (Mus musculus)
Dnajc19  (DnaJ heat shock protein family (Hsp40) member C19)
Grpel1  (GrpE-like 1, mitochondrial)
Grpel2  (GrpE-like 2, mitochondrial)
Hspa9  (heat shock protein 9)
Pam16  (presequence translocase-asssociated motor 16)
Romo1  (reactive oxygen species modulator 1)
Timm17a  (translocase of inner mitochondrial membrane 17a)
Timm21  (translocase of inner mitochondrial membrane 21)
Timm23  (translocase of inner mitochondrial membrane 23)
Timm44  (translocase of inner mitochondrial membrane 44)
Timm50  (translocase of inner mitochondrial membrane 50)
Tomm20  (translocase of outer mitochondrial membrane 20)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)
Tomm5  (translocase of outer mitochondrial membrane 5)
Tomm6  (translocase of outer mitochondrial membrane 6)
Tomm7  (translocase of outer mitochondrial membrane 7)
Tomm70a  (translocase of outer mitochondrial membrane 70A)

Genes (Homo sapiens)
DNAJC19  (DnaJ heat shock protein family (Hsp40) member C19)
GRPEL1  (GrpE like 1, mitochondrial)
GRPEL2  (GrpE like 2, mitochondrial)
HSPA9  (heat shock protein family A (Hsp70) member 9)
PAM16  (presequence translocase associated motor 16)
ROMO1  (reactive oxygen species modulator 1)
TIMM17A  (translocase of inner mitochondrial membrane 17A)
TIMM21  (translocase of inner mitochondrial membrane 21)
TIMM23  (translocase of inner mitochondrial membrane 23)
TIMM44  (translocase of inner mitochondrial membrane 44)
TIMM50  (translocase of inner mitochondrial membrane 50)
TOMM20  (translocase of outer mitochondrial membrane 20)
TOMM22  (translocase of outer mitochondrial membrane 22)
TOMM40  (translocase of outer mitochondrial membrane 40)
TOMM5  (translocase of outer mitochondrial membrane 5)
TOMM6  (translocase of outer mitochondrial membrane 6)
TOMM7  (translocase of outer mitochondrial membrane 7)
TOMM70  (translocase of outer mitochondrial membrane 70)


Additional Information