Sirt2 (sirtuin 2) - Rat Genome Database

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Gene: Sirt2 (sirtuin 2) Mus musculus
Analyze
Symbol: Sirt2
Name: sirtuin 2
RGD ID: 1558122
MGI Page MGI
Description: Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (sirtuin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730427M03Rik; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; regulatory protein SIR2 homolog 2; S; SI; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; SIR2-like protein 2; Sir2l; SIR2L2; sirtuin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,177 - 28,488,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)EnsemblGRCm39 Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBIMGSCv36mm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
aconitine  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
diisononyl phthalate  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nicotinic acid  (ISO)
paclitaxel  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
pirinixic acid  (ISO)
pterostilbene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
tauroursodeoxycholic acid  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cell differentiation  (IEA)
cell division  (IEA)
cellular lipid catabolic process  (IMP)
cellular response to caloric restriction  (IDA)
cellular response to epinephrine stimulus  (IDA)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to molecule of bacterial origin  (ISO)
cellular response to oxidative stress  (IDA)
central nervous system development  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
histone deacetylation  (IGI,ISO)
histone H3 deacetylation  (IMP,ISO)
histone H4 deacetylation  (IMP,ISO)
meiotic cell cycle  (IEA)
myelination in peripheral nervous system  (IMP,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of defense response to bacterium  (IMP,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (IMP)
negative regulation of NLRP3 inflammasome complex assembly  (IMP)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of oligodendrocyte progenitor proliferation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
nervous system development  (IEA)
NLRP3 inflammasome complex assembly  (IMP)
obsolete protein ADP-ribosylation  (ISO)
peptidyl-lysine deacetylation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (IMP)
positive regulation of cell division  (IMP)
positive regulation of DNA binding  (IDA)
positive regulation of execution phase of apoptosis  (IMP)
positive regulation of meiotic nuclear division  (IMP)
positive regulation of oocyte maturation  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (IDA,IMP,ISO)
protein kinase B signaling  (ISO)
regulation of cell cycle  (ISO)
regulation of fat cell differentiation  (IMP)
regulation of myelination  (IMP,ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
substantia nigra development  (ISO)
tubulin deacetylation  (IGI,IMP,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
9. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
10. Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Yin T, etal., Biomaterials. 2013 Jun;34(18):4532-43. doi: 10.1016/j.biomaterials.2013.02.067. Epub 2013 Mar 19.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11056054   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15632193   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:16512683   PMID:16602821   PMID:16648462   PMID:16933150   PMID:17521387   PMID:17560549   PMID:17634366   PMID:17681146   PMID:17765928   PMID:18824292   PMID:19037106   PMID:20059953  
PMID:20211142   PMID:20479123   PMID:20562830   PMID:20644252   PMID:21081649   PMID:21669943   PMID:21677750   PMID:21791548   PMID:21873635   PMID:21948283   PMID:21949390   PMID:22014574  
PMID:22302938   PMID:22511966   PMID:22794259   PMID:22819792   PMID:22956852   PMID:23126280   PMID:23200855   PMID:23358244   PMID:23364049   PMID:23468428   PMID:23502856   PMID:23570735  
PMID:23770196   PMID:23886946   PMID:23898190   PMID:23908241   PMID:24013120   PMID:24107942   PMID:24203696   PMID:24204656   PMID:24211200   PMID:24334550   PMID:24438005   PMID:24446434  
PMID:24457518   PMID:24457600   PMID:24568262   PMID:24572428   PMID:24652767   PMID:24681946   PMID:24769394   PMID:24793418   PMID:24825348   PMID:24866770   PMID:24946089   PMID:25003320  
PMID:25072851   PMID:25536118   PMID:25561724   PMID:26135889   PMID:26219598   PMID:26303530   PMID:26373435   PMID:26407304   PMID:26433268   PMID:26522013   PMID:26767982   PMID:27125275  
PMID:27160897   PMID:27197174   PMID:27311773   PMID:27500833   PMID:27637077   PMID:27793977   PMID:27796760   PMID:27909079   PMID:27956704   PMID:28188285   PMID:28257421   PMID:28287409  
PMID:28478325   PMID:28503576   PMID:28778545   PMID:28793258   PMID:28947430   PMID:28970254   PMID:28973648   PMID:28984064   PMID:29067790   PMID:29145149   PMID:29158185   PMID:29189472  
PMID:29296001   PMID:29440391   PMID:29449643   PMID:29504933   PMID:29694890   PMID:29748539   PMID:30102915   PMID:30154464   PMID:30166528   PMID:30203196   PMID:30405152   PMID:30487288  
PMID:30533032   PMID:30562941   PMID:30655546   PMID:30668546   PMID:30673616   PMID:30835165   PMID:30955067   PMID:31297748   PMID:31471557   PMID:31505260   PMID:31849939   PMID:31954883  
PMID:32032542   PMID:32049001   PMID:32134743   PMID:32159972   PMID:32323205   PMID:32625056   PMID:32679047   PMID:32700357   PMID:32768387   PMID:32882218   PMID:32912518   PMID:33049518  
PMID:33368409   PMID:33481678   PMID:33611744   PMID:33636024   PMID:33803627   PMID:33810233   PMID:34102645   PMID:34117507   PMID:34155309   PMID:34506725   PMID:34555594   PMID:34597608  
PMID:34929015   PMID:35108652   PMID:35493297   PMID:35523941   PMID:35636510   PMID:35679997   PMID:35743232   PMID:35830807   PMID:35918380  


Genomics

Comparative Map Data
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,177 - 28,488,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)EnsemblGRCm39 Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBIMGSCv36mm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,878,555 - 38,899,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
T2T-CHM13v2.01941,682,611 - 41,703,673 (-)NCBIT2T-CHM13v2.0
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,463,787 - 89,486,870 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0197,922,897 - 97,945,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0191,219,644 - 91,242,728 (+)NCBIRnor_WKY
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,618,889 - 113,636,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,817,111 - 114,834,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,817,428 - 114,834,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,375,328 - 114,392,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,008,029 - 114,025,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,003,788 - 115,021,492 (+)NCBIUU_Cfam_GSD_1.0
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,400,802 - 13,421,980 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,828,831 - 1,850,000 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,429 - 47,703,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,514,410 - 11,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,235,263 - 12,259,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1450
Count of miRNA genes:541
Interacting mature miRNAs:652
Transcripts:ENSMUST00000072965, ENSMUST00000122915, ENSMUST00000127953, ENSMUST00000128961, ENSMUST00000132789, ENSMUST00000141077, ENSMUST00000153956, ENSMUST00000155327, ENSMUST00000170068
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse

Markers in Region
Sirt2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1-2UniSTS
cM Map716.92UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001122766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF299337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB772353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB868649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB873718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF032392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072965   ⟹   ENSMUSP00000072732
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,466,192 - 28,488,085 (+)Ensembl
GRCm38.p6 Ensembl728,766,767 - 28,788,660 (+)Ensembl
RefSeq Acc Id: ENSMUST00000122915   ⟹   ENSMUSP00000147217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,466,160 - 28,488,085 (+)Ensembl
GRCm38.p6 Ensembl728,766,735 - 28,788,660 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127953
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,484,808 - 28,487,051 (+)Ensembl
GRCm38.p6 Ensembl728,785,383 - 28,787,626 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128961
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,484,982 - 28,487,685 (+)Ensembl
GRCm38.p6 Ensembl728,785,557 - 28,788,260 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132789
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,484,051 - 28,487,192 (+)Ensembl
GRCm38.p6 Ensembl728,784,626 - 28,787,767 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141077
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,476,283 - 28,477,109 (+)Ensembl
GRCm38.p6 Ensembl728,776,858 - 28,777,684 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,476,433 - 28,482,764 (+)Ensembl
GRCm38.p6 Ensembl728,777,008 - 28,783,339 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155327   ⟹   ENSMUSP00000146462
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,466,679 - 28,488,085 (+)Ensembl
GRCm38.p6 Ensembl728,767,254 - 28,788,660 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170068   ⟹   ENSMUSP00000132783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,466,241 - 28,488,086 (+)Ensembl
GRCm38.p6 Ensembl728,766,816 - 28,788,661 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,475,129 - 28,477,242 (+)Ensembl
GRCm38.p6 Ensembl728,775,704 - 28,777,817 (+)Ensembl
RefSeq Acc Id: NM_001122765   ⟹   NP_001116237
