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Gene: Sirt2 (sirtuin 2) Rattus norvegicus
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Symbol: Sirt2
Name: sirtuin 2
Description: Exhibits NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Localizes to several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Used to study malignant glioma and non-alcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (sirtuin 2); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5E5 antigen; MGC105900; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; regulatory protein SIR2 homolog 2; SIR2-like protein 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT2 (sirtuin 2)  HGNC  Alliance
Mus musculus (house mouse) : Sirt2 (sirtuin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt2 (sirtuin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT2 (sirtuin 2)
Canis lupus familiaris (dog) : SIRT2 (sirtuin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt2 (sirtuin 2)
Sus scrofa (pig) : SIRT2 (sirtuin 2)
Chlorocebus sabaeus (African green monkey) : SIRT2 (sirtuin 2)
Heterocephalus glaber (naked mole-rat) : Sirt2 (sirtuin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 6.0)
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Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Sirt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621481
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



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