MIR181B2 (microRNA 181b-2) - Rat Genome Database

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Gene: MIR181B2 (microRNA 181b-2) Homo sapiens
Analyze
Symbol: MIR181B2
Name: microRNA 181b-2
RGD ID: 1349974
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cellular response to lipid; long-term synaptic potentiation; and regulation of gene expression.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-181b-2; MIRN181B2
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9124,693,710 - 124,693,798 (+)EnsemblGRCh38hg38GRCh38
GRCh389124,693,710 - 124,693,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379127,455,989 - 127,456,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,495,809 - 126,495,897 (+)NCBINCBI36hg18NCBI36
Celera998,103,875 - 98,103,963 (+)NCBI
Cytogenetic Map9q33.3NCBI
HuRef997,068,713 - 97,068,801 (+)NCBIHuRef
CHM1_19127,604,858 - 127,604,946 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12624257   PMID:15634332   PMID:15800047   PMID:16039986   PMID:16381832   PMID:17604727   PMID:17616659   PMID:19547998   PMID:20347265   PMID:20596961   PMID:21037258   PMID:21130495  
PMID:22232059   PMID:23515710   PMID:23613247   PMID:23993976   PMID:25410655   PMID:25505240   PMID:25762865   PMID:26646931   PMID:26935905   PMID:27756793   PMID:28236165   PMID:28323882  
PMID:30579356   PMID:30580904   PMID:30627917   PMID:30977354   PMID:31518563   PMID:32066445   PMID:32552940   PMID:32552945   PMID:32733938   PMID:33000224  


Genomics

Comparative Map Data
MIR181B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9124,693,710 - 124,693,798 (+)EnsemblGRCh38hg38GRCh38
GRCh389124,693,710 - 124,693,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379127,455,989 - 127,456,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,495,809 - 126,495,897 (+)NCBINCBI36hg18NCBI36
Celera998,103,875 - 98,103,963 (+)NCBI
Cytogenetic Map9q33.3NCBI
HuRef997,068,713 - 97,068,801 (+)NCBIHuRef
CHM1_19127,604,858 - 127,604,946 (+)NCBICHM1_1
Mir181b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,743,842 - 38,743,930 (+)NCBIGRCm39mm39
GRCm39 Ensembl238,743,842 - 38,743,930 (+)Ensembl
GRCm38238,853,830 - 38,853,918 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,853,830 - 38,853,918 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,709,350 - 38,709,438 (+)NCBIGRCm37mm9NCBIm37
Celera240,577,942 - 40,578,030 (+)NCBICelera
Cytogenetic Map2BNCBI
Mir181b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2322,616,948 - 22,617,035 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl322,616,948 - 22,617,035 (+)Ensembl
Rnor_6.0323,151,455 - 23,151,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl323,151,455 - 23,151,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,375,872 - 28,375,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera321,050,405 - 21,050,492 (+)NCBICelera
Cytogenetic Map3q12NCBI
MIR181B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,301,314 - 58,301,373 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,301,300 - 58,301,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,499,947 - 57,500,006 (-)NCBI
ROS_Cfam_1.0959,221,648 - 59,221,707 (-)NCBI
UMICH_Zoey_3.1957,980,488 - 57,980,547 (-)NCBI
UNSW_CanFamBas_1.0958,296,855 - 58,296,914 (-)NCBI
UU_Cfam_GSD_1.0958,387,339 - 58,387,398 (-)NCBI
MIR181B-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,499,108 - 265,499,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,499,111 - 265,499,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,324,014 - 299,324,099 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PLAG1hsa-miR-181b-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//MicroarraFunctional MTI19692702
SIRT1hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22228303
GRIA2hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase assay/RT-PCR//Reporter assay;OtherFunctional MTI18184693
BCL2hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20162574
BCL2hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22610076
KAT2Bhsa-miR-181b-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI18728182
TCL1Ahsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI17178851
MAP3K10hsa-miR-181b-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20596961
CYLDhsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20797623
TMED7hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22446332
IGF1Rhsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23431408
E2F1hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23083446
E2F1hsa-miR-181b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
GRIA2hsa-miR-181b-5pTarbaseexternal_infoReporter GenePOSITIVE
TCL1Ahsa-miR-181b-5pTarbaseexternal_infoWesternblitPOSITIVE
BCL2hsa-miR-181b-5pOncomiRDBexternal_infoNANA22610076
CREB1hsa-miR-181b-5pOncomiRDBexternal_infoNANA22539488
TIMP3hsa-miR-181b-5pOncomiRDBexternal_infoNANA22009755
MCL1hsa-miR-181b-5pOncomiRDBexternal_infoNANA21636858
RASSF1hsa-miR-181b-5pOncomiRDBexternal_infoNANA21352471
ATMhsa-miR-181b-5pOncomiRDBexternal_infoNANA21102523
CYLDhsa-miR-181b-5pOncomiRDBexternal_infoNANA20797623
MCL1hsa-miR-181b-5pOncomiRDBexternal_infoNANA20693279
MAP3K10hsa-miR-181b-5pOncomiRDBexternal_infoNANA20596961
CBX7hsa-miR-181b-5pOncomiRDBexternal_infoNANA21779448
BCL2hsa-miR-181b-5pOncomiRDBexternal_infoNANA20162574
TIMP3hsa-miR-181b-5pOncomiRDBexternal_infoNANA20023698
PLAG1hsa-miR-181b-5pOncomiRDBexternal_infoNANA19692702
CDX2hsa-miR-181b-5pOncomiRDBexternal_infoNANA19585654
KAT2Bhsa-miR-181b-5pOncomiRDBexternal_infoNANA18728182
TCL1Ahsa-miR-181b-5pOncomiRDBexternal_infoNANA17178851
NLKhsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19585654
CBX7hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21779448
TIMP3hsa-miR-181b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20023698
TIMP3hsa-miR-181b-5pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//qRT-PFunctional MTI22009755

