Fosb (FBJ osteosarcoma oncogene B) - Rat Genome Database

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Gene: Fosb (FBJ osteosarcoma oncogene B) Mus musculus
Analyze
Symbol: Fosb
Name: FBJ osteosarcoma oncogene B
RGD ID: 1317838
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to calcium ion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; skeleton; and skin. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: osteosarcoma oncoprotein B FosB; transcription factor AP-1 subunit FosB
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,036,621 - 19,043,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,036,621 - 19,043,976 (-)EnsemblGRCm39 Ensembl
GRCm38719,302,696 - 19,310,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,888,045 - 19,895,394 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,461,436 - 18,468,273 (-)NCBIMGSCv36mm8
Celera716,719,831 - 16,727,180 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
8-OH-DPAT  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agmatine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
amiodarone  (ISO)
amphetamine  (EXP,ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (EXP)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
DDT  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,IEP,ISO)
ferric oxide  (ISO)
fluoxetine  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
haloperidol  (EXP,ISO)
heroin  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
ibuprofen  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
kenpaullone  (ISO)
L-methionine  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
mechlorethamine  (EXP,ISO)
melphalan  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morphine  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
naloxone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phencyclidine  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pifithrin-?  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
potassium chloride  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
rimonabant  (ISO)
SCH 23390  (EXP,ISO)
Shikonin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP)
SL-327  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium hypochlorite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
toluene  (EXP)
tramadol  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tungsten  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens. Carneiro de Oliveira PE, etal., Front Behav Neurosci. 2016 Sep 12;10:173. doi: 10.3389/fnbeh.2016.00173. eCollection 2016.
2. H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference. Chen M, etal., PLoS One. 2019 Aug 23;14(8):e0221506. doi: 10.1371/journal.pone.0221506. eCollection 2019.
3. Withdrawal induces distinct patterns of FosB/∆FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization. De Pauli RF, etal., Pharmacol Biochem Behav. 2014 Feb;117:70-8. doi: 10.1016/j.pbb.2013.12.007. Epub 2013 Dec 16.
4. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. El Rawas R, etal., Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.
5. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
6. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. Gajewski PA, etal., PLoS One. 2016 Aug 5;11(8):e0160355. doi: 10.1371/journal.pone.0160355. eCollection 2016.
7. Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction. García-García F, etal., Alcohol. 2021 Jun;93:63-70. doi: 10.1016/j.alcohol.2021.02.004. Epub 2021 Mar 1.
8. Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. García-Pérez D, etal., PLoS One. 2012;7(11):e50264. doi: 10.1371/journal.pone.0050264. Epub 2012 Nov 21.
9. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
10. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Guo L, etal., Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi: 10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.
11. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
12. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Hiroi N, etal., Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10397-402. doi: 10.1073/pnas.94.19.10397.
13. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
14. Differences in basal and morphine-induced FosB/DeltaFosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats. Kaste K, etal., Pharmacol Biochem Behav. 2009 Jun;92(4):655-62. doi: 10.1016/j.pbb.2009.03.004. Epub 2009 Mar 24.
15. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Larson EB, etal., J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3.
16. Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Li J, etal., Alcohol Clin Exp Res. 2010 Oct;34(10):1742-50. doi: 10.1111/j.1530-0277.2010.01261.x. Epub 2010 Jul 9.
17. Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions. Li J, etal., PLoS One. 2012;7(7):e40347. doi: 10.1371/journal.pone.0040347. Epub 2012 Jul 9.
18. Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats. Liu H, etal., Neurosci Lett. 2011 Apr 20;494(1):70-4. doi: 10.1016/j.neulet.2011.02.059. Epub 2011 Mar 6.
19. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Marttila K, etal., Brain Res. 2007 Jul 30;1160:82-90. doi: 10.1016/j.brainres.2007.05.036. Epub 2007 May 31.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats. Moon S, etal., Neurochem Res. 2019 Apr;44(4):874-883. doi: 10.1007/s11064-019-02720-9. Epub 2019 Jan 10.
23. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
24. Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
25. Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
26. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. Núñez C, etal., J Neurochem. 2010 Jul;114(2):475-87. doi: 10.1111/j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice. Robins MT, etal., PLoS One. 2016 Jul 5;11(7):e0158189. doi: 10.1371/journal.pone.0158189. eCollection 2016.
31. Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Ryabinin AE and Wang YM, Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54.
32. Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
33. Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA. van de Wetering R and Schenk S, Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.
34. Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway. Yazdanfar N, etal., Brain Res Bull. 2021 May;170:98-105. doi: 10.1016/j.brainresbull.2021.02.005. Epub 2021 Feb 13.
35. Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. Zhu H, etal., Hum Mol Genet. 2007 Apr 1;16(7):820-36. doi: 10.1093/hmg/ddm027.
Additional References at PubMed
PMID:1741260   PMID:2498083   PMID:8668344   PMID:8706134   PMID:8757326   PMID:8889548   PMID:9204924   PMID:9530622   PMID:9710644   PMID:9712664   PMID:9858769   PMID:10349636  
PMID:10352021   PMID:10834841   PMID:10973317   PMID:11006248   PMID:11039731   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11526197   PMID:11893245   PMID:12220541   PMID:12223567  
PMID:12376177   PMID:12477932   PMID:12525489   PMID:14681479   PMID:14741752   PMID:15024071   PMID:15276803   PMID:15327773   PMID:15652785   PMID:15866165   PMID:16141072   PMID:16141073  
PMID:16263220   PMID:16313514   PMID:16380431   PMID:16602821   PMID:16699069   PMID:16869965   PMID:17482371   PMID:17640529   PMID:17707653   PMID:18287559   PMID:18407360   PMID:18423429  
PMID:18433296   PMID:18630601   PMID:18753407   PMID:19041372   PMID:19303854   PMID:19331462   PMID:19574399   PMID:19890265   PMID:20226774   PMID:20412781   PMID:20473292   PMID:20813842  
PMID:21215388   PMID:21258411   PMID:21267068   PMID:21677750   PMID:21679928   PMID:21873635   PMID:21962331   PMID:21996678   PMID:22308434   PMID:22461201   PMID:22474389   PMID:22950040  
PMID:23102405   PMID:23303048   PMID:23319622   PMID:23475960   PMID:23601929   PMID:24118411   PMID:24194600   PMID:24623766   PMID:24771617   PMID:25193242   PMID:25313003   PMID:25347353  
PMID:26099530   PMID:26416771   PMID:26446228   PMID:26555229   PMID:26718003   PMID:26731014   PMID:27147595   PMID:27282087   PMID:27626380   PMID:28462942   PMID:28724635   PMID:29035369  
PMID:29181403   PMID:29272704   PMID:29408867   PMID:29891732   PMID:30902680   PMID:30998833   PMID:31291246   PMID:31455727   PMID:32877400   PMID:32901027   PMID:33299180   PMID:34211013  
PMID:35020897   PMID:36002569   PMID:36359852   PMID:37173692   PMID:37252932   PMID:37517704   PMID:38355793   PMID:38642602  


Genomics

Comparative Map Data
Fosb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,036,621 - 19,043,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,036,621 - 19,043,976 (-)EnsemblGRCm39 Ensembl
GRCm38719,302,696 - 19,310,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,888,045 - 19,895,394 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,461,436 - 18,468,273 (-)NCBIMGSCv36mm8
Celera716,719,831 - 16,727,180 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.56NCBI
FOSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,467,996 - 45,475,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,467,995 - 45,475,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,971,254 - 45,978,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,663,093 - 50,670,276 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,663,092 - 50,670,276NCBI
Celera1942,777,353 - 42,784,537 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,400,874 - 42,408,060 (+)NCBIHuRef
CHM1_11945,974,496 - 45,981,682 (+)NCBICHM1_1
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBIT2T-CHM13v2.0
Fosb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,082,324 - 88,089,506 (-)NCBIGRCr8
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
Fosb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,438,864 - 2,445,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,438,864 - 2,445,846 (+)NCBIChiLan1.0ChiLan1.0
FOSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,628,596 - 51,636,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,500,106 - 53,507,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,416,781 - 42,424,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,013,350 - 51,020,570 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,013,350 - 51,020,570 (+)Ensemblpanpan1.1panPan2
FOSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,088,686 - 110,092,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,087,036 - 110,092,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,572,939 - 109,577,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,619,054 - 110,625,469 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,619,068 - 110,625,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,297,099 - 110,301,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,931,231 - 109,935,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,800,596 - 110,804,728 (-)NCBIUU_Cfam_GSD_1.0
