(+)-epicatechin-3-O-gallate multiple interactions ISO RGD:1318374 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 (+)-pilocarpine multiple interactions EXP 6480464 dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] more ... CTD PMID:23211629 (+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of SIRT1 protein CTD PMID:23211629 (+)-taxifolin multiple interactions EXP 6480464 taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein CTD PMID:22742579 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1318374 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 (20S)-ginsenoside Rg3 increases activity EXP 6480464 ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 (R)-lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of SIRT1 protein CTD PMID:22327056 (R)-lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 (S)-nicotine decreases expression ISO RGD:1318375 6480464 Nicotine results in decreased expression of SIRT1 mRNA CTD PMID:22687363 (S)-nicotine multiple interactions ISO RGD:1318374 6480464 [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA more ... CTD PMID:23199342 (S)-nicotine multiple interactions ISO RGD:1318375 6480464 resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] CTD PMID:22687363 1,2-dimethylhydrazine multiple interactions ISO RGD:1318375 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of SIRT1 mRNA] CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1318375 6480464 1, 2-Dimethylhydrazine results in decreased expression of SIRT1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol decreases phosphorylation ISO RGD:1318375 6480464 Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein CTD PMID:34058177 17alpha-ethynylestradiol multiple interactions ISO RGD:1318375 6480464 Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein] CTD PMID:34058177 17beta-estradiol multiple interactions ISO RGD:1318374 6480464 Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]] CTD PMID:24771768 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1318375 6480464 Tetrachlorodibenzodioxin affects the expression of SIRT1 mRNA CTD PMID:21570461 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of SIRT1 protein CTD PMID:24782617 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of SIRT1 mRNA CTD PMID:21346803 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of SIRT1 protein CTD PMID:19167416 2-butoxyethanol increases expression ISO RGD:1318375 6480464 n-butoxyethanol results in increased expression of SIRT1 mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:1318374 6480464 beta-methylcholine affects the expression of SIRT1 mRNA CTD PMID:21179406 3,3',5-triiodo-L-thyronine affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Triiodothyronine CTD PMID:23209300 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein] more ... CTD PMID:23209300 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of SIRT1 mRNA CTD PMID:23209300 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1318375 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SIRT1 mRNA CTD PMID:26251327 3-hydroxybutyric acid multiple interactions ISO RGD:1318374 6480464 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1318374 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] more ... CTD PMID:26435214 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1318375 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein, [rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein CTD PMID:29288687 3-nitropropanoic acid decreases expression ISO RGD:1318375 6480464 3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 3-nitropropanoic acid decreases expression EXP 6480464 3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 4-hydroxynon-2-enal multiple interactions ISO RGD:1318375 6480464 SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal] CTD PMID:24633890 4-nitrophenol decreases expression ISO RGD:1318375 6480464 4-nitrophenol results in decreased expression of SIRT1 mRNA CTD PMID:34673133 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [SIRT1 protein affects the expression of ATF4 mRNA] more ... CTD PMID:29653943 5-(2-chloroethyl)-4-methylthiazole decreases expression ISO RGD:1318375 6480464 Chlormethiazole results in decreased expression of SIRT1 protein CTD PMID:24892905 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO RGD:1318375 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:24892905 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:20426787 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression EXP 6480464 6-chloro-2 more ... CTD PMID:29653943 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:32017914 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:29990529 , PMID:34216621 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:29545174 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity EXP 6480464 6-chloro-2 more ... CTD PMID:22968147 , PMID:32087266 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:21212096 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:20426787 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:20370652 more ... 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide increases expression ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:24726431 6alpha-methylprednisolone multiple interactions ISO RGD:1318375 6480464 Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 8-Br-cAMP multiple interactions ISO RGD:1318374 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein CTD PMID:16709600 acadesine multiple interactions ISO RGD:1318374 6480464 acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 acadesine increases expression ISO RGD:1318374 6480464 acadesine results in increased expression of SIRT1 protein CTD PMID:28556920 acetylcholine affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Acetylcholine CTD PMID:23422569 acetylsalicylic acid multiple interactions ISO RGD:1318374 6480464 Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] more ... CTD PMID:19520256 actinomycin D multiple interactions ISO RGD:1318374 6480464 Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] CTD PMID:30055241 aflatoxin B1 increases expression ISO RGD:1318375 6480464 Aflatoxin B1 results in increased expression of SIRT1 mRNA CTD PMID:19770486 aflatoxin B1 multiple interactions EXP 6480464 [Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA more ... CTD PMID:32894639 aflatoxin M1 decreases expression ISO RGD:1318374 6480464 Aflatoxin M1 results in decreased expression of SIRT1 mRNA CTD PMID:30928695 AICA ribonucleotide multiple interactions ISO RGD:1318375 6480464 AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:22058332 more ... AICA ribonucleotide multiple interactions ISO RGD:1318374 6480464 AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] CTD PMID:27688165 AICA ribonucleotide multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide CTD PMID:25108154 AICA ribonucleotide increases expression ISO RGD:1318375 6480464 AICA ribonucleotide results in increased expression of SIRT1 protein CTD PMID:24465016 aldehydo-D-glucose multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... aldehydo-D-glucose increases expression ISO RGD:1318374 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA, Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 , PMID:24802182 aldehydo-D-glucose increases phosphorylation ISO RGD:1318374 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 aldehydo-D-glucose decreases expression ISO RGD:1318374 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... aldehydo-D-glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 aldehydo-D-glucose affects abundance ISO RGD:1318375 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 aldehydo-D-glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 aldehydo-D-glucose decreases response to substance ISO RGD:1318375 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 aldehydo-D-glucose decreases expression ISO RGD:1318375 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 , PMID:23090186 aldehydo-D-glucose multiple interactions ISO RGD:1318375 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... aldehydo-D-glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of SIRT1 mRNA CTD PMID:33051911 , PMID:33396045 alpha-D-galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] CTD PMID:25892055 alpha-D-galactose decreases expression ISO RGD:1318374 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:29426000 alpha-D-galactose multiple interactions ISO RGD:1318374 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 alpha-D-galactose decreases expression EXP 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:25892055 amino acid multiple interactions ISO RGD:1318374 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 aminoguanidine multiple interactions EXP 6480464 [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] CTD PMID:22669716 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1318374 6480464 pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]], pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein] CTD PMID:31082419 antimony trichloride decreases expression ISO RGD:1318374 6480464 antimony trichloride results in decreased expression of SIRT1 mRNA, antimony trichloride results in decreased expression of SIRT1 protein CTD PMID:30055241 antimony trichloride multiple interactions ISO RGD:1318374 6480464 Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] more ... CTD PMID:30055241 apocynin multiple interactions ISO RGD:1318375 6480464 acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 arsenite(3-) multiple interactions ISO RGD:1318374 6480464 arsenite promotes the reaction [TP53 protein binds to SIRT1 promoter], Taurine inhibits the reaction [arsenite results in decreased expression of SIRT1 mRNA] CTD PMID:23744399 , PMID:25281835 arsenite(3-) decreases expression ISO RGD:1318374 6480464 arsenite results in decreased expression of SIRT1 mRNA CTD PMID:23744399 arsenite(3-) increases expression ISO RGD:1318374 6480464 arsenite results in increased expression of SIRT1 mRNA, arsenite results in increased expression of SIRT1 protein CTD PMID:25281835 arsenite(3-) increases methylation ISO RGD:1318374 6480464 arsenite results in increased methylation of SIRT1 promoter CTD PMID:25281835 arsenous acid multiple interactions ISO RGD:1318374 6480464 Arsenic Trioxide promotes the reaction [NVP-BKM120 results in decreased expression of SIRT1 