Creb1 (cAMP responsive element binding protein 1) - Rat Genome Database

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Gene: Creb1 (cAMP responsive element binding protein 1) Mus musculus
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Symbol: Creb1
Name: cAMP responsive element binding protein 1
RGD ID: 730887
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; protein stabilization; and regulation of lipid biosynthetic process. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; lung development; and nervous system development. Located in chromatin and nucleus. Part of ATF4-CREB1 transcription factor complex. Is expressed in several structures, including brain; genitourinary system; limb; lung; and maxillary process. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP-responsive element-binding protein 1; Cre; Creb; Creb-; Creb-1; cyclic AMP-responsive element-binding protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,571,963 - 64,643,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,571,804 - 64,643,707 (+)EnsemblGRCm39 Ensembl
GRCm38164,532,794 - 64,604,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,532,645 - 64,604,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,579,378 - 64,651,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,467,080 - 64,538,824 (+)NCBIMGSCv36mm8
Celera165,034,311 - 65,105,954 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-syringaresinol beta-D-glucoside  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-AMPA  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (EXP)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-naphthylamine  (ISO)
23-epi-26-deoxyactein  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
alpha-pinene  (ISO)
alpha-Solamarine  (EXP)
alternariol  (EXP)
AM-251  (EXP)
amino acid  (EXP)
aminoguanidine  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP,ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (EXP,ISO)
antimycin A  (EXP)
apocynin  (EXP)
arachidonic acid  (ISO)
aripiprazole  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
aspartame  (EXP)
atenolol  (ISO)
atosiban  (EXP)
Atractylone  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
baclofen  (EXP)
BAPTA  (ISO)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beryllium difluoride  (EXP)
beryllium sulfate  (EXP)
beta-naphthoflavone  (ISO)
betaxolol  (ISO)
bicuculline  (ISO)
bilobalide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brimonidine tartrate  (ISO)
bucladesine  (EXP,ISO)
buprenorphine  (ISO)
butan-1-ol  (ISO)
cabergoline  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (EXP,ISO)
cannabigerol  (EXP)
capsaicin  (ISO)
carbachol  (ISO)
carbon dioxide  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
celecoxib  (EXP)
CGS-21680  (ISO)
chaetocin  (ISO)
chlormequat chloride  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
cilostazol  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP)
crocin-1  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (EXP)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
diosmin  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
emetine  (EXP)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (EXP)
etoposide  (EXP,ISO)
eugenol  (ISO)
fenvalerate  (ISO)
fisetin  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Gastrodin  (ISO)
Geniposide  (EXP)
genistein  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rg1  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
GW 1929  (ISO)
GYKI 52466  (ISO)
haloperidol  (EXP,ISO)
heroin  (ISO)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP)
imipramine  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
kojic acid  (EXP)
KT 5823  (ISO)
Kukoamine B  (ISO)
L-methionine  (EXP)
L-mimosine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
liraglutide  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
loliolide  (EXP)
losartan  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (ISO)
melatonin  (EXP)
melittin  (EXP)
memantine  (ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
Mitotane  (ISO)
MK-2206  (EXP)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
mycophenolic acid  (ISO)
N(6)-butyryl-cAMP  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimodipine  (EXP)
nitroprusside  (ISO)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleuropein  (EXP)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
Panaxynol  (ISO)
papaverine  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
paxilline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
peroxynitrous acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (EXP)
piperine  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium atom  (ISO)
potassium chloride  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prasugrel hydrochloride  (ISO)
prazosin  (ISO)
proanthocyanidin  (ISO)
progesterone  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
puerarin  (EXP)
pyrethrins  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP,ISO)
Ro 31-8220  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
ryanodine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 415286  (ISO)
SCH 23390  (ISO)
SCH772984  (ISO)
scopolamine  (EXP)
selenium atom  (ISO)
selumetinib  (ISO)
serotonin  (EXP)
sertraline  (ISO)
sevoflurane  (EXP,ISO)
sildenafil citrate  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
SKF 38393  (ISO)
SL-327  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
suramin  (ISO)
suvorexant  (EXP)
T-2 toxin  (ISO)
tacrine  (EXP)
tadalafil  (EXP)
tamibarotene  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
toluene  (EXP)
topiramate  (ISO)
tramadol  (ISO)
tranylcypromine  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
umbelliferone  (ISO)
urethane  (EXP)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xenon atom  (ISO)
xenon(0)  (ISO)
XL147  (EXP)
Yessotoxin  (ISO)
zebularine  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (IMP)
cAMP/PKA signal transduction  (IEA)
cell differentiation  (ISO)
cellular response to fatty acid  (ISO)
cellular response to forskolin  (IEA)
cellular response to growth factor stimulus  (IDA)
cellular response to hepatocyte growth factor stimulus  (IDA)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (IMP)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to zinc ion  (IDA)
chemotaxis to arachidonate  (ISO)
circadian rhythm  (IDA,ISO)
hormone secretion  (IMP)
inhibition of non-skeletal tissue mineralization  (ISO)
lactation  (IMP)
lung epithelium development  (IMP)
lung saccule development  (IMP)
mammary gland development  (IMP)
memory  (IMP,ISO)
mRNA transcription by RNA polymerase II  (IEA)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of gene expression  (ISO)
negative regulation of transcription by competitive promoter binding  (IEA,ISO)
osteoclast differentiation  (IDA)
pituitary gland development  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac muscle tissue development  (IMP)
positive regulation of DNA-templated transcription  (IGI)
positive regulation of fat cell differentiation  (IGI)
positive regulation of hormone secretion  (IMP)
positive regulation of lipid biosynthetic process  (IGI)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of membrane depolarization  (ISO)
positive regulation of multicellular organism growth  (IMP)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein phosphorylation  (ISO)
protein stabilization  (IMP)
regulation of apoptotic process  (ISO)
regulation of cell size  (IGI)
regulation of DNA-templated transcription  (IDA)