Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Rattus norvegicus
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Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1308542
Description: Enables NAD-dependent histone deacetylase activity and protein kinase B binding activity. Involved in several processes, including cellular response to organic cyclic compound; negative regulation of apoptotic process; and regulation of peptide hormone secretion. Located in growth cone and nucleus. Used to study middle cerebral artery infarction; obesity; osteoporosis; and type 2 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); cocaine dependence; impotence; metabolic dysfunction-associated steatotic liver disease; and obesity. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; p53 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,305,953 - 25,328,000 (+)NCBIGRCr8
mRatBN7.22025,307,225 - 25,329,273 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,306,917 - 25,329,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,008,013 - 26,022,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,361,037 - 25,375,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,947,577 - 25,961,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,833,357 - 26,852,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Autosomal Dominant Intellectual Developmental Disorder 70  (ISO)
Binge Drinking  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IEP)
Carotid Atherosclerosis  (ISO)
cocaine dependence  (IEP)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (IEP,IMP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hypertrophy  (ISO)
impotence  (IEP)
Insulin Resistance  (IDA,ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (IEP)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP)
Lung Injury  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IDA,IEP,ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IEP,IMP,ISO)
osteoporosis  (IDA,IMP)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
steatotic liver disease  (ISO,ISS)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
Ventricular Dysfunction, Left  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylglutaric acid  (EXP)
3-nitropropanoic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
bafilomycin A1  (EXP)
baicalein  (ISO)
benzamide  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenanthridine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
Betanin  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP)
buta-1,3-diene  (ISO)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (EXP)
calcium oxalate  (ISO)
calycosin  (EXP)
camptothecin  (ISO)
capsaicin  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
carteolol  (ISO)
catalpol  (ISO)
CAY10591  (ISO)
CDP-choline  (EXP)
CGS-21680  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
chromium(6+)  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
corynoline  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproheptadine  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dihydrogen  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium  (ISO)
disulfiram  (ISO)
dizocilpine  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ergosterol  (EXP)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
everolimus  (ISO)
excitatory amino acid agonist  (EXP)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
fisetin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Garcinol  (ISO)
Genipin  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycyrrhizinic acid  (EXP)
glyoxylic acid  (ISO)
Goe 6976  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP,ISO)
imidacloprid  (ISO)
inositol  (EXP)
ionomycin  (EXP)
iprodione  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoquinoline-1,5-diol  (ISO)
kainic acid  (EXP,ISO)
ketoconazole  (EXP)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licarin A  (ISO)
linagliptin  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Magnolol  (EXP)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methylglyoxal  (EXP)
metiram  (ISO)
mifepristone  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monooxygen  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
naringin  (EXP,ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (EXP)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (EXP)
ochratoxin A  (ISO)
octreotide  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
organoselenium compound  (EXP)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
polymyxin B2  (ISO)
potassium atom  (EXP)
potassium dichromate  (EXP)
prasugrel hydrochloride  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrethrins  (EXP)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
ramipril  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-nitroso-L-cysteine  (ISO)
salicylic acid  (EXP)
Salidroside  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
splitomicin  (EXP,ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
suramin  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
trans-piceid  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
behavioral response to starvation  (IEA,ISO)
cardiac muscle cell apoptotic process  (IMP)
cellular response to amyloid-beta  (IEP,IMP)
cellular response to antibiotic  (IEP)
cellular response to curcumin  (IEP)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to resveratrol  (IMP)
cellular response to rotenone  (IEP)
cellular response to starvation  (IEA,ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (IEP)
cholesterol homeostasis  (IEA,ISO)
chromatin organization  (ISO)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (IEA,ISO)
circadian rhythm  (ISO)
DNA damage response  (ISO)
DNA repair-dependent chromatin remodeling  (ISO)
DNA synthesis involved in DNA repair  (IEA,ISO)
energy homeostasis  (IMP,ISO)
fatty acid homeostasis  (IEA,ISO)
heterochromatin formation  (IEA,ISO)
intracellular glucose homeostasis  (IEA,ISO)
intracellular triglyceride homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (IEA,ISO)
macrophage differentiation  (IEA,ISO)
maintenance of nucleus location  (ISO)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell cycle  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (IMP)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-templated transcription  (IBA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of fibroblast apoptotic process  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (IMP)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of phosphorylation  (IEA,ISO)
negative regulation of prostaglandin biosynthetic process  (IEA,ISO)
negative regulation of protein acetylation  (IMP,ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
negative regulation of TOR signaling  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of triglyceride biosynthetic process  (ISO)
negative regulation of tumor necrosis factor production  (IMP)
neuron apoptotic process  (IMP)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of DNA repair  (ISO)
positive regulation of double-strand break repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IEA,IMP,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (IMP)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of macrophage apoptotic process  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein deacetylation  (IMP)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of skeletal muscle cell proliferation  (IMP)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of thyroid-stimulating hormone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (IDA)
protein destabilization  (IEA,ISO)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (IEA,ISO)
rDNA heterochromatin formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (IEA,ISO)
regulation of brown fat cell differentiation  (IEA,ISO)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO,ISS)
regulation of glucose metabolic process  (ISO)
regulation of lipid storage  (IEA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
regulation of smooth muscle cell apoptotic process  (IEA,ISO)
regulation of transcription by glucose  (ISO)
response to cocaine  (IEP)
response to ethanol  (IDA)
response to fluoride  (IEP)
response to hydrogen peroxide  (ISO)
response to insulin  (IEA,ISO)
response to kainic acid  (IEP)
response to leptin  (ISO)
response to mycotoxin  (IEP)
response to nutrient levels  (IEP)
response to oxidative stress  (ISO)
response to resveratrol  (IEP)
single strand break repair  (ISO)
spermatogenesis  (IEA,ISO)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (IEA,ISO)
UV-damage excision repair  (ISO)
vasodilation  (IMP)
white fat cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
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Additional References at PubMed
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