Arrb1 (arrestin, beta 1) - Rat Genome Database

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Gene: Arrb1 (arrestin, beta 1) Rattus norvegicus
Analyze
Symbol: Arrb1
Name: arrestin, beta 1
RGD ID: 2156
Description: Exhibits several functions, including AP-2 adaptor complex binding activity; arrestin family protein binding activity; and signaling receptor binding activity. Involved in several processes, including regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and regulation of cellular protein metabolic process. Localizes to several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (arrestin beta 1); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: arrestin beta-1; BARRES; beta-arrestin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,837,964 - 153,912,111 (+)NCBI
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Celera1151,924,752 - 151,989,492 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
AH23848  (ISO)
alprenolol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
genistein  (EXP)
glyphosate  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
mesalamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
metoprolol  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
ouabain  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
tamoxifen  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IDA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (TAS)
apoptotic process  (IEA)
endocytosis  (IDA)
follicle-stimulating hormone signaling pathway  (IDA)
G protein-coupled receptor internalization  (IBA,ISO)
G protein-coupled receptor signaling pathway  (IDA)
histone acetylation  (IEA)
negative regulation of apoptotic process  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of GTPase activity  (IDA)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of Notch signaling pathway  (IBA,ISO,ISS)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein ubiquitination  (ISO)
phototransduction  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of GTPase activity  (IEA)
positive regulation of histone acetylation  (ISO)
positive regulation of histone H4 acetylation  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (IMP,ISO,ISS)
positive regulation of protein ubiquitination  (IMP)
positive regulation of receptor internalization  (ISO,ISS)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of smooth muscle cell apoptotic process  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein transport  (IEA)
protein ubiquitination  (ISO)
regulation of apoptotic process  (ISO)
regulation of G protein-coupled receptor signaling pathway  (IDA,ISO,TAS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IDA)
response to drug  (IEP)
sensory perception of pain  (TAS)
sensory perception of touch  (TAS)
stress fiber assembly  (ISO)
ubiquitin-dependent protein catabolic process  (ISO,ISS)

Cellular Component

References

References - curated
1. Ahn S, etal., J Biol Chem. 2009 Mar 27;284(13):8855-65. Epub 2009 Jan 26.
2. Attramadal H, etal., J Biol Chem 1992 Sep 5;267(25):17882-90.
3. Avissar S, etal., Am J Psychiatry. 2004 Nov;161(11):2066-72.
4. Bagher AM, etal., Eur J Pharmacol. 2017 Oct 15;813:66-83. doi: 10.1016/j.ejphar.2017.07.034. Epub 2017 Jul 19.
5. Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22.
6. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
7. Chen W, etal., Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14889-94. Epub 2001 Dec 11.
8. Dalle S, etal., Mol Cell Biol 2002 Sep;22(17):6272-85.
9. DeFea KA, etal., J Cell Biol. 2000 Mar 20;148(6):1267-81.
10. Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058.
11. Dominguez R, etal., J Neurosci. 2009 Apr 1;29(13):4228-38.
12. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Golan M, etal., Int J Neuropsychopharmacol. 2011 Nov;14(10):1289-300. doi: 10.1017/S1461145710001550. Epub 2011 Jan 12.
16. Hara MR, etal., Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.
17. Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79.
18. Iacovelli L, etal., J Biol Chem 2003 Apr 4;278(14):12433-42. Epub 2003 Jan 07.
19. Jia JJ, etal., Cell Cycle. 2014;13(19):3121-31. doi: 10.4161/15384101.2014.949214.
20. Kang J, etal., Cell. 2005 Dec 2;123(5):833-47.
21. Khoury E, etal., J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.
22. Kim J, etal., J Biol Chem. 2009 May 1;284(18):11953-62. Epub 2009 Mar 2.
23. Komori N, etal., Brain Res 2003 Oct 24;988(1-2):121-9.
24. Liao Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Oct;30(10):1067-72.
25. Lombardi MS, etal., Stroke 2004 Apr;35(4):981-6. Epub 2004 Mar 11.
26. Lymperopoulos A, etal., J Am Coll Cardiol. 2011 Jan 18;57(3):356-65.
27. Lymperopoulos A, etal., Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5825-30. Epub 2009 Mar 16.
28. Marion S, etal., J Endocrinol. 2006 Aug;190(2):341-50.
29. MGD data from the GO Consortium
30. Mishra SK, etal., J Biol Chem. 2005 May 13;280(19):19270-80. Epub 2005 Feb 22.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Nobles KN, etal., J Biol Chem. 2007 Jul 20;282(29):21370-81. Epub 2007 May 18.
33. Perry SJ, etal., Science 2002 Oct 25;298(5594):834-6.
34. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Puca L, etal., J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. doi: 10.1242/jcs.130500. Epub 2013 Jul 25.
37. RGD automated data pipeline
38. RGD automated import pipeline for gene-chemical interactions
39. Schmidlin F, etal., Am J Physiol Cell Physiol 2003 Oct;285(4):C945-58.
40. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
41. Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22.
42. Shukla AK, etal., Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.
43. Stanasila L, etal., Mol Pharmacol. 2008 Sep;74(3):562-73. Epub 2008 Jun 3.
44. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
45. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
46. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
47. Vinge LE, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2490-9.
48. Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19.
49. Wang WY, etal., Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. Epub 2015 Nov 24.
50. Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3.
51. Zhu Z and Reiser G, Neurochem Int. 2014 Feb;67:46-56. doi: 10.1016/j.neuint.2013.12.007. Epub 2013 Dec 27.
52. Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.
53. Zoudilova M, etal., J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11.
Additional References at PubMed
PMID:9400383   PMID:10196135   PMID:10521508   PMID:10644702   PMID:10823817   PMID:11171997   PMID:11278883   PMID:11853756   PMID:12582207   PMID:12821670   PMID:15308653   PMID:15456867  
PMID:15561704   PMID:15611106   PMID:15878855   PMID:16378096   PMID:16641100   PMID:17456469   PMID:18276584   PMID:18445652   PMID:18505723   PMID:19915011   PMID:21323643   PMID:21466165  
PMID:22457824   PMID:23174211   PMID:23353685   PMID:23633677   PMID:23690069   PMID:25081544   PMID:25081814   PMID:25480575   PMID:25542150   PMID:25803606   PMID:26399643   PMID:26531813  
PMID:29476059   PMID:30347436   PMID:31269046   PMID:31506606  


Genomics

Candidate Gene Status
Arrb1 is a candidate Gene for QTL Bp138
Comparative Map Data
Arrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,837,964 - 153,912,111 (+)NCBI
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Celera1151,924,752 - 151,989,492 (+)NCBICelera
Cytogenetic Map1q32NCBI
ARRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1175,260,122 - 75,351,705 (-)EnsemblGRCh38hg38GRCh38
GRCh381175,260,122 - 75,351,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371174,971,166 - 75,062,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBINCBI36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
Arrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,184,356 - 99,255,979 (+)NCBIGRCm39mm39
GRCm39 Ensembl799,184,673 - 99,255,978 (+)Ensembl
GRCm38799,535,147 - 99,606,772 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,535,466 - 99,606,771 (+)EnsemblGRCm38mm10GRCm38
MGSCv377106,683,996 - 106,755,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv36799,409,569 - 99,480,854 (+)NCBImm8
Celera799,859,615 - 99,932,041 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.09NCBI
Arrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,478,843 - 16,562,135 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,478,843 - 16,568,050 (+)NCBIChiLan1.0ChiLan1.0
ARRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11173,624,254 - 73,670,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1173,630,276 - 73,654,155 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01170,319,935 - 70,411,276 (-)NCBIMhudiblu_PPA_v0panPan3
ARRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,261,020 - 23,304,448 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,235,711 - 23,297,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,990,721 - 23,068,006 (+)NCBI
ROS_Cfam_1.02123,428,040 - 23,505,333 (+)NCBI
UMICH_Zoey_3.12123,226,359 - 23,303,832 (+)NCBI
UNSW_CanFamBas_1.02123,422,622 - 23,499,929 (+)NCBI
UU_Cfam_GSD_1.02123,340,581 - 23,417,904 (+)NCBI
Arrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBI
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,513,856 - 9,597,959 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,516,944 - 9,597,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,659,892 - 10,767,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,489,358 - 66,580,167 (-)NCBI
ChlSab1.1 Ensembl166,490,102 - 66,580,154 (-)Ensembl
Arrb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248171,750,448 - 1,828,399 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144723107174343537Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1156446196214277437Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1153656062198656062Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1156446783188289244Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1154337847215828102Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1156446783189514504Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1161072673178935582Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:77
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000043554
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 16 6 19 6 72 25 29 11
Low 1 41 41 35 35 8 11 2 10 12 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000043554   ⟹   ENSRNOP00000046069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)Ensembl
RefSeq Acc Id: NM_012910   ⟹   NP_037042
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,080 - 153,904,061 (+)NCBI
Rnor_6.01164,502,452 - 164,568,430 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
RGSC_v3.41156,871,564 - 156,937,540 (+)RGD
Celera1151,924,752 - 151,989,492 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229734   ⟹   XP_006229796
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,534,778 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229735   ⟹   XP_006229797
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,912,111 (+)NCBI
Rnor_6.01164,534,778 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229736   ⟹   XP_006229798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,870,838 - 153,912,111 (+)NCBI
Rnor_6.01164,534,779 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229737   ⟹   XP_006229799
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,870,838 - 153,912,111 (+)NCBI
Rnor_6.01164,534,779 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229738   ⟹   XP_006229800
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
Rnor_6.01164,534,776 - 164,568,248 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229739   ⟹   XP_006229801
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,881,564 - 153,912,111 (+)NCBI
Rnor_6.01164,545,993 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229740   ⟹   XP_006229802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,837,964 - 153,912,111 (+)NCBI
Rnor_6.01164,502,099 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229741   ⟹   XP_006229803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,871,427 - 153,912,111 (+)NCBI
Rnor_6.01164,537,698 - 164,573,947 (+)NCBI
Rnor_5.01170,705,795 - 170,777,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101614   ⟹   XP_038957542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,912,111 (+)NCBI
RefSeq Acc Id: XM_039101625   ⟹   XP_038957553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
RefSeq Acc Id: XM_039101643   ⟹   XP_038957571
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
RefSeq Acc Id: XM_039101664   ⟹   XP_038957592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,903,879 (+)NCBI
RefSeq Acc Id: XM_039101685   ⟹   XP_038957613
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,894,158 (+)NCBI
RefSeq Acc Id: XR_005500235
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,838,000 - 153,897,229 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037042   ⟸   NM_012910
- UniProtKB: P29066 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229802   ⟸   XM_006229740
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_006229800   ⟸   XM_006229738
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006229796   ⟸   XM_006229734
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229797   ⟸   XM_006229735
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006229798   ⟸   XM_006229736
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006229799   ⟸   XM_006229737
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006229803   ⟸   XM_006229741
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006229801   ⟸   XM_006229739
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: ENSRNOP00000046069   ⟸   ENSRNOT00000043554
RefSeq Acc Id: XP_038957542   ⟸   XM_039101614
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957553   ⟸   XM_039101625
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038957571   ⟸   XM_039101643
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038957592   ⟸   XM_039101664
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038957613   ⟸   XM_039101685
- Peptide Label: isoform X12

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690229
Promoter ID:EPDNEW_R753
Type:initiation region
Name:Arrb1_1
Description:arrestin, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,502,430 - 164,502,490EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2156 AgrOrtholog
Ensembl Genes ENSRNOG00000030404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000046069 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043554 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
  2.60.40.840 UniProtKB/Swiss-Prot
InterPro Arrestin UniProtKB/Swiss-Prot
  Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_CS UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:25387 UniProtKB/Swiss-Prot
NCBI Gene 25387 ENTREZGENE
PANTHER PTHR11792 UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Arrb1 PhenoGen
PRINTS ARRESTIN UniProtKB/Swiss-Prot
PROSITE ARRESTINS UniProtKB/Swiss-Prot
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
TIGR TC228510
UniProt ARRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Arrb1  Arrestin, beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to postsynaptic sites 631708
gene_expression expressed in neuronal tissues and spleen 631708
gene_expression expressed in endothelial cells 628504
gene_process inhibited beta 2AR function 631708
gene_process may work with beta ARK to regulate G protein-coupled neurotransmitter receptors 631797
gene_process mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) 631708
gene_process mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs) 631797
gene_process mediates desensitization and downregulation of G protein-coupled receptors (GPCRs) 628504
gene_regulation insulin induces ubiquitination and proteosomal degradation 631797
gene_regulation mRNA level increases in postinfarction (heart) failure 628504