Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Rattus norvegicus
Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1308542
Description: Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in cytosol; growth cone; and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); impotence; non-alcoholic fatty liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22025,307,143 - 25,329,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKY
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Binge Drinking  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IEP)
Carotid Atherosclerosis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (IEP,IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (IEP)
Insulin Resistance  (IDA,ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (IEP)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (IDA,IEP,ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
obesity  (IEP,IMP,ISO)
osteoporosis  (IDA,IMP)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-lipoic acid  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
apocynin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
bafilomycin A1  (EXP)
benzamide  (ISO)
benzophenanthridine  (ISO)
berberine  (EXP,ISO)
Betanin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (EXP)
calcium oxalate  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CAY10591  (ISO)
CDP-choline  (EXP)
CGS-21680  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
chromium(6+)  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproheptadine  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dihydrogen  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ergosterol  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
everolimus  (ISO)
excitatory amino acid agonist  (EXP)
fenbendazole  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fisetin  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Genipin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycyrrhizinic acid  (EXP)
glyoxylic acid  (ISO)
Goe 6976  (ISO)
GW 501516  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP,ISO)
imidacloprid  (ISO)
inositol  (EXP)
ionomycin  (EXP)
iprodione  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoquinoline-1,5-diol  (ISO)
kainic acid  (EXP,ISO)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
Licarin A  (ISO)
linagliptin  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Magnolol  (EXP)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methotrexate  (EXP)
methylglyoxal  (EXP)
metiram  (ISO)
mifepristone  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monooxygen  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP,ISO)
naringin  (EXP)
nickel dichloride  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (EXP)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
olaparib  (ISO)
oleic acid  (EXP,ISO)
organoselenium compound  (EXP)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
prasugrel hydrochloride  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propionic acid  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
ramipril  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-nitroso-L-cysteine  (ISO)
salicylic acid  (EXP)
Salidroside  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
splitomicin  (EXP,ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
suramin  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
trans-piceid  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
behavioral response to starvation  (ISO)
cellular response to amyloid-beta  (IEP,IMP)
cellular response to antibiotic  (IEP)
cellular response to curcumin  (IEP)
cellular response to DNA damage stimulus  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to rotenone  (IEP)
cellular response to starvation  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (IEP)
cholesterol homeostasis  (ISO)
chromatin organization  (ISO)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
DNA synthesis involved in DNA repair  (ISO)
energy homeostasis  (IMP,ISO)
fatty acid homeostasis  (ISO)
heterochromatin formation  (ISO)
histone deacetylation  (ISO)
histone H3 deacetylation  (IBA,IMP,ISO)
intracellular glucose homeostasis  (ISO)
intracellular triglyceride homeostasis  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (ISO)
macrophage differentiation  (ISO)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cAMP-dependent protein kinase activity  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (ISO)
negative regulation of cell death  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (IMP)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (IBA,ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of fibroblast apoptotic process  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (IMP)
negative regulation of helicase activity  (ISO)
negative regulation of histone H3-K14 acetylation  (ISO)
negative regulation of histone H3-K9 trimethylation  (ISO)
negative regulation of histone H4-K16 acetylation  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of neuron death  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostaglandin biosynthetic process  (ISO)
negative regulation of protein acetylation  (IMP,ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IMP)
ovulation from ovarian follicle  (ISO)
peptidyl-lysine acetylation  (ISO)
peptidyl-lysine deacetylation  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IMP,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (IMP)
positive regulation of histone deacetylation  (ISO)
positive regulation of histone H3-K9 methylation  (ISO)
positive regulation of histone methylation  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of macroautophagy  (ISO)
positive regulation of macrophage apoptotic process  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein deacetylation  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle cell proliferation  (IMP)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of thyroid-stimulating hormone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (IDA,ISO)
protein depropionylation  (ISO,ISS)
protein destabilization  (ISO)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (ISO)
rDNA heterochromatin formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (ISO)
regulation of brown fat cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO,ISS)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of glucose metabolic process  (ISO)
regulation of lipid storage  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
regulation of protein serine/threonine kinase activity  (ISO)
regulation of smooth muscle cell apoptotic process  (ISO)
regulation of transcription by glucose  (ISO)
response to ethanol  (IDA)
response to fluoride  (IEP)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to kainic acid  (IEP)
response to leptin  (ISO)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to oxidative stress  (ISO)
response to resveratrol  (IEP)
single strand break repair  (ISO)
spermatogenesis  (ISO)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (ISO)
UV-damage excision repair  (ISO)
vasodilation  (IMP)
white fat cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. Akieda-Asai S, etal., PLoS One. 2010 Jul 23;5(7):e11755. doi: 10.1371/journal.pone.0011755.
2. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Alcendor RR, etal., Circ Res. 2004 Nov 12;95(10):971-80. Epub 2004 Oct 14.
3. 17-beta Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation. Bendale DS, etal., Br J Pharmacol. 2013 Oct;170(4):779-95. doi: 10.1111/bph.12290.
4. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. Bordone L, etal., PLoS Biol. 2006 Feb;4(2):e31. Epub 2005 Dec 27.
5. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. Castro RE, etal., J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15.
6. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. Caton PW, etal., J Endocrinol. 2011 Mar;208(3):273-83. doi: 10.1530/JOE-10-0190. Epub 2011 Jan 6.
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8. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Choi J, etal., Ann Clin Transl Neurol. 2014 Aug;1(8):589-604. doi: 10.1002/acn3.86. Epub 2014 Aug 19.
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49. GOA pipeline RGD automated data pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Comprehensive gene review and curation RGD comprehensive gene curation
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65. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. Wu A, etal., J Neurotrauma. 2007 Oct;24(10):1587-95.
66. Novel Role of Resveratrol: Suppression of HMGB1 Nucleocytoplasmic Translocation by the Up-Regulation of SIRT1 in Sepsis-Induced Liver Injury. Xu W, etal., Shock. 2014 Jul 4.
67. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury. Yan H, etal., Crit Care Med. 2014 May;42(5):e373-81. doi: 10.1097/CCM.0000000000000246.
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69. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Yar AS, etal., Genet Mol Res. 2011 Nov 29;10(4):2962-75. doi: 10.4238/2011.November.29.7.
70. Resveratrol ameliorates experimental autoimmune myocarditis. Yoshida Y, etal., Circ J. 2007 Mar;71(3):397-404.
71. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Yoshizaki T, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8.
72. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Zarzuelo MJ, etal., Biochem Pharmacol. 2013 May 1;85(9):1288-96. doi: 10.1016/j.bcp.2013.02.015. Epub 2013 Feb 17.
73. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Zhang J, etal., Age (Dordr). 2013 Jun;35(3):807-20. doi: 10.1007/s11357-012-9412-z. Epub 2012 May 4.
74. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.
75. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease. Zhang QS, etal., J Biosci. 2017 Sep;42(3):397-404.
76. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Zheng T and Lu Y, Curr Eye Res. 2011 May;36(5):449-55. doi: 10.3109/02713683.2011.559301.
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22025,307,143 - 25,329,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKY
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
T2T-CHM13v2.01068,753,401 - 68,787,131 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391063,154,784 - 63,174,814 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,154,784 - 63,217,483 (-)EnsemblGRCm39 Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,319,005 - 63,381,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBIMGSCv36mm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542520,279,963 - 20,307,663 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,280,725 - 20,307,663 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11066,681,983 - 66,714,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,681,598 - 66,715,069 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01064,368,878 - 64,401,684 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1419,188,616 - 19,220,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,188,675 - 19,218,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,317,273 - 19,349,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,454,692 - 19,486,553 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,454,710 - 19,546,039 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,337,295 - 19,369,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,559,257 - 19,591,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,901,939 - 19,934,337 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721361,803,376 - 61,829,477 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652110,296,097 - 10,322,215 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493652110,296,097 - 10,316,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1471,091,167 - 71,123,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,091,167 - 71,126,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,182,651 - 77,184,716 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21477,053,991 - 77,079,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1963,463,059 - 63,497,893 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl963,462,389 - 63,497,867 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604824,231,602 - 24,266,452 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247542,304,634 - 2,330,946 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,304,476 - 2,332,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sirt1
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000000427, ENSRNOT00000057829
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,328,230 - 25,328,418 (-)MAPPERmRatBN7.2
Rnor_6.02026,832,814 - 26,833,001NCBIRnor6.0
Rnor_5.0208,140,697 - 8,140,884UniSTSRnor5.0
RGSC_v3.42025,667,457 - 25,667,644UniSTSRGSC3.4
Celera2026,626,314 - 26,626,501UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map20p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,327,437 - 25,327,686 (-)MAPPERmRatBN7.2
Rnor_6.02026,833,546 - 26,833,794NCBIRnor6.0
Rnor_5.0208,141,429 - 8,141,677UniSTSRnor5.0
RGSC_v3.42025,668,189 - 25,668,437UniSTSRGSC3.4
Celera2026,625,521 - 26,625,769UniSTS
Cytogenetic Map20p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 31 40 24 19 24 6 6 72 35 39 11 6
Low 12 17 17 17 2 5 2 2 2
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078739   ⟹   ENSRNOP00000070943
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,306,917 - 25,327,667 (+)Ensembl
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095567   ⟹   ENSRNOP00000086140
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111766   ⟹   ENSRNOP00000094805
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,307,221 - 25,329,260 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119601   ⟹   ENSRNOP00000094468
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,315,088 - 25,329,260 (+)Ensembl
RefSeq Acc Id: NM_001372090   ⟹   NP_001359019
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.22025,315,088 - 25,329,260 (+)NCBI
RefSeq Acc Id: XM_039098755   ⟹   XP_038954683
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22025,307,143 - 25,329,260 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001359019 (Get FASTA)   NCBI Sequence Viewer  
  NP_001401888 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954683 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0G2JZ79 (Get FASTA)   NCBI Sequence Viewer  
  EDL97350 (Get FASTA)   NCBI Sequence Viewer  
  EDL97351 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000070943   ⟸   ENSRNOT00000078739
RefSeq Acc Id: XP_038954683   ⟸   XM_039098755
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A306 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001359019   ⟸   NM_001372090
- UniProtKB: A0A8I6B0Z5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094468   ⟸   ENSRNOT00000119601
RefSeq Acc Id: ENSRNOP00000094805   ⟸   ENSRNOT00000111766
RefSeq Acc Id: ENSRNOP00000086140   ⟸   ENSRNOT00000095567
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ79-F1-model_v2 AlphaFold A0A0G2JZ79 1-555 view protein structure
AF-A0A182DWI7-F1-model_v2 AlphaFold A0A182DWI7 1-730 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308542 AgrOrtholog
BioCyc Gene G2FUF-3820 BioCyc
Ensembl Genes ENSRNOG00000051592 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070943.2 UniProtKB/TrEMBL
  ENSRNOP00000086140.1 UniProtKB/TrEMBL
  ENSRNOP00000094468.1 UniProtKB/TrEMBL
  ENSRNOP00000094805.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078739.2 UniProtKB/TrEMBL
  ENSRNOT00000095567.1 UniProtKB/TrEMBL
  ENSRNOT00000111766.1 UniProtKB/TrEMBL
  ENSRNOT00000119601.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt1 PhenoGen
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIR1_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt1  sirtuin 1  Sirt1  sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sirt1  sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)  Sirt1  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sirt1  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)   Sirt1_predicted  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sirt1_predicted  sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED