(S)-amphetamine decreases expression ISO Sirt2 (Mus musculus) 6480464 Dextroamphetamine results in decreased expression of SIRT2 mRNA CTD PMID:12558987 1,2-dimethylhydrazine affects expression ISO Sirt2 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine affects the expression of SIRT2 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Sirt2 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SIRT2 mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Sirt2 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:27235848 17beta-estradiol multiple interactions ISO SIRT2 (Homo sapiens) 6480464 Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]] CTD PMID:24771768 17beta-estradiol decreases expression ISO SIRT2 (Homo sapiens) 6480464 Estradiol results in decreased expression of SIRT2 mRNA CTD PMID:32030086 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO SIRT2 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SIRT2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SIRT2 mRNA CTD PMID:33387578 and PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sirt2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SIRT2 protein CTD PMID:29935226 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sirt2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SIRT2 mRNA CTD PMID:21570461 2,4,6-tribromophenol decreases expression ISO SIRT2 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 3,3',5,5'-tetrabromobisphenol A decreases expression ISO SIRT2 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of SIRT2 protein CTD PMID:31675489 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of SIRT2 protein CTD PMID:34915118 3-methylcholanthrene multiple interactions ISO Sirt2 (Mus musculus) 6480464 [Methylcholanthrene co-treated with Nanotubes and Carbon] results in decreased expression of SIRT2 mRNA CTD PMID:25926378 4,4'-diaminodiphenylmethane decreases expression ISO Sirt2 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of SIRT2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases methylation ISO Sirt2 (Mus musculus) 6480464 bisphenol S results in increased methylation of SIRT2 exon CTD PMID:33297965 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT2 mRNA CTD PMID:36041667 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases activity ISO SIRT2 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:24998427 and PMID:26518726 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide decreases expression ISO SIRT2 (Homo sapiens) 6480464 6-chloro-2 more ... CTD PMID:29545174 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SIRT2 mRNA CTD PMID:24780913 and PMID:30047161 aconitine increases expression EXP 6480464 Aconitine results in increased expression of SIRT2 protein CTD PMID:33236894 amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of SIRT2 mRNA CTD PMID:30047161 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SIRT2 mRNA CTD PMID:16483693 aristolochic acid A increases expression ISO SIRT2 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SIRT2 mRNA CTD PMID:33212167 aspartame multiple interactions ISO Sirt2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 benzo[a]pyrene increases expression ISO Sirt2 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SIRT2 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I increases expression ISO SIRT2 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 berberine multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SIRT2 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT2 mRNA CTD PMID:36041667 bisphenol A decreases expression ISO SIRT2 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SIRT2 mRNA and bisphenol A results in decreased expression of SIRT2 protein CTD PMID:31675489 and PMID:32030086 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of SIRT2 mRNA CTD PMID:36041667 caffeine increases phosphorylation ISO SIRT2 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of SIRT2 protein CTD PMID:35688186 cannabidiol multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Cannabidiol results in increased expression of MIR1972-2 mRNA] which results in decreased expression of SIRT2 mRNA CTD PMID:30713602 cannabidiol decreases expression ISO SIRT2 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of SIRT2 mRNA CTD PMID:30713602 carbon nanotube multiple interactions ISO Sirt2 (Mus musculus) 6480464 [Methylcholanthrene co-treated with Nanotubes and Carbon] results in decreased expression of SIRT2 mRNA CTD PMID:25926378 cerium trichloride multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of SIRT2 mRNA CTD PMID:28954213 cerium trichloride decreases expression ISO SIRT2 (Homo sapiens) 6480464 cerous chloride results in decreased