(+)-epicatechin-3-O-gallate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 (+)-pilocarpine multiple interactions EXP 6480464 dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] more ... CTD PMID:23211629 (+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of SIRT1 protein CTD PMID:23211629 (+)-taxifolin multiple interactions EXP 6480464 taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] and taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 and PMID:36198370 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein CTD PMID:22742579 (-)-epigallocatechin 3-gallate multiple interactions ISO Sirt1 (Mus musculus) 6480464 epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 mRNA] and epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] CTD PMID:36056792 (-)-epigallocatechin 3-gallate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 (20S)-ginsenoside Rg3 increases activity EXP 6480464 ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 (R)-carnitine multiple interactions EXP 6480464 Carnitine inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:37312617 (R)-lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of SIRT1 protein CTD PMID:22327056 (R)-lipoic acid increases expression ISO Sirt1 (Mus musculus) 6480464 Thioctic Acid results in increased expression of SIRT1 mRNA CTD PMID:37739047 (R)-lipoic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] CTD PMID:37739047 (R)-lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 (S)-naringenin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA CTD PMID:36235125 (S)-nicotine decreases expression ISO Sirt1 (Mus musculus) 6480464 Nicotine results in decreased expression of SIRT1 mRNA CTD PMID:22687363 (S)-nicotine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA more ... CTD PMID:23199342 (S)-nicotine multiple interactions ISO Sirt1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] CTD PMID:22687363 1,2-dimethylhydrazine multiple interactions ISO Sirt1 (Mus musculus) 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of SIRT1 mRNA] CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO Sirt1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of SIRT1 mRNA CTD PMID:22206623 1-naphthyl isothiocyanate multiple interactions ISO Sirt1 (Mus musculus) 6480464 liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA] and liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] CTD PMID:36008890 1-naphthyl isothiocyanate decreases expression ISO Sirt1 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein CTD PMID:36008890 17alpha-ethynylestradiol decreases phosphorylation ISO Sirt1 (Mus musculus) 6480464 Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein CTD PMID:34058177 17alpha-ethynylestradiol multiple interactions ISO Sirt1 (Mus musculus) 6480464 Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein] CTD PMID:34058177 17beta-estradiol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]] CTD PMID:24771768 17beta-estradiol decreases expression ISO SIRT1 (Homo sapiens) 6480464 Estradiol results in decreased expression of SIRT1 mRNA CTD PMID:32030086 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sirt1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SIRT1 mRNA CTD PMID:21570461 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of SIRT1 protein CTD PMID:24782617 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of SIRT1 mRNA CTD PMID:21346803 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of SIRT1 protein CTD PMID:19167416 2-butoxyethanol increases expression ISO Sirt1 (Mus musculus) 6480464 n-butoxyethanol results in increased expression of SIRT1 mRNA CTD PMID:19812364 2-methylcholine affects expression ISO SIRT1 (Homo sapiens) 6480464 beta-methylcholine affects the expression of SIRT1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Sirt1 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 3,3',5-triiodo-L-thyronine affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Triiodothyronine CTD PMID:23209300 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein] more ... CTD PMID:23209300 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of SIRT1 mRNA CTD PMID:23209300 3,4-methylenedioxymethamphetamine decreases expression ISO Sirt1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SIRT1 mRNA CTD PMID:26251327 3-hydroxybutyric acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] more ... CTD PMID:26435214 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Sirt1 (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein more ... CTD PMID:29288687 and PMID:34968464 3-methylglutaric acid decreases expression EXP 6480464 3-methylglutaric acid results in decreased expression of SIRT1 protein CTD PMID:32169667 3-methylglutaric acid multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [3-methylglutaric acid results in decreased expression of SIRT1 protein] CTD PMID:32169667 3-nitropropanoic acid decreases expression ISO Sirt1 (Mus musculus) 6480464 3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 3-nitropropanoic acid decreases expression EXP 6480464 3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT1 mRNA CTD PMID:36041667 4-hydroxynon-2-enal multiple interactions ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal] CTD PMID:24633890 4-nitrophenol decreases expression ISO Sirt1 (Mus musculus) 6480464 4-nitrophenol results in decreased expression of SIRT1 mRNA CTD PMID:34673133 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA] more ... CTD PMID:29653943 5-(2-chloroethyl)-4-methylthiazole decreases expression ISO Sirt1 (Mus musculus) 6480464 Chlormethiazole results in decreased expression of SIRT1 protein CTD PMID:24892905 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO Sirt1 (Mus musculus) 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:24892905 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:20426787 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression EXP 6480464 6-chloro-2 more ... CTD PMID:29653943 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:32017914 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:29990529 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:29545174 and PMID:37436145 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity EXP 6480464 6-chloro-2 more ... CTD PMID:22968147 and PMID:32087266 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:21212096 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:20426787 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:20370652 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide increases expression ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:24726431 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SIRT1 mRNA and Propylthiouracil results in decreased expression of SIRT1 protein CTD PMID:34609722 and PMID:36506574 6-propyl-2-thiouracil multiple interactions EXP 6480464 thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 mRNA] and thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 protein] CTD PMID:36506574 6alpha-methylprednisolone multiple interactions ISO Sirt1 (Mus musculus) 6480464 Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 8-Br-cAMP multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein CTD PMID:16709600 acadesine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 acadesine increases expression ISO SIRT1 (Homo sapiens) 6480464 acadesine results in increased expression of SIRT1 protein CTD PMID:28556920 acetic acid multiple interactions EXP 6480464 Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] and Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] CTD PMID:35122774 acetic acid decreases expression EXP 6480464 Acetic Acid results in decreased expression of SIRT1 mRNA CTD PMID:35122774 acetylcholine affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Acetylcholine CTD PMID:23422569 acetylsalicylic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] more ... CTD PMID:19520256 actinomycin D multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] CTD PMID:30055241 actinomycin D multiple interactions ISO Sirt1 (Mus musculus) 6480464 TAF15 mRNA inhibits the reaction [Dactinomycin results in decreased expression of SIRT1 mRNA] CTD PMID:35307376 aflatoxin B1 increases expression ISO Sirt1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of SIRT1 mRNA CTD PMID:19770486 aflatoxin B1 multiple interactions EXP 6480464 [Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA more ... CTD PMID:32894639 aflatoxin M1 decreases expression ISO SIRT1 (Homo sapiens) 6480464 Aflatoxin M1 results in decreased expression of SIRT1 mRNA CTD PMID:30928695 agomelatine multiple interactions EXP 6480464 agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] CTD PMID:36356678 AICA ribonucleotide multiple interactions ISO Sirt1 (Mus musculus) 6480464 AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:22058332 more ... AICA ribonucleotide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] CTD PMID:27688165 AICA ribonucleotide multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide CTD PMID:25108154 AICA ribonucleotide increases expression ISO Sirt1 (Mus musculus) 6480464 AICA ribonucleotide results in increased expression of SIRT1 protein CTD PMID:24465016 aldehydo-D-glucose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... aldehydo-D-glucose increases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA and Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 and PMID:24802182 aldehydo-D-glucose increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 aldehydo-D-glucose decreases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... aldehydo-D-glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 aldehydo-D-glucose affects abundance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 aldehydo-D-glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 aldehydo-D-glucose decreases response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 aldehydo-D-glucose decreases expression ISO Sirt1 (Mus musculus) 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 and PMID:23090186 aldehydo-D-glucose multiple interactions ISO Sirt1 (Mus musculus) 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... aldehydo-D-glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA more ... CTD PMID:33051911 more ... alpha-D-galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] CTD PMID:25892055 alpha-D-galactose decreases expression ISO SIRT1 (Homo sapiens) 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:29426000 alpha-D-galactose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 alpha-D-galactose decreases expression EXP 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:25892055 amino acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 aminoguanidine multiple interactions EXP 6480464 [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] CTD PMID:22669716 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO SIRT1 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]] and pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein] CTD PMID:31082419 antimony trichloride decreases expression ISO SIRT1 (Homo sapiens) 6480464 antimony trichloride results in decreased expression of SIRT1 mRNA and antimony trichloride results in decreased expression of SIRT1 protein CTD PMID:30055241 antimony trichloride multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] more ... CTD PMID:30055241 apocynin multiple interactions ISO Sirt1 (Mus musculus) 6480464 acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 aristolochic acid A multiple interactions EXP 6480464 Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA] and Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein] CTD PMID:36037877 aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of SIRT1 mRNA and aristolochic acid I results in decreased expression of SIRT1 protein CTD PMID:36037877 arsenite(3-) multiple interactions ISO SIRT1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to SIRT1 mRNA] more ... CTD PMID:23744399 more ... arsenite(3-) decreases expression ISO SIRT1 (Homo sapiens) 6480464 arsenite results in decreased expression of SIRT1 mRNA CTD PMID:23744399 arsenite(3-) increases expression ISO SIRT1 (Homo sapiens) 6480464 arsenite results in increased