CREB1 (cAMP responsive element binding protein 1) - Rat Genome Database
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Gene: CREB1 (cAMP responsive element binding protein 1) Sus scrofa
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Symbol: CREB1
Name: cAMP responsive element binding protein 1
RGD ID: 14118457
Description: ENCODES a protein that exhibits arrestin family protein binding (ortholog); double-stranded DNA binding (ortholog); histone acetyltransferase binding (ortholog); INVOLVED IN aging (ortholog); cellular response to fatty acid (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; follicle-stimulating hormone signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH Angiomatoid Fibrous Histiocytoma (ortholog); brain ischemia (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN axon (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH brimonidine tartrate; colforsin daropate hydrochloride; N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP response element binding protein; CREB; cyclic AMP-responsive element binding protein, delta; cyclic AMP-responsive element-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,697,408 - 110,771,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,705,548 - 110,773,037 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,245,218 - 122,278,060 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
axonogenesis  (IEA)
cellular response to fatty acid  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (IEA)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leukemia inhibitory factor  (IEA)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to zinc ion  (IEA)
chemotaxis to arachidonic acid  (ISO)
circadian rhythm  (IEA)
lactation  (IEA)
lung epithelium development  (ISO)
lung saccule development  (IEA)
mammary gland development  (ISO)
memory  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transcription by competitive promoter binding  (IEA)
pituitary gland development  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac muscle tissue development  (IEA)
positive regulation of fat cell differentiation  (IEA)
positive regulation of hormone secretion  (IEA)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of multicellular organism growth  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein phosphorylation  (IEA)
protein stabilization  (IEA)
regulation of apoptotic process  (ISO)
regulation of cell size  (IEA)
regulation of circadian rhythm  (ISO)
regulation of fibroblast proliferation  (ISO)
regulation of glial cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to activity  (ISO)
response to drug  (IEA)
response to glucagon  (IEA)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to nicotine  (ISO)
response to organic substance  (ISO)
secretory granule organization  (IEA)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
type I pneumocyte differentiation  (IEA)
visual learning  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:17401658   PMID:26659441  


Genomics

Comparative Map Data
CREB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,697,408 - 110,771,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,705,548 - 110,773,037 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,245,218 - 122,278,060 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2207,529,737 - 207,605,988 (+)EnsemblGRCh38hg38GRCh38
GRCh382207,529,943 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372208,394,616 - 208,470,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBI
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,534 (+)NCBICHM1_1
Creb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,571,963 - 64,643,707 (+)NCBIGRCm39mm39
GRCm38164,532,794 - 64,604,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,532,645 - 64,604,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,579,378 - 64,651,122 (+)NCBIGRCm37mm9NCBIm37
MGSCv36164,467,080 - 64,538,824 (+)NCBImm8
Celera165,034,311 - 65,105,954 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
Creb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
Creb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,431,736 - 7,491,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,424,403 - 7,490,630 (-)NCBIChiLan1.0ChiLan1.0
CREB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B212,891,261 - 212,963,584 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,891,261 - 212,958,130 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B94,762,796 - 94,836,304 (+)NCBIMhudiblu_PPA_v0panPan3
CREB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3715,939,138 - 15,977,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13715,921,214 - 15,978,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Creb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366313,721,307 - 3,785,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,316,774 - 93,395,187 (+)NCBI
ChlSab1.1 Ensembl1093,316,840 - 93,388,832 (+)Ensembl
Creb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247658,374,160 - 8,436,969 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 22 1 3 3
Low 2 2 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001099929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021075312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002339129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002339130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002339131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH014154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK349367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY862387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU928271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01072390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000039485   ⟹   ENSSSCP00000044086
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15110,705,585 - 110,771,755 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000040624   ⟹   ENSSSCP00000057004
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15110,705,585 - 110,770,927 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045029   ⟹   ENSSSCP00000047913
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15110,705,604 - 110,771,729 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000051771   ⟹   ENSSSCP00000035901
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15110,697,408 - 110,770,908 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069681   ⟹   ENSSSCP00000059723
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15110,697,408 - 110,755,528 (+)Ensembl
RefSeq Acc Id: XM_021075304   ⟹   XP_020930963
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,554 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075306   ⟹   XP_020930965
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,586 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075307   ⟹   XP_020930966
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,551 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075308   ⟹   XP_020930967
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,596 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075309   ⟹   XP_020930968
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,588 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075310   ⟹   XP_020930969
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,591 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075311   ⟹   XP_020930970
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,733,524 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075312   ⟹   XP_020930971
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,581 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339129
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,586 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339130
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,548 - 110,773,037 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002339131
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115110,705,588 - 110,773,037 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020930966   ⟸   XM_021075307
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020930963   ⟸   XM_021075304
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930971   ⟸   XM_021075312
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020930965   ⟸   XM_021075306
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930968   ⟸   XM_021075309
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020930969   ⟸   XM_021075310
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020930967   ⟸   XM_021075308
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020930970   ⟸   XM_021075311
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000044086   ⟸   ENSSSCT00000039485
RefSeq Acc Id: ENSSSCP00000057004   ⟸   ENSSSCT00000040624
RefSeq Acc Id: ENSSSCP00000035901   ⟸   ENSSSCT00000051771
RefSeq Acc Id: ENSSSCP00000047913   ⟸   ENSSSCT00000045029
RefSeq Acc Id: ENSSSCP00000059723   ⟸   ENSSSCT00000069681
Protein Domains
bZIP   KID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034395 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020566 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000035901 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000044086 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000047913 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000057004 UniProtKB/TrEMBL
  ENSSSCP00000059723 UniProtKB/TrEMBL
  ENSSSCP00070034438 UniProtKB/TrEMBL
  ENSSSCP00070034442 UniProtKB/TrEMBL
  ENSSSCP00070034453 UniProtKB/TrEMBL
  ENSSSCP00070034455 UniProtKB/TrEMBL
  ENSSSCP00070034464 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039485 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000040624 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045029 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000051771 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000069681 UniProtKB/TrEMBL
  ENSSSCT00070041031 UniProtKB/TrEMBL
  ENSSSCT00070041035 UniProtKB/TrEMBL
  ENSSSCT00070041047 UniProtKB/TrEMBL
  ENSSSCT00070041051 UniProtKB/TrEMBL
  ENSSSCT00070041058 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  Coactivator_CBP_pKID UniProtKB/TrEMBL
  CREB1 UniProtKB/TrEMBL
  Leuzip_CREB UniProtKB/TrEMBL
NCBI Gene CREB1 ENTREZGENE
PANTHER PTHR45879 UniProtKB/TrEMBL
  PTHR45879:SF1 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
  pKID UniProtKB/TrEMBL
PRINTS LEUZIPPRCREB UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
  KID UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
UniGene Ssc.16173 ENTREZGENE
  Ssc.80814 ENTREZGENE
UniProt A0A286ZWB0_PIG UniProtKB/TrEMBL
  A0A287AJL6_PIG UniProtKB/TrEMBL
  A0A287AVH0_PIG UniProtKB/TrEMBL
  A0A287BLQ7_PIG UniProtKB/TrEMBL
  A0A4X1UWC0_PIG UniProtKB/TrEMBL
  A0A4X1V0B9_PIG UniProtKB/TrEMBL
  A0A4X1V0E3_PIG UniProtKB/TrEMBL
  A0A4X1V1D2_PIG UniProtKB/TrEMBL
  A0A5G2Q6T2_PIG UniProtKB/TrEMBL
  Q5I240_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96004 ENTREZGENE