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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | decreases expression | ISO | RGD:1558122 | 6480464 | Dextroamphetamine results in decreased expression of SIRT2 mRNA | CTD | PMID:12558987 | 1,2-dimethylhydrazine | affects expression | ISO | RGD:1558122 | 6480464 | 1, 2-Dimethylhydrazine affects the expression of SIRT2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1558122 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SIRT2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | RGD:733995 | 6480464 | Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]] | CTD | PMID:24771768 | 17beta-estradiol | decreases expression | ISO | RGD:733995 | 6480464 | Estradiol results in decreased expression of SIRT2 mRNA | CTD | PMID:32030086 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:733995 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SIRT2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIRT2 mRNA | CTD | PMID:33387578, PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558122 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIRT2 protein | CTD | PMID:29935226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558122 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIRT2 mRNA | CTD | PMID:21570461 | 2,4,6-tribromophenol | decreases expression | ISO | RGD:733995 | 6480464 | 2 more ... | CTD | PMID:31675489 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RGD:733995 | 6480464 | tetrabromobisphenol A results in decreased expression of SIRT2 protein | CTD | PMID:31675489 | 3-methylcholanthrene | multiple interactions | ISO | RGD:1558122 | 6480464 | [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SIRT2 mRNA | CTD | PMID:25926378 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1558122 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of SIRT2 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RGD:1558122 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased methylation of SIRT2 exon | CTD | PMID:33297965 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | decreases activity | ISO | RGD:733995 | 6480464 | 6-chloro-2 more ... | CTD | PMID:24998427, PMID:26518726 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | decreases expression | ISO | RGD:733995 | 6480464 | 6-chloro-2 more ... | CTD | PMID:29545174 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SIRT2 mRNA | CTD | PMID:24780913 | aconitine | increases expression | EXP | | 6480464 | Aconitine results in increased expression of SIRT2 protein | CTD | PMID:33236894 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SIRT2 mRNA | CTD | PMID:16483693 | aristolochic acid | increases expression | ISO | RGD:733995 | 6480464 | aristolochic acid I results in increased expression of SIRT2 mRNA | CTD | PMID:33212167 | aspartame | multiple interactions | ISO | RGD:1558122 | 6480464 | [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA | CTD | PMID:23783067 | benzo[a]pyrene | increases expression | ISO | RGD:1558122 | 6480464 | Benzo(a)pyrene results in increased expression of SIRT2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:733995 | 6480464 | 7 more ... | CTD | PMID:19150397 | berberine | multiple interactions | ISO | RGD:733995 | 6480464 | [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein | CTD | PMID:26712469 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SIRT2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:733995 | 6480464 | bisphenol A results in decreased expression of SIRT2 mRNA, bisphenol A results in decreased expression of SIRT2 protein | CTD | PMID:31675489, PMID:32030086 | cannabidiol | multiple interactions | ISO | RGD:733995 | 6480464 | [Cannabidiol results in increased expression of MIR1972-2 mRNA] which results in decreased expression of SIRT2 mRNA | CTD | PMID:30713602 | cannabidiol | decreases expression | ISO | RGD:733995 | 6480464 | Cannabidiol results in decreased expression of SIRT2 mRNA | CTD | PMID:30713602 | carbon nanotube | multiple interactions | ISO | RGD:1558122 | 6480464 | [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SIRT2 mRNA | CTD | PMID:25926378 | cerium trichloride | multiple interactions | ISO | RGD:733995 | 6480464 | [cerous chloride co-treated with lanthanum chloride] results in increased expression of SIRT2 mRNA | CTD | PMID:28954213 | cerium trichloride | decreases expression | ISO | RGD:733995 | 6480464 | cerous chloride results in decreased expression of SIRT2 mRNA | CTD | PMID:28954213 | cerium trichloride | increases expression | ISO | RGD:733995 | 6480464 | cerous chloride results in increased expression of SIRT2 mRNA | CTD | PMID:28954213 | chromium(6+) | affects expression | ISO | RGD:1558122 | 6480464 | chromium hexavalent ion affects the expression of SIRT2 mRNA | CTD | PMID:28472532 | cisplatin | increases expression | ISO | RGD:733995 | 6480464 | Cisplatin results in increased expression of SIRT2 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | RGD:733995 | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SIRT2 mRNA | CTD | PMID:27392435 | decabromodiphenyl ether | decreases expression | ISO | RGD:733995 | 6480464 | decabromobiphenyl ether results in decreased expression of SIRT2 protein | CTD | PMID:31675489 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of SIRT2 mRNA | CTD | PMID:22546817 | dibutyl phthalate | decreases expression | ISO | RGD:1558122 | 6480464 | Dibutyl Phthalate results in decreased expression of SIRT2 mRNA | CTD | PMID:21266533 | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of SIRT2 mRNA | CTD | PMID:22546817 | diisononyl phthalate | decreases expression | ISO | RGD:733995 | 6480464 | diisononyl phthalate results in decreased expression of SIRT2 mRNA | CTD | PMID:31423773 | ethanol | multiple interactions | EXP | | 6480464 | ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] | CTD | PMID:23544086 | ethanol | multiple interactions | ISO | RGD:733995 | 6480464 | Ethanol promotes the reaction [NFATC4 protein binds to SIRT2 protein] more ... | CTD | PMID:34474091 | ethanol | decreases expression | ISO | RGD:733995 | 6480464 | Ethanol results in decreased expression of SIRT2 protein | CTD | PMID:34474091 | ethanol | affects splicing | ISO | RGD:1558122 | 6480464 | Ethanol affects