Sirt2 (sirtuin 2) - Rat Genome Database

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Gene: Sirt2 (sirtuin 2) Rattus norvegicus
Analyze
Symbol: Sirt2
Name: sirtuin 2
RGD ID: 621481
Description: Enables NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Part of heterochromatin. Is active in glutamatergic synapse. Used to study high grade glioma and non-alcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (sirtuin 2); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5E5 antigen; MGC105900; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; regulatory protein SIR2 homolog 2; SIR2-like protein 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,463,787 - 89,486,870 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0197,922,897 - 97,945,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0191,219,644 - 91,242,728 (+)NCBIRnor_WKY
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diisononyl phthalate  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
nicotinamide  (ISO)
nicotinic acid  (ISO)
paclitaxel  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pterostilbene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sirolimus  (ISO)
sirtinol  (ISO)
tauroursodeoxycholic acid  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cell division  (IEA)
cellular lipid catabolic process  (IEA,ISO,ISS)
cellular response to caloric restriction  (IEA,ISO,ISS)
cellular response to epinephrine stimulus  (IEA,ISO,ISS)
cellular response to hypoxia  (ISO,ISS)
cellular response to oxidative stress  (IEA,ISO,ISS)
chromatin organization  (ISO)
chromatin remodeling  (IEA)
epigenetic regulation of gene expression  (IEA,ISO,ISS)
histone deacetylation  (ISO)
meiotic cell cycle  (IEA)
myelination in peripheral nervous system  (IEA,IMP,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (IEA,ISO,ISS)
negative regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
negative regulation of oligodendrocyte differentiation  (IMP)
negative regulation of oligodendrocyte progenitor proliferation  (IMP)
negative regulation of peptidyl-threonine phosphorylation  (IEA,ISO,ISS)
negative regulation of protein catabolic process  (IEA,ISO,ISS)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO,ISS)
negative regulation of striated muscle tissue development  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (IEA,ISO,ISS)
NLRP3 inflammasome complex assembly  (IEA,ISO)
peptidyl-lysine deacetylation  (IEA,ISO,ISS)
positive regulation of attachment of spindle microtubules to kinetochore  (IEA,ISO,ISS)
positive regulation of cell division  (IEA,ISO,ISS)
positive regulation of DNA binding  (IEA,ISO,ISS)
positive regulation of execution phase of apoptosis  (IEA,ISO,ISS)
positive regulation of fatty acid biosynthetic process  (IEA,ISO)
positive regulation of meiotic nuclear division  (IEA,ISO,ISS)
positive regulation of oocyte maturation  (IEA,ISO,ISS)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO,ISS)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
post-translational protein modification  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
protein deacetylation  (IMP,ISO,ISS)
regulation of cell cycle  (ISO,ISS)
regulation of fat cell differentiation  (ISO)
regulation of myelination  (IEA,IMP,ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (EXP,IDA,IEP,IMP)
substantia nigra development  (ISO)
tubulin deacetylation  (IDA,IEA,ISO)

Cellular Component
centriole  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
chromosome  (IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO,ISS)
glial cell projection  (IDA)
glutamatergic synapse  (EXP,IDA,IEP,IMP)
growth cone  (IEA)
heterochromatin  (IDA)
juxtaparanode region of axon  (IDA)
lateral loop  (IDA)
meiotic spindle  (IEA,ISO,ISS)
microtubule  (IEA,ISO)
midbody  (IEA,ISO,ISS)
mitochondrion  (IEA,ISO)
mitotic spindle  (IEA,ISO,ISS)
myelin sheath  (IDA,ISO,ISS)
myelin sheath abaxonal region  (IDA)
nucleolus  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
paranodal junction  (IDA,IEA,ISO,ISS)
paranode region of axon  (IDA)
perikaryon  (IDA,IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
Schmidt-Lanterman incisure  (IDA,IEA,ISO,ISS)
spindle  (ISO,ISS)
terminal loop  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Beirowski B, etal., Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61. doi: 10.1073/pnas.1104969108. Epub 2011 Sep 26.
2. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. De Smet C, etal., J Neurochem 2002 May;81(3):575-88.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. Gurd BJ, etal., Metabolism. 2012 May;61(5):733-41. doi: 10.1016/j.metabol.2011.09.016. Epub 2011 Nov 9.
5. Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. Li W, etal., J Neurosci. 2007 Mar 7;27(10):2606-16.
6. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Cloning and sequence analysis of cDNA for a possible DNA-binding protein 5E5 in the nervous system. Suzuki E, etal., J Biochem (Tokyo) 1995 Jul;118(1):122-8.
13. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
14. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
15. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Wang G, etal., Cell Rep. 2017 Aug 8;20(6):1335-1347. doi: 10.1016/j.celrep.2017.07.030.
16. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
17. Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Yin T, etal., Biomaterials. 2013 Jun;34(18):4532-43. doi: 10.1016/j.biomaterials.2013.02.067. Epub 2013 Mar 19.
Additional References at PubMed
PMID:10381378   PMID:11056054   PMID:11427894   PMID:12477932   PMID:12620231   PMID:12697818   PMID:12887892   PMID:15126506   PMID:15213244   PMID:15489334   PMID:16079181   PMID:16648462  
PMID:16933150   PMID:17172643   PMID:17488717   PMID:17521387   PMID:17634366   PMID:17681146   PMID:17726514   PMID:18624766   PMID:18640115   PMID:18722353   PMID:19037106   PMID:20543840  
PMID:20562830   PMID:21841822   PMID:22871113   PMID:22926577   PMID:23126280   PMID:23502856   PMID:23886946   PMID:23908241   PMID:23932781   PMID:24177535   PMID:24239092   PMID:24334550  
PMID:24535021   PMID:24681946   PMID:25672834   PMID:26022124   PMID:26089639   PMID:26209361   PMID:26767982   PMID:27264719   PMID:28078537   PMID:29222643   PMID:29304479   PMID:29325994  
PMID:29476059   PMID:31238070   PMID:31255733   PMID:31651707   PMID:32122297   PMID:32134743   PMID:32711564   PMID:32882218   PMID:33159115   PMID:33611744   PMID:33754030   PMID:33821324  
PMID:34666848   PMID:34708398   PMID:34979841   PMID:36915976  


Genomics

Comparative Map Data
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,463,787 - 89,486,870 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0197,922,897 - 97,945,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0191,219,644 - 91,242,728 (+)NCBIRnor_WKY
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,878,555 - 38,899,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
T2T-CHM13v2.01941,682,611 - 41,703,673 (-)NCBIT2T-CHM13v2.0
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,192 - 28,488,086 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)EnsemblGRCm39 Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBIMGSCv36mm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11947,051,896 - 47,073,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,618,889 - 113,636,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,817,111 - 114,834,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,817,428 - 114,834,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,375,328 - 114,392,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,008,029 - 114,025,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,003,788 - 115,021,492 (+)NCBIUU_Cfam_GSD_1.0
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,400,802 - 13,421,980 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,828,831 - 1,850,000 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,429 - 47,703,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,514,410 - 11,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,235,263 - 12,259,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt2
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:54
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000064153
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
RH143384  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,057,170 - 84,057,304 (+)MAPPERmRatBN7.2
Rnor_6.0186,952,154 - 86,952,287NCBIRnor6.0
Rnor_5.0188,133,286 - 88,133,419UniSTSRnor5.0
RGSC_v3.4183,876,319 - 83,876,452UniSTSRGSC3.4
Celera178,449,330 - 78,449,463UniSTS
RH 3.4 Map1840.7UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064153   ⟹   ENSRNOP00000059450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,053,985 - 84,076,975 (+)Ensembl
Rnor_6.0 Ensembl186,949,413 - 86,971,952 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084839   ⟹   ENSRNOP00000069934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,052,903 - 84,076,956 (+)Ensembl
Rnor_6.0 Ensembl186,948,918 - 86,971,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095928   ⟹   ENSRNOP00000080491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,053,862 - 84,076,960 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105704   ⟹   ENSRNOP00000086968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,054,158 - 84,076,973 (+)Ensembl
