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Gene: CREB1 (cAMP responsive element binding protein 1) Homo sapiens
Symbol: CREB1
Name: cAMP responsive element binding protein 1
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in protein phosphorylation; regulation of transcription, DNA-templated; and response to organic substance. Localizes to the ATF4-CREB1 transcription factor complex; nuclear euchromatin; and nucleoplasm. Biomarker of Pick's disease and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
Mus musculus (house mouse) : Creb1 (cAMP responsive element binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Creb1 (cAMP responsive element binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Creb1 (cAMP responsive element binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CREB1 (cAMP responsive element binding protein 1)
Canis lupus familiaris (dog) : CREB1 (cAMP responsive element binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Creb1 (cAMP responsive element binding protein 1)
Sus scrofa (pig) : CREB1 (cAMP responsive element binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382207,529,943 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372208,394,616 - 208,470,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBI
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,534 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CREB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730886
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.