Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Rattus norvegicus
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Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1308542
Description: Enables histone deacetylase activity, NAD-dependent and protein kinase B binding activity. Involved in several processes, including cellular response to ketone; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Autosomal Dominant Intellectual Developmental Disorder 70  (ISO)
Binge Drinking  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IEP)
Carotid Atherosclerosis  (ISO)
cocaine dependence  (IEP)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
endocrine system disease  (ISO)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Fibrosis  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (IEP,IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (IEP)
Insulin Resistance  (IDA,ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (IEP)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IDA,IEP,ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuron