FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
Analyze
Symbol: FOSB
Name: FosB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 1317837
HGNC Page HGNC:3797
Description: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to calcium ion. Located in nucleoplasm. Biomarker of depressive disorder; substance dependence; and tongue squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activator protein 1; AP-1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FosB proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; oncogene FOS-B; transcription factor AP-1 subunit FosB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,467,996 - 45,475,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,467,995 - 45,475,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,971,254 - 45,978,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,663,093 - 50,670,276 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,663,092 - 50,670,276NCBI
Celera1942,777,353 - 42,784,537 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,400,874 - 42,408,060 (+)NCBIHuRef
CHM1_11945,974,496 - 45,981,682 (+)NCBICHM1_1
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-palmitoylglycerol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
8-OH-DPAT  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
agmatine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (EXP)
amiodarone  (EXP)
amphetamine  (EXP,ISO)
amphotericin B  (EXP)
antimycin A  (EXP)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
butanal  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
cylindrospermopsin  (EXP)
DDE  (EXP)
DDT  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diisopropyl fluorophosphate  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (ISO)
disulfiram  (EXP)
dizocilpine maleate  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
fluoxetine  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
gentamycin  (ISO)
haloperidol  (ISO)
heroin  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
ibuprofen  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
kenpaullone  (ISO)
L-methionine  (ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
luteolin  (EXP)
mechlorethamine  (EXP,ISO)
melphalan  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
naloxone  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phencyclidine  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pifithrin-?  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
rac-lactic acid  (EXP)
rimonabant  (ISO)
SCH 23390  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (EXP)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium hypochlorite  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
tamibarotene  (EXP)
tebufenpyrad  (EXP)
temozolomide  (EXP)
thalidomide  (EXP)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
toluene  (ISO)
tramadol  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISA)
cytosol  (IEA,ISO)
intracellular membrane-bounded organelle  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens. Carneiro de Oliveira PE, etal., Front Behav Neurosci. 2016 Sep 12;10:173. doi: 10.3389/fnbeh.2016.00173. eCollection 2016.
2. H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference. Chen M, etal., PLoS One. 2019 Aug 23;14(8):e0221506. doi: 10.1371/journal.pone.0221506. eCollection 2019.
3. Withdrawal induces distinct patterns of FosB/∆FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization. De Pauli RF, etal., Pharmacol Biochem Behav. 2014 Feb;117:70-8. doi: 10.1016/j.pbb.2013.12.007. Epub 2013 Dec 16.
4. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. El Rawas R, etal., Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.
5. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
6. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. Gajewski PA, etal., PLoS One. 2016 Aug 5;11(8):e0160355. doi: 10.1371/journal.pone.0160355. eCollection 2016.
7. Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction. García-García F, etal., Alcohol. 2021 Jun;93:63-70. doi: 10.1016/j.alcohol.2021.02.004. Epub 2021 Mar 1.
8. Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. García-Pérez D, etal., PLoS One. 2012;7(11):e50264. doi: 10.1371/journal.pone.0050264. Epub 2012 Nov 21.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Guo L, etal., Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi: 10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.
11. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
12. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Hiroi N, etal., Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10397-402. doi: 10.1073/pnas.94.19.10397.
13. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
14. Differences in basal and morphine-induced FosB/DeltaFosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats. Kaste K, etal., Pharmacol Biochem Behav. 2009 Jun;92(4):655-62. doi: 10.1016/j.pbb.2009.03.004. Epub 2009 Mar 24.
15. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Larson EB, etal., J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3.
16. Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Li J, etal., Alcohol Clin Exp Res. 2010 Oct;34(10):1742-50. doi: 10.1111/j.1530-0277.2010.01261.x. Epub 2010 Jul 9.
17. Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions. Li J, etal., PLoS One. 2012;7(7):e40347. doi: 10.1371/journal.pone.0040347. Epub 2012 Jul 9.
18. Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats. Liu H, etal., Neurosci Lett. 2011 Apr 20;494(1):70-4. doi: 10.1016/j.neulet.2011.02.059. Epub 2011 Mar 6.
19. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Marttila K, etal., Brain Res. 2007 Jul 30;1160:82-90. doi: 10.1016/j.brainres.2007.05.036. Epub 2007 May 31.
20. Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats. Moon S, etal., Neurochem Res. 2019 Apr;44(4):874-883. doi: 10.1007/s11064-019-02720-9. Epub 2019 Jan 10.
21. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
22. Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
23. Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
24. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. Núñez C, etal., J Neurochem. 2010 Jul;114(2):475-87. doi: 10.1111/j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice. Robins MT, etal., PLoS One. 2016 Jul 5;11(7):e0158189. doi: 10.1371/journal.pone.0158189. eCollection 2016.
27. Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Ryabinin AE and Wang YM, Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54.
28. Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
29. Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA. van de Wetering R and Schenk S, Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.
30. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
31. Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway. Yazdanfar N, etal., Brain Res Bull. 2021 May;170:98-105. doi: 10.1016/j.brainresbull.2021.02.005. Epub 2021 Feb 13.
32. Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. Zhu H, etal., Hum Mol Genet. 2007 Apr 1;16(7):820-36. doi: 10.1093/hmg/ddm027.
Additional References at PubMed
PMID:1301997   PMID:1702972   PMID:1900040   PMID:1903195   PMID:8125298   PMID:8144043   PMID:8706134   PMID:8985116   PMID:10220381   PMID:10942775   PMID:12371906   PMID:12477932  
PMID:12602926   PMID:12618758   PMID:14741347   PMID:15025563   PMID:15489334   PMID:15926923   PMID:16344560   PMID:17495958   PMID:17601350   PMID:18207134   PMID:18490653   PMID:18491952  
PMID:18802113   PMID:18977241   PMID:19133651   PMID:19274049   PMID:19381435   PMID:19453261   PMID:19795327   PMID:20398657   PMID:20571966   PMID:20813842   PMID:20826776   PMID:21543584  
PMID:21616539   PMID:21873635   PMID:21937452   PMID:22387553   PMID:23614275   PMID:23810250   PMID:23824909   PMID:23933656   PMID:24374978   PMID:24551192   PMID:24952347   PMID:25043949  
PMID:25446562   PMID:25609649   PMID:26608367   PMID:26949019   PMID:27248170   PMID:27515856   PMID:27889568   PMID:28009608   PMID:28387432   PMID:28473536   PMID:28514442   PMID:28653602  
PMID:28724635   PMID:28981703   PMID:28986522   PMID:29020630   PMID:29527734   PMID:29858576   PMID:30256258   PMID:30459475   PMID:31262712   PMID:31735020   PMID:31894310   PMID:32296183  
PMID:32482537   PMID:32513696   PMID:32819575   PMID:32891613   PMID:32911434   PMID:33961781   PMID:34048709   PMID:34153682   PMID:35211278   PMID:35271311   PMID:35910761   PMID:35981363  
PMID:36008878   PMID:36898276   PMID:37173692   PMID:37461273   PMID:37478314   PMID:37553246   PMID:37616343  


Genomics

Comparative Map Data
FOSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,467,996 - 45,475,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,467,995 - 45,475,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,971,254 - 45,978,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,663,093 - 50,670,276 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,663,092 - 50,670,276NCBI
Celera1942,777,353 - 42,784,537 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,400,874 - 42,408,060 (+)NCBIHuRef
CHM1_11945,974,496 - 45,981,682 (+)NCBICHM1_1
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBIT2T-CHM13v2.0
Fosb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,036,621 - 19,043,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,036,621 - 19,043,976 (-)EnsemblGRCm39 Ensembl
GRCm38719,302,696 - 19,310,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,888,045 - 19,895,394 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,461,436 - 18,468,273 (-)NCBIMGSCv36mm8
