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Gene: CREB1 (cAMP responsive element binding protein 1) Homo sapiens
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Symbol: CREB1
Name: cAMP responsive element binding protein 1
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in protein phosphorylation; regulation of transcription, DNA-templated; and response to organic substance. Localizes to the ATF4-CREB1 transcription factor complex; nuclear euchromatin; and nucleoplasm. Biomarker of Pick's disease and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
Orthologs:
Mus musculus (house mouse) : Creb1 (cAMP responsive element binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Creb1 (cAMP responsive element binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Creb1 (cAMP responsive element binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CREB1 (cAMP responsive element binding protein 1)
Canis lupus familiaris (dog) : CREB1 (cAMP responsive element binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Creb1 (cAMP responsive element binding protein 1)
Sus scrofa (pig) : CREB1 (cAMP responsive element binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,529,943 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372208,394,616 - 208,470,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBI
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,534 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CREB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730886
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.