Hnrnpk (heterogeneous nuclear ribonucleoprotein K) - Rat Genome Database

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Gene: Hnrnpk (heterogeneous nuclear ribonucleoprotein K) Rattus norvegicus
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Symbol: Hnrnpk
Name: heterogeneous nuclear ribonucleoprotein K
RGD ID: 71058
Description: Enables several functions, including ATPase binding activity; lamin binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to organonitrogen compound; nervous system development; and regulation of gene expression. Located in axon terminus; cell cortex; and dendritic spine. Part of protein-DNA complex. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Csbp; dC stretch-binding protein; hnRNP K; Hnrpk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2176,262,936 - 6,275,001 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,262,998 - 6,274,997 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,288,534 - 6,297,617 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,821,878 - 7,830,965 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,284,906 - 6,293,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,664,730 - 6,676,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,665,659 - 6,676,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,868,934 - 8,881,126 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,196,630 - 12,205,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11712,196,629 - 12,205,720 (+)NCBI
Celera176,375,531 - 6,384,621 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
7,12-dimethyltetraphene  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bufalin  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloromethylisothiazolinone  (ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fructose  (EXP)
gentamycin  (EXP)
glucose  (EXP)
glycine  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
isobutanol  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
maneb  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
propiconazole  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
thapsigargin  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
warfarin  (ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
camera-type eye development  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to forskolin  (IDA)
cellular response to glucose stimulus  (IEP)
cellular response to insulin stimulus  (IDA,IEP)
cellular response to lead ion  (IEP)
cellular response to rapamycin  (IEP)
cerebellum development  (IEP)
cerebral cortex development  (IDA,IEP)
hippocampus development  (IEP)
kidney development  (IEP)
liver development  (IEP)
lung development  (IEP)
male gonad development  (IEP)
modulation of chemical synaptic transmission  (IDA,IMP)
mRNA processing  (IEA)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of branching morphogenesis of a nerve  (IMP)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of gene expression  (IMP)
negative regulation of mRNA splicing, via spliceosome  (IEA,ISO)
negative regulation of protein binding  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP)
ovarian follicle development  (IMP)
peripheral nervous system development  (IEP)
positive regulation of dendrite extension  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of myelination  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of protein localization to cell surface  (IMP)
positive regulation of receptor-mediated endocytosis  (IEA,ISO)
positive regulation of RNA splicing  (IMP)
positive regulation of synapse maturation  (IMP)
positive regulation of synaptic transmission  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
regulation of low-density lipoprotein particle clearance  (IEA,ISO)
regulation of mRNA splicing, via spliceosome  (IBA,IEA)
regulation of postsynapse organization  (IDA,IMP)
regulation of transcription by RNA polymerase II  (IBA,IEA,IMP)
response to activity  (IEP)
response to salt  (IEP)
RNA splicing  (IEA)
thymus development  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Antibodies against heterogeneous nuclear ribonucleoprotein K in patients with cardiac allograft vasculopathy. Acevedo MJ, etal., J Heart Lung Transplant. 2011 Sep;30(9):1051-9. doi: 10.1016/j.healun.2011.02.014. Epub 2011 Apr 13.
2. Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer. Barboro P, etal., Br J Cancer. 2009 May 19;100(10):1608-16. doi: 10.1038/sj.bjc.6605057. Epub 2009 Apr 28.
3. Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system. Blanchette AR, etal., Gene Expr Patterns. 2006 Aug;6(6):596-606. Epub 2006 Feb 20.
4. Characterization of Staufen 1 ribonucleoprotein complexes. Brendel C, etal., Biochem J. 2004 Dec 1;384(Pt 2):239-46.
5. Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation. Cao W, etal., Nucleic Acids Res. 2012 Sep;40(16):8059-71. doi: 10.1093/nar/gks504. Epub 2012 Jun 8.
6. Multitarget neuroprotection by quercetin: Changes in gene expression in two perinatal asphyxia models. Cardozo V, etal., Neurochem Int. 2021 Jul;147:105064. doi: 10.1016/j.neuint.2021.105064. Epub 2021 May 2.
7. Modulation of the hippocampal protein machinery in voluntary and treadmill exercising rats. Chen WQ, etal., Biochim Biophys Acta. 2008 Mar;1784(3):555-62. doi: 10.1016/j.bbapap.2008.01.002. Epub 2008 Jan 12.
8. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
9. Regulation of neuroendocrine differentiation by AKT/hnRNPK/AR/beta-catenin signaling in prostate cancer cells. Ciarlo M, etal., Int J Cancer. 2012 Aug 1;131(3):582-90. doi: 10.1002/ijc.26402. Epub 2011 Oct 20.