mRNA] CTD PMID:30316766 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SIRT1 protein CTD PMID:33173984 arsenous acid multiple interactions EXP 6480464 Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein], trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein] CTD PMID:31332900 , PMID:33173984 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SIRT1 protein CTD PMID:31332900 arsenous acid decreases expression ISO RGD:1318374 6480464 Arsenic Trioxide results in decreased expression of SIRT1 mRNA CTD PMID:19763917 aspartame multiple interactions ISO RGD:1318375 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 ATP multiple interactions EXP 6480464 [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] more ... CTD PMID:16366736 ATP multiple interactions ISO RGD:1318374 6480464 [STK11 protein co-treated with Adenosine Triphosphate] results in increased activity of and results in increased phosphorylation of SIRT1 protein CTD PMID:34216621 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of SIRT1 mRNA CTD PMID:27114639 atrazine decreases expression ISO RGD:1318374 6480464 Atrazine results in decreased expression of SIRT1 mRNA CTD PMID:27114639 bafilomycin A1 multiple interactions EXP 6480464 bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] CTD PMID:24889822 benzamide decreases activity ISO RGD:1318374 6480464 benzamide analog results in decreased activity of SIRT1 protein CTD PMID:19616958 benzophenanthridine decreases expression ISO RGD:1318374 6480464 Benzophenanthridines analog results in decreased expression of SIRT1 mRNA CTD PMID:23117580 berberine decreases expression ISO RGD:1318374 6480464 Berberine results in decreased expression of SIRT1 mRNA, Berberine results in decreased expression of SIRT1 protein CTD PMID:26712469 berberine multiple interactions ISO RGD:1318374 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein, SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein] CTD PMID:26712469 Betanin multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:33661552 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA, Diethylhexyl Phthalate results in decreased expression of SIRT1 protein CTD PMID:32050098 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA], Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SIRT1 mRNA, bisphenol A results in increased expression of SIRT1 protein CTD PMID:28067316 , PMID:30816183 bisphenol A increases expression ISO RGD:1318374 6480464 bisphenol A results in increased expression of SIRT1 mRNA CTD PMID:28765096 bisphenol A multiple interactions EXP 6480464 bisphenol A inhibits the reaction [SIRT1 protein binds to CAV1 protein] CTD PMID:28067316 bleomycin A2 multiple interactions ISO RGD:1318375 6480464 resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 mRNA], resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 protein] CTD PMID:25707573 bleomycin A2 decreases expression ISO RGD:1318375 6480464 Bleomycin results in decreased expression of SIRT1 mRNA, Bleomycin results in decreased expression of SIRT1 protein CTD PMID:25707573 buta-1,3-diene increases expression ISO RGD:1318375 6480464 1, 3-butadiene results in increased expression of SIRT1 mRNA CTD PMID:25237060 butein increases activity ISO RGD:1318374 6480464 butein results in increased activity of SIRT1 protein CTD PMID:17327447 Butylbenzyl phthalate decreases expression ISO RGD:1318374 6480464 butylbenzyl phthalate results in decreased expression of SIRT1 mRNA, butylbenzyl phthalate results in decreased expression of SIRT1 protein CTD PMID:26520405 Butylbenzyl phthalate decreases expression ISO RGD:1318375 6480464 butylbenzyl phthalate results in decreased expression of SIRT1 mRNA, butylbenzyl phthalate results in decreased expression of SIRT1 protein CTD PMID:27923775 , PMID:34520170 cadmium atom multiple interactions ISO RGD:1318374 6480464 Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:25159133 cadmium atom multiple interactions EXP 6480464 [cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein, puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] CTD PMID:33404196 cadmium dichloride multiple interactions ISO RGD:1318374 6480464 Cadmium Chloride inhibits the reaction [SIRT1 protein binds to XBP1 protein alternative form] more ... CTD PMID:25159133 , PMID:30796460 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SIRT1 mRNA CTD PMID:31433112 cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein, Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:31433112 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of SIRT1 mRNA, Caffeine results in decreased expression of SIRT1 protein CTD PMID:30776459 , PMID:30825513 caffeine decreases expression ISO RGD:1318374 6480464 Caffeine results in decreased expression of SIRT1 mRNA CTD PMID:30825513 caffeine multiple interactions ISO RGD:1318374 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] more ... CTD PMID:30825513 Calcimycin affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to Calcimycin CTD PMID:23422569 calcium oxalate multiple interactions ISO RGD:1318374 6480464 phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein] more ... CTD PMID:34333021 calcium oxalate decreases expression ISO RGD:1318374 6480464 Calcium Oxalate results in decreased expression of SIRT1 protein CTD PMID:34333021 camptothecin multiple interactions ISO RGD:1318374 6480464 [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein more ... CTD PMID:24726431 camptothecin decreases expression ISO RGD:1318374 6480464 Camptothecin results in decreased expression of SIRT1 protein CTD PMID:24726431 carbon nanotube decreases expression ISO RGD:1318375 6480464 Nanotubes more ... CTD PMID:25554681 carnosic acid multiple interactions ISO RGD:1318374 6480464 Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]] more ... CTD PMID:24557422 carnosic acid increases expression ISO RGD:1318374 6480464 salvin results in increased expression of SIRT1 mRNA, salvin results in increased expression of SIRT1 protein CTD PMID:24557422 CDP-choline increases expression EXP 6480464 Cytidine Diphosphate Choline results in increased expression of SIRT1 protein CTD PMID:23600725 CDP-choline multiple interactions EXP 6480464 Cytidine Diphosphate Choline results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:23600725 CGS-21680 multiple interactions ISO RGD:1318374 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] CTD PMID:30825513 Chikusetsusaponin-V multiple interactions ISO RGD:1318374 6480464 chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] CTD PMID:25073091 chlorpyrifos multiple interactions ISO RGD:1318374 6480464 SIRT1 protein inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA] more ... CTD PMID:30835941 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of SIRT1 mRNA CTD PMID:33586219 chlorpyrifos multiple interactions EXP 6480464 [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA CTD PMID:33586219 chlorpyrifos decreases expression ISO RGD:1318374 6480464 Chlorpyrifos results in decreased expression of SIRT1 mRNA, Chlorpyrifos results in decreased expression of SIRT1 protein CTD PMID:30835941 cholesterol multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:21212096 , PMID:25833014 chromium(6+) multiple interactions EXP 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of SIRT1 protein CTD PMID:30974164 cilostazol multiple interactions ISO RGD:1318375 6480464 (E)-3-(2 more ... CTD PMID:24254769 cilostazol increases expression ISO RGD:1318374 6480464 cilostazol results in increased expression of SIRT1 protein CTD PMID:18556572 cilostazol multiple interactions ISO RGD:1318374 6480464 cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] more ... CTD PMID:19520256 cilostazol increases phosphorylation ISO RGD:1318375 6480464 cilostazol results in increased phosphorylation of SIRT1 protein CTD PMID:24254769 cilostazol affects expression ISO RGD:1318375 6480464 cilostazol affects the expression of SIRT1 mRNA CTD PMID:24254769 cisplatin multiple interactions ISO RGD:1318375 6480464 Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:21593185 , PMID:26723870 cisplatin multiple interactions ISO RGD:1318374 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA, [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SIRT1 mRNA CTD PMID:27392435 , PMID:30871063 cisplatin increases expression ISO RGD:1318375 6480464 Cisplatin results in increased expression of SIRT1 protein CTD PMID:26723870 cisplatin decreases activity EXP 6480464 Cisplatin results in decreased activity of SIRT1 protein CTD PMID:33661552 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SIRT1 mRNA CTD PMID:33522649 , PMID:33661552 cisplatin multiple interactions EXP 6480464 6-chloro-2 more ... CTD PMID:33522649 , PMID:33661552 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of SIRT1 protein CTD PMID:21416250 cisplatin decreases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in decreased susceptibility to Cisplatin CTD PMID:21416250 clofibrate multiple interactions ISO RGD:1318375 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA] CTD PMID:17585979 cobalt atom multiple interactions ISO RGD:1318374 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA CTD PMID:18078969 cobalt dichloride multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein], sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] CTD PMID:22669716 cobalt dichloride increases expression ISO RGD:1318374 6480464 cobaltous chloride results in increased expression of SIRT1 protein CTD PMID:22245592 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SIRT1 protein CTD PMID:22669716 cobalt dichloride multiple interactions ISO RGD:1318374 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]], SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]] CTD PMID:26174951 colforsin daropate hydrochloride multiple interactions EXP 6480464 SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]] more ... CTD PMID:23292070 colforsin daropate hydrochloride multiple interactions ISO RGD:1318374 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] CTD PMID:30825513 copper atom multiple interactions ISO RGD:1318374 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:1318374 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 copper(II) sulfate increases expression ISO RGD:1318374 6480464 Copper Sulfate results in increased expression of SIRT1 mRNA CTD PMID:19549813 cortisol decreases expression ISO RGD:1318374 6480464 Hydrocortisone results in decreased expression of SIRT1 mRNA CTD PMID:30776459 cortisol multiple interactions ISO RGD:1318374 6480464 NR3C1 protein affects the reaction [Hydrocortisone results in decreased expression of SIRT1 mRNA] CTD PMID:30776459 coumestrol decreases expression ISO RGD:1318374 6480464 Coumestrol results in decreased expression of SIRT1 mRNA CTD PMID:19167446 crocidolite asbestos increases expression ISO RGD:1318374 6480464 Asbestos, Crocidolite results in increased expression of SIRT1 mRNA CTD PMID:18687144 cudraflavone B increases expression ISO RGD:1318374 6480464 cudraflavone B results in increased expression of SIRT1 mRNA, cudraflavone B results in increased expression of SIRT1 protein CTD PMID:23881456 cudraflavone B multiple interactions ISO RGD:1318374 6480464 resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] more ... CTD PMID:23881456 Cuprizon multiple interactions ISO RGD:1318375 6480464 Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA] CTD PMID:29864483 Cuprizon decreases expression ISO RGD:1318375 6480464 Cuprizone results in decreased expression of SIRT1 mRNA CTD PMID:29864483 curcumin increases expression ISO RGD:1318375 6480464 Curcumin results in increased expression of SIRT1 mRNA CTD PMID:18403477 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein] CTD PMID:32569592 cycloheximide decreases expression ISO RGD:1318374 6480464 Cycloheximide results in decreased expression of SIRT1 protein CTD PMID:31082419 cycloheximide multiple interactions ISO RGD:1318374 6480464 Cycloheximide promotes the reaction [antimony trichloride results in decreased expression of SIRT1 protein] more ... CTD PMID:30055241 , PMID:31082419 cyclosporin A increases expression ISO RGD:1318374 6480464 Cyclosporine results in increased expression of SIRT1 mRNA CTD PMID:25562108 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of SIRT1 protein CTD PMID:32569592 cyclosporin A multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein] CTD PMID:32569592 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of SIRT1 mRNA CTD PMID:33051911 , PMID:33396045 cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of SIRT1 mRNA CTD PMID:33051911 , PMID:33396045 cyproheptadine increases expression EXP 6480464 Cyproheptadine results in increased expression of SIRT1 protein CTD PMID:33675893 D-glucose decreases response to substance ISO RGD:1318375 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 D-glucose increases phosphorylation ISO RGD:1318374 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 D-glucose increases expression ISO RGD:1318374 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA, Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 , PMID:24802182 D-glucose decreases expression ISO RGD:1318374 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... D-glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 D-glucose decreases expression ISO RGD:1318375 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 , PMID:23090186 D-glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 D-glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... D-glucose multiple interactions ISO RGD:1318375 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... D-glucose multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... D-glucose affects abundance ISO RGD:1318375 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 dehydroepiandrosterone affects expression ISO RGD:1318375 6480464 Dehydroepiandrosterone affects the expression of SIRT1 protein CTD PMID:20195491 dehydroepiandrosterone decreases expression ISO RGD:1318374 6480464 Dehydroepiandrosterone results in decreased expression of SIRT1 protein CTD PMID:20195491 dehydroepiandrosterone sulfate increases expression EXP 6480464 Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 desferrioxamine B increases expression ISO RGD:1318374 6480464 Deferoxamine results in increased expression of SIRT1 protein CTD PMID:22245592 dexamethasone multiple interactions EXP 6480464 [Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]] which results in decreased acetylation of FOXO1 protein more ... CTD PMID:17884810 more ... dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SIRT1 mRNA, Dexamethasone results in decreased expression of SIRT1 protein CTD PMID:33619658 dexamethasone multiple interactions ISO RGD:1318375 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein, [rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein CTD PMID:29288687 dexamethasone multiple interactions ISO RGD:1318374 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] more ... CTD PMID:26435214 dexamethasone increases expression ISO RGD:1318374 6480464 Dexamethasone results in increased expression of SIRT1 mRNA CTD PMID:19853017 dextran sulfate multiple interactions ISO RGD:1318375 6480464 ADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA] more ... CTD PMID:19940103 , PMID:24548422 dextran sulfate decreases expression ISO RGD:1318375 6480464 Dextran Sulfate results in decreased expression of SIRT1 mRNA, Dextran Sulfate results in decreased expression of SIRT1 protein CTD PMID:19940103 , PMID:24548422 Di-n-hexyl phthalate decreases expression EXP 6480464 di-n-hexyl phthalate results in decreased expression of SIRT1 protein CTD PMID:32693021 diarsenic trioxide decreases expression ISO RGD:1318374 6480464 Arsenic Trioxide results in decreased expression of SIRT1 mRNA CTD PMID:19763917 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of SIRT1 protein CTD PMID:33173984 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of SIRT1 protein CTD PMID:31332900 diarsenic trioxide multiple interactions EXP 6480464 Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein], trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of SIRT1 protein] CTD PMID:31332900 , PMID:33173984 diarsenic trioxide multiple interactions ISO RGD:1318374 6480464 Arsenic Trioxide promotes the reaction [NVP-BKM120 results in decreased expression of SIRT1 mRNA] CTD PMID:30316766 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SIRT1 protein CTD PMID:32525071 dibutyl phthalate multiple interactions EXP 6480464 taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 dihydrogen multiple interactions ISO RGD:1318374 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]], Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] CTD PMID:26271894 dihydrogen increases expression ISO RGD:1318374 6480464 Hydrogen results in increased expression of SIRT1 protein CTD PMID:26271894 diisononyl phthalate decreases expression ISO RGD:1318374 6480464 diisononyl phthalate results in decreased expression of SIRT1 mRNA, diisononyl phthalate results in decreased expression of SIRT1 protein CTD PMID:31423773 dioxygen multiple interactions ISO RGD:1318374 6480464 [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of CTNNB1] more ... CTD PMID:22245592 more ... dioxygen decreases expression ISO RGD:1318374 6480464 Oxygen deficiency results in decreased expression of SIRT1 protein CTD PMID:25707573 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of SIRT1 mRNA, Oxygen deficiency results in decreased expression of SIRT1 protein CTD PMID:25352008 dioxygen multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein more ... CTD PMID:22892143 more ... dioxygen affects response to substance ISO RGD:1318374 6480464 SIRT1 protein affects the susceptibility to Oxygen deficiency CTD PMID:22245592 dioxygen decreases expression ISO RGD:1318375 6480464 Oxygen deficiency results in decreased expression of SIRT1 protein, Oxygen results in decreased expression of SIRT1 protein CTD PMID:21113404 , PMID:25447406 dioxygen multiple interactions ISO RGD:1318375 6480464 [Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein more ... CTD PMID:19303870 more ... dioxygen increases expression ISO RGD:1318374 6480464 Oxygen deficiency results in increased expression of SIRT1 mRNA, Oxygen deficiency results in increased expression of SIRT1 protein CTD PMID:22245592 dipentyl phthalate decreases expression EXP 6480464 di-n-pentyl phthalate results in decreased expression of SIRT1 protein CTD PMID:33798595 diprotium increases expression ISO RGD:1318374 6480464 Hydrogen results in increased expression of SIRT1 protein CTD PMID:26271894 diprotium multiple interactions ISO RGD:1318374 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]], Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] CTD PMID:26271894 disulfiram multiple interactions ISO RGD:1318374 6480464 [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA CTD PMID:24690739 dizocilpine maleate multiple interactions ISO RGD:1318374 6480464 Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein], Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 dorsomorphin multiple interactions ISO RGD:1318374 6480464 [dorsomorphin co-treated with TNF protein] results in decreased expression of SIRT1 protein more ... CTD PMID:24145604 more ... dorsomorphin multiple interactions EXP 6480464 dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] CTD PMID:23211629 dorsomorphin decreases expression ISO RGD:1318375 6480464 dorsomorphin results in decreased expression of SIRT1 protein CTD PMID:24465016 dorsomorphin multiple interactions ISO RGD:1318375 6480464 dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] more ... CTD PMID:24465016 dorsomorphin decreases expression ISO RGD:1318374 6480464 dorsomorphin results in decreased expression of SIRT1 protein CTD PMID:25943029 doxorubicin affects response to substance ISO RGD:1318374 6480464 SIRT1 protein affects the susceptibility to Doxorubicin CTD PMID:19839049 doxorubicin increases expression ISO RGD:1318375 6480464 Doxorubicin results in increased expression of SIRT1 protein CTD PMID:31768571 doxorubicin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] CTD PMID:29966675 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SIRT1 protein CTD PMID:29966675 , PMID:31545955 doxorubicin decreases expression ISO RGD:1318374 6480464 Doxorubicin results in decreased expression of SIRT1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:1318374 6480464 Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:28456571 doxorubicin decreases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in decreased susceptibility to Doxorubicin CTD PMID:28456571 doxorubicin decreases activity ISO RGD:1318375 6480464 Doxorubicin results in decreased activity of SIRT1 protein CTD PMID:25665036 , PMID:26450947 doxorubicin multiple interactions ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:25665036 more ... elemental selenium decreases expression ISO RGD:1318374 6480464 Selenium results in decreased expression of SIRT1 mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1318374 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SIRT1 protein CTD PMID:23301498 ergosterol multiple interactions EXP 6480464 [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA, resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:25833014 Erythropoietin multiple interactions ISO RGD:1318374 6480464 Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein] more ... CTD PMID:28456571 ethanol decreases activity ISO RGD:1318375 6480464 Ethanol results in decreased activity of SIRT1 protein CTD PMID:18239056 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SIRT1 mRNA, Ethanol results in increased expression of SIRT1 protein CTD PMID:18793633 , PMID:32894639 ethanol decreases expression ISO RGD:1318374 6480464 Ethanol results in decreased expression of SIRT1 mRNA, Ethanol results in decreased expression of SIRT1 protein CTD PMID:24224909 more ... ethanol multiple interactions ISO RGD:1318374 6480464 3-(3 more ... CTD PMID:24224909 more ... ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SIRT1 mRNA, Ethanol results in decreased expression of SIRT1 protein CTD PMID:24769256 more ... ethanol multiple interactions EXP 6480464 3-(3 more ... CTD PMID:18239056 more ... ethanol decreases expression ISO RGD:1318375 6480464 Ethanol results in decreased expression of SIRT1 mRNA, Ethanol results in decreased expression of SIRT1 protein CTD PMID:18755807 more ... ethanol multiple interactions ISO RGD:1318375 6480464 5-aminoisoquinolinone inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein] more ... CTD PMID:18239056 more ... everolimus multiple interactions ISO RGD:1318374 6480464 Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein], cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] CTD PMID:19520256 everolimus decreases expression ISO RGD:1318374 6480464 Everolimus results in decreased expression of SIRT1 protein CTD PMID:19520256 excitatory amino acid agonist multiple interactions EXP 6480464 Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein, Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:19288225 fenofibrate multiple interactions ISO RGD:1318374 6480464 Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein] CTD PMID:32730863 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of SIRT1 mRNA, [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of SIRT1 mRNA CTD PMID:33051911 , PMID:33396045 fisetin multiple interactions ISO RGD:1318375 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein], fisetin results in increased activity of and results in increased phosphorylation of SIRT1 protein CTD PMID:31539617 , PMID:34216621 folic acid multiple interactions ISO RGD:1318375 6480464 Folic Acid inhibits the reaction [1 more ... CTD PMID:22206623 , PMID:29068127 folic acid multiple interactions ISO RGD:1318374 6480464 Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 fructose multiple interactions ISO RGD:1318375 6480464 SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] CTD PMID:18192211 fructose multiple interactions ISO RGD:1318374 6480464 [Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein, Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein] CTD PMID:32730863 fructose decreases expression EXP 6480464 Fructose results in decreased expression of SIRT1 mRNA, Fructose results in decreased expression of SIRT1 protein CTD PMID:25108154 , PMID:26488877 fructose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:21212096 more ... fructose increases expression ISO RGD:1318375 6480464 Fructose results in increased expression of SIRT1 protein CTD PMID:18192211 fulvestrant multiple interactions ISO RGD:1318374 6480464 fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]] CTD PMID:24771768 galactose decreases expression EXP 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:25892055 galactose decreases expression ISO RGD:1318374 6480464 Galactose results in decreased expression of SIRT1 protein CTD PMID:29426000 galactose multiple interactions ISO RGD:1318374 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] CTD PMID:27358235 galactose multiple interactions EXP 6480464 Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] CTD PMID:25892055 gallic acid multiple interactions ISO RGD:1318374 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 gallocatechin multiple interactions ISO RGD:1318374 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] CTD PMID:29061316 Genipin multiple interactions ISO RGD:1318375 6480464 genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein], sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] CTD PMID:28477916 genistein multiple interactions ISO RGD:1318374 6480464 Genistein inhibits the reaction [malondialdehyde-low density lipoprotein more ... CTD PMID:28688900 genistein increases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in increased susceptibility to Genistein CTD PMID:28688900 geraniol increases expression ISO RGD:1318374 6480464 geraniol results in increased expression of SIRT1 mRNA CTD PMID:27683099 ginsenoside Rg1 multiple interactions ISO RGD:1318374 6480464 ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of SIRT1 protein] CTD PMID:30918470 glucose affects abundance ISO RGD:1318375 6480464 SIRT1 protein affects the abundance of Glucose CTD PMID:18849969 glucose increases phosphorylation ISO RGD:1318374 6480464 Glucose deficiency results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:22561310 more ... glucose increases expression ISO RGD:1318374 6480464 Glucose deficiency results in increased expression of SIRT1 mRNA, Glucose deficiency results in increased expression of SIRT1 protein CTD PMID:20195491 , PMID:24802182 glucose decreases expression ISO RGD:1318374 6480464 Glucose results in decreased expression of SIRT1 mRNA, Glucose results in decreased expression of SIRT1 protein CTD PMID:20068143 more ... glucose affects expression EXP 6480464 Glucose affects the expression of SIRT1 protein CTD PMID:24349266 glucose decreases expression ISO RGD:1318375 6480464 Glucose results in decreased expression of SIRT1 protein CTD PMID:20370652 , PMID:23090186 glucose increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Glucose CTD PMID:16366736 glucose multiple interactions EXP 6480464 [6-chloro-2 more ... CTD PMID:16366736 more ... glucose multiple interactions ISO RGD:1318375 6480464 [6-chloro-2 more ... CTD PMID:19303870 more ... glucose multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:18482975 more ... glucose decreases response to substance ISO RGD:1318375 6480464 SIRT1 protein results in decreased susceptibility to Glucose CTD PMID:20370652 glutathione multiple interactions ISO RGD:1318374 6480464 [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein], GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] CTD PMID:24451382 glutathione decreases abundance ISO RGD:1318375 6480464 SIRT1 protein results in decreased abundance of Glutathione CTD PMID:29134718 glycyrrhizinic acid multiple interactions EXP 6480464 Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:25162824 glyoxylic acid decreases expression ISO RGD:1318375 6480464 glyoxylic acid results in decreased expression of SIRT1 protein CTD PMID:34333021 Goe 6976 multiple interactions ISO RGD:1318374 6480464 Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein], Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 GW 501516 multiple interactions ISO RGD:1318374 6480464 GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA], Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 hexadecanoic acid multiple interactions EXP 6480464 [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein, resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA] CTD PMID:22968147 , PMID:26854922 hexadecanoic acid decreases activity ISO RGD:1318374 6480464 Palmitic Acid results in decreased activity of SIRT1 protein CTD PMID:25943029 hexadecanoic acid multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:24451382 more ... hexadecanoic acid decreases expression EXP 6480464 Palmitic Acid results in decreased expression of SIRT1 mRNA, Palmitic Acid results in decreased expression of SIRT1 protein CTD PMID:22968147 , PMID:25108154 hydrogen peroxide multiple interactions ISO RGD:1318375 6480464 [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein more ... CTD PMID:20335659 more ... hydrogen peroxide affects localization ISO RGD:1318374 6480464 Hydrogen Peroxide affects the localization of SIRT1 protein CTD PMID:25512378 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SIRT1 mRNA, Hydrogen Peroxide results in decreased expression of SIRT1 protein CTD PMID:23891692 more ... hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of SIRT1 protein CTD PMID:17581637 hydrogen peroxide multiple interactions EXP 6480464 bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] more ... CTD PMID:18424637 more ... hydrogen peroxide decreases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:18681908 hydrogen peroxide decreases expression ISO RGD:1318374 6480464 Hydrogen Peroxide results in decreased expression of SIRT1 more ... CTD PMID:18681908 more ... hydrogen peroxide decreases response to substance ISO RGD:1318375 6480464 SIRT1 results in decreased susceptibility to Hydrogen Peroxide CTD PMID:20335659 hydrogen peroxide affects expression ISO RGD:1318374 6480464 Hydrogen Peroxide affects the expression of SIRT1 mRNA, Hydrogen Peroxide affects the expression of SIRT1 protein CTD PMID:20044591 more ... hydrogen peroxide multiple interactions ISO RGD:1318374 6480464 [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] more ... CTD PMID:18681908 more ... hydroquinone multiple interactions ISO RGD:1318374 6480464 SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of ATG5 mRNA], SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of BECN1 mRNA] CTD PMID:28263894 icariin increases expression ISO RGD:1318374 6480464 icariin results in increased expression of SIRT1 mRNA, icariin results in increased expression of SIRT1 protein CTD PMID:25472572 icariin multiple interactions ISO RGD:1318375 6480464 icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA] more ... CTD