Celera716,719,831 - 16,727,180 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.56NCBI
Fosb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,082,324 - 88,089,506 (-)NCBIGRCr8
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
Fosb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,438,864 - 2,445,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,438,864 - 2,445,846 (+)NCBIChiLan1.0ChiLan1.0
FOSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,628,596 - 51,636,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,500,106 - 53,507,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,416,781 - 42,424,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,013,350 - 51,020,570 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,013,350 - 51,020,570 (+)Ensemblpanpan1.1panPan2
FOSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,088,686 - 110,092,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,087,036 - 110,092,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,572,939 - 109,577,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,619,054 - 110,625,469 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,619,068 - 110,625,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,297,099 - 110,301,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,931,231 - 109,935,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,800,596 - 110,804,728 (-)NCBIUU_Cfam_GSD_1.0
Fosb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,553,572 - 17,560,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,900,931 - 1,906,772 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,900,954 - 1,907,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,837,719 - 51,844,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,836,780 - 51,844,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FOSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,916,039 - 38,924,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,534,366 - 18,539,824 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,328,691 - 2,339,099 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,332,746 - 2,338,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FOSB
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_006732.3(FOSB):c.371C>T (p.Ser124Phe) single nucleotide variant not specified [RCV004106799] Chr19:45470873 [GRCh38]
Chr19:45974131 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh38/hg38 19q13.32(chr19:45287256-45734078)x3 copy number gain See cases [RCV000054152] Chr19:45287256..45734078 [GRCh38]
Chr19:45790514..46237336 [GRCh37]
Chr19:50482354..50929176 [NCBI36]
Chr19:19q13.32
uncertain significance
GRCh38/hg38 19q13.32-13.33(chr19:44971420-48257402)x3 copy number gain See cases [RCV000136578] Chr19:44971420..48257402 [GRCh38]
Chr19:45474677..48760659 [GRCh37]
Chr19:50166517..53452471 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32(chr19:45387389-46831000)x1 copy number loss See cases [RCV000137832] Chr19:45387389..46831000 [GRCh38]
Chr19:45890647..47334257 [GRCh37]
Chr19:50582487..52026097 [NCBI36]
Chr19:19q13.32
likely pathogenic
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1 copy number loss See cases [RCV000240182] Chr19:43013365..47241534 [GRCh37]
Chr19:19q13.2-13.32
pathogenic
GRCh37/hg19 19q13.32(chr19:45284576-45978239)x3 copy number gain See cases [RCV000239782] Chr19:45284576..45978239 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.220A>G (p.Thr74Ala) single nucleotide variant not specified [RCV004319824] Chr19:45470722 [GRCh38]
Chr19:45973980 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19q13.32(chr19:45945375-46215558)x3 copy number gain not provided [RCV000684077] Chr19:45945375..46215558 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:45531056-48174177)x3 copy number gain not provided [RCV001007051] Chr19:45531056..48174177 [GRCh37]
Chr19:19q13.32-13.33
uncertain significance