expression of SIRT1 mRNA and arsenite results in increased expression of SIRT1 protein CTD PMID:25281835 arsenite(3-) increases methylation ISO SIRT1 (Homo sapiens) 6480464 arsenite results in increased methylation of SIRT1 promoter CTD PMID:25281835 arsenous acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Arsenic Trioxide promotes the reaction [NVP-BKM120 results in decreased expression of SIRT1 mRNA] CTD PMID:30316766 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SIRT1 protein CTD PMID:33173984 arsenous acid multiple interactions EXP 6480464 Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein] and trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein] CTD PMID:31332900 and PMID:33173984 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SIRT1 protein CTD PMID:31332900 arsenous acid decreases expression ISO SIRT1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SIRT1 mRNA CTD PMID:19763917 aspartame multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 atorvastatin calcium increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Atorvastatin results in increased phosphorylation of SIRT1 protein CTD PMID:33073877 atorvastatin calcium multiple interactions EXP 6480464 [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein] CTD PMID:34939712 ATP multiple interactions EXP 6480464 [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] more ... CTD PMID:16366736 ATP multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [STK11 protein co-treated with Adenosine Triphosphate] results in increased activity of and results in increased phosphorylation of SIRT1 protein CTD PMID:34216621 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of SIRT1 mRNA CTD PMID:27114639 and PMID:34663174 atrazine decreases expression ISO SIRT1 (Homo sapiens) 6480464 Atrazine results in decreased expression of SIRT1 mRNA CTD PMID:27114639 bafilomycin A1 multiple interactions EXP 6480464 bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] CTD PMID:24889822 baicalein multiple interactions ISO SIRT1 (Homo sapiens) 6480464 baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein] more ... CTD PMID:37354967 benzamide decreases activity ISO SIRT1 (Homo sapiens) 6480464 benzamide analog results in decreased activity of SIRT1 protein CTD PMID:19616958 benzo[a]pyrene diol epoxide I decreases expression ISO SIRT1 (Homo sapiens) 6480464 7 more ... CTD PMID:37436145 benzo[a]pyrene diol epoxide I multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:37436145 benzophenanthridine decreases expression ISO SIRT1 (Homo sapiens) 6480464 Benzophenanthridines analog results in decreased expression of SIRT1 mRNA CTD PMID:23117580 berberine decreases expression ISO SIRT1 (Homo sapiens) 6480464 Berberine results in decreased expression of SIRT1 mRNA and Berberine results in decreased expression of SIRT1 protein CTD PMID:26712469 berberine multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein] CTD PMID:35121005 berberine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein and SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein] CTD PMID:26712469 Bergenin multiple interactions EXP 6480464 bergenin inhibits the reaction [Cadmium results in decreased expression of SIRT1 protein] CTD PMID:37949422 Betanin multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:33661552 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [3-methylglutaric acid results in decreased expression of SIRT1 protein] CTD PMID:32169667 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA and Diethylhexyl Phthalate results in decreased expression of SIRT1 protein CTD PMID:32050098 and PMID:36198370 bis(2-ethylhexyl) phthalate decreases expression ISO SIRT1 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA and Diethylhexyl Phthalate results in decreased expression of SIRT1 protein CTD PMID:34822940 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA] more ... CTD PMID:32050098 and PMID:36198370 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SIRT1 mRNA and bisphenol A results in increased expression of SIRT1 protein CTD PMID:28067316 and PMID:30816183 bisphenol A multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Dietary Fats co-treated with bisphenol A co-treated with Cholesterol] results in decreased expression of SIRT1 protein and Resveratrol inhibits the reaction [[Dietary Fats co-treated with bisphenol A co-treated with Cholesterol] results in decreased expression of SIRT1 protein] CTD PMID:33239236 bisphenol A decreases expression ISO Sirt1 (Mus musculus) 6480464 bisphenol A results in decreased expression of SIRT1 mRNA CTD PMID:33239236 bisphenol A multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA CTD PMID:36235125 bisphenol A decreases expression ISO SIRT1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SIRT1 mRNA CTD PMID:36235125 bisphenol A decreases expression EXP 6480464 bisphenol A analog results in decreased expression of SIRT1 protein and bisphenol A results in decreased expression of SIRT1 protein CTD PMID:35810996 and PMID:35887390 bisphenol A increases expression ISO SIRT1 (Homo sapiens) 6480464 bisphenol A results in increased expression of SIRT1 mRNA CTD PMID:28765096 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT1 mRNA more ... CTD PMID:28067316 more ... bisphenol F decreases expression EXP 6480464 bisphenol F results in decreased expression of SIRT1 protein CTD PMID:35803362 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT1 mRNA CTD PMID:36041667 bleomycin A2 multiple interactions ISO Sirt1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 mRNA] and resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 protein] CTD PMID:25707573 bleomycin A2 decreases expression ISO Sirt1 (Mus musculus) 6480464 Bleomycin results in decreased expression of SIRT1 mRNA and Bleomycin results in decreased expression of SIRT1 protein CTD PMID:25707573 bortezomib decreases expression EXP 6480464 Bortezomib results in decreased expression of SIRT1 protein CTD PMID:35121005 bortezomib multiple interactions EXP 6480464 Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein] CTD PMID:35121005 buta-1,3-diene increases expression ISO Sirt1 (Mus musculus) 6480464 1 and 3-butadiene results in increased expression of SIRT1 mRNA CTD PMID:25237060 butein increases activity ISO SIRT1 (Homo sapiens) 6480464 butein results in increased activity of SIRT1 protein CTD PMID:17327447 Butylbenzyl phthalate decreases expression ISO SIRT1 (Homo sapiens) 6480464 butylbenzyl phthalate results in decreased expression of SIRT1 mRNA and butylbenzyl phthalate results in decreased expression of SIRT1 protein CTD PMID:26520405 Butylbenzyl phthalate decreases expression ISO Sirt1 (Mus musculus) 6480464 butylbenzyl phthalate results in decreased expression of SIRT1 mRNA and butylbenzyl phthalate results in decreased expression of SIRT1 protein CTD PMID:27923775 and PMID:34520170 cadmium atom multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein and Polystyrenes promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein] CTD PMID:37022104 cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of SIRT1 protein CTD PMID:37949422 cadmium atom multiple interactions EXP 6480464 [cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein more ... CTD PMID:33404196 more ... cadmium atom multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:25159133 cadmium dichloride multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Cadmium Chloride inhibits the reaction [SIRT1 protein binds to XBP1 protein alternative form] more ... CTD PMID:25159133 and PMID:30796460 cadmium dichloride multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein and Polystyrenes promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein] CTD PMID:37022104 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SIRT1 mRNA and Cadmium Chloride results in decreased expression of SIRT1 protein CTD PMID:31433112 more ... cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:31433112 more ... caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of SIRT1 mRNA and Caffeine results in decreased expression of SIRT1 protein CTD PMID:30776459 and PMID:30825513 caffeine affects phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of SIRT1 protein CTD PMID:35688186 caffeine decreases expression ISO SIRT1 (Homo sapiens) 6480464 Caffeine results in decreased expression of SIRT1 mRNA CTD PMID:30825513 caffeine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] more ... CTD PMID:30825513 Calcimycin affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Calcimycin CTD PMID:23422569 calcium oxalate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein] more ... CTD PMID:34333021 calcium oxalate decreases expression ISO SIRT1 (Homo sapiens) 6480464 Calcium Oxalate results in decreased expression of SIRT1 protein CTD PMID:34333021 calycosin multiple interactions EXP 6480464 7 and 3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein] CTD PMID:36436616 camptothecin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein more ... CTD PMID:24726431 camptothecin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Camptothecin results in decreased expression of SIRT1 protein CTD PMID:24726431 capsaicin affects expression ISO SIRT1 (Homo sapiens) 6480464 Capsaicin affects the expression of SIRT1 mRNA and Capsaicin affects the expression of SIRT1 protein CTD PMID:34939720 Carbaprostacyclin increases expression ISO Sirt1 (Mus musculus) 6480464 carboprostacyclin results in increased expression of SIRT1 mRNA CTD PMID:25339356 carbon nanotube decreases expression ISO Sirt1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 carnosic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]] more ... CTD PMID:24557422 carnosic acid increases expression ISO SIRT1 (Homo sapiens) 6480464 salvin results in increased expression of SIRT1 mRNA and salvin results in increased expression of SIRT1 protein CTD PMID:24557422 carteolol affects expression ISO SIRT1 (Homo sapiens) 6480464 Carteolol affects the expression of SIRT1 mRNA CTD PMID:37120125 catalpol multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:37436358 catalpol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] more ... CTD PMID:37436358 CAY10591 increases activity ISO SIRT1 (Homo sapiens) 6480464 CAY10591 results in increased activity of SIRT1 protein CTD PMID:34520103 CDP-choline increases expression EXP 6480464 Cytidine Diphosphate Choline results in increased expression of SIRT1 protein CTD PMID:23600725 CDP-choline multiple interactions EXP 6480464 Cytidine Diphosphate Choline results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:23600725 CGS-21680 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] CTD PMID:30825513 Chikusetsusaponin-V multiple interactions ISO SIRT1 (Homo sapiens) 6480464 chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] CTD PMID:25073091 chlorpyrifos multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA] more ... CTD PMID:30835941 chlorpyrifos decreases expression ISO Sirt1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SIRT1 mRNA CTD PMID:37019170 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of SIRT1 mRNA CTD PMID:33586219 and PMID:34060014 chlorpyrifos multiple interactions EXP 6480464 [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA and iprodione promotes the reaction [Chlorpyrifos results in decreased expression of SIRT1 mRNA] CTD PMID:33586219 and PMID:34060014 chlorpyrifos decreases expression ISO SIRT1 (Homo sapiens) 6480464 Chlorpyrifos results in decreased expression of SIRT1 mRNA and Chlorpyrifos results in decreased expression of SIRT1 protein CTD PMID:30835941 cholesterol multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:21212096 and PMID:25833014 cholesterol multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Dietary Fats co-treated with bisphenol A co-treated with Cholesterol] results in decreased expression of SIRT1 protein and Resveratrol inhibits the reaction [[Dietary Fats co-treated with bisphenol A co-treated with Cholesterol] results in decreased expression of SIRT1 protein] CTD PMID:33239236 chromium(6+) multiple interactions EXP 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] inhibits the reaction [TP53 protein modified form