Predicted Targets
Summary Value
Count of predictions:19055
Count of gene targets:7543
Count of transcripts:14445
Interacting mature miRNAs:hsa-miR-181b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 1 1 1 1
Low 77 17 97 21 187 23 146 43 115 60 102 196 7 3 30 2
Below cutoff 43 28 36 10 31 4 65 25 35 9 37 49 6 2 41

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9124,693,710 - 124,693,798 (+)Ensembl
RefSeq Acc Id: NR_029782
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,693,710 - 124,693,798 (+)NCBI
GRCh379127,455,989 - 127,456,077 (+)RGD
Celera998,103,875 - 98,103,963 (+)RGD
HuRef997,068,713 - 97,068,801 (+)RGD
CHM1_19127,604,858 - 127,604,946 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-33.3(chr9:123095598-126693843)x1 copy number loss See cases [RCV000141589] Chr9:123095598..126693843 [GRCh38]
Chr9:125857877..129456122 [GRCh37]
Chr9:124897698..128495943 [NCBI36]
Chr9:9q33.2-33.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q33.2-34.3(chr9:124642754-141146461)x3 copy number gain See cases [RCV000448784] Chr9:124642754..141146461 [GRCh37]
Chr9:9q33.2-34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31551 AgrOrtholog
COSMIC MIR181B2 COSMIC
Ensembl Genes ENSG00000207737 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385004 ENTREZGENE
GTEx ENSG00000207737 GTEx
HGNC ID HGNC:31551 ENTREZGENE
Human Proteome Map MIR181B2 Human Proteome Map
miRBase MI0000683 ENTREZGENE
NCBI Gene 406956 ENTREZGENE
OMIM 612745 OMIM
PharmGKB PA164722524 PharmGKB
RNAcentral URS0000605E00 RNACentral
  URS000075BF74 RNACentral
  URS0000764165 RNACentral