PMID:19303870 icariin affects expression EXP 6480464 icariin affects the expression of SIRT1 mRNA, icariin affects the expression of SIRT1 protein CTD PMID:25472572 icariin multiple interactions ISO RGD:1318374 6480464 icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein], Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] CTD PMID:25472572 imidacloprid decreases expression ISO RGD:1318375 6480464 imidacloprid results in decreased expression of SIRT1 protein CTD PMID:27960282 ionomycin increases expression EXP 6480464 Ionomycin results in increased expression of SIRT1 protein CTD PMID:17581637 iprodione multiple interactions EXP 6480464 [iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA CTD PMID:33586219 iprodione decreases expression EXP 6480464 iprodione results in decreased expression of SIRT1 mRNA CTD PMID:33586219 isoniazide decreases expression ISO RGD:1318374 6480464 Isoniazid results in decreased expression of SIRT1 protein CTD PMID:28556920 , PMID:31332904 isoniazide multiple interactions ISO RGD:1318374 6480464 acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein], Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 , PMID:31332904 isonicotinamide increases activity ISO RGD:1318374 6480464 isonicotinamide results in increased activity of SIRT1 protein CTD PMID:21745208 isonicotinamide increases expression ISO RGD:1318374 6480464 isonicotinamide results in increased expression of SIRT1 mRNA CTD PMID:21745208 isoquinoline-1,5-diol multiple interactions ISO RGD:1318374 6480464 1 more ... CTD PMID:25517228 kainic acid decreases expression ISO RGD:1318375 6480464 Kainic Acid results in decreased expression of SIRT1 protein CTD PMID:18538940 kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of SIRT1 protein CTD PMID:18538940 KT 5720 multiple interactions ISO RGD:1318375 6480464 KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]], KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] CTD PMID:24254769 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:33978298 lead(0) decreases expression ISO RGD:1318375 6480464 Lead results in decreased expression of SIRT1 protein CTD PMID:31539617 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:33978298 lead(0) multiple interactions ISO RGD:1318375 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 lead(2+) multiple interactions ISO RGD:1318375 6480464 fisetin inhibits the reaction [Lead results in decreased expression of SIRT1 protein] CTD PMID:31539617 lead(2+) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA more ... CTD PMID:33978298 lead(2+) decreases expression ISO RGD:1318375 6480464 Lead results in decreased expression of SIRT1 protein CTD PMID:31539617 Licarin A multiple interactions ISO RGD:1318375 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein CTD PMID:29288687 linagliptin multiple interactions ISO RGD:1318375 6480464 Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA] CTD PMID:29864483 lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein more ... CTD PMID:22327056 lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of SIRT1 protein CTD PMID:22327056 lipopolysaccharide multiple interactions ISO RGD:1318374 6480464 [Lipopolysaccharides co-treated with Bee Venoms] affects the expression of SIRT1 mRNA more ... CTD PMID:20844277 more ... lipopolysaccharide increases expression ISO RGD:1318374 6480464 Lipopolysaccharides results in increased expression of SIRT1, Lipopolysaccharides results in increased expression of SIRT1 protein CTD PMID:22000456 , PMID:30918470 lipopolysaccharide decreases expression ISO RGD:1318374 6480464 Lipopolysaccharides results in decreased expression of SIRT1, Lipopolysaccharides results in decreased expression of SIRT1 mRNA CTD PMID:20844277 more ... lipopolysaccharide multiple interactions EXP 6480464 [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA more ... CTD PMID:24289075 lipopolysaccharide decreases expression ISO RGD:1318375 6480464 Lipopolysaccharides results in decreased expression of SIRT1 protein CTD PMID:22952890 more ... lipopolysaccharide decreases activity ISO RGD:1318375 6480464 Lipopolysaccharides results in decreased activity of SIRT1 protein CTD PMID:19279313 lipopolysaccharide multiple interactions ISO RGD:1318375 6480464 AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] more ... CTD PMID:19279313 more ... lithocholic acid multiple interactions ISO RGD:1318374 6480464 Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein], VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]] CTD PMID:31472180 luzindole multiple interactions ISO RGD:1318374 6480464 luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]], luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] CTD PMID:25159133 lycopene multiple interactions ISO RGD:1318374 6480464 lycopene inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] CTD PMID:28974442 Magnolol multiple interactions EXP 6480464 [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 malonaldehyde multiple interactions ISO RGD:1318375 6480464 SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] CTD PMID:24633890 mancozeb decreases activity ISO RGD:1318374 6480464 mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 maneb decreases activity ISO RGD:1318374 6480464 Maneb results in decreased activity of SIRT1 protein CTD PMID:21251949 manganese atom multiple interactions ISO RGD:1318375 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein CTD PMID:34018660 manganese(0) multiple interactions ISO RGD:1318375 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein CTD PMID:34018660 manganese(II) chloride multiple interactions ISO RGD:1318375 6480464 [manganese chloride results in increased abundance of Manganese] which results in decreased expression of SIRT1 protein CTD PMID:34018660 medroxyprogesterone acetate multiple interactions ISO RGD:1318374 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein CTD PMID:16709600 melatonin decreases expression ISO RGD:1318375 6480464 Melatonin results in decreased expression of SIRT1 protein CTD PMID:21062352 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] CTD PMID:29966675 melatonin decreases expression ISO RGD:1318374 6480464 Melatonin results in decreased expression of SIRT1 protein CTD PMID:21062352 melatonin multiple interactions ISO RGD:1318374 6480464 luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] more ... CTD PMID:25159133 metformin multiple interactions ISO RGD:1318375 6480464 Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein] more ... CTD PMID:23090186 more ... metformin increases expression ISO RGD:1318374 6480464 Metformin results in increased expression of SIRT1 mRNA CTD PMID:32808185 metformin increases phosphorylation ISO RGD:1318375 6480464 Metformin results in increased phosphorylation of SIRT1 protein CTD PMID:34058177 metformin increases expression EXP 6480464 Metformin results in increased expression of SIRT1 protein CTD PMID:25108154 , PMID:31332900 metformin multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin more ... CTD PMID:25108154 , PMID:31332900 metformin multiple interactions ISO RGD:1318374 6480464 SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] CTD PMID:23315983 metformin increases expression ISO RGD:1318375 6480464 Metformin results in increased expression of SIRT1 mRNA CTD PMID:23166782 , PMID:24687991 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of SIRT1 mRNA, Methotrexate results in decreased expression of SIRT1 protein CTD PMID:34737150 methotrexate multiple interactions EXP 6480464 Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA], Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:34737150 methylglyoxal multiple interactions EXP 6480464 [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein, [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 metiram decreases activity ISO RGD:1318374 6480464 polymarcine results in decreased activity of SIRT1 protein CTD PMID:21251949 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of SIRT1 mRNA] CTD PMID:33619658 mithramycin multiple interactions ISO RGD:1318374 6480464 Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:1318375 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT1 mRNA, mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT1 protein CTD PMID:31016965 monooxygen increases expression ISO RGD:1318374 6480464 Singlet Oxygen results in increased expression of SIRT1 mRNA, Singlet Oxygen results in increased expression of SIRT1 protein CTD PMID:22860104 monosodium L-glutamate multiple interactions ISO RGD:1318375 6480464 [Fats more ... CTD PMID:23783067 , PMID:28708105 myricetin increases activity ISO RGD:1318374 6480464 myricetin results in increased activity of SIRT1 protein CTD PMID:22245592 myricetin increases expression ISO RGD:1318374 6480464 myricetin results in increased expression of SIRT1 protein CTD PMID:22245592 myricetin multiple interactions ISO RGD:1318374 6480464 [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein more ... CTD PMID:22245592 N,N-dimethylglycine multiple interactions ISO RGD:1318375 6480464 dimethylglycine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SIRT1 mRNA] CTD PMID:27171376 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:1318374 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with TNF protein] results in decreased expression of SIRT1 protein more ... CTD PMID:24145604 more ... N-acetyl-L-cysteine multiple interactions ISO RGD:1318374 6480464 Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] more ... CTD PMID:21031461 more ... N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1318374 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein, [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA CTD PMID:17583434 , PMID:22742579 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1318374 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA, 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein CTD PMID:25073091 more ... N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1318374 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein more ... CTD PMID:25073091 more ... N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SIRT1 protein CTD PMID:18538940 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 mRNA, 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein CTD PMID:17583434 more ... N-methyl-D-aspartic acid multiple interactions ISO RGD:1318374 6480464 1 more ... CTD