binds to SIRT1 protein] more ... CTD PMID:30974164 more ... chromium(6+) decreases expression EXP 6480464 chromium hexavalent ion results in decreased expression of SIRT1 mRNA and chromium hexavalent ion results in decreased expression of SIRT1 protein CTD PMID:35024197 cilostazol multiple interactions ISO Sirt1 (Mus musculus) 6480464 (E)-3-(2 more ... CTD PMID:24254769 cilostazol increases expression ISO SIRT1 (Homo sapiens) 6480464 cilostazol results in increased expression of SIRT1 protein CTD PMID:18556572 cilostazol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] more ... CTD PMID:19520256 cilostazol increases phosphorylation ISO Sirt1 (Mus musculus) 6480464 cilostazol results in increased phosphorylation of SIRT1 protein CTD PMID:24254769 cilostazol affects expression ISO Sirt1 (Mus musculus) 6480464 cilostazol affects the expression of SIRT1 mRNA CTD PMID:24254769 cisplatin multiple interactions ISO Sirt1 (Mus musculus) 6480464 Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:21593185 and PMID:26723870 cisplatin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SIRT1 protein CTD PMID:37497868 cisplatin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA and [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SIRT1 mRNA CTD PMID:27392435 and PMID:30871063 cisplatin increases expression ISO Sirt1 (Mus musculus) 6480464 Cisplatin results in increased expression of SIRT1 protein CTD PMID:26723870 cisplatin decreases activity EXP 6480464 Cisplatin results in decreased activity of SIRT1 protein CTD PMID:33661552 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SIRT1 mRNA CTD PMID:33522649 and PMID:33661552 cisplatin multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:33522649 and PMID:33661552 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of SIRT1 protein CTD PMID:21416250 cisplatin decreases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in decreased susceptibility to Cisplatin CTD PMID:21416250 clofibrate multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA] CTD PMID:17585979 cobalt atom multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA CTD PMID:18078969 cobalt dichloride multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] and sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] CTD PMID:22669716 cobalt dichloride increases expression ISO SIRT1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of SIRT1 protein CTD PMID:22245592 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SIRT1 protein CTD PMID:22669716 cobalt dichloride multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] and SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]] CTD PMID:26174951 cocaine increases expression EXP 401900166 cocaine increases expression of Sirt1 protein in nucleus accumbens RGD colforsin daropate hydrochloride multiple interactions EXP 6480464 SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]] more ... CTD PMID:23292070 colforsin daropate hydrochloride multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] CTD PMID:30825513 copper atom multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 copper(II) sulfate increases expression ISO SIRT1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SIRT1 mRNA CTD PMID:19549813 cordycepin affects expression ISO SIRT1 (Homo sapiens) 6480464 cordycepin affects the expression of SIRT1 mRNA CTD PMID:36881089 cordycepin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 sirtinol inhibits the reaction [cordycepin results in increased expression of SIRT1 mRNA] CTD PMID:36881089 cordycepin affects phosphorylation ISO SIRT1 (Homo sapiens) 6480464 cordycepin affects the phosphorylation of SIRT1 protein CTD PMID:36881089 cortisol decreases expression ISO SIRT1 (Homo sapiens) 6480464 Hydrocortisone results in decreased expression of SIRT1 mRNA CTD PMID:30776459 cortisol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 NR3C1 protein affects the reaction [Hydrocortisone results in decreased expression of SIRT1 mRNA] CTD PMID:30776459 corynoline multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:36161741 coumestrol decreases expression ISO SIRT1 (Homo sapiens) 6480464 Coumestrol results in decreased expression of SIRT1 mRNA CTD PMID:19167446 crocidolite asbestos increases expression ISO SIRT1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of SIRT1 mRNA CTD PMID:18687144 cudraflavone B increases expression ISO SIRT1 (Homo sapiens) 6480464 cudraflavone B results in increased expression of SIRT1 mRNA and cudraflavone B results in increased expression of SIRT1 protein CTD PMID:23881456 cudraflavone B multiple interactions ISO SIRT1 (Homo sapiens) 6480464 resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] more ... CTD PMID:23881456 Cuprizon multiple interactions ISO Sirt1 (Mus musculus) 6480464 Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA] CTD PMID:29864483 Cuprizon decreases expression ISO Sirt1 (Mus musculus) 6480464 Cuprizone results in decreased expression of SIRT1 mRNA CTD PMID:29864483 curcumin increases expression ISO Sirt1 (Mus musculus) 6480464 Curcumin results in increased expression of SIRT1 mRNA CTD PMID:18403477 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA] more ... CTD PMID:32569592 and PMID:36037877 cycloheximide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Cycloheximide results in decreased expression of SIRT1 protein CTD PMID:31082419 cycloheximide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Cycloheximide promotes the reaction [antimony trichloride results in decreased expression of SIRT1 protein] more ... CTD PMID:30055241 and PMID:31082419 cyclosporin A increases expression ISO SIRT1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of SIRT1 mRNA CTD PMID:25562108 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of SIRT1 protein CTD PMID:32569592 cyclosporin A multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein] CTD PMID:32569592 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA more ... CTD PMID:33051911 more ... cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA more ... CTD PMID:33051911 more ... cypermethrin decreases expression ISO Sirt1 (Mus musculus) 6480464 cypermethrin results in decreased expression of SIRT1 mRNA CTD PMID:34714723 cyproheptadine increases expression EXP 6480464 Cyproheptadine results in increased expression of SIRT1 protein CTD PMID:33675893 D-glucose decreases response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 D-glucose decreases expression ISO SIRT1 (Homo sapiens) 158012687 D-glucose decreases expression of SIRT1 mRNA and protein in retinal epithelial cells RGD D-glucose increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 D-glucose increases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA and Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 and PMID:24802182 D-glucose decreases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... D-glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 D-glucose decreases expression ISO Sirt1 (Mus musculus) 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 and PMID:23090186 D-glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 D-glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... D-glucose multiple interactions ISO Sirt1 (Mus musculus) 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... D-glucose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... D-glucose affects abundance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 dapagliflozin multiple interactions EXP 6480464 [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SIRT1 protein] more ... CTD PMID:34939712 and PMID:37741535 decabromodiphenyl ether multiple interactions EXP 6480464 decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein] more ... CTD PMID:36566971 dehydroepiandrosterone affects expression ISO Sirt1 (Mus musculus) 6480464 Dehydroepiandrosterone affects the expression of SIRT1 protein CTD PMID:20195491 dehydroepiandrosterone decreases expression ISO SIRT1 (Homo sapiens) 6480464 Dehydroepiandrosterone results in decreased expression of SIRT1 protein CTD PMID:20195491 dehydroepiandrosterone sulfate increases expression EXP 6480464 Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 deoxynivalenol increases expression ISO SIRT1 (Homo sapiens) 6480464 deoxynivalenol results in increased expression of SIRT1 mRNA CTD PMID:34677630 deoxynivalenol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of SIRT1 mRNA] CTD PMID:34677630 desferrioxamine B increases expression ISO SIRT1 (Homo sapiens) 6480464 Deferoxamine results in increased expression of SIRT1 protein CTD PMID:22245592 dexamethasone multiple interactions EXP 6480464 [Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]] which results in decreased acetylation of FOXO1 protein more ... CTD PMID:17884810 more ... dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SIRT1 mRNA and Dexamethasone results in decreased expression of SIRT1 protein CTD PMID:33619658 dexamethasone multiple interactions ISO Sirt1 (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein more ... CTD PMID:29288687 and PMID:34968464 dexamethasone multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] more ... CTD PMID:26435214 dexamethasone increases expression ISO SIRT1 (Homo sapiens) 6480464 Dexamethasone results in increased expression of SIRT1 mRNA CTD PMID:19853017 dextran sulfate multiple interactions ISO Sirt1 (Mus musculus) 6480464 ADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA] more ... CTD PMID:19940103 and PMID:24548422 dextran sulfate decreases expression ISO Sirt1 (Mus musculus) 6480464 Dextran Sulfate results in decreased expression of SIRT1 mRNA and Dextran Sulfate results in decreased expression of SIRT1 protein CTD PMID:19940103 and PMID:24548422 Di-n-hexyl phthalate decreases expression EXP 6480464 di-n-hexyl phthalate results in decreased expression of SIRT1 protein CTD PMID:32693021 Di-n-octyl phthalate decreases expression ISO SIRT1 (Homo sapiens) 6480464 di-n-octyl phthalate results in decreased expression of SIRT1 mRNA and di-n-octyl phthalate results in decreased expression of SIRT1 protein CTD PMID:34822940 diarsenic trioxide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SIRT1 mRNA CTD PMID:19763917 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SIRT1 protein CTD PMID:33173984 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SIRT1 protein CTD PMID:31332900 diarsenic trioxide multiple interactions EXP 6480464 Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein] and trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein] CTD PMID:31332900 and PMID:33173984 diarsenic trioxide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Arsenic Trioxide promotes the reaction [NVP-BKM120 results in decreased expression of SIRT1 mRNA] CTD PMID:30316766 diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of SIRT1 mRNA CTD PMID:35403302 diazinon multiple interactions EXP 6480464 Resveratrol inhibits the reaction [Diazinon results in decreased expression of SIRT1 mRNA] CTD PMID:35403302 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SIRT1 protein CTD PMID:32525071 dibutyl phthalate multiple interactions EXP 6480464 taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of SIRT1 mRNA CTD PMID:37077353 dihydrogen multiple interactions ISO SIRT1 (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]] and Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] CTD PMID:26271894 dihydrogen increases expression ISO SIRT1 (Homo sapiens) 6480464 Hydrogen results in increased expression of SIRT1 protein CTD PMID:26271894 diisononyl phthalate decreases expression ISO SIRT1 (Homo sapiens) 6480464 diisononyl phthalate results in decreased expression of SIRT1 mRNA and diisononyl phthalate results in decreased expression of SIRT1 protein CTD PMID:31423773 dioxygen multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of CTNNB1] more ... CTD PMID:22245592 more ... dioxygen decreases expression ISO SIRT1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of SIRT1 protein CTD PMID:25707573 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of SIRT1 mRNA and Oxygen deficiency results in decreased expression of SIRT1 protein CTD PMID:25352008 dioxygen multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein more ... CTD PMID:22892143 more ... dioxygen affects response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the susceptibility to Oxygen deficiency CTD PMID:22245592 dioxygen decreases expression ISO Sirt1 (Mus musculus) 6480464 Oxygen deficiency results in decreased expression of SIRT1 protein more ... CTD PMID:21113404 more ... dioxygen multiple interactions ISO Sirt1 (Mus musculus) 6480464 [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SIRT1 mRNA more ... CTD PMID:19303870 more ... dioxygen increases expression ISO SIRT1 (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of SIRT1 mRNA and Oxygen deficiency results in increased expression of SIRT1 protein CTD PMID:22245592 dipentyl phthalate decreases expression EXP 6480464 di-n-pentyl phthalate results in decreased expression of SIRT1 protein CTD PMID:33798595 and PMID:36715143 diprotium increases expression ISO SIRT1 (Homo sapiens) 6480464 Hydrogen results in increased expression of SIRT1 protein CTD PMID:26271894 diprotium multiple interactions ISO SIRT1 (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]] and Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] CTD PMID:26271894 disulfiram multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 dizocilpine increases expression EXP 401900166 dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbens RGD dizocilpine maleate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein] and Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 dorsomorphin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [dorsomorphin co-treated with TNF protein] results in decreased expression of SIRT1 protein more ... CTD PMID:24145604 more ... dorsomorphin multiple interactions EXP 6480464 dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] CTD PMID:23211629 dorsomorphin decreases expression ISO Sirt1 (Mus musculus) 6480464 dorsomorphin results in decreased expression of SIRT1 protein CTD PMID:24465016 dorsomorphin multiple interactions ISO Sirt1 (Mus musculus) 6480464 dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] more ... CTD PMID:24465016 dorsomorphin decreases expression ISO SIRT1 (Homo sapiens) 6480464 dorsomorphin results in decreased expression of SIRT1 protein CTD PMID:25943029 doxorubicin affects response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the susceptibility to Doxorubicin CTD PMID:19839049 doxorubicin affects response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the susceptibility to Doxorubicin CTD PMID:37030624 doxorubicin increases expression ISO Sirt1 (Mus musculus) 6480464 Doxorubicin results in increased expression of SIRT1 protein CTD PMID:31768571 doxorubicin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] more ... CTD PMID:29966675 and PMID:37030624 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SIRT1 protein CTD PMID:29966675 more ... doxorubicin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of SIRT1 mRNA CTD PMID:29803840 and PMID:36634904 doxorubicin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:28456571 doxorubicin decreases expression ISO Sirt1 (Mus musculus) 6480464 Doxorubicin results in decreased expression of SIRT1 protein CTD PMID:36811345 doxorubicin decreases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in decreased susceptibility to Doxorubicin CTD PMID:28456571 doxorubicin decreases activity ISO Sirt1 (Mus musculus) 6480464 Doxorubicin results in decreased activity of SIRT1 protein CTD PMID:25665036 and PMID:26450947 doxorubicin multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:25665036 more ... elemental selenium decreases expression ISO SIRT1 (Homo sapiens) 6480464 Selenium results in decreased expression of SIRT1 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SIRT1 protein CTD PMID:23301498 ergosterol multiple interactions EXP 6480464 [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA and resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:25833014 Erythropoietin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein] more ... CTD PMID:28456571 ethanol decreases activity ISO Sirt1 (Mus musculus) 6480464 Ethanol results in decreased activity of SIRT1 protein CTD PMID:18239056 ethanol decreases activity EXP 6480464 Ethanol results in decreased activity of SIRT1 protein CTD PMID:34470993 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SIRT1 mRNA and Ethanol results in increased expression of SIRT1 protein CTD PMID:18793633 and PMID:32894639 ethanol decreases expression ISO SIRT1 (Homo sapiens) 6480464 Ethanol results in decreased expression of SIRT1 mRNA and Ethanol results in decreased expression of SIRT1 protein CTD PMID:24224909 more ... ethanol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 3-(3 more ... CTD PMID:24224909 more ... ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SIRT1 mRNA and Ethanol results in decreased expression of SIRT1 protein CTD PMID:24769256 more ... ethanol multiple interactions EXP 6480464 3-(3 more ... CTD PMID:18239056 more ... ethanol decreases expression ISO Sirt1 (Mus musculus) 6480464 Ethanol results in decreased expression of SIRT1 mRNA and Ethanol results in decreased expression of SIRT1 protein CTD PMID:18755807 more ... ethanol multiple interactions ISO Sirt1 (Mus musculus) 6480464 5-aminoisoquinolinone inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein] more ... CTD PMID:18239056 more ... everolimus multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] and cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] CTD PMID:19520256 everolimus decreases expression ISO SIRT1 (Homo sapiens) 6480464 Everolimus results in decreased expression of SIRT1 protein CTD PMID:19520256 excitatory amino acid agonist multiple interactions EXP 6480464 Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein and Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:19288225 fenbendazole increases expression ISO SIRT1 (Homo sapiens) 6480464 Fenbendazole analog results in increased expression of SIRT1 mRNA and Fenbendazole results in increased expression of SIRT1 mRNA CTD PMID:35569513 fenitrothion multiple interactions EXP 6480464 Resveratrol inhibits the reaction [Fenitrothion results in decreased expression of SIRT1 mRNA] CTD PMID:34968465 fenitrothion decreases expression EXP 6480464 Fenitrothion results in decreased expression of SIRT1 mRNA CTD PMID:34968465 fenofibrate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein] more ... CTD PMID:32730863 and PMID:34520103 fenofibrate increases expression ISO SIRT1 (Homo sapiens) 6480464 Fenofibrate results in increased expression of SIRT1 protein CTD PMID:34520103 fenofibrate increases expression ISO Sirt1 (Mus musculus) 6480464 Fenofibrate results in increased expression of SIRT1 protein CTD PMID:34520103 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA more ... CTD PMID:33051911 more ... ferric ammonium citrate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein more ... CTD PMID:34826546 ferric ammonium citrate multiple interactions ISO Sirt1 (Mus musculus) 6480464 Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein] CTD PMID:36087815 ferric ammonium citrate decreases expression ISO Sirt1 (Mus musculus) 6480464 ferric ammonium citrate results in decreased expression of SIRT1 protein CTD PMID:36087815 fisetin multiple interactions ISO Sirt1 (Mus musculus) 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] and fisetin results in increased activity of and results in increased phosphorylation of SIRT1 protein CTD PMID:31539617 and PMID:34216621 folic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 Folic Acid inhibits the reaction [1 more ... CTD PMID:22206623 and PMID:29068127 folic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 FR900359 increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of SIRT1 protein CTD PMID:37730182 fructose multiple interactions ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] CTD PMID:18192211 fructose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein and Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein] CTD PMID:32730863 fructose decreases expression EXP 6480464 Fructose results in decreased expression of SIRT1 mRNA and Fructose results in decreased expression of SIRT1 protein CTD PMID:25108154 and PMID:26488877 fructose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:21212096 more ... fructose increases expression ISO Sirt1 (Mus musculus) 6480464 Fructose results in increased expression of SIRT1 protein CTD PMID:18192211 fulvestrant multiple interactions ISO SIRT1 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]] CTD PMID:24771768 galactose decreases expression EXP 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:25892055 galactose decreases expression ISO SIRT1 (Homo sapiens) 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:29426000 galactose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] CTD PMID:25892055 gallic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 gallocatechin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 Garcinol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 garcinol inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] CTD PMID:36629037 Genipin multiple interactions ISO Sirt1 (Mus musculus) 6480464 genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] and sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] CTD PMID:28477916 genistein multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Genistein inhibits the reaction [malondialdehyde-low density lipoprotein more ... CTD PMID:28688900 genistein increases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in increased susceptibility to Genistein CTD PMID:28688900 geraniol increases expression ISO SIRT1 (Homo sapiens) 6480464 geraniol results in increased expression of SIRT1 mRNA CTD PMID:27683099 ginsenoside Rg1 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of SIRT1 protein] CTD PMID:30918470 glucose affects abundance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 glucose increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... glucose increases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA and Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 and PMID:24802182 glucose decreases expression ISO SIRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of SIRT1 mRNA and Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 glucose decreases expression ISO Sirt1 (Mus musculus) 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 and PMID:23090186 glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... glucose multiple interactions ISO Sirt1 (Mus musculus) 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... glucose multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... glucose decreases response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 glutathione multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein] and GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] CTD PMID:24451382 glutathione decreases abundance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in decreased abundance of Glutathione CTD PMID:29134718 glycyrrhizinic acid multiple interactions EXP 6480464 Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:25162824 glyoxylic acid decreases expression ISO Sirt1 (Mus musculus) 6480464 glyoxylic acid results in decreased expression of SIRT1 protein CTD PMID:34333021 Goe 6976 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein] and Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 GW 4064 multiple interactions ISO Sirt1 (Mus musculus) 6480464 GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein] CTD PMID:37028458 GW 501516 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA] and Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 hexadecanoic acid multiple interactions EXP 6480464 [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein more ... CTD PMID:22968147 more ... hexadecanoic acid increases expression ISO Sirt1 (Mus musculus) 6480464 Palmitic Acid results in increased expression of SIRT1 mRNA CTD PMID:34968464 hexadecanoic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA more ... CTD PMID:34968464 hexadecanoic acid decreases activity ISO SIRT1 (Homo sapiens) 6480464 Palmitic Acid results in decreased activity of SIRT1 protein CTD PMID:25943029 hexadecanoic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:24451382 more ... hexadecanoic acid decreases expression EXP 6480464 Palmitic Acid results in decreased expression of SIRT1 mRNA and Palmitic Acid results in decreased expression of SIRT1 protein CTD PMID:22968147 more ... hydrogen peroxide multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein more ... CTD PMID:20335659 more ... hydrogen peroxide affects localization ISO SIRT1 (Homo sapiens) 6480464 Hydrogen Peroxide affects the localization of SIRT1 protein CTD PMID:25512378 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SIRT1 mRNA and Hydrogen Peroxide results in decreased expression of SIRT1 protein CTD PMID:23891692 more ... hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of SIRT1 protein CTD PMID:17581637 hydrogen peroxide multiple interactions EXP 6480464 bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] more ... CTD PMID:18424637 more ... hydrogen peroxide decreases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:18681908 hydrogen peroxide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of SIRT1 more ... CTD PMID:18681908 more ... hydrogen peroxide decreases response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 results in decreased susceptibility to Hydrogen Peroxide CTD PMID:20335659 hydrogen peroxide affects expression ISO SIRT1 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of SIRT1 mRNA and Hydrogen Peroxide affects the expression of SIRT1 protein CTD PMID:20044591 more ... hydrogen peroxide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] more ... CTD PMID:18681908 more ... hydroquinone multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [SIRT1 protein affects the susceptibility to hydroquinone] which affects the expression of H2AX protein more ... CTD PMID:27515134 and PMID:28263894 hydroquinone affects response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the susceptibility to hydroquinone CTD PMID:27515134 hydroquinone affects expression ISO SIRT1 (Homo sapiens) 6480464 hydroquinone affects the expression of SIRT1 mRNA and hydroquinone affects the expression of SIRT1 protein CTD PMID:27515134 icariin increases expression ISO SIRT1 (Homo sapiens) 6480464 icariin results in increased expression of SIRT1 mRNA and icariin results in increased expression of SIRT1 protein CTD PMID:25472572 icariin multiple interactions ISO Sirt1 (Mus musculus) 6480464 icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA] more ... CTD PMID:19303870 icariin affects expression EXP 6480464 icariin affects the expression of SIRT1 mRNA and icariin affects the expression of SIRT1 protein CTD PMID:25472572 icariin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] and Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] CTD PMID:25472572 imidacloprid decreases expression ISO Sirt1 (Mus musculus) 6480464 imidacloprid results in decreased expression of SIRT1 protein CTD PMID:27960282 inositol multiple interactions EXP 6480464 Inositol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:35243728 ionomycin increases expression EXP 6480464 Ionomycin results in increased expression of SIRT1 protein CTD PMID:17581637 iprodione multiple interactions EXP 6480464 [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA and iprodione promotes the reaction [Chlorpyrifos results in decreased expression of SIRT1 mRNA] CTD PMID:33586219 and PMID:34060014 iprodione decreases expression EXP 6480464 iprodione results in decreased expression of SIRT1 mRNA CTD PMID:33586219 iron atom multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein more ... CTD PMID:34826546 iron(0) multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein more ... CTD PMID:34826546 isoniazide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Isoniazid results in decreased expression of SIRT1 protein CTD PMID:28556920 and PMID:31332904 isoniazide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] and Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 and PMID:31332904 isonicotinamide increases activity ISO SIRT1 (Homo sapiens) 6480464 isonicotinamide results in increased activity of SIRT1 protein CTD PMID:21745208 isonicotinamide increases expression ISO SIRT1 (Homo sapiens) 6480464 isonicotinamide results in increased expression of SIRT1 mRNA CTD PMID:21745208 isoquinoline-1,5-diol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 1 more ... CTD PMID:25517228 kainic acid decreases expression ISO Sirt1 (Mus musculus) 6480464 Kainic Acid results in decreased expression of SIRT1 protein CTD PMID:18538940 kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of SIRT1 protein CTD PMID:18538940 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of SIRT1 mRNA CTD PMID:37077353 KT 5720 multiple interactions ISO Sirt1 (Mus musculus) 6480464 KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] and KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] CTD PMID:24254769 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:33978298 lead diacetate decreases expression ISO SIRT1 (Homo sapiens) 6480464 lead acetate results in decreased expression of SIRT1 protein CTD PMID:34842334 lead diacetate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SRT1720 inhibits the reaction [lead acetate results in decreased expression of SIRT1 protein] CTD PMID:34842334 lead(0) decreases expression ISO Sirt1 (Mus musculus) 6480464 Lead results in decreased expression of SIRT1 protein CTD PMID:31539617 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of SIRT1 protein CTD PMID:37244597 lead(0) multiple interactions EXP 6480464 [Dietary Fats co-treated with Lead] results in decreased expression of SIRT1 protein more ... CTD PMID:33978298 and PMID:37244597 lead(0) multiple interactions ISO Sirt1 (Mus musculus) 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 Licarin A multiple interactions ISO Sirt1 (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein CTD PMID:29288687 linagliptin multiple interactions ISO Sirt1 (Mus musculus) 6480464 Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA] CTD PMID:29864483 linagliptin multiple interactions EXP 6480464 Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] CTD PMID:35122774 lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 lipoic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] CTD PMID:37739047 lipoic acid increases expression ISO Sirt1 (Mus musculus) 6480464 Thioctic Acid results in increased expression of SIRT1 mRNA CTD PMID:37739047 lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of SIRT1 protein CTD PMID:22327056 lipopolysaccharide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Lipopolysaccharides co-treated with Bee Venoms] affects the expression of SIRT1 mRNA more ... CTD PMID:20844277 more ... lipopolysaccharide increases expression ISO SIRT1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of SIRT1 and Lipopolysaccharides results in increased expression of SIRT1 protein CTD PMID:22000456 and PMID:30918470 lipopolysaccharide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of SIRT1 more ... CTD PMID:20844277 more ... lipopolysaccharide multiple interactions EXP 6480464 [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA more ... CTD PMID:24289075 lipopolysaccharide decreases expression ISO Sirt1 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of SIRT1 mRNA and Lipopolysaccharides results in decreased expression of SIRT1 protein CTD PMID:22952890 more ... lipopolysaccharide decreases activity ISO Sirt1 (Mus musculus) 6480464 Lipopolysaccharides results in decreased activity of SIRT1 protein CTD PMID:19279313 lipopolysaccharide multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:19279313 more ... liquiritin multiple interactions ISO Sirt1 (Mus musculus) 6480464 liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA] and liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] CTD PMID:36008890 lithocholic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein] and VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]] CTD PMID:31472180 luzindole multiple interactions ISO SIRT1 (Homo sapiens) 6480464 luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] and luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 LY294002 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of SIRT1 mRNA] CTD PMID:34677630 lycopene multiple interactions ISO SIRT1 (Homo sapiens) 6480464 lycopene inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] CTD PMID:28974442 Magnolol multiple interactions EXP 6480464 [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 malonaldehyde multiple interactions ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] CTD PMID:24633890 mancozeb decreases activity ISO SIRT1 (Homo sapiens) 6480464 mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 maneb decreases activity ISO SIRT1 (Homo sapiens) 6480464 Maneb results in decreased activity of SIRT1 protein CTD PMID:21251949 manganese atom multiple interactions ISO Sirt1 (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein CTD PMID:34018660 manganese(0) multiple interactions ISO Sirt1 (Mus musculus) 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein CTD PMID:34018660 manganese(II) chloride multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:34018660 and PMID:34738708 manganese(II) chloride decreases expression ISO Sirt1 (Mus musculus) 6480464 manganese chloride results in decreased expression of SIRT1 mRNA and manganese chloride results in decreased expression of SIRT1 protein CTD PMID:34738708 medroxyprogesterone acetate multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein CTD PMID:16709600 melatonin decreases expression ISO Sirt1 (Mus musculus) 6480464 Melatonin results in decreased expression of SIRT1 protein CTD PMID:21062352 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein]] more ... CTD PMID:29966675 and PMID:36566971 melatonin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Melatonin results in decreased expression of SIRT1 protein CTD PMID:21062352 melatonin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] more ... CTD PMID:25159133 menadione multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [[Vitamin K 3 results in increased phosphorylation of JAK3 protein] which results in increased phosphorylation of and affects the localization of ELAVL1 protein] inhibits the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA] more ... CTD PMID:24106086 mesalamine multiple interactions EXP 6480464 Mesalamine inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] CTD PMID:35122774 metformin multiple interactions ISO Sirt1 (Mus musculus) 6480464 Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein] more ... CTD PMID:23090186 more ... metformin increases expression ISO SIRT1 (Homo sapiens) 6480464 Metformin results in increased expression of SIRT1 mRNA CTD PMID:32808185 metformin increases phosphorylation ISO Sirt1 (Mus musculus) 6480464 Metformin results in increased phosphorylation of SIRT1 protein CTD PMID:34058177 metformin increases expression EXP 6480464 Metformin results in increased expression of SIRT1 protein CTD PMID:25108154 and PMID:31332900 metformin multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin more ... CTD PMID:25108154 and PMID:31332900 metformin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] CTD PMID:23315983 metformin increases expression ISO Sirt1 (Mus musculus) 6480464 Metformin results in increased expression of SIRT1 mRNA CTD PMID:23166782 and PMID:24687991 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of SIRT1 protein CTD PMID:35863504 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of SIRT1 mRNA and Methotrexate results in decreased expression of SIRT1 protein CTD PMID:34737150 and PMID:37312617 methotrexate multiple interactions EXP 6480464 Carnitine inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] more ... CTD PMID:34737150 and PMID:37312617 methylglyoxal multiple interactions EXP 6480464 [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein and [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 metiram decreases activity ISO SIRT1 (Homo sapiens) 6480464 polymarcine results in decreased activity of SIRT1 protein CTD PMID:21251949 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of SIRT1 mRNA] CTD PMID:33619658 mithramycin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 mono(2-ethylhexyl) phthalate decreases expression ISO Sirt1 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT1 mRNA and mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT1 protein CTD PMID:31016965 monooxygen increases expression ISO SIRT1 (Homo sapiens) 6480464 Singlet Oxygen results in increased expression of SIRT1 mRNA and Singlet Oxygen results in increased expression of SIRT1 protein CTD PMID:22860104 monosodium L-glutamate multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Fats more ... CTD PMID:23783067 and PMID:28708105 myricetin increases activity ISO SIRT1 (Homo sapiens) 6480464 myricetin results in increased activity of SIRT1 protein CTD PMID:22245592 myricetin increases expression ISO SIRT1 (Homo sapiens) 6480464 myricetin results in increased expression of SIRT1 protein CTD PMID:22245592 myricetin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein more ... CTD PMID:22245592 N,N-dimethylglycine multiple interactions ISO Sirt1 (Mus musculus) 6480464 dimethylglycine inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with TNF protein] results in decreased expression of SIRT1 protein more ... CTD PMID:24145604 more ... N-acetyl-L-cysteine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] more ... CTD PMID:21031461 more ... N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SIRT1 protein] and Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 and PMID:36493885 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO SIRT1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein and [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA CTD PMID:17583434 and PMID:22742579 N-methyl-4-phenylpyridinium decreases expression ISO SIRT1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein CTD PMID:25073091 more ... N-methyl-4-phenylpyridinium multiple interactions ISO SIRT1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:25073091 more ... N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SIRT1 protein CTD PMID:18538940 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein CTD PMID:17583434 more ... N-methyl-D-aspartic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 1 more ... CTD PMID:31945382 N-methyl-D-aspartic acid decreases expression ISO SIRT1 (Homo sapiens) 6480464 N-Methylaspartate results in decreased expression of SIRT1 mRNA CTD PMID:31945382 N-methylformamide increases expression ISO Sirt1 (Mus musculus) 6480464 methylformamide analog results in increased expression of SIRT1 mRNA and methylformamide results in increased expression of SIRT1 mRNA CTD PMID:17040096 N-nitrosodiethylamine decreases expression ISO Sirt1 (Mus musculus) 6480464 Diethylnitrosamine results in decreased expression of SIRT1 mRNA CTD PMID:19996281 N-nitrosodiethylamine multiple interactions ISO Sirt1 (Mus musculus) 6480464 AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SIRT1 mRNA] CTD PMID:19996281 NAD zwitterion decreases abundance EXP 6480464 SIRT1 protein results in decreased abundance of NAD CTD PMID:19288225 NAD zwitterion multiple interactions ISO Sirt1 (Mus musculus) 6480464 [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein CTD PMID:23834033 NAD zwitterion increases activity EXP 6480464 NAD results in increased activity of SIRT1 protein CTD PMID:19288225 and PMID:22561310 NAD zwitterion increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to NAD CTD PMID:22561310 NAD zwitterion multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:19928762 more ... NAD zwitterion multiple interactions EXP 6480464 NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:19288225 and PMID:22561310 NAD(+) multiple interactions EXP 6480464 NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:19288225 and PMID:22561310 NAD(+) multiple interactions ISO Sirt1 (Mus musculus) 6480464 [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein CTD PMID:23834033 NAD(+) increases activity EXP 6480464 NAD results in increased activity of SIRT1 protein CTD PMID:19288225 and PMID:22561310 NAD(+) increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to NAD CTD PMID:22561310 NAD(+) multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:19928762 more ... NAD(+) decreases abundance EXP 6480464 SIRT1 protein results in decreased abundance of NAD CTD PMID:19288225 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] CTD PMID:18793633 naringin multiple interactions ISO Sirt1 (Mus musculus) 6480464 naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] more ... CTD PMID:36811345 nickel dichloride increases expression ISO SIRT1 (Homo sapiens) 6480464 nickel chloride results in increased expression of SIRT1 mRNA CTD PMID:17547211 nicotinamide multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [SIRT1 protein results in increased expression of PPARGC1A mRNA] more ... CTD PMID:16366736 more ... nicotinamide decreases expression EXP 6480464 Niacinamide results in decreased expression of SIRT1 protein CTD PMID:22561310 nicotinamide decreases expression ISO SIRT1 (Homo sapiens) 6480464 Niacinamide results in decreased expression of SIRT1 mRNA and Niacinamide results in decreased expression of SIRT1 protein CTD PMID:19928762 and PMID:21745208 nicotinamide multiple interactions EXP 6480464 [Niacinamide co-treated with Resveratrol] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA] more ... CTD PMID:18420994 more ... nicotinamide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein more ... CTD PMID:18482975 more ... nicotinamide decreases activity ISO SIRT1 (Homo sapiens) 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:17103016 more ... nicotinamide decreases activity EXP 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:16366736 more ... nicotinamide decreases activity ISO Sirt1 (Mus musculus) 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:16366736 and PMID:34216621 nicotine multiple interactions ISO Sirt1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] CTD PMID:22687363 nicotine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA more ... CTD PMID:23199342 nicotine decreases expression ISO Sirt1 (Mus musculus) 6480464 Nicotine results in decreased expression of SIRT1 mRNA CTD PMID:22687363 nimesulide multiple interactions ISO Sirt1 (Mus musculus) 6480464 nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:25339356 nitric oxide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide] and SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] CTD PMID:20960276 nitrites multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein more ... CTD PMID:22892143 nitroprusside multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Nitroprusside results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:18204789 nitroxoline multiple interactions ISO SIRT1 (Homo sapiens) 6480464 nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] CTD PMID:31638783 nitroxoline decreases expression ISO SIRT1 (Homo sapiens) 6480464 nitroxoline results in decreased expression of SIRT1 protein CTD PMID:31638783 NMN zwitterion increases expression EXP 6480464 Nicotinamide Mononucleotide results in increased expression of SIRT1 mRNA CTD PMID:32087266 NMN zwitterion multiple interactions EXP 6480464 Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] and Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:32087266 ochratoxin A increases expression ISO SIRT1 (Homo sapiens) 6480464 ochratoxin A results in increased expression of SIRT1 mRNA CTD PMID:34481902 octreotide multiple interactions ISO Sirt1 (Mus musculus) 6480464 Octreotide inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of SIRT1 mRNA] more ... CTD PMID:35307376 olaparib increases expression ISO SIRT1 (Homo sapiens) 6480464 olaparib results in increased expression of SIRT1 protein CTD PMID:34826546 olaparib multiple interactions ISO SIRT1 (Homo sapiens) 6480464 olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein] CTD PMID:34826546 oleanolic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein] and SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein] CTD PMID:37028458 oleanolic acid decreases expression ISO Sirt1 (Mus musculus) 6480464 Oleanolic Acid results in decreased expression of SIRT1 mRNA and Oleanolic Acid results in decreased expression of SIRT1 protein CTD PMID:37028458 oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of SIRT1 protein CTD PMID:24349266 oleic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:25536389 oleic acid decreases activity ISO SIRT1 (Homo sapiens) 6480464 Oleic Acid results in decreased activity of SIRT1 protein CTD PMID:25536389 oleic acid multiple interactions EXP 6480464 [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein CTD PMID:26854922 organoselenium compound multiple interactions EXP 6480464 Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] CTD PMID:25301743 oxaloacetic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 oxidopamine decreases expression ISO SIRT1 (Homo sapiens) 6480464 Oxidopamine results in decreased expression of SIRT1 protein CTD PMID:18675900 oxidopamine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 puag-haad inhibits the reaction [Oxidopamine results in decreased expression of SIRT1 protein] CTD PMID:18675900 P(1),P(5)-bis(5'-adenosyl) pentaphosphate multiple interactions EXP 6480464 P(1) and P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 paclitaxel multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] and cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] CTD PMID:19520256 paclitaxel decreases expression ISO SIRT1 (Homo sapiens) 6480464 Paclitaxel results in decreased expression of SIRT1 protein CTD PMID:19520256 paracetamol multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA more ... CTD PMID:17585979 more ... paracetamol affects response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 affects the susceptibility to Acetaminophen CTD PMID:31077331 paracetamol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 MIR19B1 inhibits the reaction [Acetaminophen results in increased expression of SIRT1 protein] more ... CTD PMID:31077331 paracetamol increases expression ISO Sirt1 (Mus musculus) 6480464 Acetaminophen results in increased expression of SIRT1 mRNA and Acetaminophen results in increased expression of SIRT1 protein CTD PMID:31077331 paracetamol affects response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 affects the susceptibility to Acetaminophen CTD PMID:31077331 paracetamol affects expression ISO Sirt1 (Mus musculus) 6480464 Acetaminophen affects the expression of SIRT1 mRNA CTD PMID:17562736 paracetamol increases expression ISO SIRT1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SIRT1 mRNA and Acetaminophen results in increased expression of SIRT1 protein CTD PMID:21420995 more ... paraquat increases expression ISO Sirt1 (Mus musculus) 6480464 Paraquat results in increased expression of SIRT1 mRNA and Paraquat results in increased expression of SIRT1 protein CTD PMID:22563483 and PMID:26708779 paraquat multiple interactions ISO Sirt1 (Mus musculus) 6480464 resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 mRNA] more ... CTD PMID:26708779 and PMID:26935021 paraquat affects expression ISO Sirt1 (Mus musculus) 6480464 Paraquat affects the expression of SIRT1 protein CTD PMID:26935021 pentachlorophenol decreases expression EXP 6480464 Pentachlorophenol results in decreased expression of SIRT1 protein CTD PMID:19442831 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of SIRT1 protein CTD PMID:30489073 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 perfluorooctane sulfonic acid affects the localization of and results in increased expression of and results in increased activity of and results in decreased phosphorylation of SIRT1 protein CTD PMID:28973641 perfluorooctane-1-sulfonic acid affects binding ISO Sirt1 (Mus musculus) 6480464 perfluorooctane sulfonic acid binds to SIRT1 protein CTD PMID:33689947 perfluorooctane-1-sulfonic acid decreases activity ISO Sirt1 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in decreased activity of SIRT1 protein CTD PMID:33689947 perfluorooctane-1-sulfonic acid decreases expression ISO SIRT1 