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Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.

Authors: Lee, J  Kim, CH  Simon, DK  Aminova, LR  Andreyev, AY  Kushnareva, YE  Murphy, AN  Lonze, BE  Kim, KS  Ginty, DD  Ferrante, RJ  Ryu, H  Ratan, RR 
Citation: Lee J, etal., J Biol Chem. 2005 Dec 9;280(49):40398-401. Epub 2005 Oct 5.
Pubmed: (View Article at PubMed) PMID:16207717
DOI: Full-text: DOI:10.1074/jbc.C500140200

Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established. Here we report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome. Disruption of CREB activity in the mitochondria decreases the expression of a subset of mitochondrial genes, including the ND5 subunit of complex I, down-regulates complex I-dependent mitochondrial respiration, and increases susceptibility to 3-nitropropionic acid, a mitochondrial toxin that induces a clinical and pathological phenotype similar to Huntington disease. These results demonstrate that regulation of mitochondrial gene expression by mitochondrial CREB, in part, underlies the protective effects of CREB and raise the possibility that decreased mitochondrial CREB activity contributes to the mitochondrial dysfunction and neuronal loss associated with neurodegenerative disorders.


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RGD Object Information
RGD ID: 10059428
Created: 2015-08-18
Species: All species
Last Modified: 2015-08-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.