Fosb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,553,572 - 17,560,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,900,931 - 1,906,772 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,900,954 - 1,907,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,837,719 - 51,844,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,836,780 - 51,844,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FOSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,916,039 - 38,924,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,534,366 - 18,539,824 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,328,691 - 2,339,099 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,332,746 - 2,338,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fosb
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1031
Count of miRNA genes:511
Interacting mature miRNAs:632
Transcripts:ENSMUST00000003640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000003640   ⟹   ENSMUSP00000003640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,036,621 - 19,043,976 (-)Ensembl
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207334   ⟹   ENSMUSP00000147210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,036,626 - 19,043,971 (-)Ensembl
GRCm38.p6 Ensembl719,302,701 - 19,310,046 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207716   ⟹   ENSMUSP00000146949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,036,627 - 19,043,971 (-)Ensembl
GRCm38.p6 Ensembl719,302,702 - 19,310,046 (-)Ensembl
Ensembl Acc Id: ENSMUST00000208230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,040,341 - 19,043,969 (-)Ensembl
GRCm38.p6 Ensembl719,306,416 - 19,310,044 (-)Ensembl
Ensembl Acc Id: ENSMUST00000208326   ⟹   ENSMUSP00000146569
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,036,627 - 19,043,971 (-)Ensembl
GRCm38.p6 Ensembl719,302,702 - 19,310,046 (-)Ensembl
Ensembl Acc Id: ENSMUST00000208446   ⟹   ENSMUSP00000146789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,038,722 - 19,043,525 (-)Ensembl
GRCm38.p6 Ensembl719,304,797 - 19,309,600 (-)Ensembl
Ensembl Acc Id: ENSMUST00000208505   ⟹   ENSMUSP00000146525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,036,627 - 19,043,971 (-)Ensembl
GRCm38.p6 Ensembl719,302,702 - 19,310,046 (-)Ensembl
RefSeq Acc Id: NM_001347586   ⟹   NP_001334515
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,036,621 - 19,043,970 (-)NCBI
GRCm38719,302,696 - 19,310,045 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008036   ⟹   NP_032062
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,036,621 - 19,043,970 (-)NCBI
GRCm38719,302,696 - 19,310,045 (-)NCBI
MGSCv37719,888,045 - 19,895,394 (-)RGD
Celera716,719,831 - 16,727,180 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032062   ⟸   NM_008036
- Peptide Label: isoform 1
- UniProtKB: A0A140LIE4 (UniProtKB/Swiss-Prot),   P13346 (UniProtKB/Swiss-Prot),   A2RSD4 (UniProtKB/TrEMBL),   A0A140LHW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334515   ⟸   NM_001347586
- Peptide Label: isoform 2
- UniProtKB: A0A140LIE4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000146525   ⟸   ENSMUST00000208505
Ensembl Acc Id: ENSMUSP00000146789   ⟸   ENSMUST00000208446
Ensembl Acc Id: ENSMUSP00000146569   ⟸   ENSMUST00000208326
Ensembl Acc Id: ENSMUSP00000003640   ⟸   ENSMUST00000003640
Ensembl Acc Id: ENSMUSP00000147210   ⟸   ENSMUST00000207334
Ensembl Acc Id: ENSMUSP00000146949   ⟸   ENSMUST00000207716
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13346-F1-model_v2 AlphaFold P13346 1-338 view protein structure

Promoters
RGD ID:6892070
Promoter ID:EPDNEW_M9486
Type:initiation region
Name:Fosb_1
Description:Mus musculus FBJ osteosarcoma oncogene B , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38719,310,045 - 19,310,105EPDNEW
RGD ID:6841131
Promoter ID:MM_KWN:49050
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4
Transcripts:NM_008036
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36719,895,001 - 19,895,501 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95575 AgrOrtholog
Ensembl Genes ENSMUSG00000003545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003640 ENTREZGENE
  ENSMUST00000003640.4 UniProtKB/Swiss-Prot
  ENSMUST00000207334.2 UniProtKB/TrEMBL
  ENSMUST00000207716.2 UniProtKB/TrEMBL
  ENSMUST00000208326.2 UniProtKB/TrEMBL
  ENSMUST00000208446 ENTREZGENE
  ENSMUST00000208446.2 UniProtKB/Swiss-Prot
  ENSMUST00000208505.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95575 ENTREZGENE
NCBI Gene 14282 ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fosb PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LHS3_MOUSE UniProtKB/TrEMBL
  A0A140LHW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A140LIE4 ENTREZGENE
  A0A140LIT4_MOUSE UniProtKB/TrEMBL
  A0A140LJH0_MOUSE UniProtKB/TrEMBL
  A2RSD4 ENTREZGENE, UniProtKB/TrEMBL
  FOSB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A140LIE4 UniProtKB/Swiss-Prot