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in decreased expression of SIRT1 mRNA and perfluorooctane sulfonic acid results in decreased expression of SIRT1 protein CTD PMID:31508952 perfluorooctanoic acid increases expression ISO Sirt1 (Mus musculus) 6480464 perfluorooctanoic acid results in increased expression of SIRT1 mRNA CTD PMID:31016965 perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA] and Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:34737150 perindopril increases expression EXP 6480464 Perindopril results in increased expression of SIRT1 mRNA and Perindopril results in increased expression of SIRT1 protein CTD PMID:34737150 phenformin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Phenformin results in decreased expression of SIRT1 protein CTD PMID:26768367 phenobarbital affects expression ISO SIRT1 (Homo sapiens) 6480464 Phenobarbital affects the expression of SIRT1 mRNA CTD PMID:19159669 phenobarbital affects expression ISO Sirt1 (Mus musculus) 6480464 Phenobarbital affects the expression of SIRT1 mRNA CTD PMID:23091169 phenol increases expression ISO SIRT1 (Homo sapiens) 6480464 Phenol results in increased expression of SIRT1 mRNA CTD PMID:17547211 polymyxin B2 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein] more ... CTD PMID:37354967 polymyxin B2 decreases expression ISO SIRT1 (Homo sapiens) 6480464 Polymyxin B results in decreased expression of SIRT1 protein CTD PMID:37354967 potassium atom affects expression EXP 6480464 Potassium affects the expression of SIRT1 mRNA and Potassium affects the expression of SIRT1 protein CTD PMID:17583434 potassium dichromate multiple interactions EXP 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] inhibits the reaction [TP53 protein modified form binds to SIRT1 protein] more ... CTD PMID:30974164 more ... prasugrel hydrochloride multiple interactions EXP 6480464 Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SIRT1 protein] CTD PMID:34174262 pravastatin increases phosphorylation ISO SIRT1 (Homo sapiens) 6480464 Pravastatin results in increased phosphorylation of SIRT1 protein CTD PMID:33073877 pregnenolone 16alpha-carbonitrile multiple interactions ISO Sirt1 (Mus musculus) 6480464 SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] CTD PMID:21933665 Primycin increases expression ISO SIRT1 (Homo sapiens) 6480464 primycin results in increased expression of SIRT1 mRNA CTD PMID:28916286 propionic acid decreases expression ISO SIRT1 (Homo sapiens) 6480464 propionic acid results in decreased expression of SIRT1 mRNA CTD PMID:31526819 prostaglandin E2 multiple interactions ISO Sirt1 (Mus musculus) 6480464 Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] CTD PMID:20335659 prostaglandin E2 decreases expression ISO SIRT1 (Homo sapiens) 6480464 Dinoprostone results in decreased expression of SIRT1 mRNA and Dinoprostone results in decreased expression of SIRT1 protein CTD PMID:30409902 prostaglandin E2 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein] more ... CTD PMID:20844277 more ... prostaglandin F2alpha multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 pterostilbene multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA and [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein CTD PMID:26459286 puerarin multiple interactions EXP 6480464 puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] CTD PMID:33404196 puerarin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] more ... CTD PMID:35331853 pyrethrins decreases expression EXP 6480464 Pyrethrins results in decreased expression of SIRT1 mRNA CTD PMID:36053783 pyrethrins affects expression EXP 6480464 Pyrethrins affects the expression of SIRT1 mRNA CTD PMID:34896426 pyruvic acid increases expression ISO Sirt1 (Mus musculus) 6480464 Pyruvic Acid results in increased expression of SIRT1 mRNA CTD PMID:21933665 pyruvic acid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] and [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:19071085 and PMID:27358235 pyruvic acid multiple interactions ISO Sirt1 (Mus musculus) 6480464 [PDK4 affects the abundance of Pyruvic Acid] which results in increased expression of SIRT1 and SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] CTD PMID:21182459 and PMID:21933665 quercetin increases expression ISO Sirt1 (Mus musculus) 6480464 Quercetin results in increased expression of SIRT1 mRNA and Quercetin results in increased expression of SIRT1 protein CTD PMID:19211721 and PMID:24465016 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] and Quercetin inhibits the reaction [Vincristine results in decreased expression of SIRT1 protein] CTD PMID:28347707 and PMID:36808657 quercetin affects activity ISO Sirt1 (Mus musculus) 6480464 Quercetin affects the activity of SIRT1 protein CTD PMID:24025686 quercetin increases activity ISO SIRT1 (Homo sapiens) 6480464 Quercetin results in increased activity of SIRT1 protein CTD PMID:22245592 quercetin increases expression ISO SIRT1 (Homo sapiens) 6480464 Quercetin results in increased expression of SIRT1 protein CTD PMID:22245592 quercetin decreases expression ISO SIRT1 (Homo sapiens) 6480464 Quercetin results in decreased expression of SIRT1 protein CTD PMID:25896587 quercetin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein more ... CTD PMID:22245592 more ... quercetin multiple interactions ISO Sirt1 (Mus musculus) 6480464 dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] more ... CTD PMID:24025686 more ... quercetin 3-O-beta-D-galactopyranoside multiple interactions ISO SIRT1 (Homo sapiens) 6480464 hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] CTD PMID:18552516 ramipril multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein CTD PMID:31062909 reactive oxygen species multiple interactions EXP 6480464 SIRT1 protein affects the reaction [[Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of NDUFA13 protein] CTD PMID:23891692 reactive oxygen species increases chemical synthesis ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:29134718 rebaudioside A multiple interactions ISO Sirt1 (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 resveratrol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:15152190 more ... resveratrol decreases expression EXP 6480464 Resveratrol results in decreased expression of SIRT1 mRNA and Resveratrol results in decreased expression of SIRT1 protein CTD PMID:20195491 more ... resveratrol increases activity ISO Sirt1 (Mus musculus) 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:17112576 more ... resveratrol affects response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:22523472 more ... resveratrol decreases activity ISO SIRT1 (Homo sapiens) 6480464 resveratrol results in decreased activity of SIRT1 protein CTD PMID:24429678 resveratrol affects response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:23090186 and PMID:24782617 resveratrol affects activity ISO SIRT1 (Homo sapiens) 6480464 resveratrol affects the activity of SIRT1 protein CTD PMID:24064760 resveratrol increases expression EXP 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:17583434 more ... resveratrol decreases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in decreased susceptibility to resveratrol CTD PMID:23248098 resveratrol increases phosphorylation ISO Sirt1 (Mus musculus) 6480464 resveratrol results in increased phosphorylation of SIRT1 protein CTD PMID:24296261 resveratrol affects localization ISO SIRT1 (Homo sapiens) 6480464 resveratrol affects the localization of SIRT1 protein CTD PMID:24587049 resveratrol increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to resveratrol CTD PMID:22561310 more ... resveratrol increases activity ISO SIRT1 (Homo sapiens) 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:15749705 more ... resveratrol increases expression ISO SIRT1 (Homo sapiens) 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:16849586 more ... resveratrol increases response to substance ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein results in increased susceptibility to resveratrol CTD PMID:19664641 and PMID:26174951 resveratrol increases expression ISO Sirt1 (Mus musculus) 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:18755807 more ... resveratrol increases activity EXP 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:18077353 more ... resveratrol increases response to substance ISO Sirt1 (Mus musculus) 6480464 SIRT1 protein results in increased susceptibility to resveratrol and SIRT1 results in increased susceptibility to resveratrol CTD PMID:21593185 more ... resveratrol affects expression ISO Sirt1 (Mus musculus) 6480464 resveratrol affects the expression of SIRT1 protein CTD PMID:24254769 resveratrol decreases expression ISO SIRT1 (Homo sapiens) 6480464 Resveratrol results in decreased expression of SIRT1 mRNA and Resveratrol results in decreased expression of SIRT1 protein CTD PMID:20195491 more ... resveratrol affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:20651248 resveratrol multiple interactions EXP 6480464 [Niacinamide co-treated with Resveratrol] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA] more ... CTD PMID:17583434 more ... resveratrol multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:17581637 more ... rotenone increases expression EXP 6480464 Rotenone results in increased expression of SIRT1 protein CTD PMID:18538940 rotenone multiple interactions ISO SIRT1 (Homo sapiens) 6480464 polydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] more ... CTD PMID:25991017 and PMID:31926197 rotenone decreases expression ISO SIRT1 (Homo sapiens) 6480464 Rotenone results in decreased expression of SIRT1 mRNA and Rotenone results in decreased expression of SIRT1 protein CTD PMID:25991017 and PMID:31926197 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SIRT1 protein CTD PMID:18538940 rutin increases expression EXP 6480464 Rutin results in increased expression of SIRT1 mRNA and Rutin results in increased expression of SIRT1 protein CTD PMID:30365940 S-nitroso-L-cysteine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] and S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 salicylic acid multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid CTD PMID:25108154 Salidroside multiple interactions ISO SIRT1 (Homo sapiens) 6480464 rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:28851138 Salvianolic acid A multiple interactions ISO Sirt1 (Mus musculus) 6480464 Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA] more ... CTD PMID:23993977 salvianolic acid B increases expression ISO SIRT1 (Homo sapiens) 6480464 salvianolic acid B results in increased expression of SIRT1 protein CTD PMID:24769256 and PMID:27989594 salvianolic acid B multiple interactions ISO SIRT1 (Homo sapiens) 6480464 salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] and SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] CTD PMID:27989594 salvianolic acid B multiple interactions EXP 6480464 salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] more ... CTD PMID:24769256 and PMID:27989594 SB 203580 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of SIRT1 protein] CTD PMID:25512378 SB 203580 multiple interactions ISO Sirt1 (Mus musculus) 6480464 SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]] and SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] CTD PMID:19303870 SB 431542 multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of SIRT1 protein CTD PMID:37664457 selenium atom decreases expression ISO SIRT1 (Homo sapiens) 6480464 Selenium results in decreased expression of SIRT1 mRNA CTD PMID:19244175 silibinin multiple interactions ISO Sirt1 (Mus musculus) 6480464 Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein] CTD PMID:36087815 silicon dioxide increases expression ISO SIRT1 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of SIRT1 mRNA CTD PMID:25351596 silicon dioxide decreases expression ISO Sirt1 (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of SIRT1 protein CTD PMID:31082419 silicon dioxide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]] more ... CTD PMID:31082419 silver atom increases expression ISO SIRT1 (Homo sapiens) 6480464 Silver results in increased expression of SIRT1 mRNA CTD PMID:26014281 silver(0) increases expression ISO SIRT1 (Homo sapiens) 6480464 Silver results in increased expression of SIRT1 mRNA CTD PMID:26014281 sirolimus multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of SIRT1 protein more ... CTD PMID:19520256 and PMID:25307878 sirolimus decreases expression ISO SIRT1 (Homo sapiens) 6480464 Sirolimus results in decreased expression of SIRT1 protein CTD PMID:19520256 and PMID:25307878 sirolimus increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Sirolimus CTD PMID:22561310 sirolimus increases expression EXP 6480464 Sirolimus results in increased expression of SIRT1 protein CTD PMID:22561310 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:22561310 sirtinol decreases activity ISO SIRT1 (Homo sapiens) 6480464 sirtinol analog results in decreased activity of SIRT1 protein and sirtinol results in decreased activity of SIRT1 protein CTD PMID:16302818 more ... sirtinol decreases activity ISO Sirt1 (Mus musculus) 6480464 sirtinol results in decreased activity of SIRT1 protein CTD PMID:20370652 sirtinol multiple interactions ISO Sirt1 (Mus musculus) 6480464 [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose more ... CTD PMID:20370652 more ... sirtinol decreases activity EXP 6480464 sirtinol results in decreased activity of SIRT1 protein CTD PMID:23479127 sirtinol multiple interactions EXP 6480464 sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] and sirtinol inhibits the reaction [Resveratrol results in increased expression of and results in increased activity of SIRT1 protein] CTD PMID:22669716 and PMID:24395567 sirtinol multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] more ... CTD PMID:18681908 more ... sodium arsenite decreases expression ISO SIRT1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA and sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:25982963 and PMID:33360347 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA and sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:33360347 sodium arsenite multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 sodium arsenite multiple interactions ISO Sirt1 (Mus musculus) 6480464 [DOT1L protein affects the susceptibility to sodium arsenite] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:30130555 and PMID:34968464 sodium arsenite decreases degradation ISO SIRT1 (Homo sapiens) 6480464 sodium arsenite results in decreased degradation of SIRT1 mRNA CTD PMID:24106086 sodium arsenite multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] more ... CTD PMID:24106086 more ... sodium arsenite increases expression ISO Sirt1 (Mus musculus) 6480464 sodium arsenite results in increased expression of SIRT1 mRNA CTD PMID:19822182 and PMID:34968464 sodium arsenite decreases expression ISO Sirt1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA and sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:25610880 sodium arsenite increases expression ISO SIRT1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SIRT1 mRNA CTD PMID:17879257 sodium fluoride increases expression ISO Sirt1 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of SIRT1 mRNA CTD PMID:24296261 sodium fluoride decreases expression ISO Sirt1 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of SIRT1 mRNA CTD PMID:37739047 sodium fluoride multiple interactions EXP 6480464 Sodium Fluoride results in increased phosphorylation of and results in increased expression of SIRT1 protein CTD PMID:24296261 sodium fluoride multiple interactions ISO Sirt1 (Mus musculus) 6480464 Sodium Fluoride results in increased phosphorylation of and results in increased activity of SIRT1 protein and Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] CTD PMID:24296261 and PMID:37739047 splitomicin decreases activity ISO SIRT1 (Homo sapiens) 6480464 splitomicin results in decreased activity of SIRT1 protein CTD PMID:18482975 and PMID:20978007 splitomicin decreases expression EXP 6480464 splitomicin results in decreased expression of SIRT1 mRNA CTD PMID:25447406 splitomicin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6 more ... CTD PMID:18482975 staurosporine multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein and resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 steviol multiple interactions ISO Sirt1 (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 stevioside multiple interactions ISO Sirt1 (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 streptozocin multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of SIRT1 mRNA more ... CTD PMID:21778425 more ... streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of SIRT1 mRNA and Streptozocin results in decreased expression of SIRT1 protein CTD PMID:22733486 more ... streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with bisphenol A] results in decreased expression of SIRT1 protein more ... CTD PMID:22733486 more ... streptozocin decreases expression ISO Sirt1 (Mus musculus) 6480464 Streptozocin results in decreased expression of SIRT1 protein CTD PMID:21778425 more ... streptozocin decreases activity ISO Sirt1 (Mus musculus) 6480464 Streptozocin results in decreased activity of SIRT1 protein CTD PMID:22058332 sulforaphane increases expression ISO SIRT1 (Homo sapiens) 6480464 sulforaphane results in increased expression of SIRT1 protein CTD PMID:33894213 sulindac increases expression ISO SIRT1 (Homo sapiens) 6480464 Sulindac results in increased expression of SIRT1 mRNA CTD PMID:11906190 sunitinib increases expression ISO SIRT1 (Homo sapiens) 6480464 Sunitinib results in increased expression of SIRT1 mRNA CTD PMID:31533062 superoxide multiple interactions EXP 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 suramin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] and Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 and PMID:23217256 suramin multiple interactions ISO Sirt1 (Mus musculus) 6480464 [Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol CTD PMID:24252177 taurine multiple interactions ISO SIRT1 (Homo sapiens) 6480464 Taurine inhibits the reaction [arsenite results in decreased expression of SIRT1 mRNA] CTD PMID:23744399 taurine increases expression ISO Sirt1 (Mus musculus) 6480464 Taurine results in increased expression of SIRT1 mRNA and Taurine results in increased expression of SIRT1 protein CTD PMID:32017914 taurine multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:26930420 and PMID:32017914 temozolomide increases expression ISO SIRT1 (Homo sapiens) 6480464 Temozolomide results in increased expression of SIRT1 mRNA CTD PMID:31758290 tert-butanol increases expression ISO Sirt1 (Mus musculus) 6480464 tert-Butyl Alcohol results in increased expression of SIRT1 mRNA and tert-Butyl Alcohol results in increased expression of SIRT1 protein CTD PMID:29134718 tert-butyl hydroperoxide decreases expression ISO SIRT1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of SIRT1 protein CTD PMID:18552516 tert-butyl hydroperoxide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] CTD PMID:18552516 testosterone decreases expression ISO SIRT1 (Homo sapiens) 6480464 Testosterone results in decreased expression of SIRT1 mRNA CTD PMID:33359661 tetrachloromethane decreases response to substance EXP 6480464 SIRT1 results in decreased susceptibility to Carbon Tetrachloride CTD PMID:23993977 tetrachloromethane increases expression ISO Sirt1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of SIRT1 mRNA CTD PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] CTD PMID:28347707 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SIRT1 protein CTD PMID:28347707 tetrachloromethane decreases expression ISO Sirt1 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of SIRT1 protein CTD PMID:26435214 thapsigargin multiple interactions EXP 6480464 Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 mRNA]] CTD PMID:37741535 thimerosal multiple interactions ISO SIRT1 (Homo sapiens) 6480464 SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein]] CTD PMID:30503815 thymoquinone multiple interactions ISO Sirt1 (Mus musculus) 6480464 thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:27688165 thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 mRNA] and thymoquinone inhibits the reaction [Propylthiouracil results in decreased expression of SIRT1 protein] CTD PMID:36506574 thymoquinone multiple interactions ISO SIRT1 (Homo sapiens) 6480464 thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] CTD PMID:27688165 thyroxine increases expression ISO SIRT1 (Homo sapiens) 6480464 Thyroxine results in increased expression of SIRT1 protein CTD PMID:18204789 trans-piceid multiple interactions ISO SIRT1 (Homo sapiens) 6480464 polydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] CTD PMID:31926197 triphenylstannane decreases expression EXP 6480464 triphenyltin results in decreased expression of SIRT1 protein CTD PMID:31765896 triphenylstannane decreases expression ISO SIRT1 (Homo sapiens) 6480464 triphenyltin results in decreased expression of SIRT1 protein CTD PMID:31765896 Triptolide decreases expression ISO Sirt1 (Mus musculus) 6480464 triptolide results in decreased expression of SIRT1 protein CTD PMID:29723566 Triptolide multiple interactions EXP 6480464 7 and 3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein] CTD PMID:36436616 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of SIRT1 protein CTD PMID:29723566 and PMID:36436616 Triptolide multiple interactions ISO Sirt1 (Mus musculus) 6480464 [triptolide co-treated with resveratrol] results in increased expression of SIRT1 protein CTD PMID:29723566 triptonide increases expression ISO Sirt1 (Mus musculus) 6480464 triptonide results in increased expression of SIRT1 mRNA CTD PMID:33045310 tris(2-chloroethyl) phosphate increases expression ISO SIRT1 (Homo sapiens) 6480464 tris(chloroethyl)phosphate results in increased expression of SIRT1 mRNA and tris(chloroethyl)phosphate results in increased expression of SIRT1 protein CTD PMID:26378621 Tungsten carbide multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA CTD PMID:18078969 umbelliferone multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA] CTD PMID:33522649 umbelliferone increases expression EXP 6480464 7-hydroxycoumarin results in increased expression of SIRT1 mRNA CTD PMID:33522649 urethane increases expression ISO SIRT1 (Homo sapiens) 6480464 Urethane results in increased expression of SIRT1 mRNA CTD PMID:28818685 valproic acid decreases expression ISO Sirt1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of SIRT1 mRNA CTD PMID:15799026 and PMID:19136453 valproic acid decreases methylation ISO SIRT1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of SIRT1 gene CTD PMID:28853863 and PMID:29201983 valproic acid decreases expression ISO SIRT1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SIRT1 mRNA CTD PMID:23179753 and PMID:27188386 valproic acid affects expression ISO SIRT1 (Homo sapiens) 6480464 Valproic Acid affects the expression of SIRT1 mRNA CTD PMID:25979313 vincristine multiple interactions EXP 6480464 Quercetin inhibits the reaction [Vincristine results in decreased expression of SIRT1 protein] CTD PMID:36808657 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of SIRT1 protein CTD PMID:36808657 vitamin E decreases expression ISO SIRT1 (Homo sapiens) 6480464 Vitamin E results in decreased expression of SIRT1 mRNA CTD PMID:19244175 wortmannin multiple interactions ISO Sirt1 (Mus musculus) 6480464 wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] CTD PMID:22952890 wortmannin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] CTD PMID:18298901 zearalenone decreases expression ISO Sirt1 (Mus musculus) 6480464 Zearalenone results in decreased expression of SIRT1 protein CTD PMID:36161741 zearalenone multiple interactions ISO Sirt1 (Mus musculus) 6480464 6-chloro-2 more ... CTD PMID:36161741 zinc atom multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA CTD PMID:18593933 zinc protoporphyrin multiple interactions ISO SIRT1 (Homo sapiens) 6480464 zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein] CTD PMID:34520103 zinc(0) multiple interactions ISO SIRT1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA CTD PMID:18593933 ziram decreases expression EXP 6480464 Ziram results in decreased expression of SIRT1 protein CTD PMID:30422632