expression of SIRT2 mRNA CTD PMID:28954213 cerium trichloride increases expression ISO SIRT2 (Homo sapiens) 6480464 cerous chloride results in increased expression of SIRT2 mRNA CTD PMID:28954213 chromium(6+) affects expression ISO Sirt2 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of SIRT2 mRNA CTD PMID:28472532 cisplatin increases expression ISO SIRT2 (Homo sapiens) 6480464 Cisplatin results in increased expression of SIRT2 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of SIRT2 mRNA CTD PMID:27392435 clozapine increases expression ISO SIRT2 (Homo sapiens) 6480464 Clozapine results in increased expression of SIRT2 protein CTD PMID:36482696 cocaine increases expression EXP 401900166 cocaine increases expression of Sirt2 protein in caudate putamen RGD coumarin increases phosphorylation ISO SIRT2 (Homo sapiens) 6480464 coumarin results in increased phosphorylation of SIRT2 protein CTD PMID:35688186 decabromodiphenyl ether decreases expression ISO SIRT2 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of SIRT2 protein CTD PMID:31675489 diazinon affects expression EXP 6480464 Diazinon affects the expression of SIRT2 mRNA CTD PMID:22546817 dibutyl phthalate decreases expression ISO Sirt2 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of SIRT2 mRNA CTD PMID:21266533 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of SIRT2 mRNA CTD PMID:22546817 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of SIRT2 mRNA CTD PMID:37077353 diisononyl phthalate decreases expression ISO SIRT2 (Homo sapiens) 6480464 diisononyl phthalate results in decreased expression of SIRT2 mRNA CTD PMID:31423773 ethanol multiple interactions EXP 6480464 ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] CTD PMID:23544086 ethanol multiple interactions ISO SIRT2 (Homo sapiens) 6480464 Ethanol promotes the reaction [NFATC4 protein binds to SIRT2 protein] more ... CTD PMID:34474091 ethanol decreases expression ISO SIRT2 (Homo sapiens) 6480464 Ethanol results in decreased expression of SIRT2 protein CTD PMID:34474091 ethanol affects splicing ISO Sirt2 (Mus musculus) 6480464 Ethanol affects the splicing of SIRT2 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SIRT2 protein CTD PMID:23544086 ethyl methanesulfonate increases expression ISO SIRT2 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of SIRT2 mRNA CTD PMID:23649840 fenthion increases expression ISO Sirt2 (Mus musculus) 6480464 Fenthion results in increased expression of SIRT2 mRNA CTD PMID:34813904 folic acid multiple interactions ISO Sirt2 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SIRT2 mRNA CTD PMID:22206623 formaldehyde increases expression ISO SIRT2 (Homo sapiens) 6480464 Formaldehyde results in increased expression of SIRT2 mRNA CTD PMID:23649840 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SIRT2 mRNA CTD PMID:33387578 hydrogen peroxide multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein CTD PMID:18951874 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of SIRT2 mRNA CTD PMID:37077353 lipopolysaccharide multiple interactions ISO Sirt2 (Mus musculus) 6480464 [stearic acid co-treated with Lipopolysaccharides] affects the expression of SIRT2 protein CTD PMID:33810233 mancozeb decreases activity ISO SIRT2 (Homo sapiens) 6480464 mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 maneb decreases activity ISO SIRT2 (Homo sapiens) 6480464 Maneb results in decreased activity of SIRT2 protein CTD PMID:21251949 manganese atom increases expression ISO SIRT2 (Homo sapiens) 6480464 Manganese results in increased expression of SIRT2 mRNA CTD PMID:17175027 manganese(0) increases expression ISO SIRT2 (Homo sapiens) 6480464 Manganese results in increased expression of SIRT2 mRNA CTD PMID:17175027 manganese(II) chloride increases expression ISO SIRT2 (Homo sapiens) 6480464 manganese chloride results in increased expression of SIRT2 mRNA CTD PMID:17175027 metformin increases expression ISO Sirt2 (Mus musculus) 6480464 Metformin results in increased expression of SIRT2 mRNA and Metformin results in increased expression of SIRT2 protein CTD PMID:24687991 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of SIRT2 mRNA CTD PMID:25452209 methidathion increases expression ISO Sirt2 (Mus musculus) 6480464 methidathion results in increased expression of SIRT2 mRNA CTD PMID:34813904 methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of SIRT2 mRNA CTD PMID:30047161 methotrexate decreases expression ISO SIRT2 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SIRT2 mRNA CTD PMID:17400583 methyl methanesulfonate increases expression ISO SIRT2 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of SIRT2 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO SIRT2 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of SIRT2 mRNA CTD PMID:29581082 metiram decreases activity ISO SIRT2 (Homo sapiens) 6480464 polymarcine results in decreased activity of SIRT2 protein CTD PMID:21251949 mono(2-ethylhexyl) phthalate decreases expression ISO Sirt2 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT2 mRNA and mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT2 protein CTD PMID:31016965 monosodium L-glutamate multiple interactions ISO Sirt2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SIRT2 mRNA CTD PMID:28801915 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SIRT2 mRNA CTD PMID:20360939 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of SIRT2 mRNA CTD PMID:22546817 nicotinamide decreases activity ISO SIRT2 (Homo sapiens) 6480464 Niacinamide results in decreased activity of SIRT2 protein CTD PMID:17341628 nicotinamide multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 nicotinic acid increases expression ISO SIRT2 (Homo sapiens) 6480464 Niacin deficiency results in increased expression of SIRT2 mRNA CTD PMID:22860104 NORCANTHARIDIN decreases expression ISO SIRT2 (Homo sapiens) 6480464 norcantharidin results in decreased expression of SIRT2 mRNA CTD PMID:34272796 octadecanoic acid multiple interactions ISO Sirt2 (Mus musculus) 6480464 [stearic acid co-treated with Lipopolysaccharides] affects the expression of SIRT2 protein CTD PMID:33810233 paclitaxel decreases expression ISO SIRT2 (Homo sapiens) 6480464 Paclitaxel results in decreased expression of SIRT2 mRNA CTD PMID:34272796 perfluorooctane-1-sulfonic acid increases expression ISO Sirt2 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in increased expression of SIRT2 mRNA CTD PMID:31016965 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SIRT2 mRNA CTD PMID:20360939 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of SIRT2 mRNA CTD PMID:30047161 phenobarbital decreases expression ISO SIRT2 (Homo sapiens) 6480464 Phenobarbital results in decreased expression of SIRT2 protein CTD PMID:35881160 pirinixic acid multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIRT2 mRNA CTD PMID:19710929 pterostilbene multiple interactions ISO SIRT2 (Homo sapiens) 6480464 pterostilbene inhibits the reaction [Ethanol results in decreased expression of SIRT2 protein] more ... CTD PMID:34474091 resveratrol multiple interactions ISO SIRT2 (Homo sapiens) 6480464 resveratrol inhibits the reaction [TNF protein promotes the reaction [SIRT2 protein binds to IL6 promoter]] CTD PMID:24771768 resveratrol increases expression ISO Sirt2 (Mus musculus) 6480464 resveratrol results in increased expression of SIRT2 mRNA CTD PMID:25338179 resveratrol decreases expression ISO SIRT2 (Homo sapiens) 6480464 resveratrol results in decreased expression of SIRT2 mRNA CTD PMID:21980390 rotenone increases expression EXP 6480464 Rotenone results in increased expression of SIRT2 mRNA CTD PMID:28374803 sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of SIRT2 protein CTD PMID:31713761 sirolimus multiple interactions ISO SIRT2 (Homo sapiens) 6480464 Sirolimus inhibits the reaction [TP73 protein results in increased expression of SIRT2 mRNA] CTD PMID:21245298 sirtinol decreases activity ISO SIRT2 (Homo sapiens) 6480464 sirtinol analog results in decreased activity of SIRT2 protein and sirtinol results in decreased activity of SIRT2 protein CTD PMID:16302818 and PMID:24998427 sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of SIRT2 mRNA CTD PMID:30047161 tauroursodeoxycholic acid multiple interactions EXP 6480464 ursodoxicoltaurine inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] CTD PMID:23544086 tetrachloromethane decreases expression ISO Sirt2 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of SIRT2 protein CTD PMID:32063085 theophylline multiple interactions ISO SIRT2 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein CTD PMID:18951874 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of SIRT2 mRNA CTD PMID:34492290 titanium dioxide increases expression ISO Sirt2 (Mus musculus) 6480464 titanium dioxide results in increased expression of SIRT2 mRNA CTD PMID:29264374 triptonide increases expression ISO Sirt2 (Mus musculus) 6480464 triptonide results in increased expression of SIRT2 mRNA CTD PMID:33045310 urethane increases expression ISO SIRT2 (Homo sapiens) 6480464 Urethane results in increased expression of SIRT2 mRNA CTD PMID:28818685 valproic acid increases expression ISO Sirt2 (Mus musculus) 6480464 Valproic Acid results in increased expression of SIRT2 mRNA CTD PMID:21427059 valproic acid increases methylation ISO SIRT2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SIRT2 gene CTD PMID:29154799