RefSeq Acc Id: NM_001008368   ⟹   NP_001008369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,054,430 - 84,076,975 (+)NCBI
Rnor_6.0186,949,413 - 86,971,954 (+)NCBI
Rnor_5.0188,130,012 - 88,153,086 (+)NCBI
RGSC_v3.4183,873,578 - 83,896,121 (+)RGD
Celera178,446,589 - 78,469,133 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228672   ⟹   XP_006228734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,053,883 - 84,076,975 (+)NCBI
Rnor_6.0186,948,866 - 86,971,954 (+)NCBI
Rnor_5.0188,130,012 - 88,153,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228673   ⟹   XP_006228735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,053,889 - 84,076,653 (+)NCBI
Rnor_6.0186,948,913 - 86,971,954 (+)NCBI
Rnor_5.0188,130,012 - 88,153,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228675   ⟹   XP_006228737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,053,883 - 84,076,975 (+)NCBI
Rnor_6.0186,948,866 - 86,971,954 (+)NCBI
Rnor_5.0188,130,012 - 88,153,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228676   ⟹   XP_006228738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,053,889 - 84,076,975 (+)NCBI
Rnor_6.0186,948,913 - 86,971,954 (+)NCBI
Rnor_5.0188,130,012 - 88,153,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589353   ⟹   XP_017444842
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,054,145 - 84,076,653 (+)NCBI
Rnor_6.0186,949,111 - 86,971,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081893   ⟹   XP_038937821
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,054,140 - 84,076,653 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008369   ⟸   NM_001008368
- Sequence:
RefSeq Acc Id: XP_006228734   ⟸   XM_006228672
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006228737   ⟸   XM_006228675
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZQA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228735   ⟸   XM_006228673
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006228738   ⟸   XM_006228676
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JWM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444842   ⟸   XM_017589353
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000069934   ⟸   ENSRNOT00000084839
RefSeq Acc Id: ENSRNOP00000059450   ⟸   ENSRNOT00000064153
RefSeq Acc Id: XP_038937821   ⟸   XM_039081893
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000080491   ⟸   ENSRNOT00000095928
RefSeq Acc Id: ENSRNOP00000086968   ⟸   ENSRNOT00000105704
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJQ4-F1-model_v2 AlphaFold Q5RJQ4 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689887
Promoter ID:EPDNEW_R407
Type:initiation region
Name:Sirt2_1
Description:sirtuin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R408  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,948,945 - 86,949,005EPDNEW
RGD ID:13689884
Promoter ID:EPDNEW_R408
Type:initiation region
Name:Sirt2_2
Description:sirtuin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R407  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,949,398 - 86,949,458EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621481 AgrOrtholog
BioCyc Gene G2FUF-60220 BioCyc
Ensembl Genes ENSRNOG00000020102 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059450 ENTREZGENE
  ENSRNOP00000059450.2 UniProtKB/TrEMBL
  ENSRNOP00000069934.2 UniProtKB/TrEMBL
  ENSRNOP00000080491 ENTREZGENE
  ENSRNOP00000080491.1 UniProtKB/TrEMBL
  ENSRNOP00000086968.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064153 ENTREZGENE
  ENSRNOT00000064153.2 UniProtKB/TrEMBL
  ENSRNOT00000084839.2 UniProtKB/TrEMBL
  ENSRNOT00000095928 ENTREZGENE
  ENSRNOT00000095928.1 UniProtKB/TrEMBL
  ENSRNOT00000105704.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134377 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361532 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105900 IMAGE-MGC_LOAD
NCBI Gene 361532 ENTREZGENE
PANTHER NAD-DEPENDENT HISTONE DEACETYLASE HST4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt2 PhenoGen
PIRSF SIR2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7I4_RAT UniProtKB/TrEMBL
  A0A8L2UN46 ENTREZGENE, UniProtKB/TrEMBL
  Q5RJQ4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt2  sirtuin 2  Sirt2  sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Sirt2  sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)    sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)  Name updated 1299863 APPROVED
2002-08-07 Sirt2  sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a region of basic amino acids, especially arginine, and includes a glycine-rich region and a proline cluster 633963
gene_protein 825 amino acids 633963