PMID:31945382 N-methyl-D-aspartic acid decreases expression ISO RGD:1318374 6480464 N-Methylaspartate results in decreased expression of SIRT1 mRNA CTD PMID:31945382 N-methylformamide increases expression ISO RGD:1318375 6480464 methylformamide analog results in increased expression of SIRT1 mRNA, methylformamide results in increased expression of SIRT1 mRNA CTD PMID:17040096 N-nitrosodiethylamine decreases expression ISO RGD:1318375 6480464 Diethylnitrosamine results in decreased expression of SIRT1 mRNA CTD PMID:19996281 N-nitrosodiethylamine multiple interactions ISO RGD:1318375 6480464 AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SIRT1 mRNA] CTD PMID:19996281 NAD zwitterion decreases abundance EXP 6480464 SIRT1 protein results in decreased abundance of NAD CTD PMID:19288225 NAD zwitterion multiple interactions ISO RGD:1318375 6480464 [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein CTD PMID:23834033 NAD zwitterion increases activity EXP 6480464 NAD results in increased activity of SIRT1 protein CTD PMID:19288225 , PMID:22561310 NAD zwitterion increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to NAD CTD PMID:22561310 NAD zwitterion multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:19928762 more ... NAD zwitterion multiple interactions EXP 6480464 NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:19288225 , PMID:22561310 NAD(+) multiple interactions EXP 6480464 NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:19288225 , PMID:22561310 NAD(+) multiple interactions ISO RGD:1318375 6480464 [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein CTD PMID:23834033 NAD(+) increases activity EXP 6480464 NAD results in increased activity of SIRT1 protein CTD PMID:19288225 , PMID:22561310 NAD(+) increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to NAD CTD PMID:22561310 NAD(+) multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:19928762 more ... NAD(+) decreases abundance EXP 6480464 SIRT1 protein results in decreased abundance of NAD CTD PMID:19288225 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] CTD PMID:18793633 nickel dichloride increases expression ISO RGD:1318374 6480464 nickel chloride results in increased expression of SIRT1 mRNA CTD PMID:17547211 nicotinamide multiple interactions ISO RGD:1318375 6480464 [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [SIRT1 protein results in increased expression of PPARGC1A mRNA] more ... CTD PMID:16366736 more ... nicotinamide decreases expression EXP 6480464 Niacinamide results in decreased expression of SIRT1 protein CTD PMID:22561310 nicotinamide decreases expression ISO RGD:1318374 6480464 Niacinamide results in decreased expression of SIRT1 mRNA, Niacinamide results in decreased expression of SIRT1 protein CTD PMID:19928762 , PMID:21745208 nicotinamide multiple interactions EXP 6480464 [Niacinamide co-treated with Resveratrol] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA] more ... CTD PMID:18420994 more ... nicotinamide multiple interactions ISO RGD:1318374 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein more ... CTD PMID:18482975 more ... nicotinamide decreases activity ISO RGD:1318374 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:17103016 more ... nicotinamide decreases activity EXP 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:16366736 more ... nicotinamide decreases activity ISO RGD:1318375 6480464 Niacinamide results in decreased activity of SIRT1 protein CTD PMID:16366736 , PMID:34216621 nicotine multiple interactions ISO RGD:1318375 6480464 resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] CTD PMID:22687363 nicotine multiple interactions ISO RGD:1318374 6480464 [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA more ... CTD PMID:23199342 nicotine decreases expression ISO RGD:1318375 6480464 Nicotine results in decreased expression of SIRT1 mRNA CTD PMID:22687363 nimesulide multiple interactions ISO RGD:1318375 6480464 nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:25339356 nitric oxide multiple interactions ISO RGD:1318374 6480464 SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide], SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] CTD PMID:20960276 nitrites multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein more ... CTD PMID:22892143 nitroprusside multiple interactions ISO RGD:1318374 6480464 Nitroprusside results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:18204789 nitroxoline multiple interactions ISO RGD:1318374 6480464 nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] CTD PMID:31638783 nitroxoline decreases expression ISO RGD:1318374 6480464 nitroxoline results in decreased expression of SIRT1 protein CTD PMID:31638783 NMN zwitterion increases expression EXP 6480464 Nicotinamide Mononucleotide results in increased expression of SIRT1 mRNA CTD PMID:32087266 NMN zwitterion multiple interactions EXP 6480464 Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA], Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:32087266 ochratoxin A increases expression ISO RGD:1318374 6480464 ochratoxin A results in increased expression of SIRT1 mRNA CTD PMID:34481902 oleic acid increases expression EXP 6480464 Oleic Acid results in increased expression of SIRT1 protein CTD PMID:24349266 oleic acid multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:25536389 oleic acid decreases activity ISO RGD:1318374 6480464 Oleic Acid results in decreased activity of SIRT1 protein CTD PMID:25536389 oleic acid multiple interactions EXP 6480464 [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein CTD PMID:26854922 organoselenium compound multiple interactions EXP 6480464 Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] CTD PMID:25301743 oxaloacetic acid multiple interactions ISO RGD:1318374 6480464 Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 oxidopamine decreases expression ISO RGD:1318374 6480464 Oxidopamine results in decreased expression of SIRT1 protein CTD PMID:18675900 oxidopamine multiple interactions ISO RGD:1318374 6480464 puag-haad inhibits the reaction [Oxidopamine results in decreased expression of SIRT1 protein] CTD PMID:18675900 P(1),P(5)-bis(5'-adenosyl) pentaphosphate multiple interactions EXP 6480464 P(1), P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 paclitaxel multiple interactions ISO RGD:1318374 6480464 Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein], cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] CTD PMID:19520256 paclitaxel decreases expression ISO RGD:1318374 6480464 Paclitaxel results in decreased expression of SIRT1 protein CTD PMID:19520256 paracetamol multiple interactions ISO RGD:1318375 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA more ... CTD PMID:17585979 more ... paracetamol affects response to substance ISO RGD:1318375 6480464 SIRT1 affects the susceptibility to Acetaminophen CTD PMID:31077331 paracetamol multiple interactions ISO RGD:1318374 6480464 MIR19B1 inhibits the reaction [Acetaminophen results in increased expression of SIRT1 protein] more ... CTD PMID:31077331 paracetamol increases expression ISO RGD:1318375 6480464 Acetaminophen results in increased expression of SIRT1 mRNA, Acetaminophen results in increased expression of SIRT1 protein CTD PMID:31077331 paracetamol affects response to substance ISO RGD:1318374 6480464 SIRT1 affects the susceptibility to Acetaminophen CTD PMID:31077331 paracetamol affects expression ISO RGD:1318375 6480464 Acetaminophen affects the expression of SIRT1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1318374 6480464 Acetaminophen results in increased expression of SIRT1 mRNA, Acetaminophen results in increased expression of SIRT1 protein CTD PMID:21420995 more ... paraquat increases expression ISO RGD:1318375 6480464 Paraquat results in increased expression of SIRT1 mRNA, Paraquat results in increased expression of SIRT1 protein CTD PMID:22563483 , PMID:26708779 paraquat multiple interactions ISO RGD:1318375 6480464 resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 mRNA] more ... CTD PMID:26708779 , PMID:26935021 paraquat affects expression ISO RGD:1318375 6480464 Paraquat affects the expression of SIRT1 protein CTD PMID:26935021 pentachlorophenol decreases expression EXP 6480464 Pentachlorophenol results in decreased expression of SIRT1 protein CTD PMID:19442831 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of SIRT1 protein CTD PMID:30489073 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 perfluorooctane sulfonic acid affects the localization of and results in increased expression of and results in increased activity of and results in decreased phosphorylation of SIRT1 protein CTD PMID:28973641 perfluorooctane-1-sulfonic acid affects binding ISO RGD:1318375 6480464 perfluorooctane sulfonic acid binds to SIRT1 protein CTD PMID:33689947 perfluorooctane-1-sulfonic acid decreases activity ISO RGD:1318375 6480464 perfluorooctane sulfonic acid results in decreased activity of SIRT1 protein CTD PMID:33689947 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1318374 6480464 perfluorooctane sulfonic acid results in decreased expression of SIRT1 mRNA, perfluorooctane sulfonic acid results in decreased expression of SIRT1 protein CTD PMID:31508952 perfluorooctanoic acid increases expression ISO RGD:1318375 6480464 perfluorooctanoic acid results in increased expression of SIRT1 mRNA CTD PMID:31016965 perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA], Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:34737150 perindopril increases expression EXP 6480464 Perindopril results in increased expression of SIRT1 mRNA, Perindopril results in increased expression of SIRT1 protein CTD PMID:34737150 phenformin decreases expression ISO RGD:1318374 6480464 Phenformin results in decreased expression of SIRT1 protein CTD PMID:26768367 phenobarbital affects expression ISO RGD:1318374 6480464 Phenobarbital affects the expression of SIRT1 mRNA CTD PMID:19159669 phenobarbital affects expression ISO RGD:1318375 6480464 Phenobarbital affects the expression of SIRT1 mRNA CTD PMID:23091169 phenol increases expression ISO RGD:1318374 6480464 Phenol results in increased expression of SIRT1 mRNA CTD PMID:17547211 potassium atom affects expression EXP 6480464 Potassium affects the expression of SIRT1 mRNA, Potassium affects the expression of SIRT1 protein CTD PMID:17583434 potassium dichromate multiple interactions EXP 