10. Identification in the rat brain of a set of nuclear proteins interacting with H1 degrees mRNA. Di Liegro CM, etal., Neuroscience. 2013 Jan 15;229:71-6. doi: 10.1016/j.neuroscience.2012.10.072. Epub 2012 Nov 14.
11. The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin. Dzwonek A, etal., FEBS Lett. 2006 Mar 20;580(7):1839-45. Epub 2006 Feb 24.
12. Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons. Folci A, etal., J Neurosci. 2014 Jul 2;34(27):9088-95. doi: 10.1523/JNEUROSCI.0303-14.2014.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis. Hope NR and Murray GI, Hum Pathol. 2011 Mar;42(3):393-402. doi: 10.1016/j.humpath.2010.08.006. Epub 2010 Dec 30.
15. Cloning and characterization of a single-stranded DNA binding protein that specifically recognizes deoxycytidine stretch. Ito K, etal., Nucleic Acids Res 1994 Jan 11;22(1):53-8.
16. Insulin increases glutamate transporter GLT1 in cultured astrocytes. Ji YF, etal., Biochem Biophys Res Commun. 2011 Feb 25;405(4):691-6. doi: 10.1016/j.bbrc.2011.01.105. Epub 2011 Feb 1.
17. Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-small ka, CyrillicB cascade in astrocytic oxygen-glucose deprivation. Ji YF, etal., Glia. 2013 Dec;61(12):1959-75. doi: 10.1002/glia.22566. Epub 2013 Sep 24.
18. Age-associated changes in hypothalamic and pituitary neuroendocrine gene expression in the rat. Kappeler L, etal., J Neuroendocrinol. 2003 Jun;15(6):592-601.
19. Mitochondria-associated satellite I RNA binds to hnRNP K protein. Klimek-Tomczak K, etal., Acta Biochim Pol. 2006;53(1):169-78. Epub 2006 Feb 23.
20. Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K. Laursen LS, etal., J Cell Biol. 2011 Mar 7;192(5):797-811. doi: 10.1083/jcb.201007014. Epub 2011 Feb 28.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. Miau LH, etal., J Biol Chem. 1998 Apr 24;273(17):10784-91.
24. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein. Ostrowski J, etal., J Biol Chem. 2004 Dec 24;279(52):54599-609. Epub 2004 Oct 13.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. Proepper C, etal., PLoS One. 2011;6(11):e27045. doi: 10.1371/journal.pone.0027045. Epub 2011 Nov 15.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter. Stains JP, etal., Biochem J. 2005 Jan 15;385(Pt 2):613-23.
33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. An exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mRNA. Szeszel-Fedorowicz W, etal., J Biol Chem. 2006 Nov 10;281(45):34146-58. Epub 2006 Sep 15.
35. Dynamic endogenous association of neurofilament mRNAs with K-homology domain ribonucleoproteins in developing cerebral cortex. Thyagarajan A and Szaro BG, Brain Res. 2008 Jan 16;1189:33-42. Epub 2007 Nov 17.
36. Renal regional proteomes in young Dahl salt-sensitive rats. Tian Z, etal., Hypertension. 2008 Apr;51(4):899-904. doi: 10.1161/HYPERTENSIONAHA.107.109173. Epub 2008 Mar 3.
37. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
38. Hnrnpk, a protein differentially expressed in immature rat ovarian development, is required for normal primordial follicle assembly and development. Wang N, etal., Endocrinology. 2011 Mar;152(3):1024-35. doi: 10.1210/en.2010-0797. Epub 2010 Dec 29.
39. Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells. Wei CC, etal., J Biol Chem. 2006 Sep 1;281(35):25344-55. Epub 2006 Jul 12.
40. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Weng Z, etal., Mol Cell Biol. 1994 Jul;14(7):4509-21.
41. Expression analysis of multifunctional RNA-binding protein hnRNP K during development of mammalian testis. Xu H, etal., Pol J Vet Sci. 2018 Jun;21(2):343-351. doi: 10.24425/122603.
42. Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon. Yang L, etal., Rheumatology (Oxford). 2015 Feb;54(2):349-58. doi: 10.1093/rheumatology/keu325. Epub 2014 Aug 28.
43. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Yang Y, etal., Neuron. 2009 Mar 26;61(6):880-94. doi: 10.1016/j.neuron.2009.02.010.
44. Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models. Zhu G, etal., J Environ Sci Health C Toxicol Carcinog. 2021;39(1):1-16. doi: 10.1080/26896583.2020.1854596.
Additional References at PubMed
PMID:10749975   PMID:11747608   PMID:11991638   PMID:16189514   PMID:16396499   PMID:16448870   PMID:16854843   PMID:19420131   PMID:19946888   PMID:20131911   PMID:20371611   PMID:20458337  
PMID:20548952   PMID:20673990   PMID:21423176   PMID:22365833   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23533145   PMID:23636947   PMID:23979707   PMID:24530304   PMID:24625528  
PMID:25416956   PMID:25468996   PMID:26316108   PMID:27430620   PMID:29255796   PMID:29476059   PMID:29892012  


Genomics

Comparative Map Data
Hnrnpk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2176,262,936 - 6,275,001 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,262,998 - 6,274,997 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,288,534 - 6,297,617 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,821,878 - 7,830,965 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,284,906 - 6,293,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,664,730 - 6,676,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,665,659 - 6,676,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,868,934 - 8,881,126 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,196,630 - 12,205,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11712,196,629 - 12,205,720 (+)NCBI
Celera176,375,531 - 6,384,621 (+)NCBICelera
Cytogenetic Map17p14NCBI
HNRNPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38983,968,083 - 83,980,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl983,968,083 - 83,980,631 (-)EnsemblGRCh38hg38GRCh38
GRCh37986,582,998 - 86,595,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36985,772,912 - 85,785,339 (-)NCBINCBI36Build 36hg18NCBI36
Build 34983,812,645 - 83,824,636NCBI
Celera957,154,011 - 57,166,581 (-)NCBICelera
Cytogenetic Map9q21.32NCBI
HuRef956,408,631 - 56,421,199 (-)NCBIHuRef
CHM1_1986,729,595 - 86,742,166 (-)NCBICHM1_1
T2T-CHM13v2.0996,118,364 - 96,130,896 (-)NCBIT2T-CHM13v2.0
Hnrnpk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,538,946 - 58,551,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,538,956 - 58,551,157 (-)EnsemblGRCm39 Ensembl
GRCm381358,391,132 - 58,403,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,391,142 - 58,403,343 (-)EnsemblGRCm38mm10GRCm38
MGSCv371358,493,312 - 58,503,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,401,574 - 58,412,139 (-)NCBIMGSCv36mm8
Celera1359,454,314 - 59,464,879 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.04NCBI
Hnrnpk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554323,246,092 - 3,257,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554323,246,090 - 3,257,774 (+)NCBIChiLan1.0ChiLan1.0
HNRNPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1983,133,588 - 83,145,280 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0940,898,593 - 40,911,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1983,324,235 - 83,336,884 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl983,324,238 - 83,336,756 (-)Ensemblpanpan1.1panPan2
HNRNPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1175,499,334 - 75,511,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl175,499,393 - 75,511,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,149,689 - 76,161,319 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0175,800,635 - 75,812,819 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl175,800,674 - 75,812,816 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1175,615,073 - 75,626,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0175,377,881 - 75,389,506 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,080,753 - 76,092,378 (+)NCBIUU_Cfam_GSD_1.0
Hnrnpk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947122,185,614 - 122,197,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936828828,837 - 838,720 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936828827,660 - 839,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1030,975,702 - 30,987,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11030,975,639 - 30,987,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21035,102,731 - 35,115,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11294,768,403 - 94,789,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1294,768,480 - 94,789,743 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603883,198,762 - 83,211,203 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248097,538,568 - 7,548,272 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnrnpk
28 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir450a1rno-miR-450a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18230805

Predicted Target Of
Summary Value
Count of predictions:630
Count of miRNA genes:266
Interacting mature miRNAs:346
Transcripts:ENSRNOT00000025916, ENSRNOT00000025980
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat

Markers in Region
HNRPK-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,272,905 - 6,273,699 (+)MAPPERmRatBN7.2
Rnor_6.0176,674,658 - 6,675,451NCBIRnor6.0
Rnor_5.0178,879,031 - 8,879,824UniSTSRnor5.0
RGSC_v3.41712,203,724 - 12,204,517UniSTSRGSC3.4
Celera176,382,625 - 6,383,418UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 72 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D17711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000025916   ⟹   ENSRNOP00000025915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,263,012 - 6,274,994 (+)Ensembl
Rnor_6.0 Ensembl176,667,564 - 6,676,654 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025980   ⟹   ENSRNOP00000025980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,262,998 - 6,274,997 (+)Ensembl
Rnor_6.0 Ensembl176,665,659 - 6,675,944 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107930   ⟹   ENSRNOP00000080312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,262,998 - 6,273,984 (+)Ensembl
RefSeq Acc Id: NM_057141   ⟹   NP_476482
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,265,812 - 6,274,902 (+)NCBI
Rnor_6.0176,667,564 - 6,676,654 (+)NCBI
Rnor_5.0178,868,934 - 8,881,126 (+)NCBI
RGSC_v3.41712,196,630 - 12,205,720 (+)RGD
Celera176,375,531 - 6,384,621 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253553   ⟹   XP_006253615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,264,183 - 6,275,001 (+)NCBI
Rnor_6.0176,665,969 - 6,676,753 (+)NCBI
Rnor_5.0178,868,934 - 8,881,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253554   ⟹   XP_006253616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,262,998 - 6,275,001 (+)NCBI
Rnor_6.0176,664,730 - 6,676,571 (+)NCBI
Rnor_5.0178,868,934 - 8,881,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253555   ⟹   XP_006253617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,263,129 - 6,275,001 (+)NCBI
Rnor_6.0176,664,730 - 6,676,753 (+)NCBI
Rnor_5.0178,868,934 - 8,881,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600445   ⟹   XP_017455934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,263,129 - 6,275,001 (+)NCBI
Rnor_6.0176,664,730 - 6,676,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095311   ⟹   XP_038951239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,262,981 - 6,275,001 (+)NCBI
RefSeq Acc Id: XM_039095312   ⟹   XP_038951240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,262,936 - 6,275,001 (+)NCBI
RefSeq Acc Id: XM_039095313   ⟹   XP_038951241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,264,826 - 6,275,001 (+)NCBI
RefSeq Acc Id: XM_039095314   ⟹   XP_038951242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2176,264,633 - 6,275,001 (+)NCBI
RefSeq Acc Id: NP_476482   ⟸   NM_057141
- UniProtKB: P61980 (UniProtKB/Swiss-Prot),   A6KAK1 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253617   ⟸   XM_006253555
- Peptide Label: isoform X3
- UniProtKB: F8WG62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253616   ⟸   XM_006253554
- Peptide Label: isoform X2
- UniProtKB: P61980 (UniProtKB/Swiss-Prot),   A6KAK1 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253615   ⟸   XM_006253553
- Peptide Label: isoform X1
- UniProtKB: Q5D059 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455934   ⟸   XM_017600445
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QEP8 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025915   ⟸   ENSRNOT00000025916
RefSeq Acc Id: ENSRNOP00000025980   ⟸   ENSRNOT00000025980
RefSeq Acc Id: XP_038951240   ⟸   XM_039095312
- Peptide Label: isoform X1
- UniProtKB: Q5D059 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951239   ⟸   XM_039095311
- Peptide Label: isoform X1
- UniProtKB: Q5D059 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951242   ⟸   XM_039095314
- Peptide Label: isoform X1
- UniProtKB: Q5D059 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951241   ⟸   XM_039095313
- Peptide Label: isoform X1
- UniProtKB: Q5D059 (UniProtKB/TrEMBL),   F8WG62 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080312   ⟸   ENSRNOT00000107930
Protein Domains
K Homology   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61980-F1-model_v2 AlphaFold P61980 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700293
Promoter ID:EPDNEW_R10802
Type:initiation region
Name:Hnrnpk_1
Description:heterogeneous nuclear ribonucleoprotein K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0176,665,619 - 6,665,679EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71058 AgrOrtholog
BioCyc Gene G2FUF-10358 BioCyc
Ensembl Genes ENSRNOG00000019113 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025916 ENTREZGENE
  ENSRNOT00000025916.6 UniProtKB/TrEMBL
  ENSRNOT00000025980 ENTREZGENE
  ENSRNOT00000025980.8 UniProtKB/TrEMBL
  ENSRNOT00000107930 ENTREZGENE
  ENSRNOT00000107930.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598872 IMAGE-MGC_LOAD
InterPro KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72338 IMAGE-MGC_LOAD
NCBI Gene 117282 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH DOMAIN CONTAINING RNA BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROKNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpk PhenoGen
PROSITE KH_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019113 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQ15_RAT UniProtKB/TrEMBL
  A0A8L2QEP8 ENTREZGENE, UniProtKB/TrEMBL
  A6KAK1 ENTREZGENE, UniProtKB/TrEMBL
  F8WG62 ENTREZGENE, UniProtKB/TrEMBL
  HNRPK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5D059 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q07244 UniProtKB/Swiss-Prot
  Q15671 UniProtKB/Swiss-Prot
  Q60577 UniProtKB/Swiss-Prot
  Q922Y7 UniProtKB/Swiss-Prot
  Q96J62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-19 Hnrnpk  heterogeneous nuclear ribonucleoprotein K  Hnrpk  heterogeneous nuclear ribonucleoprotein K  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hnrpk  heterogeneous nuclear ribonucleoprotein K      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver 728600
gene_function binds strongly to cytidine-rich (poly-C) sequence of single-stranded DNA, weakly to double-stranded DNA and C-rich RNA 728600
gene_protein putative protein contains 463 aa residues 728600