CREB1 (cAMP responsive element binding protein 1) - Rat Genome Database

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Gene: CREB1 (cAMP responsive element binding protein 1) Homo sapiens
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Symbol: CREB1
Name: cAMP responsive element binding protein 1
RGD ID: 730886
HGNC Page HGNC:2345
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and identical protein binding activity. Involved in several processes, including cAMP-mediated signaling; cellular response to forskolin; and mRNA transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in RNA polymerase II transcription regulator complex and nucleoplasm. Part of ATF4-CREB1 transcription factor complex and euchromatin. Implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Biomarker of Pick's disease; nicotine dependence; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC100421287   LOC100421288   LOC100421292  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,529,962 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,529,737 - 207,605,988 (+)EnsemblGRCh38hg38GRCh38
GRCh372208,394,686 - 208,470,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,105 (+)NCBICHM1_1
T2T-CHM13v2.02208,003,958 - 208,080,006 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R)-salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (ISO)
(S)-AMPA  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dichloroethane  (ISO)
1,2-naphthoquinone  (EXP)
1,3-benzothiazole-2-thiol  (EXP)
1,3-dichloropropan-2-ol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP)
2,4-dinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-naphthylamine  (EXP)
23-epi-26-deoxyactein  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-aminobenzoic acid  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
adenosine  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP,ISO)
allethrin  (ISO)
alpha-pinene  (EXP)
alpha-Solamarine  (ISO)
alternariol  (ISO)
AM-251  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
ammonium hexachloroplatinate  (EXP)
amphetamine  (ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atenolol  (EXP)
atosiban  (ISO)
Atractylone  (EXP)
atrazine  (ISO)
atropine  (ISO)
baclofen  (ISO)
BAPTA  (EXP)
bathocuproine disulfonic acid  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (ISO)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-naphthoflavone  (EXP)
betaxolol  (ISO)
bicuculline  (ISO)
bilobalide  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brimonidine tartrate  (ISO)
bucladesine  (EXP,ISO)
buprenorphine  (ISO)
butan-1-ol  (ISO)
cabergoline  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (EXP,ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
carbachol  (ISO)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
casticin  (EXP)
celecoxib  (ISO)
CGS-21680  (ISO)
chaetocin  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
corticosterone  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
daunorubicin  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (EXP)
dizocilpine maleate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxycycline  (EXP)
elemental selenium  (EXP,ISO)
emetine  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
eticlopride(1+)  (ISO)
etoposide  (EXP,ISO)
eugenol  (EXP)
fenvalerate  (ISO)
fisetin  (ISO)
fluoxetine  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (EXP)
fructose  (ISO)
furan  (ISO)
gallic acid  (EXP)
gallocatechin  (EXP)
Geniposide  (ISO)
genistein  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rg1  (ISO)
glucagon  (ISO)
glucose  (ISO)
glycidol  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP)
GW 1929  (EXP)
GYKI 52466  (ISO)
haloperidol  (ISO)
heroin  (ISO)
hexadecanoic acid  (EXP,ISO)
histamine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
icariin  (ISO)
imipramine  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
JTE-013  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kojic acid  (ISO)
KT 5823  (EXP)
Kukoamine B  (EXP)
L-methionine  (ISO)
L-mimosine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
liraglutide  (ISO)
lithium chloride  (EXP,ISO)
lithocholic acid  (EXP)
loliolide  (ISO)
losartan  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (ISO)
melatonin  (ISO)
melittin  (ISO)
memantine  (ISO)
menadione  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methyl salicylate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
methylseleninic acid  (EXP)
Mitotane  (EXP)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (ISO)
mycophenolic acid  (EXP)
N(6)-butyryl-cAMP  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimodipine  (ISO)
nitroprusside  (ISO)
Nonylphenol  (ISO)
o-anisidine  (EXP)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
oleuropein  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
Panaxynol  (ISO)
papaverine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paxilline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (EXP,ISO)
phenobarbital  (ISO)
phenol  (EXP)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
piperine  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
potassium atom  (ISO)
potassium chloride  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
prasugrel hydrochloride  (ISO)
prazosin  (ISO)
proanthocyanidin  (EXP)
progesterone  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP)
puerarin  (ISO)
pyrethrins  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (EXP)
ryanodine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 415286  (EXP,ISO)
SCH 23390  (ISO)
SCH772984  (ISO)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
selumetinib  (EXP)
serotonin  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
SKF 38393  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
sphingosine 1-phosphate  (EXP)
staurosporine  (EXP)
streptozocin  (ISO)
sucrose  (ISO)
suramin  (EXP)
suvorexant  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tadalafil  (ISO)
tamibarotene  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
toluene  (ISO)
topiramate  (ISO)
tramadol  (ISO)
tranylcypromine  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
umbelliferone  (ISO)
urethane  (ISO)
Ursonic acid  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
Xamoterol  (EXP)
xanthohumol  (EXP)
xenon atom  (ISO)
xenon(0)  (ISO)
XL147  (ISO)
Yessotoxin  (EXP)
zebularine  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (IEA,ISO)
cAMP-mediated signaling  (IDA)
cell differentiation  (IEA,ISO)
cellular response to fatty acid  (ISO)
cellular response to forskolin  (IDA)
cellular response to growth factor stimulus  (IEA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (IEA,ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to zinc ion  (IEA,ISO)
chemotaxis to arachidonate  (ISO)
circadian rhythm  (IEA,ISO,ISS)
hormone secretion  (IEA,ISO)
lactation  (IEA,ISO)
lung epithelium development  (IEA,ISO)
lung saccule development  (IEA,ISO)
mammary gland development  (IEA,ISO)
memory  (IEA,ISO)
mRNA transcription by RNA polymerase II  (IDA)
negative regulation of apoptotic process  (IEA,ISS)
negative regulation of gene expression  (ISO)
negative regulation of transcription by competitive promoter binding  (IDA)
osteoclast differentiation  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac muscle tissue development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISS)
positive regulation of fat cell differentiation  (IEA,ISS)
positive regulation of hormone secretion  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISS)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of membrane depolarization  (ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO,ISS)
positive regulation of transforming growth factor beta3 production  (ISO)
protein phosphorylation  (IDA)
protein stabilization  (IEA,ISS)
regulation of apoptotic process  (ISO)
regulation of cell size  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fibroblast proliferation  (ISO)
regulation of glial cell proliferation  (ISO)
regulation of testosterone biosynthetic process  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,NAS)
response to activity  (ISO)
response to cocaine  (ISO)
response to dehydroepiandrosterone  (ISO)
response to erythropoietin  (ISO)
response to ethanol  (ISO)
response to glucagon  (IEA,ISS)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to morphine  (ISO)
response to nicotine  (ISO)
response to purine-containing compound  (IDA)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic process  (IEA)
secretory granule organization  (IEA,ISO)
signal transduction  (TAS)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
type I pneumocyte differentiation  (IEA,ISO)
visual learning  (ISO)

Cellular Component