MIR34B (microRNA 34b) - Rat Genome Database

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Gene: MIR34B (microRNA 34b) Homo sapiens
Analyze
Symbol: MIR34B
Name: microRNA 34b
RGD ID: 1352034
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; embryonic brain development; and motile cilium assembly. Biomarker of Parkinson's disease.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-34b; MIRN34B; miRNA34B
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11111,512,938 - 111,513,021 (+)EnsemblGRCh38hg38GRCh38
GRCh3811111,512,938 - 111,513,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711111,383,663 - 111,383,746 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,888,872 - 110,888,955 (+)NCBINCBI36hg18NCBI36
Celera11108,536,852 - 108,536,935 (+)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,307,861 - 107,307,944 (+)NCBIHuRef
CHM1_111111,266,758 - 111,266,841 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:12919684   PMID:16381832   PMID:17554337   PMID:17604727   PMID:18320040   PMID:18451145   PMID:18519671   PMID:19461653   PMID:19536169   PMID:19632201   PMID:20309940   PMID:20889907  
PMID:20924086   PMID:21037258   PMID:21537871   PMID:21610744   PMID:21949788   PMID:21960261   PMID:21976676   PMID:22047961   PMID:22052540   PMID:22082000   PMID:22439831   PMID:22593438  
PMID:22703336   PMID:22844323   PMID:23100280   PMID:23147995   PMID:23155254   PMID:23183747   PMID:23305226   PMID:23314612   PMID:23504554   PMID:23516510   PMID:23525472   PMID:23632240  
PMID:23935875   PMID:24065649   PMID:24130071   PMID:24337371   PMID:24503183   PMID:24559316   PMID:24573638   PMID:24686393   PMID:24704024   PMID:24811488   PMID:24885463   PMID:24892887  
PMID:24945256   PMID:24970812   PMID:25190019   PMID:25190020   PMID:25227823   PMID:25326793   PMID:25381598   PMID:25398683   PMID:25475831   PMID:25541488   PMID:25647415   PMID:25658980  
PMID:25894979   PMID:26061495   PMID:26107383   PMID:26320502   PMID:26380954   PMID:26402809   PMID:26619844   PMID:26861642   PMID:26924291   PMID:27227383   PMID:27296951   PMID:27458165  
PMID:27576168   PMID:27636879   PMID:27796811   PMID:27808368   PMID:27886674   PMID:27983526   PMID:28039468   PMID:28106538   PMID:28275243   PMID:28277300   PMID:28363996   PMID:28415817  
PMID:28431233   PMID:28461137   PMID:28512015   PMID:28840508   PMID:28977792   PMID:29039021   PMID:29257105   PMID:29270777   PMID:30106161   PMID:30286050   PMID:30334298   PMID:30373654  
PMID:30778022   PMID:30861198   PMID:30915747   PMID:30915776   PMID:30935968   PMID:30942424   PMID:31014439   PMID:31129659   PMID:31199581   PMID:31298387   PMID:31432176   PMID:31467172  
PMID:31499476   PMID:31583029   PMID:31665127   PMID:31996191   PMID:32083300   PMID:32166848   PMID:32319382   PMID:32609950   PMID:32939938   PMID:33377704   PMID:33494641   PMID:33512625  
PMID:33720323   PMID:34038763  


Genomics

Comparative Map Data
MIR34B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11111,512,938 - 111,513,021 (+)EnsemblGRCh38hg38GRCh38
GRCh3811111,512,938 - 111,513,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711111,383,663 - 111,383,746 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,888,872 - 110,888,955 (+)NCBINCBI36hg18NCBI36
Celera11108,536,852 - 108,536,935 (+)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,307,861 - 107,307,944 (+)NCBIHuRef
CHM1_111111,266,758 - 111,266,841 (+)NCBICHM1_1
Mir34b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,014,862 - 51,014,945 (-)NCBIGRCm39mm39
GRCm39 Ensembl951,014,862 - 51,014,945 (-)Ensembl
GRCm38951,103,562 - 51,103,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,103,562 - 51,103,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,911,667 - 50,911,750 (-)NCBIGRCm37mm9NCBIm37
Celera948,390,072 - 48,390,155 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
Mir34b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2851,410,244 - 51,410,327 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl851,410,244 - 51,410,327 (-)Ensembl
Rnor_6.0855,492,542 - 55,492,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,492,542 - 55,492,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,088,899 - 54,088,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera850,956,685 - 50,956,768 (-)NCBICelera
Cytogenetic Map8q23NCBI
MIR34B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,558,685 - 21,558,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,558,685 - 21,558,768 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,480,327 - 21,480,410 (-)NCBI
ROS_Cfam_1.0521,584,341 - 21,584,424 (-)NCBI
UMICH_Zoey_3.1521,645,437 - 21,645,520 (-)NCBI
UNSW_CanFamBas_1.0521,545,409 - 21,545,492 (-)NCBI
UU_Cfam_GSD_1.0521,594,394 - 21,594,477 (-)NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BCL2hsa-miR-34b-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18803879
CREB1hsa-miR-34b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19258499
CREB1hsa-miR-34b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19461653
MYBhsa-miR-34b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19461653
HNF4Ahsa-miR-34b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22232426
SMAD3hsa-miR-34b-5pOncomiRDBexternal_infoNANA23305226
METhsa-miR-34b-5pOncomiRDBexternal_infoNANA22419847
SNAI1hsa-miR-34b-5pOncomiRDBexternal_infoNANA22134354
CCND1hsa-miR-34b-5pOncomiRDBexternal_infoNANA22113133
SNAI1hsa-miR-34b-5pOncomiRDBexternal_infoNANA22024162
ZAP70hsa-miR-34b-5pOncomiRDBexternal_infoNANA21205967
CREB1hsa-miR-34b-5pOncomiRDBexternal_infoNANA19258499
METhsa-miR-34b-5pOncomiRDBexternal_infoNANA19074879
BCL2hsa-miR-34b-5pOncomiRDBexternal_infoNANA18803879
BCL2hsa-miR-34b-5pOncomiRDBexternal_infoNANA17656095
NOTCH1hsa-miR-34b-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI22498974
JAG1hsa-miR-34b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22113133
MYCNhsa-miR-34b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22020437
CDK4hsa-miR-34b-3pMirtarbaseexternal_infoMicroarray//Western blot//RTPCRFunctional MTI20924086
CDK6hsa-miR-34b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18768788
VEGFAhsa-miR-34b-3pMirtarbaseexternal_infoELISA//Luciferase reporter assayNon-Functional MTI18320040
METhsa-miR-34b-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22419847
MYChsa-miR-34b-3pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCRFunctional MTI (Weak)18802929
ZAP70hsa-miR-34b-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21205967
ENOSF1hsa-miR-34b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
NOTCH4hsa-miR-34b-3pMirecordsexternal_info{changed}NA18803879
BCL2hsa-miR-34b-3pMirecordsexternal_infoNANA18803879
MYChsa-miR-34b-3pMirecordsexternal_info{changed}NA18802929

Predicted Targets
Summary Value
Count of predictions:44858
Count of gene targets:15875
Count of transcripts:34728
Interacting mature miRNAs:hsa-miR-34b-3p, hsa-miR-34b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 2 2
Low 6 5 1 15 2 16 2 19 3 123 53 1 1 1
Below cutoff 4 7 5 1 8 2 11 11 23 4 64 19 1 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385076
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11111,512,938 - 111,513,021 (+)Ensembl
RefSeq Acc Id: NR_029839
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,512,938 - 111,513,021 (+)NCBI
GRCh3711111,383,663 - 111,383,746 (+)RGD
Celera11108,536,852 - 108,536,935 (+)RGD
HuRef11107,307,861 - 107,307,944 (+)ENTREZGENE
CHM1_111111,266,758 - 111,266,841 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q23.1-23.3(chr11:110969076-114578509)x1 copy number loss not provided [RCV000848936] Chr11:110969076..114578509 [GRCh37]
Chr11:11q23.1-23.3
uncertain significance
NC_000011.9:g.(?_111171709)_(111965694_?)del deletion Carney-Stratakis syndrome [RCV001032115] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
Chr11:11q22.3-23.2
pathogenic
NC_000011.9:g.(?_111171709)_(111965694_?)dup duplication Carney-Stratakis syndrome [RCV001300223] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
uncertain significance
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31636 AgrOrtholog
COSMIC MIR34B COSMIC
Ensembl Genes ENSG00000207811 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385076 ENTREZGENE
GTEx ENSG00000207811 GTEx
HGNC ID HGNC:31636 ENTREZGENE
Human Proteome Map MIR34B Human Proteome Map
miRBase MI0000742 ENTREZGENE
NCBI Gene 407041 ENTREZGENE
OMIM 611374 OMIM
PharmGKB PA164722676 PharmGKB
RNAcentral URS000027352D RNACentral
  URS0000432971 RNACentral
  URS0000699DB3 RNACentral