Bdnf (brain derived neurotrophic factor) - Rat Genome Database

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Gene: Bdnf (brain derived neurotrophic factor) Mus musculus
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Symbol: Bdnf
Name: brain derived neurotrophic factor
RGD ID: 10235
MGI Page MGI
Description: Predicted to enable growth factor activity; nerve growth factor receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of neuron projection development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and secretory granule. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: anorexia BDNF; brain-derived neurotrophic factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,505,045 - 109,557,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,505,045 - 109,557,352 (+)EnsemblGRCm39 Ensembl
GRCm382109,674,700 - 109,727,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,674,700 - 109,727,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,514,857 - 109,567,200 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,475,539 - 109,527,845 (+)NCBIMGSCv36mm8
Celera2110,835,441 - 110,887,723 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
alcohol use disorder  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (IEP)
amphetamine abuse  (ISO)
Amyloid Plaques  (IEP)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (IMP)
atopic dermatitis  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (IEP,ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Pain  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
colitis  (IEP)
color blindness  (ISO)
congenital central hypoventilation syndrome  (ISO)
cystitis  (ISO)
Deafness  (IDA,ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Drug Eruptions  (IEP)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
focal epilepsy  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (IEP,IMP,ISO)
heroin dependence  (ISO)
Huntington's disease  (IEP,ISO)
Hyperalgesia  (IMP,ISO)
Hyperoxia  (ISO)
hypertensive encephalopathy  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inner ear disease  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
keratoconus  (ISO)
Leukoencephalopathies  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
Nasal Polyps  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Degeneration  (ISO)
Nerve Injuries  (ISO)
nervous system disease  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (IDA,ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (IEP,ISO)
post-traumatic stress disorder  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
psychotic disorder  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Injuries  (ISO)
Referred Pain  (ISO)
Reperfusion Injury  (ISO)
Respiration Disorders  (IMP)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (IDA,IMP,ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sensorineural hearing loss  (IEP)
Sjogren's syndrome  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tinnitus  (ISO)
Tobacco Use Disorder  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vascular dementia  (ISO)
Visceral Pain  (IMP)
visual epilepsy  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(R)-Salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-3,5-dihydroxyphenylglycine  (EXP)
(S)-AMPA  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
13,14-dihydro-Delta(12)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (EXP)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
6-anilino-5,8-quinolinedione  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
[6]-Shogaol  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
agathisflavone  (ISO)
agmatine  (EXP)
agomelatine  (EXP,ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (ISO)
alpha-Solamarine  (EXP)
AM-251  (EXP)
amantadine  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsanilic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Asiaticoside  (ISO)
Atractylone  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromocriptine  (EXP)
bucladesine  (ISO)
bupivacaine  (ISO)
buprenorphine  (ISO)
Butylparaben  (ISO)
C60 fullerene  (ISO)
cabergoline  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon dioxide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
celastrol  (EXP)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP)
chondroitin sulfate  (ISO)
chrysin  (EXP)
cisplatin  (ISO)
Citreoviridin  (EXP)
clofibrate  (EXP)
clopidogrel  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP,ISO)
creatine  (EXP)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
dantrolene  (EXP)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (EXP,ISO)
dermatan sulfate  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydroactinidiolide  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
echinacoside  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (EXP)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (EXP)
fisetin  (ISO)
fluoranthene  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (EXP)
formaldehyde  (EXP,ISO)
fulvestrant  (ISO)
Fusaric acid  (ISO)