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of SIRT1 protein CTD PMID:30974164 prasugrel hydrochloride multiple interactions EXP 6480464 Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SIRT1 protein] CTD PMID:34174262 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:1318375 6480464 SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] CTD PMID:21933665 propionic acid decreases expression ISO RGD:1318374 6480464 propionic acid results in decreased expression of SIRT1 mRNA CTD PMID:31526819 prostaglandin E2 multiple interactions ISO RGD:1318375 6480464 Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] CTD PMID:20335659 prostaglandin E2 decreases expression ISO RGD:1318374 6480464 Dinoprostone results in decreased expression of SIRT1 mRNA, Dinoprostone results in decreased expression of SIRT1 protein CTD PMID:30409902 prostaglandin E2 multiple interactions ISO RGD:1318374 6480464 1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein] more ... CTD PMID:20844277 more ... prostaglandin F2alpha multiple interactions ISO RGD:1318374 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 pterostilbene multiple interactions ISO RGD:1318374 6480464 [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA, [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein CTD PMID:26459286 puerarin multiple interactions EXP 6480464 puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] CTD PMID:33404196 pyruvic acid increases expression ISO RGD:1318375 6480464 Pyruvic Acid results in increased expression of SIRT1 mRNA CTD PMID:21933665 pyruvic acid multiple interactions ISO RGD:1318374 6480464 [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein], [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein CTD PMID:19071085 , PMID:27358235 pyruvic acid multiple interactions ISO RGD:1318375 6480464 [PDK4 affects the abundance of Pyruvic Acid] which results in increased expression of SIRT1, SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] CTD PMID:21182459 , PMID:21933665 quercetin increases expression ISO RGD:1318375 6480464 Quercetin results in increased expression of SIRT1 mRNA, Quercetin results in increased expression of SIRT1 protein CTD PMID:19211721 , PMID:24465016 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] CTD PMID:28347707 quercetin affects activity ISO RGD:1318375 6480464 Quercetin affects the activity of SIRT1 protein CTD PMID:24025686 quercetin increases activity ISO RGD:1318374 6480464 Quercetin results in increased activity of SIRT1 protein CTD PMID:22245592 quercetin increases expression ISO RGD:1318374 6480464 Quercetin results in increased expression of SIRT1 protein CTD PMID:22245592 quercetin decreases expression ISO RGD:1318374 6480464 Quercetin results in decreased expression of SIRT1 protein CTD PMID:25896587 quercetin multiple interactions ISO RGD:1318374 6480464 [Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein more ... CTD PMID:22245592 more ... quercetin multiple interactions ISO RGD:1318375 6480464 dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] more ... CTD PMID:24025686 more ... quercetin 3-O-beta-D-galactopyranoside multiple interactions ISO RGD:1318374 6480464 hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] CTD PMID:18552516 ramipril multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein CTD PMID:31062909 reactive oxygen species multiple interactions EXP 6480464 SIRT1 protein affects the reaction [[Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of NDUFA13 protein] CTD PMID:23891692 reactive oxygen species increases chemical synthesis ISO RGD:1318375 6480464 SIRT1 protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:29134718 rebaudioside A multiple interactions ISO RGD:1318375 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 resveratrol multiple interactions ISO RGD:1318374 6480464 6-chloro-2 more ... CTD PMID:15152190 more ... resveratrol decreases expression EXP 6480464 Resveratrol results in decreased expression of SIRT1 mRNA, Resveratrol results in decreased expression of SIRT1 protein CTD PMID:20195491 more ... resveratrol increases activity ISO RGD:1318375 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:17112576 more ... resveratrol affects response to substance ISO RGD:1318374 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:22523472 more ... resveratrol decreases activity ISO RGD:1318374 6480464 resveratrol results in decreased activity of SIRT1 protein CTD PMID:24429678 resveratrol affects response to substance ISO RGD:1318375 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:23090186 , PMID:24782617 resveratrol affects activity ISO RGD:1318374 6480464 resveratrol affects the activity of SIRT1 protein CTD PMID:24064760 resveratrol increases expression EXP 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:17583434 more ... resveratrol decreases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in decreased susceptibility to resveratrol CTD PMID:23248098 resveratrol increases phosphorylation ISO RGD:1318375 6480464 resveratrol results in increased phosphorylation of SIRT1 protein CTD PMID:24296261 resveratrol affects localization ISO RGD:1318374 6480464 resveratrol affects the localization of SIRT1 protein CTD PMID:24587049 resveratrol increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to resveratrol CTD PMID:22561310 more ... resveratrol increases activity ISO RGD:1318374 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:15749705 more ... resveratrol increases expression ISO RGD:1318374 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:16849586 more ... resveratrol increases response to substance ISO RGD:1318374 6480464 SIRT1 protein results in increased susceptibility to resveratrol CTD PMID:19664641 , PMID:26174951 resveratrol increases expression ISO RGD:1318375 6480464 Resveratrol results in increased expression of SIRT1 more ... CTD PMID:18755807 more ... resveratrol increases activity EXP 6480464 resveratrol results in increased activity of SIRT1 protein CTD PMID:18077353 more ... resveratrol increases response to substance ISO RGD:1318375 6480464 SIRT1 protein results in increased susceptibility to resveratrol, SIRT1 results in increased susceptibility to resveratrol CTD PMID:21593185 more ... resveratrol affects expression ISO RGD:1318375 6480464 resveratrol affects the expression of SIRT1 protein CTD PMID:24254769 resveratrol decreases expression ISO RGD:1318374 6480464 Resveratrol results in decreased expression of SIRT1 mRNA, Resveratrol results in decreased expression of SIRT1 protein CTD PMID:20195491 more ... resveratrol affects response to substance EXP 6480464 SIRT1 protein affects the susceptibility to resveratrol CTD PMID:20651248 resveratrol multiple interactions EXP 6480464 [Niacinamide co-treated with Resveratrol] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA] more ... CTD PMID:17583434 more ... resveratrol multiple interactions ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:17581637 more ... rotenone increases expression EXP 6480464 Rotenone results in increased expression of SIRT1 protein CTD PMID:18538940 rotenone multiple interactions ISO RGD:1318374 6480464 polydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] more ... CTD PMID:25991017 , PMID:31926197 rotenone decreases expression ISO RGD:1318374 6480464 Rotenone results in decreased expression of SIRT1 mRNA, Rotenone results in decreased expression of SIRT1 protein CTD PMID:25991017 , PMID:31926197 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SIRT1 protein CTD PMID:18538940 rutin increases expression EXP 6480464 Rutin results in increased expression of SIRT1 mRNA, Rutin results in increased expression of SIRT1 protein CTD PMID:30365940 S-nitroso-L-cysteine multiple interactions ISO RGD:1318374 6480464 S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein], S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 salicylic acid multiple interactions EXP 6480464 [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid CTD PMID:25108154 Salidroside multiple interactions ISO RGD:1318374 6480464 rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SIRT1 protein] CTD PMID:28851138 Salvianolic acid A multiple interactions ISO RGD:1318375 6480464 Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA] more ... CTD PMID:23993977 salvianolic acid B increases expression ISO RGD:1318374 6480464 salvianolic acid B results in increased expression of SIRT1 protein CTD PMID:24769256 , PMID:27989594 salvianolic acid B multiple interactions ISO RGD:1318374 6480464 salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein], SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] CTD PMID:27989594 salvianolic acid B multiple interactions EXP 6480464 salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] more ... CTD PMID:24769256 , PMID:27989594 SB 203580 multiple interactions ISO RGD:1318374 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of SIRT1 protein] CTD PMID:25512378 SB 203580 multiple interactions ISO RGD:1318375 6480464 SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]], SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] CTD PMID:19303870 selenium atom decreases expression ISO RGD:1318374 6480464 Selenium results in decreased expression of SIRT1 mRNA CTD PMID:19244175 silicon dioxide increases expression ISO RGD:1318374 6480464 Silicon Dioxide results in increased expression of SIRT1 mRNA CTD PMID:25351596 silicon dioxide decreases expression ISO RGD:1318375 6480464 Silicon Dioxide results in decreased expression of SIRT1 protein CTD PMID:31082419 silicon dioxide multiple interactions ISO RGD:1318374 6480464 pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]] more ... CTD PMID:31082419 silver atom increases expression ISO RGD:1318374 6480464 Silver results in increased expression of SIRT1 mRNA CTD PMID:26014281 silver(0) increases expression ISO RGD:1318374 6480464 Silver results in increased expression of SIRT1 mRNA CTD PMID:26014281 sirolimus multiple interactions ISO RGD:1318374 6480464 [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of SIRT1 protein more ... CTD PMID:19520256 , PMID:25307878 sirolimus decreases expression ISO RGD:1318374 6480464 Sirolimus results in decreased expression of SIRT1 protein CTD PMID:19520256 , PMID:25307878 sirolimus increases response to substance EXP 6480464 SIRT1 protein results in increased susceptibility to Sirolimus CTD PMID:22561310 sirolimus increases expression EXP 