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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa9
Name: heat shock protein family A (Hsp70) member 9
Acc ID: CHEBI:69120
Term: withaferin A
Definition: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Chemical ID: MESH:C009684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa9affects bindingISORGD:13234516480464CTDwithaferin A binds to HSPA9 protein

PMID:22973447
Hspa9multiple interactionsISORGD:13234516480464CTD[6 7-epoxy-5 17-dihydroxy-1-oxowitha-2 24-dienolide co-treated with withaferin A] results in decreased expression of HSPA9 protein [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]

PMID:22973447 PMID:25236891
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