the splicing of SIRT2 mRNA | CTD | PMID:30319688 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of SIRT2 protein | CTD | PMID:23544086 | ethyl methanesulfonate | increases expression | ISO | RGD:733995 | 6480464 | Ethyl Methanesulfonate results in increased expression of SIRT2 mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | RGD:1558122 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SIRT2 mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | RGD:733995 | 6480464 | Formaldehyde results in increased expression of SIRT2 mRNA | CTD | PMID:23649840 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SIRT2 mRNA | CTD | PMID:33387578 | hydrogen peroxide | multiple interactions | ISO | RGD:733995 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein | CTD | PMID:18951874 | mancozeb | decreases activity | ISO | RGD:733995 | 6480464 | mancozeb results in decreased activity of SIRT2 protein | CTD | PMID:21251949 | maneb | decreases activity | ISO | RGD:733995 | 6480464 | Maneb results in decreased activity of SIRT2 protein | CTD | PMID:21251949 | manganese atom | increases expression | ISO | RGD:733995 | 6480464 | Manganese results in increased expression of SIRT2 mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | RGD:733995 | 6480464 | Manganese results in increased expression of SIRT2 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | RGD:733995 | 6480464 | manganese chloride results in increased expression of SIRT2 mRNA | CTD | PMID:17175027 | metformin | increases expression | ISO | RGD:1558122 | 6480464 | Metformin results in increased expression of SIRT2 mRNA, Metformin results in increased expression of SIRT2 protein | CTD | PMID:24687991 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of SIRT2 mRNA | CTD | PMID:25452209 | methotrexate | decreases expression | ISO | RGD:733995 | 6480464 | Methotrexate results in decreased expression of SIRT2 mRNA | CTD | PMID:17400583 | methyl methanesulfonate | increases expression | ISO | RGD:733995 | 6480464 | Methyl Methanesulfonate results in increased expression of SIRT2 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | RGD:733995 | 6480464 | methylmercuric chloride results in decreased expression of SIRT2 mRNA | CTD | PMID:29581082 | metiram | decreases activity | ISO | RGD:733995 | 6480464 | polymarcine results in decreased activity of SIRT2 protein | CTD | PMID:21251949 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1558122 | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT2 mRNA, mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT2 protein | CTD | PMID:31016965 | monosodium L-glutamate | multiple interactions | ISO | RGD:1558122 | 6480464 | [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA | CTD | PMID:23783067 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SIRT2 mRNA | CTD | PMID:28801915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SIRT2 mRNA | CTD | PMID:20360939 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of SIRT2 mRNA | CTD | PMID:22546817 | nicotinamide | decreases activity | ISO | RGD:733995 | 6480464 | Niacinamide results in decreased activity of SIRT2 protein | CTD | PMID:17341628 | nicotinamide | multiple interactions | ISO | RGD:733995 | 6480464 | [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein | CTD | PMID:26712469 | nicotinic acid | increases expression | ISO | RGD:733995 | 6480464 | Niacin deficiency results in increased expression of SIRT2 mRNA | CTD | PMID:22860104 | paclitaxel | decreases expression | ISO | RGD:733995 | 6480464 | Paclitaxel results in decreased expression of SIRT2 mRNA | CTD | PMID:34272796 | perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:1558122 | 6480464 | perfluorooctane sulfonic acid results in increased expression of SIRT2 mRNA | CTD | PMID:31016965 | phenethyl caffeate | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SIRT2 mRNA | CTD | PMID:20360939 | pirinixic acid | multiple interactions | ISO | RGD:733995 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIRT2 mRNA | CTD | PMID:19710929 | pterostilbene | multiple interactions | ISO | RGD:733995 | 6480464 | pterostilbene inhibits the reaction [Ethanol results in decreased expression of SIRT2 protein] more ... | CTD | PMID:34474091 | resveratrol | multiple interactions | ISO | RGD:733995 | 6480464 | resveratrol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]] | CTD | PMID:24771768 | resveratrol | increases expression | ISO | RGD:1558122 | 6480464 | resveratrol results in increased expression of SIRT2 mRNA | CTD | PMID:25338179 | resveratrol | decreases expression | ISO | RGD:733995 | 6480464 | resveratrol results in decreased expression of SIRT2 mRNA | CTD | PMID:21980390 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SIRT2 mRNA | CTD | PMID:28374803 | sirolimus | multiple interactions | ISO | RGD:733995 | 6480464 | Sirolimus inhibits the reaction [TP73 protein results in increased expression of SIRT2 mRNA] | CTD | PMID:21245298 | sirtinol | decreases activity | ISO | RGD:733995 | 6480464 | sirtinol analog results in decreased activity of SIRT2 protein, sirtinol results in decreased activity of SIRT2 protein | CTD | PMID:16302818, PMID:24998427 | tauroursodeoxycholic acid | multiple interactions | EXP | | 6480464 | ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] | CTD | PMID:23544086 | theophylline | multiple interactions | ISO | RGD:733995 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein | CTD | PMID:18951874 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SIRT2 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | RGD:1558122 | 6480464 | titanium dioxide results in increased expression of SIRT2 mRNA | CTD | PMID:29264374 | triptonide | increases expression | ISO | RGD:1558122 | 6480464 | triptonide results in increased expression of SIRT2 mRNA | CTD | PMID:33045310 | urethane | increases expression | ISO | RGD:733995 | 6480464 | Urethane results in increased expression of SIRT2 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | RGD:1558122 | 6480464 | Valproic Acid results in increased expression of SIRT2 mRNA | CTD | PMID:21427059 | valproic acid | increases methylation | ISO | RGD:733995 | 6480464 | Valproic Acid results in increased methylation of SIRT2 gene | CTD | PMID:29154799 | |