RGD Reference Report - NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. - Rat Genome Database

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NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior.

Authors: Nygard, Stephanie K  Klambatsen, Anthony  Balouch, Bailey  Quinones-Jenab, Vanya  Jenab, Shirzad 
Citation: Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
RGD ID: 401900166
Pubmed: PMID:27664298   (View Abstract at PubMed)
PMCID: PMC5107324   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbr.2016.09.047   (Journal Full-text)

The aim of this study was to investigate the intracellular responses associated with the acquisition and expression of cocaine-context associations. ERK (extracellular regulated kinase), CREB (cAMP responsive element binding protein), FosB and ΔFosB proteins were of particular interest due to their involvement in cocaine reward and in synaptic plasticity underlying learning and memory. We used the conditioned place preference (CPP) paradigm, which employs a Pavlovian conditioning procedure to establish an association between a drug-paired environment and the drug's rewarding effects, to study the role of these signaling pathways in cocaine-context associations. N-methyl-D-aspartate receptor (NMDAR) antagonism prior to cocaine administration during conditioning blocked the acquisition of cocaine CPP and reduced Nucleus Accumbens (NAc) phosphorylated-ERK (pERK) and phosphorylated CREB (pCREB) levels following the CPP test (drug-free). We also show that cocaine-induced increases in Caudate Putamen (CPu) FosB and ΔFosB levels are decreased after MK-801 pre-treatment during conditioning. In addition, our results provide evidence for the involvement of striatal SIRT (Silent Information Regulator of Transcription) proteins in cocaine-CPP. These results will aid in the advancement of general knowledge about the molecular formation and retrieval of cocaine-associated memories that can be used in the future when designing treatments for cocaine addiction that target both prevention and relapse.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CREB1Humancocaine dependence treatmentISOCreb1 (Rattus norvegicus) RGD 
Creb1Mousecocaine dependence treatmentISOCreb1 (Rattus norvegicus) RGD 
Creb1Ratcocaine dependence treatmentIEP  RGD 
FOSBHumancocaine dependence treatmentISOFosb (Rattus norvegicus) RGD 
FosbMousecocaine dependence treatmentISOFosb (Rattus norvegicus) RGD 
FosbRatcocaine dependence treatmentIEP  RGD 
SIRT1Humancocaine dependence  ISOSirt1 (Rattus norvegicus)protein:increased expression:brain and nucleus accumbens (rat)RGD 
SIRT2Humancocaine dependence treatmentISOSirt2 (Rattus norvegicus) RGD 
Sirt1Mousecocaine dependence  ISOSirt1 (Rattus norvegicus)protein:increased expression:brain and nucleus accumbens (rat)RGD 
Sirt1Ratcocaine dependence  IEP protein:increased expression:brain and nucleus accumbens (rat)RGD 
Sirt2Ratcocaine dependence treatmentIEP  RGD 
Sirt2Mousecocaine dependence treatmentISOSirt2 (Rattus norvegicus) RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CREB1Humancocaine increases phosphorylationISOCreb1 (Rattus norvegicus)cocaine increases phosphorylation of Creb1 protein in nucleus accumbensRGD 
Creb1Ratcocaine increases phosphorylationEXP cocaine increases phosphorylation of Creb1 protein in nucleus accumbensRGD 
Creb1Mousecocaine increases phosphorylationISOCreb1 (Rattus norvegicus)cocaine increases phosphorylation of Creb1 protein in nucleus accumbensRGD 
FOSBHumancocaine increases expression ISOFosb (Rattus norvegicus)Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamenRGD 
FosbRatcocaine increases expression EXP Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamenRGD 
FosbMousecocaine increases expression ISOFosb (Rattus norvegicus)Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamenRGD 
SIRT1Humancocaine increases expression ISOSirt1 (Rattus norvegicus)cocaine increases expression of Sirt1 protein in nucleus accumbens RGD 
SIRT2Humancocaine increases expression ISOSirt2 (Rattus norvegicus)cocaine increases expression of Sirt2 protein in caudate putamenRGD 
Sirt1Ratcocaine increases expression EXP cocaine increases expression of Sirt1 protein in nucleus accumbens RGD 
Sirt1Mousecocaine increases expression ISOSirt1 (Rattus norvegicus)cocaine increases expression of Sirt1 protein in nucleus accumbens RGD 
Sirt2Ratcocaine increases expression EXP cocaine increases expression of Sirt2 protein in caudate putamenRGD 
Sirt2Mousecocaine increases expression ISOSirt2 (Rattus norvegicus)cocaine increases expression of Sirt2 protein in caudate putamenRGD 
SIRT1Humandizocilpine increases expressionISOSirt1 (Rattus norvegicus)dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbensRGD 
Sirt1Mousedizocilpine increases expressionISOSirt1 (Rattus norvegicus)dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbensRGD 
Sirt1Ratdizocilpine increases expressionEXP dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbensRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Creb1Ratresponse to cocaine  IEP  RGD 
FosbRatresponse to cocaine  IEP  RGD 
Sirt1Ratresponse to cocaine  IEP  RGD 
Sirt2Ratresponse to cocaine  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Creb1  (cAMP responsive element binding protein 1)
Fosb  (FosB proto-oncogene, AP-1 transcription factor subunit)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)

Genes (Mus musculus)
Creb1  (cAMP responsive element binding protein 1)
Fosb  (FBJ osteosarcoma oncogene B)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)

Genes (Homo sapiens)
CREB1  (cAMP responsive element binding protein 1)
FOSB  (FosB proto-oncogene, AP-1 transcription factor subunit)
SIRT1  (sirtuin 1)
SIRT2  (sirtuin 2)


Additional Information