NM_006732.3(FOSB):c.660G>A (p.Pro220=) single nucleotide variant not provided [RCV000940551] Chr19:45472655 [GRCh38]
Chr19:45975913 [GRCh37]
Chr19:19q13.32
likely benign
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
NM_006732.3(FOSB):c.97G>A (p.Gly33Ser) single nucleotide variant not provided [RCV000967521] Chr19:45468683 [GRCh38]
Chr19:45971941 [GRCh37]
Chr19:19q13.32
benign
NM_006732.3(FOSB):c.537G>C (p.Leu179=) single nucleotide variant not provided [RCV000935334] Chr19:45471283 [GRCh38]
Chr19:45974541 [GRCh37]
Chr19:19q13.32
likely benign
GRCh37/hg19 19q13.31-13.32(chr19:45074342-46133841) copy number gain not specified [RCV002052686] Chr19:45074342..46133841 [GRCh37]
Chr19:19q13.31-13.32
uncertain significance
NM_006732.3(FOSB):c.340A>C (p.Ser114Arg) single nucleotide variant not specified [RCV004298625] Chr19:45470842 [GRCh38]
Chr19:45974100 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.759C>A (p.Ser253Arg) single nucleotide variant not specified [RCV004288142] Chr19:45472754 [GRCh38]
Chr19:45976012 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.394C>T (p.Pro132Ser) single nucleotide variant not specified [RCV004159200] Chr19:45470896 [GRCh38]
Chr19:45974154 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.376A>G (p.Ser126Gly) single nucleotide variant not specified [RCV004110712] Chr19:45470878 [GRCh38]
Chr19:45974136 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.709G>A (p.Glu237Lys) single nucleotide variant not specified [RCV004184446] Chr19:45472704 [GRCh38]
Chr19:45975962 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.416G>A (p.Arg139Gln) single nucleotide variant not specified [RCV004087138] Chr19:45470918 [GRCh38]
Chr19:45974176 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.818C>G (p.Pro273Arg) single nucleotide variant not specified [RCV004139677] Chr19:45472813 [GRCh38]
Chr19:45976071 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.541G>A (p.Asp181Asn) single nucleotide variant not specified [RCV004143036] Chr19:45471287 [GRCh38]
Chr19:45974545 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.390T>G (p.Ser130Arg) single nucleotide variant not specified [RCV004201566] Chr19:45470892 [GRCh38]
Chr19:45974150 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.284A>C (p.Asp95Ala) single nucleotide variant not specified [RCV004095912] Chr19:45470786 [GRCh38]
Chr19:45974044 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.805A>G (p.Ser269Gly) single nucleotide variant not specified [RCV004214981] Chr19:45472800 [GRCh38]
Chr19:45976058 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.415C>G (p.Arg139Gly) single nucleotide variant not specified [RCV004133239] Chr19:45470917 [GRCh38]
Chr19:45974175 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.136G>T (p.Gly46Cys) single nucleotide variant not specified [RCV004251153] Chr19:45470638 [GRCh38]
Chr19:45973896 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.670A>T (p.Ile224Phe) single nucleotide variant not specified [RCV004392095] Chr19:45472665 [GRCh38]
Chr19:45975923 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.379G>A (p.Gly127Arg) single nucleotide variant not specified [RCV004392093] Chr19:45470881 [GRCh38]
Chr19:45974139 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_006732.3(FOSB):c.541G>C (p.Asp181His) single nucleotide variant not specified [RCV004392094] Chr19:45471287 [GRCh38]
Chr19:45974545 [GRCh37]
Chr19:19q13.32
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10631
Count of miRNA genes:1061
Interacting mature miRNAs:1339
Transcripts:ENST00000353609, ENST00000417353, ENST00000443841, ENST00000585836, ENST00000586113, ENST00000586615, ENST00000587358, ENST00000589593, ENST00000590335, ENST00000591858, ENST00000592436, ENST00000592811
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559110SCL22_HSerum cholesterol level QTL 22 (human)3.590.000241Lipid levelLDL cholesterol193190759457907594Human
