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Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene.

Authors: Fujita, M  Nagai, Y  Sawada, T  Heese, K 
Citation: Fujita M, etal., Mol Cell Biochem. 2004 Mar;258(1-2):183-9.
Pubmed: (View Article at PubMed) PMID:15030183

Active cell death ('apoptosis' or 'programmed cell death') is essential in the development and homeostasis of multicellular organisms and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Here we demonstrate new isoforms of the rat homologue of the drosophila tumor suppressor l(2)tid gene (rTid-1). Moreover, we show that rTid-1 interacts isoform-specifically with the heat-shock-cognate-glucose-regulated protein hscGRP75 and neither induces nor inhibits directly neuronal apoptosis. This finding points to a pivotal role of Tid-1 in the control of cellular survival.


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RGD Object Information
RGD ID: 6784522
Created: 2012-08-02
Species: All species
Last Modified: 2012-08-02
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.