6480464 Sirolimus results in increased expression of SIRT1 protein CTD PMID:22561310 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] more ... CTD PMID:22561310 sirtinol decreases activity ISO RGD:1318374 6480464 sirtinol analog results in decreased activity of SIRT1 protein, sirtinol results in decreased activity of SIRT1 protein CTD PMID:16302818 more ... sirtinol decreases activity ISO RGD:1318375 6480464 sirtinol results in decreased activity of SIRT1 protein CTD PMID:20370652 sirtinol multiple interactions ISO RGD:1318375 6480464 [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose more ... CTD PMID:20370652 more ... sirtinol decreases activity EXP 6480464 sirtinol results in decreased activity of SIRT1 protein CTD PMID:23479127 sirtinol multiple interactions EXP 6480464 sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein], sirtinol inhibits the reaction [Resveratrol results in increased expression of and results in increased activity of SIRT1 protein] CTD PMID:22669716 , PMID:24395567 sirtinol multiple interactions ISO RGD:1318374 6480464 [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] more ... CTD PMID:18681908 more ... sodium arsenite decreases expression ISO RGD:1318374 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA, sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:25982963 , PMID:33360347 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA, sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:33360347 sodium arsenite multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] CTD PMID:33360347 sodium arsenite multiple interactions ISO RGD:1318375 6480464 [DOT1L protein affects the susceptibility to sodium arsenite] which results in decreased expression of SIRT1 mRNA CTD PMID:30130555 sodium arsenite multiple interactions ISO RGD:1318374 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] more ... CTD PMID:25982963 , PMID:33360347 sodium arsenite increases expression ISO RGD:1318375 6480464 sodium arsenite results in increased expression of SIRT1 mRNA CTD PMID:19822182 sodium arsenite decreases expression ISO RGD:1318375 6480464 sodium arsenite results in decreased expression of SIRT1 mRNA, sodium arsenite results in decreased expression of SIRT1 protein CTD PMID:25610880 sodium arsenite increases expression ISO RGD:1318374 6480464 sodium arsenite results in increased expression of SIRT1 mRNA CTD PMID:17879257 sodium fluoride increases expression ISO RGD:1318375 6480464 Sodium Fluoride results in increased expression of SIRT1 mRNA CTD PMID:24296261 sodium fluoride multiple interactions EXP 6480464 Sodium Fluoride results in increased phosphorylation of and results in increased expression of SIRT1 protein CTD PMID:24296261 sodium fluoride multiple interactions ISO RGD:1318375 6480464 Sodium Fluoride results in increased phosphorylation of and results in increased activity of SIRT1 protein CTD PMID:24296261 splitomicin decreases activity ISO RGD:1318374 6480464 splitomicin results in decreased activity of SIRT1 protein CTD PMID:18482975 , PMID:20978007 splitomicin decreases expression EXP 6480464 splitomicin results in decreased expression of SIRT1 mRNA CTD PMID:25447406 splitomicin multiple interactions ISO RGD:1318374 6480464 [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6 more ... CTD PMID:18482975 staurosporine multiple interactions ISO RGD:1318375 6480464 [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein, resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 steviol multiple interactions ISO RGD:1318375 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 stevioside multiple interactions ISO RGD:1318375 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 streptozocin multiple interactions ISO RGD:1318375 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of SIRT1 mRNA more ... CTD PMID:21778425 more ... streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of SIRT1 mRNA, Streptozocin results in decreased expression of SIRT1 protein CTD PMID:22733486 more ... streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein more ... CTD PMID:22733486 more ... streptozocin decreases expression ISO RGD:1318375 6480464 Streptozocin results in decreased expression of SIRT1 protein CTD PMID:21778425 more ... streptozocin decreases activity ISO RGD:1318375 6480464 Streptozocin results in decreased activity of SIRT1 protein CTD PMID:22058332 sulforaphane increases expression ISO RGD:1318374 6480464 sulforaphane results in increased expression of SIRT1 protein CTD PMID:33894213 sulindac increases expression ISO RGD:1318374 6480464 Sulindac results in increased expression of SIRT1 mRNA CTD PMID:11906190 sunitinib increases expression ISO RGD:1318374 6480464 Sunitinib results in increased expression of SIRT1 mRNA CTD PMID:31533062 superoxide multiple interactions EXP 6480464 SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 suramin multiple interactions ISO RGD:1318374 6480464 Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein], Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 , PMID:23217256 suramin multiple interactions ISO RGD:1318375 6480464 [Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol CTD PMID:24252177 taurine multiple interactions ISO RGD:1318374 6480464 Taurine inhibits the reaction [arsenite results in decreased expression of SIRT1 mRNA] CTD PMID:23744399 taurine increases expression ISO RGD:1318375 6480464 Taurine results in increased expression of SIRT1 mRNA, Taurine results in increased expression of SIRT1 protein CTD PMID:32017914 taurine multiple interactions ISO RGD:1318375 6480464 6-chloro-2 more ... CTD PMID:26930420 , PMID:32017914 temozolomide increases expression ISO RGD:1318374 6480464 Temozolomide results in increased expression of SIRT1 mRNA CTD PMID:31758290 tert-butanol increases expression ISO RGD:1318375 6480464 tert-Butyl Alcohol results in increased expression of SIRT1 mRNA, tert-Butyl Alcohol results in increased expression of SIRT1 protein CTD PMID:29134718 tert-butyl hydroperoxide decreases expression ISO RGD:1318374 6480464 tert-Butylhydroperoxide results in decreased expression of SIRT1 protein CTD PMID:18552516 tert-butyl hydroperoxide multiple interactions ISO RGD:1318374 6480464 hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] CTD PMID:18552516 testosterone decreases expression ISO RGD:1318374 6480464 Testosterone results in decreased expression of SIRT1 mRNA CTD PMID:33359661 tetrachloromethane decreases response to substance EXP 6480464 SIRT1 results in decreased susceptibility to Carbon Tetrachloride CTD PMID:23993977 tetrachloromethane increases expression ISO RGD:1318375 6480464 Carbon Tetrachloride results in increased expression of SIRT1 mRNA CTD PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] CTD PMID:28347707 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SIRT1 protein CTD PMID:28347707 tetrachloromethane decreases expression ISO RGD:1318375 6480464 Carbon Tetrachloride results in decreased expression of SIRT1 protein CTD PMID:26435214 thimerosal multiple interactions ISO RGD:1318374 6480464 SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein]] CTD PMID:30503815 thymoquinone multiple interactions ISO RGD:1318375 6480464 thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:27688165 thymoquinone multiple interactions ISO RGD:1318374 6480464 thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] CTD PMID:27688165 thyroxine increases expression ISO RGD:1318374 6480464 Thyroxine results in increased expression of SIRT1 protein CTD PMID:18204789 trans-piceid multiple interactions ISO RGD:1318374 6480464 polydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] CTD PMID:31926197 triphenylstannane decreases expression EXP 6480464 triphenyltin results in decreased expression of SIRT1 protein CTD PMID:31765896 triphenylstannane decreases expression ISO RGD:1318374 6480464 triphenyltin results in decreased expression of SIRT1 protein CTD PMID:31765896 Triptolide decreases expression ISO RGD:1318375 6480464 triptolide results in decreased expression of SIRT1 protein CTD PMID:29723566 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of SIRT1 protein CTD PMID:29723566 Triptolide multiple interactions ISO RGD:1318375 6480464 [triptolide co-treated with resveratrol] results in increased expression of SIRT1 protein CTD PMID:29723566 triptonide increases expression ISO RGD:1318375 6480464 triptonide results in increased expression of SIRT1 mRNA CTD PMID:33045310 tris(2-chloroethyl) phosphate increases expression ISO RGD:1318374 6480464 tris(chloroethyl)phosphate results in increased expression of SIRT1 mRNA, tris(chloroethyl)phosphate results in increased expression of SIRT1 protein CTD PMID:26378621 Tungsten carbide multiple interactions ISO RGD:1318374 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA CTD PMID:18078969 umbelliferone multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA] CTD PMID:33522649 umbelliferone increases expression EXP 6480464 7-hydroxycoumarin results in increased expression of SIRT1 mRNA CTD PMID:33522649 urethane increases expression ISO RGD:1318374 6480464 Urethane results in increased expression of SIRT1 mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:1318375 6480464 Valproic Acid results in decreased expression of SIRT1 mRNA CTD PMID:15799026 , PMID:19136453 valproic acid decreases methylation ISO RGD:1318374 6480464 Valproic Acid results in decreased methylation of SIRT1 gene CTD PMID:28853863 , PMID:29201983 valproic acid decreases expression ISO RGD:1318374 6480464 Valproic Acid results in decreased expression of SIRT1 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid affects expression ISO RGD:1318374 6480464 Valproic Acid affects the expression of SIRT1 mRNA CTD PMID:25979313 vitamin E decreases expression ISO RGD:1318374 6480464 Vitamin E results in decreased expression of SIRT1 mRNA CTD PMID:19244175 wortmannin multiple interactions ISO RGD:1318375 6480464 wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] CTD PMID:22952890 wortmannin multiple interactions ISO RGD:1318374 6480464 wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] CTD PMID:18298901 zinc atom multiple interactions ISO RGD:1318374 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:1318374 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA CTD PMID:18593933 ziram decreases expression EXP 6480464 Ziram results in decreased expression of SIRT1 protein CTD PMID:30422632