galactose  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
gingerol  (EXP)
glycidol  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
haloperidol  (EXP,ISO)
herbicide  (ISO)
heroin  (ISO)
hydrogen peroxide  (EXP,ISO)
ifosfamide  (ISO)
imipramine  (EXP,ISO)
kainic acid  (ISO)
ketamine  (EXP,ISO)
ketanserin  (ISO)
KT 5823  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP)
lamotrigine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methyl beta-cyclodextrin  (EXP)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
mevastatin  (EXP)
mifepristone  (ISO)
morin  (ISO)
morphine  (EXP,ISO)
muscimol  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
naproxen  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nimodipine  (EXP)
nitric oxide  (ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
ouabain  (ISO)
Oxadiazon  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
panaxydol  (ISO)
papaverine  (ISO)
paracetamol  (EXP,ISO)
paraldehyde  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
paroxetine  (EXP)
pentetrazol  (EXP,ISO)
pentobarbital  (ISO)
perchlorate  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
picrotoxin  (EXP,ISO)
pioglitazone  (EXP)
poly(I:C)  (EXP,ISO)
potassium atom  (EXP,ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
prasugrel hydrochloride  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
quetiapine fumarate  (ISO)
quinolinic acid  (ISO)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
risperidone  (ISO)
ritanserin  (ISO)
rivastigmine  (ISO)
rolipram  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (EXP)
saxagliptin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (ISO)
serotonin  (EXP,ISO)
sertraline  (EXP)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP)
SKF-96365 hydrochloride  (EXP)
SL-327  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sumatriptan  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tadalafil  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (ISO)
Testosterone propionate  (ISO)
tetrodotoxin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topiramate  (ISO)
torcetrapib  (ISO)
tranylcypromine  (ISO)
triacsin C  (ISO)
triazolam  (EXP)
triazophos  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
veratridine  (EXP,ISO)
vinclozolin  (ISO)
VX nerve agent  (EXP)
wortmannin  (EXP,ISO)
xenon atom  (ISO)
xenon(0)  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
axon extension  (IDA)
axon guidance  (IMP)
axon target recognition  (IMP)
behavioral fear response  (IMP)
behavioral response to cocaine  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
cellular response to potassium ion  (ISO)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (ISO)
circadian rhythm  (IEP)
cognition  (ISO)
collateral sprouting  (ISO)
conditioned place preference  (ISO)
dendrite development  (IMP)
dendrite extension  (IDA)
excitatory postsynaptic potential  (ISO)
fear response  (IMP)
feeding behavior  (IMP)
gamma-aminobutyric acid signaling pathway  (IDA)
glutamate secretion  (IPI)
inhibitory postsynaptic potential  (IMP)
inner ear development  (IMP)
learning  (ISO)
learning or memory  (IMP)
mechanoreceptor differentiation  (IGI)
memory  (IBA)
mitochondrial electron transport, NADH to ubiquinone  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of apoptotic signaling pathway  (IGI)
negative regulation of cell death  (IMP)
negative regulation of myotube differentiation  (ISO)
negative regulation of neuroblast proliferation  (IDA)
negative regulation of neuron apoptotic process  (IBA,IMP)
negative regulation of neuron death  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of synaptic transmission, GABAergic  (IDA)
nerve development  (IBA,IMP)
nerve growth factor signaling pathway  (IBA)
nervous system development  (ISO)
neuron apoptotic process  (IMP)
neuron projection extension  (ISO)
neuron projection morphogenesis  (IBA)
neuron recognition  (IMP)
peptidyl-serine phosphorylation  (IMP)
positive regulation of axon extension  (IMP)
positive regulation of collateral sprouting  (IBA,IDA,IMP,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of neuron projection development  (IGI)
positive regulation of peptidyl-serine phosphorylation  (IBA,IMP,ISO)
positive regulation of receptor binding  (ISO)
positive regulation of synapse assembly  (ISO)
regeneration  (ISO)
regulation of axon extension  (ISO)
regulation of collateral sprouting  (IGI)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of neuron apoptotic process  (IDA)
regulation of neuron differentiation  (IBA)
regulation of retinal cell programmed cell death  (IDA)
regulation of short-term neuronal synaptic plasticity  (ISO)
regulation of synaptic plasticity  (IDA)
response to activity  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to electrical stimulus  (ISO)
response to food  (ISO)
response to hormone  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to light intensity  (ISO)
response to light stimulus  (ISO)
response to nerve growth factor  (ISO)
response to nutrient levels  (ISO)
response to potassium ion  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (IMP,ISO)
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (IMP)
synapse assembly  (ISO)
taste bud development  (IMP)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (EXP,IDA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
ureteric bud development  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal adrenergic neuron morphology  (IAGP)
abnormal axon pruning  (IAGP)
abnormal barrel cortex morphology  (IAGP)
abnormal brain interneuron morphology  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal circumvallate papillae morphology  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cochlear OHC afferent innervation pattern  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal crista ampullaris morphology  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal fungiform papillae morphology  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal geniculate ganglion morphology  (IAGP)
abnormal gustatory papillae taste bud morphology  (IAGP)
abnormal gustatory system morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hippocampus CA2 region morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal innervation  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal kindling response  (IAGP)
abnormal liquid preference  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal medium spiny neuron morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal olfactory nerve morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal sensory ganglion morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal serotonergic neuron morphology  (IAGP)
abnormal serotonin level  (IAGP)
abnormal somatic nervous system morphology  (IAGP)
abnormal somatic sensory system morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal sympathetic system morphology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal type I vestibular cell  (IAGP)
abnormal vestibular ganglion morphology  (IAGP)
abnormal vestibular nerve morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal visual cortex morphology  (IAGP)
ataxia  (IAGP)
circling  (IAGP)
deafness  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased exploration in new environment  (IAGP)
decreased hippocampus volume  (IAGP)
decreased locomotor activity  (IAGP)
decreased pulmonary respiratory rate  (IAGP)
decreased sensory neuron number  (IAGP)
decreased striatum size  (IAGP)
decreased vertical activity  (IAGP)
delayed eyelid opening  (IAGP)
excessive scratching  (IAGP)
female infertility  (IAGP)
head bobbing  (IAGP)
head tilt  (IAGP)
hunched posture  (IAGP)
hyperactivity  (IAGP)
impaired balance  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired limb coordination  (IAGP)
impaired righting response  (IAGP)
impaired synaptic plasticity  (IAGP)
increased aggression  (IAGP)
increased aggression towards male mice  (IAGP)
increased anxiety-related response  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased locomotor activity  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuron number  (IAGP)
increased susceptibility to age related obesity  (IAGP)
insulin resistance  (IAGP)
lethargy  (IAGP)
limb grasping  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
polyphagia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced long term potentiation  (IAGP)
reduced male fertility  (IAGP)
short tongue  (IAGP)
shortened head  (IAGP)
small dorsal root ganglion  (IAGP)
small geniculate ganglion  (IAGP)
small L4 dorsal root ganglion  (IAGP)
small mesencephalic trigeminal nucleus  (IAGP)
small nodose ganglion  (IAGP)
small petrosal ganglion  (IAGP)
small trigeminal ganglion  (IAGP)
small vestibular ganglion  (IAGP)
spinning  (IAGP)
thin cerebral cortex  (IAGP)
vestibular ganglion degeneration  (IAGP)
weight loss  (IAGP)
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69. MGDs mouse GO annotations MGD data from the GO Consortium
70. MGD IEA MGD IEA
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95. Mouse MP Annotation Import Pipeline RGD automated import pipeline
96. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
97. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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99. Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury. Rich NJ, etal., J Neurosci Res. 2010 Oct;88(13):2933-9.
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101. Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats. Saadati H, etal., Regul Pept. 2014 Nov;194-195:11-5. doi: 10.1016/j.regpep.2014.11.004. Epub 2014 Nov 20.
102. No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease. Saarela MS, etal., Folia Neuropathol. 2006;44(1):12-6.
103. Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice. Saito A, etal., Environ Toxicol. 2011 Jun;26(3):224-32. doi: 10.1002/tox.20547.
104. Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia. Sakr HF, etal., J Physiol Pharmacol. 2014 Feb;65(1):41-53.
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