407145783GWAS794759_Hheel bone mineral density QTL GWAS794759 (human)3e-12heel bone mineral densitybone mineral density (CMO:0001226)194547346045473461Human
407147298GWAS796274_Hheel bone mineral density QTL GWAS796274 (human)0.000003heel bone mineral densitybone mineral density (CMO:0001226)194547346045473461Human
406979630GWAS628606_Hheel bone mineral density QTL GWAS628606 (human)1e-20heel bone mineral densitybone mineral density (CMO:0001226)194546979845469799Human
1331657COPD9_HChronic obstructive pulmonary disease QTL 9 (human)1.94Chronic airflow obstructionpost-bronchodilator FEV1193102176057021760Human
407214728GWAS863704_Hheel bone mineral density QTL GWAS863704 (human)3e-22heel bone mineral densitybone mineral density (CMO:0001226)194547346045473461Human
406932782GWAS581758_Hheel bone mineral density QTL GWAS581758 (human)2e-16heel bone mineral densitybone mineral density (CMO:0001226)194546979845469799Human

Markers in Region
RH46539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371945,975,064 - 45,975,183UniSTSGRCh37
Build 361950,666,904 - 50,667,023RGDNCBI36
Celera1942,781,164 - 42,781,283RGD
Cytogenetic Map19q13.32UniSTS
HuRef1942,404,687 - 42,404,806UniSTS
GeneMap99-GB4 RH Map19250.55UniSTS
WI-20020  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371945,978,038 - 45,978,295UniSTSGRCh37
Build 361950,669,878 - 50,670,135RGDNCBI36
Celera1942,784,138 - 42,784,395RGD
Cytogenetic Map19q13.32UniSTS
HuRef1942,407,661 - 42,407,918UniSTS
GeneMap99-GB4 RH Map19250.55UniSTS
Whitehead-RH Map19330.9UniSTS
D19S1096  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371945,978,109 - 45,978,295UniSTSGRCh37
Build 361950,669,949 - 50,670,135RGDNCBI36
Celera1942,784,209 - 42,784,395RGD
Cytogenetic Map19q13.32UniSTS
HuRef1942,407,732 - 42,407,918UniSTS
TNG Radiation Hybrid Map1917025.0UniSTS
Stanford-G3 RH Map192336.0UniSTS
NCBI RH Map19502.1UniSTS
GeneMap99-G3 RH Map192347.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4973 1726 2350 6 624 1949 465 2270 7301 6467 53 3733 1 852 1743 1616 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_015839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NG_029675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001114171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF432216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY898963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA589470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB275824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU178116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L49169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000353609   ⟹   ENSP00000245919
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,996 - 45,475,179 (+)Ensembl
Ensembl Acc Id: ENST00000417353   ⟹   ENSP00000407207
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,995 - 45,475,178 (+)Ensembl
Ensembl Acc Id: ENST00000443841   ⟹   ENSP00000414177
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,995 - 45,475,178 (+)Ensembl
Ensembl Acc Id: ENST00000585836   ⟹   ENSP00000467497
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,995 - 45,475,178 (+)Ensembl
Ensembl Acc Id: ENST00000586113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,469,886 - 45,472,067 (+)Ensembl
Ensembl Acc Id: ENST00000586615   ⟹   ENSP00000468207
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,469,913 - 45,475,179 (+)Ensembl
Ensembl Acc Id: ENST00000587358
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,471,079 - 45,473,067 (+)Ensembl
Ensembl Acc Id: ENST00000589593   ⟹   ENSP00000465528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,470,265 - 45,472,553 (+)Ensembl
Ensembl Acc Id: ENST00000590335   ⟹   ENSP00000465068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,996 - 45,472,081 (+)Ensembl
Ensembl Acc Id: ENST00000591858   ⟹   ENSP00000466530
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,995 - 45,475,178 (+)Ensembl
Ensembl Acc Id: ENST00000592436   ⟹   ENSP00000465552
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,468,435 - 45,473,040 (+)Ensembl
Ensembl Acc Id: ENST00000592811   ⟹   ENSP00000468482
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,469,876 - 45,474,597 (+)Ensembl
Ensembl Acc Id: ENST00000615753   ⟹   ENSP00000485018
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1945,467,995 - 45,473,012 (+)Ensembl
RefSeq Acc Id: NM_001114171   ⟹   NP_001107643
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,467,996 - 45,475,179 (+)NCBI
GRCh371945,971,253 - 45,978,437 (+)NCBI
HuRef1942,400,874 - 42,408,060 (+)ENTREZGENE
CHM1_11945,974,496 - 45,981,682 (+)NCBI
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411069   ⟹   NP_001397998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,467,996 - 45,475,179 (+)NCBI
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBI
RefSeq Acc Id: NM_006732   ⟹   NP_006723
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,467,996 - 45,475,179 (+)NCBI
GRCh371945,971,253 - 45,978,437 (+)ENTREZGENE
GRCh371945,971,253 - 45,978,437 (+)NCBI
Build 361950,663,093 - 50,670,276 (+)NCBI Archive
HuRef1942,400,874 - 42,408,060 (+)ENTREZGENE
CHM1_11945,974,496 - 45,981,682 (+)NCBI
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047438550   ⟹   XP_047294506
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,467,996 - 45,475,179 (+)NCBI
RefSeq Acc Id: XM_054320409   ⟹   XP_054176384
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001107643 (Get FASTA)   NCBI Sequence Viewer  
  NP_001397998 (Get FASTA)   NCBI Sequence Viewer  
  NP_006723 (Get FASTA)   NCBI Sequence Viewer  
  XP_047294506 (Get FASTA)   NCBI Sequence Viewer  
  XP_054176384 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB53946 (Get FASTA)   NCBI Sequence Viewer  
  AAH36724 (Get FASTA)   NCBI Sequence Viewer  
  AAH40197 (Get FASTA)   NCBI Sequence Viewer  
  AAI27826 (Get FASTA)   NCBI Sequence Viewer  
  AAW65374 (Get FASTA)   NCBI Sequence Viewer  
  ABW34730 (Get FASTA)   NCBI Sequence Viewer  
  ABW34731 (Get FASTA)   NCBI Sequence Viewer  
  ABW34732 (Get FASTA)   NCBI Sequence Viewer  
  ABW34733 (Get FASTA)   NCBI Sequence Viewer  
  ABW34734 (Get FASTA)   NCBI Sequence Viewer  
  ABW34735 (Get FASTA)   NCBI Sequence Viewer  
  ABW34736 (Get FASTA)   NCBI Sequence Viewer  
  ABW34737 (Get FASTA)   NCBI Sequence Viewer  
  BAF85409 (Get FASTA)   NCBI Sequence Viewer  
  CAG46898 (Get FASTA)   NCBI Sequence Viewer  
  CBX47618 (Get FASTA)   NCBI Sequence Viewer  
  EAW57351 (Get FASTA)   NCBI Sequence Viewer  
  EAW57352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000245919
  ENSP00000245919.3
  ENSP00000407207
  ENSP00000407207.1
  ENSP00000414177.1
  ENSP00000465068.1
  ENSP00000465528.1
  ENSP00000465552
  ENSP00000465552.1
  ENSP00000466530.1
  ENSP00000467497.1
  ENSP00000468207.1
  ENSP00000468482.1
GenBank Protein P53539 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_006723   ⟸   NM_006732
- Peptide Label: isoform 1
- UniProtKB: K7EMJ6 (UniProtKB/Swiss-Prot),   K7EKC1 (UniProtKB/Swiss-Prot),   E9PHJ3 (UniProtKB/Swiss-Prot),   E7EPR6 (UniProtKB/Swiss-Prot),   A8VJG9 (UniProtKB/Swiss-Prot),   A8VJG5 (UniProtKB/Swiss-Prot),   A8VJG1 (UniProtKB/Swiss-Prot),   A8VJF7 (UniProtKB/Swiss-Prot),   A8VJF3 (UniProtKB/Swiss-Prot),   A8VJF0 (UniProtKB/Swiss-Prot),   A8VJE6 (UniProtKB/Swiss-Prot),   A8VJE1 (UniProtKB/Swiss-Prot),   A8K9K5 (UniProtKB/Swiss-Prot),   Q49AD7 (UniProtKB/Swiss-Prot),   P53539 (UniProtKB/Swiss-Prot),   Q6FGK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001107643   ⟸   NM_001114171
- Peptide Label: isoform 2
- UniProtKB: Q6FGK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000467497   ⟸   ENST00000585836
Ensembl Acc Id: ENSP00000468207   ⟸   ENST00000586615
Ensembl Acc Id: ENSP00000407207   ⟸   ENST00000417353
Ensembl Acc Id: ENSP00000465528   ⟸   ENST00000589593
Ensembl Acc Id: ENSP00000414177   ⟸   ENST00000443841
Ensembl Acc Id: ENSP00000485018   ⟸   ENST00000615753
Ensembl Acc Id: ENSP00000245919   ⟸   ENST00000353609
Ensembl Acc Id: ENSP00000465068   ⟸   ENST00000590335
Ensembl Acc Id: ENSP00000466530   ⟸   ENST00000591858
Ensembl Acc Id: ENSP00000468482   ⟸   ENST00000592811
Ensembl Acc Id: ENSP00000465552   ⟸   ENST00000592436
RefSeq Acc Id: XP_047294506   ⟸   XM_047438550
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001397998   ⟸   NM_001411069
- Peptide Label: isoform 3
RefSeq Acc Id: XP_054176384   ⟸   XM_054320409
- Peptide Label: isoform X1
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53539-F1-model_v2 AlphaFold P53539 1-338 view protein structure

Promoters
RGD ID:7240419
Promoter ID:EPDNEW_H25954
Type:initiation region
Name:FOSB_1
Description:FosB proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25955  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,467,996 - 45,468,056EPDNEW
RGD ID:7240417
Promoter ID:EPDNEW_H25955
Type:initiation region
Name:FOSB_2
Description:FosB proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25954  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381945,469,913 - 45,469,973EPDNEW
RGD ID:6795574
Promoter ID:HG_KWN:30277
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001114171,   NM_006732,   UC002PBW.2,   UC010EKA.1,   UC010EKB.1,   UC010EKC.1,   UC010EKD.1,   UC010EKE.1,   UC010EKF.1,   UC010EKG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361950,663,001 - 50,663,667 (+)MPROMDB
RGD ID:6795578
Promoter ID:HG_KWN:30278
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC002PCA.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361950,664,266 - 50,665,642 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3797 AgrOrtholog
COSMIC FOSB COSMIC
Ensembl Genes ENSG00000125740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000353609 ENTREZGENE
  ENST00000353609.8 UniProtKB/Swiss-Prot
  ENST00000417353 ENTREZGENE
  ENST00000417353.6 UniProtKB/Swiss-Prot
  ENST00000443841.6 UniProtKB/Swiss-Prot
  ENST00000585836.5 UniProtKB/Swiss-Prot
  ENST00000586615.5 UniProtKB/Swiss-Prot
  ENST00000589593.1 UniProtKB/TrEMBL
  ENST00000590335.1 UniProtKB/TrEMBL
  ENST00000591858.5 UniProtKB/Swiss-Prot
  ENST00000592436 ENTREZGENE
  ENST00000592436.5 UniProtKB/Swiss-Prot
  ENST00000592811.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000125740 GTEx
HGNC ID HGNC:3797 ENTREZGENE
Human Proteome Map FOSB Human Proteome Map
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2354 UniProtKB/Swiss-Prot
NCBI Gene 2354 ENTREZGENE
OMIM 164772 OMIM
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_2 UniProtKB/TrEMBL
PharmGKB PA28213 PharmGKB
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L186_HUMAN UniProtKB/TrEMBL
  A8K9K5 ENTREZGENE
  A8VJE1 ENTREZGENE
  A8VJE6 ENTREZGENE
  A8VJF0 ENTREZGENE
  A8VJF3 ENTREZGENE
  A8VJF7 ENTREZGENE
  A8VJG1 ENTREZGENE
  A8VJG5 ENTREZGENE
  A8VJG9 ENTREZGENE
  E7EPR6 ENTREZGENE
  E9PHJ3 ENTREZGENE
  FOSB_HUMAN UniProtKB/Swiss-Prot
  K7EJ89_HUMAN UniProtKB/TrEMBL
  K7EKA0_HUMAN UniProtKB/TrEMBL
  K7EKC1 ENTREZGENE
  K7EMJ6 ENTREZGENE
  K7ERZ8_HUMAN UniProtKB/TrEMBL
  P53539 ENTREZGENE
  Q49AD7 ENTREZGENE
  Q6FGK6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A8K9K5 UniProtKB/Swiss-Prot
  A8VJE1 UniProtKB/Swiss-Prot
  A8VJE6 UniProtKB/Swiss-Prot
  A8VJF0 UniProtKB/Swiss-Prot
  A8VJF3 UniProtKB/Swiss-Prot
  A8VJF7 UniProtKB/Swiss-Prot
  A8VJG1 UniProtKB/Swiss-Prot
  A8VJG5 UniProtKB/Swiss-Prot
  A8VJG9 UniProtKB/Swiss-Prot
  E7EPR6 UniProtKB/Swiss-Prot
  E9PHJ3 UniProtKB/Swiss-Prot
  K7EKC1 UniProtKB/Swiss-Prot
  K7EMJ6 UniProtKB/Swiss-Prot
  Q49AD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 FOSB  FosB proto-oncogene, AP-1 transcription factor subunit  FOSB  FosB proto-oncogene, AP-1 trancription factor subunit  Symbol and/or name change 5135510 APPROVED
2016-05-10 FOSB  FosB proto-oncogene, AP-1 trancription factor subunit  FOSB  FBJ murine osteosarcoma viral oncogene homolog B  Symbol and/or name change 5135510 APPROVED