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Gene: Sirt2 (sirtuin 2) Rattus norvegicus
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Symbol: Sirt2
Name: sirtuin 2
Description: Exhibits NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Localizes to several cellular components, including the Schmidt-Lanterman incisure; lateral loop; and main axon. Used to study malignant glioma and nonalcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (sirtuin 2); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5E5 antigen; MGC105900; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; regulatory protein SIR2 homolog 2; SIR2-like protein 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT2 (sirtuin 2)  HGNC  Alliance
Mus musculus (house mouse) : Sirt2 (sirtuin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt2 (sirtuin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT2 (sirtuin 2)
Canis lupus familiaris (dog) : SIRT2 (sirtuin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt2 (sirtuin 2)
Sus scrofa (pig) : SIRT2 (sirtuin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sirt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621481
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.