Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Rattus norvegicus
Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1308542
Description: Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Autosomal Dominant Intellectual Developmental Disorder 70  (ISO)
Binge Drinking  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IEP)
Carotid Atherosclerosis  (ISO)
cocaine dependence  (IEP)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (IEP,IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (IEP)
Insulin Resistance  (IDA,ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (IEP)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IDA,IEP,ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IEP,IMP,ISO)
osteoporosis  (IDA,IMP)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
steatotic liver disease  (ISO,ISS)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
Ventricular Dysfunction, Left  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylglutaric acid  (EXP)
3-nitropropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP,ISO)
bafilomycin A1  (EXP)
baicalein  (ISO)
benzamide  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenanthridine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
Betanin  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (EXP)
calcium oxalate  (ISO)
calycosin  (EXP)
camptothecin  (ISO)
capsaicin  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carteolol  (ISO)
catalpol  (ISO)
CAY10591  (ISO)
CDP-choline  (EXP)
CGS-21680  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium(6+)  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
corynoline  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproheptadine  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dihydrogen  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium  (ISO)
disulfiram  (ISO)
dizocilpine  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ergosterol  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
everolimus  (ISO)
excitatory amino acid agonist  (EXP)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fisetin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Garcinol  (ISO)
Genipin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycyrrhizinic acid  (EXP)
glyoxylic acid  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP,ISO)
imidacloprid  (ISO)
inositol  (EXP)
ionomycin  (EXP)
iprodione  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoquinoline-1,5-diol  (ISO)
kainic acid  (EXP,ISO)
ketoconazole  (EXP)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licarin A  (ISO)
linagliptin  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Magnolol  (EXP)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methylglyoxal  (EXP)
metiram  (ISO)
mifepristone  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monooxygen  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP,ISO)
naringin  (EXP,ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (EXP)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
organoselenium compound  (EXP)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
polymyxin B2  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
prasugrel hydrochloride  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrethrins  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
ramipril  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-nitroso-L-cysteine  (ISO)
salicylic acid  (EXP)
Salidroside  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
splitomicin  (EXP,ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
suramin  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
trans-piceid  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
behavioral response to starvation  (IEA,ISO)
cardiac muscle cell apoptotic process  (IMP)
cellular response to amyloid-beta  (IEP,IMP)
cellular response to antibiotic  (IEP)
cellular response to curcumin  (IEP)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to resveratrol  (IMP)
cellular response to rotenone  (IEP)
cellular response to starvation  (IEA,ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (IEP)
cholesterol homeostasis  (IEA,ISO)
chromatin organization  (ISO)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (IEA,ISO)
circadian rhythm  (ISO)
DNA damage response  (ISO)
DNA repair-dependent chromatin remodeling  (ISO)
DNA synthesis involved in DNA repair  (IEA,ISO)
energy homeostasis  (IMP,ISO)
fatty acid homeostasis  (IEA,ISO)
heterochromatin formation  (IEA,ISO)
intracellular glucose homeostasis  (IEA,ISO)
intracellular triglyceride homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (IEA,ISO)
macrophage differentiation  (IEA,ISO)
maintenance of nucleus location  (ISO)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (IMP)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-templated transcription  (IBA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fibroblast apoptotic process  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (IMP)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of phosphorylation  (IEA,ISO)
negative regulation of prostaglandin biosynthetic process  (IEA,ISO)
negative regulation of protein acetylation  (IMP,ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of TOR signaling  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of triglyceride biosynthetic process  (ISO)
negative regulation of tumor necrosis factor production  (IMP)
neuron apoptotic process  (IMP)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of DNA repair  (ISO)
positive regulation of double-strand break repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IEA,IMP,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (IMP)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of macrophage apoptotic process  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein deacetylation  (IMP)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of skeletal muscle cell proliferation  (IMP)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of thyroid-stimulating hormone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (IDA)
protein destabilization  (IEA,ISO)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (IEA,ISO)
rDNA heterochromatin formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (IEA,ISO)
regulation of brown fat cell differentiation  (IEA,ISO)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO,ISS)
regulation of glucose metabolic process  (ISO)
regulation of lipid storage  (IEA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
regulation of smooth muscle cell apoptotic process  (IEA,ISO)
regulation of transcription by glucose  (ISO)
response to cocaine  (IEP)
response to ethanol  (IDA)
response to fluoride  (IEP)
response to hydrogen peroxide  (ISO)
response to insulin  (IEA,ISO)
response to kainic acid  (IEP)
response to leptin  (ISO)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to oxidative stress  (ISO)
response to resveratrol  (IEP)
single strand break repair  (ISO)
spermatogenesis  (IEA,ISO)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (IEA,ISO)
UV-damage excision repair  (ISO)
vasodilation  (IMP)
white fat cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. Akieda-Asai S, etal., PLoS One. 2010 Jul 23;5(7):e11755. doi: 10.1371/journal.pone.0011755.
2. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Alcendor RR, etal., Circ Res. 2004 Nov 12;95(10):971-80. Epub 2004 Oct 14.
3. 17-beta Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation. Bendale DS, etal., Br J Pharmacol. 2013 Oct;170(4):779-95. doi: 10.1111/bph.12290.
4. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. Bordone L, etal., PLoS Biol. 2006 Feb;4(2):e31. Epub 2005 Dec 27.
5. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. Castro RE, etal., J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15.
6. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. Caton PW, etal., J Endocrinol. 2011 Mar;208(3):273-83. doi: 10.1530/JOE-10-0190. Epub 2011 Jan 6.
7. [SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models]. Chen Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Apr;33(4):528-32.
8. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Choi J, etal., Ann Clin Transl Neurol. 2014 Aug;1(8):589-604. doi: 10.1002/acn3.86. Epub 2014 Aug 19.
9. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Cohen HY, etal., Science. 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17.
10. SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. Costa Cdos S, etal., Obes Surg. 2010 May;20(5):633-9. doi: 10.1007/s11695-009-0052-z. Epub 2009 Dec 22.
11. Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide alpha-MSH and the processing enzyme CPE production in diet-induced obese male rats. Cyr NE, etal., Endocrinology. 2014 Jul;155(7):2423-35. doi: 10.1210/en.2013-1998. Epub 2014 Apr 28.
12. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Della-Morte D, etal., Neuroscience. 2009 Mar 31;159(3):993-1002. Epub 2009 Jan 19.
13. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. Deng XQ, etal., Liver Int. 2007 Jun;27(5):708-15.
14. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Erion DM, etal., Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. doi: 10.1073/pnas.0812931106. Epub 2009 Jun 22.
15. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kappaB signaling pathway. Feng J, etal., Acta Biochim Biophys Sin (Shanghai). 2014 Dec;46(12):1024-33. doi: 10.1093/abbs/gmu103. Epub 2014 Nov 6.
16. Resveratrol inhibits beta-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway. Feng X, etal., PLoS One. 2013;8(3):e59888. doi: 10.1371/journal.pone.0059888. Epub 2013 Mar 28.
17. Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells. Fujino K, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:148-53. doi: 10.1016/j.neulet.2013.10.050. Epub 2013 Oct 29.
18. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. Gao Z, etal., J Biol Chem. 2011 Jun 24;286(25):22227-34. doi: 10.1074/jbc.M111.228874. Epub 2011 May 3.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Gorenne I, etal., Circulation. 2013 Jan 22;127(3):386-96. doi: 10.1161/CIRCULATIONAHA.112.124404. Epub 2012 Dec 7.
21. The nucleolus-guardian of cellular homeostasis and genome integrity. Grummt I Chromosoma. 2013 Dec;122(6):487-97.
22. Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. Hurtado O, etal., J Neurochem. 2013 Sep;126(6):819-26. doi: 10.1111/jnc.12269. Epub 2013 May 13.
23. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Jeong H, etal., Nat Med. 2011 Dec 18;18(1):159-65. doi: 10.1038/nm.2559.
24. Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Jian B, etal., Biochim Biophys Acta. 2011 Nov;1812(11):1446-51. doi: 10.1016/j.bbadis.2011.04.010. Epub 2011 Apr 30.
25. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Jian B, etal., Mol Med. 2012 Mar 27;18:209-14. doi: 10.2119/molmed.2011.00365.
26. Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals. Joseph AM, etal., Exp Gerontol. 2013 Sep;48(9):858-68. doi: 10.1016/j.exger.2013.05.061. Epub 2013 Jun 7.
27. Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. Kahyo T, etal., FEBS Lett. 2008 Jul 23;582(17):2479-83. doi: 10.1016/j.febslet.2008.06.031. Epub 2008 Jun 25.
28. Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors. Kataoka T, etal., J Sex Med. 2014 Apr;11(4):920-9. doi: 10.1111/jsm.12447. Epub 2014 Jan 28.
29. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. Kim D, etal., EMBO J. 2007 Jul 11;26(13):3169-79. Epub 2007 Jun 21.
30. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
31. Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity. Lei M, etal., Eur J Pharmacol. 2012 Jan 15;674(2-3):73-9. doi: 10.1016/j.ejphar.2011.10.015. Epub 2011 Oct 25.
32. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Lempiainen J, etal., Br J Pharmacol. 2012 Jul;166(6):1905-15. doi: 10.1111/j.1476-5381.2012.01895.x.
33. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. Li L, etal., Can J Physiol Pharmacol. 2009 Jan;87(1):56-62. doi: 10.1139/Y08-099.
34. Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3. Li XH, etal., Mol Neurobiol. 2013 Dec;48(3):490-9. doi: 10.1007/s12035-013-8437-3. Epub 2013 Mar 10.
35. SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. Lovaas JD, etal., Prostate. 2013 Apr;73(5):522-30. doi: 10.1002/pros.22592. Epub 2012 Oct 4.
36. LncRNA H19 inhibits high glucose-induced inflammatory responses of human retinal epithelial cells by targeting miR-19b to increase SIRT1 expression. Luo R, etal., Kaohsiung J Med Sci. 2021 Feb;37(2):101-110. doi: 10.1002/kjm2.12302. Epub 2020 Oct 6.
37. Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals. Machida S and Booth FW, Exp Gerontol. 2004 Oct;39(10):1521-5.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Milne JC, etal., Nature. 2007 Nov 29;450(7170):712-6.
40. Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis. Monteserin-Garcia J, etal., FASEB J. 2013 Apr;27(4):1561-71. doi: 10.1096/fj.12-220129. Epub 2013 Jan 4.
41. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Nascimento AF, etal., Hepatobiliary Surg Nutr. 2013 Oct;2(5):252-9. doi: 10.3978/j.issn.2304-3881.2013.07.05.
42. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
43. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies. Pallas M, etal., Neuroscience. 2008 Jul 17;154(4):1388-97. doi: 10.1016/j.neuroscience.2008.04.065. Epub 2008 May 3.
44. Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. Peng CH, etal., Biomaterials. 2011 Dec;32(34):9077-88. doi: 10.1016/j.biomaterials.2011.08.008. Epub 2011 Sep 3.
45. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
46. Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. Pillai JB, etal., J Biol Chem. 2005 Dec 30;280(52):43121-30. Epub 2005 Oct 5.
47. Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. Prins SA, etal., PLoS One. 2014 Jan 8;9(1):e83166. doi: 10.1371/journal.pone.0083166. eCollection 2014.
48. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Qin W, etal., J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2.
49. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Rajamohan SB, etal., Mol Cell Biol. 2009 Aug;29(15):4116-29. doi: 10.1128/MCB.00121-09. Epub 2009 May 26.
50. Sirt1 increases skeletal muscle precursor cell proliferation. Rathbone CR, etal., Eur J Cell Biol. 2009 Jan;88(1):35-44. doi: 10.1016/j.ejcb.2008.08.003. Epub 2008 Oct 14.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Sakao Y, etal., Clin Exp Nephrol. 2011 Jun;15(3):363-72. doi: 10.1007/s10157-011-0421-5. Epub 2011 Mar 18.
56. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Schilling G, etal., Hum Mol Genet. 1999 Mar;8(3):397-407.
57. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Shen Z, etal., Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53. doi: 10.1152/ajpgi.00016.2009. Epub 2009 Mar 19.
58. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells. Sugino T, etal., FEBS Lett. 2010 Jul 2;584(13):2821-6. doi: 10.1016/j.febslet.2010.04.063. Epub 2010 Apr 29.
59. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-beta25-35 in rat cortical neurons. Sun Q, etal., Biochem Biophys Res Commun. 2014 May 23;448(1):89-94. doi: 10.1016/j.bbrc.2014.04.066. Epub 2014 Apr 19.
60. Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. Suzuki M and Bartlett JD, Biochim Biophys Acta. 2014 Feb;1842(2):245-55. doi: 10.1016/j.bbadis.2013.11.023. Epub 2013 Dec 1.
61. Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension. Takemori K, etal., Life Sci. 2011 Jun 20;88(25-26):1088-94. doi: 10.1016/j.lfs.2011.04.002. Epub 2011 Apr 14.
62. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. Tanno M, etal., J Biol Chem. 2010 Jan 20.
63. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
64. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
65. Obesity accelerates ovarian follicle development and follicle loss in rats. Wang N, etal., Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.
66. SIRT1 inhibits TNF-alpha-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Wang W, etal., Apoptosis. 2013 Jun;18(6):689-701. doi: 10.1007/s10495-013-0833-7.
67. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. Wu A, etal., J Neurotrauma. 2007 Oct;24(10):1587-95.
68. Novel Role of Resveratrol: Suppression of HMGB1 Nucleocytoplasmic Translocation by the Up-Regulation of SIRT1 in Sepsis-Induced Liver Injury. Xu W, etal., Shock. 2014 Jul 4.
69. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury. Yan H, etal., Crit Care Med. 2014 May;42(5):e373-81. doi: 10.1097/CCM.0000000000000246.
70. Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis. Yang J, etal., Arch Med Res. 2011 Jul;42(5):354-60. doi: 10.1016/j.arcmed.2011.07.005. Epub 2011 Jul 31.
71. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Yar AS, etal., Genet Mol Res. 2011 Nov 29;10(4):2962-75. doi: 10.4238/2011.November.29.7.
72. Resveratrol ameliorates experimental autoimmune myocarditis. Yoshida Y, etal., Circ J. 2007 Mar;71(3):397-404.
73. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Yoshizaki T, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8.
74. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Zarzuelo MJ, etal., Biochem Pharmacol. 2013 May 1;85(9):1288-96. doi: 10.1016/j.bcp.2013.02.015. Epub 2013 Feb 17.
75. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Zhang J, etal., Age (Dordr). 2013 Jun;35(3):807-20. doi: 10.1007/s11357-012-9412-z. Epub 2012 May 4.
76. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.
77. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. Zhang QS, etal., J Biosci. 2017 Sep;42(3):397-404.
78. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Zheng T and Lu Y, Curr Eye Res. 2011 May;36(5):449-55. doi: 10.3109/02713683.2011.559301.
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