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,466,177 - 28,488,090 (+)NCBI
GRCm38728,766,752 - 28,788,665 (+)NCBI
MGSCv37729,551,771 - 29,573,684 (+)RGD
Celera723,327,529 - 23,349,457 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001122766   ⟹   NP_001116238
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,466,177 - 28,488,090 (+)NCBI
GRCm38728,766,752 - 28,788,665 (+)NCBI
MGSCv37729,551,771 - 29,573,684 (+)RGD
Celera723,327,529 - 23,349,457 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_022432   ⟹   NP_071877
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,466,177 - 28,488,090 (+)NCBI
GRCm38728,766,752 - 28,788,665 (+)NCBI
MGSCv37729,551,771 - 29,573,684 (+)RGD
Celera723,327,529 - 23,349,457 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153325   ⟹   XP_036009218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,468,301 - 28,488,086 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071877   ⟸   NM_022432
- Peptide Label: isoform 1
- UniProtKB: U5TP50 (UniProtKB/Swiss-Prot),   Q8VDQ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116237   ⟸   NM_001122765
- Peptide Label: isoform 2
- UniProtKB: Q8VDQ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001116238   ⟸   NM_001122766
- Peptide Label: isoform 3
- UniProtKB: Q8VDQ8 (UniProtKB/Swiss-Prot),   A0A8C6HWG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000132783   ⟸   ENSMUST00000170068
RefSeq Acc Id: ENSMUSP00000072732   ⟸   ENSMUST00000072965
RefSeq Acc Id: ENSMUSP00000147217   ⟸   ENSMUST00000122915
RefSeq Acc Id: ENSMUSP00000146462   ⟸   ENSMUST00000155327
RefSeq Acc Id: XP_036009218   ⟸   XM_036153325
- Peptide Label: isoform X1
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VDQ8-F1-model_v2 AlphaFold Q8VDQ8 1-389 view protein structure

Promoters
RGD ID:6892488
Promoter ID:EPDNEW_M9695
Type:initiation region
Name:Sirt2_1
Description:Mus musculus sirtuin 2 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38728,766,782 - 28,766,842EPDNEW
RGD ID:6841636
Promoter ID:MM_KWN:49663
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000032815,   ENSMUST00000108274,   NM_001122766,   NM_022432,   OTTMUST00000041938,   OTTMUST00000041944,   UC009FZS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,550,376 - 29,551,877 (-)MPROMDB
RGD ID:6842030
Promoter ID:MM_KWN:49665
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Spleen
Transcripts:OTTMUST00000041939,   OTTMUST00000041940
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,561,116 - 29,562,257 (+)MPROMDB
RGD ID:6842033
Promoter ID:MM_KWN:49667
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000041943
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,569,141 - 29,569,872 (+)MPROMDB
RGD ID:6842032
Promoter ID:MM_KWN:49668
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000041941,   OTTMUST00000041942
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,569,716 - 29,570,216 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927664 AgrOrtholog
Ensembl Genes ENSMUSG00000015149 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000072732 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000132783 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146462.2 UniProtKB/TrEMBL
  ENSMUSP00000147217 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000072965 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000122915 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000155327.8 UniProtKB/TrEMBL
  ENSMUST00000170068 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64383 UniProtKB/Swiss-Prot
MGD MGI:1927664 ENTREZGENE
NCBI Gene 64383 ENTREZGENE
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt2 PhenoGen
PIRSF SIR2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LHL5_MOUSE UniProtKB/TrEMBL
  A0A8C6HWG2 ENTREZGENE
  Q3UJK6_MOUSE UniProtKB/TrEMBL
  Q8VDQ8 ENTREZGENE, UniProtKB/Swiss-Prot
  U5TP50 ENTREZGENE
UniProt Secondary E9PXF5 UniProtKB/Swiss-Prot
  Q9CXS5 UniProtKB/Swiss-Prot
  Q9EQ18 UniProtKB/Swiss-Prot
  Q9ERJ9 UniProtKB/Swiss-Prot
  U5TP50 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Sirt2  sirtuin 2    sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED