SIRT1 (sirtuin 1) - Rat Genome Database

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Gene: SIRT1 (sirtuin 1) Homo sapiens
Symbol: SIRT1
Name: sirtuin 1
RGD ID: 1318374
HGNC Page HGNC:14929
Description: Enables several functions, including DNA-binding transcription factor binding activity; HLH domain binding activity; and NAD-dependent histone decrotonylase activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of nucleobase-containing compound metabolic process; and regulation of protein metabolic process. Located in several cellular components, including chromatin; nuclear inner membrane; and nuclear lumen. Part of chromatin silencing complex. Colocalizes with ESC/E(Z) complex. Implicated in Huntington's disease. Biomarker of several diseases, including Huntington's disease; macular degeneration; non-alcoholic fatty liver disease; prostate cancer; and senile cataract.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; regulatory protein SIR2 homolog 1; SIR2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SIR2L1; sirtuin; sirtuin type 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
T2T-CHM13v2.01068,753,401 - 68,787,131 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (EXP)
autoimmune disease  (EXP)
Binge Drinking  (ISO)
brain infarction  (EXP)
Brain Injuries  (ISO)
Brain Neoplasms  (EXP)
Breast Neoplasms  (EXP)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (IEP)
colitis  (EXP)
congestive heart failure  (EXP)
demyelinating disease  (EXP)
diabetes mellitus  (EXP)
diabetic retinopathy  (EXP)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (EXP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
fatty liver disease  (EXP,ISO)
Fibrosis  (EXP)
Genomic Instability  (EXP)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhagic Shock  (ISO)
human immunodeficiency virus infectious disease  (EXP)
Huntington's disease  (IAGP,IEP,ISO)
Hypertrophy  (EXP)
impotence  (ISO)
Insulin Resistance  (EXP,ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (EXP)
macular degeneration  (IEP)
Metabolic Syndrome  (EXP,ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (EXP)
Neoplasm Metastasis  (EXP)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (EXP)
neurodegenerative disease  (EXP)
neuronal ceroid lipofuscinosis 1  (EXP)
non-alcoholic fatty liver disease  (EXP,IEP,ISO)
obesity  (EXP,ISO)
osteoporosis  (ISO)
osteosarcoma  (EXP)
Paralysis  (EXP)
Pneumococcal Pneumonia  (EXP)
pneumonia  (EXP)
prostate cancer  (IEP)
Prostatic Neoplasms  (EXP)
retinal disease  (EXP)
senile cataract  (IEP)
systemic scleroderma  (EXP)
thrombosis  (EXP)
type 2 diabetes mellitus  (EXP,ISO)
Wallerian Degeneration  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-hydroxybutyric acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-nitropropanoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (EXP)
acadesine  (EXP)
acetic acid  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (EXP)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (ISO)
alpha-D-galactose  (EXP,ISO)
amino acid  (EXP)
aminoguanidine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (EXP)
apocynin  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
bafilomycin A1  (ISO)
benzamide  (EXP)
benzophenanthridine  (EXP)
berberine  (EXP,ISO)
Betanin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butein  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcium oxalate  (EXP)
camptothecin  (EXP)
capsaicin  (EXP)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP)
CAY10591  (EXP)
CDP-choline  (ISO)
CGS-21680  (EXP)
Chikusetsusaponin-V  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cortisol  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cudraflavone B  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dihydrogen  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
diprotium  (EXP)
disulfiram  (EXP)
dizocilpine maleate  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enzyme inhibitor  (EXP)
ergosterol  (ISO)
Erythropoietin  (EXP)
ethanol  (EXP,ISO)
everolimus  (EXP)
excitatory amino acid agonist  (ISO)
fenbendazole  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (EXP)
fisetin  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP)
galactose  (EXP,ISO)
gallic acid  (EXP)
gallocatechin  (EXP)
Genipin  (ISO)
genistein  (EXP)
geraniol  (EXP)
ginsenoside Rg1  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (ISO)
Goe 6976  (EXP)
GW 501516  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
icariin  (EXP,ISO)
imidacloprid  (ISO)
inositol  (ISO)
ionomycin  (ISO)
iprodione  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoniazide  (EXP)
isonicotinamide  (EXP)
isoquinoline-1,5-diol  (EXP)
kainic acid  (ISO)
KT 5720  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
Licarin A  (ISO)
linagliptin  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
luzindole  (EXP)
lycopene  (EXP)
Magnolol  (ISO)
malonaldehyde  (ISO)
mancozeb  (EXP)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP,ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
metiram  (EXP)
mifepristone  (ISO)
mithramycin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monooxygen  (EXP)
monosodium L-glutamate  (ISO)
myricetin  (EXP)
N,N-dimethylglycine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP,ISO)
naringin  (ISO)
nickel dichloride  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
nitrites  (ISO)
nitroprusside  (EXP)
nitroxoline  (EXP)
NMN zwitterion  (ISO)
ochratoxin A  (EXP)
olaparib  (EXP)
oleic acid  (EXP,ISO)
organoselenium compound  (ISO)
oxaloacetic acid  (EXP)
oxidopamine  (EXP)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP)
potassium atom  (ISO)
potassium dichromate  (ISO)
prasugrel hydrochloride  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propionic acid  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP)
pterostilbene  (EXP)
puerarin  (ISO)
pyruvic acid  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
S-nitroso-L-cysteine  (EXP)
salicylic acid  (ISO)
Salidroside  (EXP)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (EXP,ISO)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
splitomicin  (EXP,ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
suramin  (EXP,ISO)
taurine  (EXP,ISO)
temozolomide  (EXP)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thimerosal  (EXP)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
trans-piceid  (EXP)
triphenylstannane  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (EXP)
Tungsten carbide  (EXP)
umbelliferone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (EXP,ISO)
zinc atom  (EXP)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA,IEA)
apoptotic process  (IEA)
behavioral response to starvation  (IEA,ISO)
cell differentiation  (IEA)
cellular glucose homeostasis  (IEA,ISS)
cellular response to amyloid-beta  (ISO)
cellular response to antibiotic  (ISO)
cellular response to curcumin  (ISO)
cellular response to DNA damage stimulus  (IDA)
cellular response to glucose starvation  (IMP)
cellular response to hydrogen peroxide  (IDA,ISO)
cellular response to hypoxia  (IMP)
cellular response to ionizing radiation  (IEA,ISS)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to rotenone  (ISO)
cellular response to starvation  (IEA,ISS)
cellular response to tumor necrosis factor  (IDA)
cellular response to vitamin B3  (ISO)
cellular triglyceride homeostasis  (IEA,ISS)
cholesterol homeostasis  (IEA,ISS)
chromatin organization  (IMP)
circadian regulation of gene expression  (IEA,IMP,ISS)
circadian rhythm  (IEA)
DNA methylation-dependent heterochromatin formation  (TAS)
DNA synthesis involved in DNA repair  (IEA,ISS)
energy homeostasis  (IMP,ISO)
fatty acid homeostasis  (IEA,ISS)
heterochromatin formation  (IDA)
histone deacetylation  (IDA,IEA,ISO)
histone H3 deacetylation  (IBA,IDA,IMP,ISO)
histone H3-K9 deacetylation  (IEA)
histone H3-K9 modification  (IEA)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IMP)
leptin-mediated signaling pathway  (IEA,ISS)
macrophage differentiation  (IEA,ISS)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (IMP)
negative regulation of apoptotic process  (IMP)
negative regulation of cAMP-dependent protein kinase activity  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (IMP)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (IMP)
negative regulation of cellular response to testosterone stimulus  (IMP)
negative regulation of cellular senescence  (IDA,IMP)
negative regulation of DNA binding  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IDA)
negative regulation of DNA-binding transcription factor activity  (IDA,IEA,IMP)
negative regulation of DNA-templated transcription  (IBA,IDA,IEA,IMP,ISO)
negative regulation of fat cell differentiation  (IEA,ISS)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of growth hormone secretion  (ISO)
negative regulation of helicase activity  (IDA)
negative regulation of histone H3-K14 acetylation  (IMP)
negative regulation of histone H3-K9 trimethylation  (IEA)
negative regulation of histone H4-K16 acetylation  (IMP)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (IEA,ISO)
negative regulation of NF-kappaB transcription factor activity  (IDA)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IMP)
negative regulation of peptidyl-lysine acetylation  (IDA)
negative regulation of phosphorylation  (IEA,IMP)
negative regulation of prostaglandin biosynthetic process  (IEA,ISS)
negative regulation of protein acetylation  (IMP,ISO)
negative regulation of protein kinase B signaling  (IEA,IMP)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TOR signaling  (IEA,IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,IMP)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISS)
negative regulation of tumor necrosis factor production  (ISO)
obsolete cell aging  (TAS)
obsolete protein ADP-ribosylation  (TAS)
ovulation from ovarian follicle  (IEA,ISO)
peptidyl-lysine acetylation  (IMP)
peptidyl-lysine deacetylation  (IDA)
positive regulation of adaptive immune response  (IDA)
positive regulation of adipose tissue development  (IEA,ISS)
positive regulation of angiogenesis  (IDA,IMP)
positive regulation of apoptotic process  (IDA,IEA,IMP)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IDA)
positive regulation of cAMP-dependent protein kinase activity  (IEA,IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cellular senescence  (IDA)
positive regulation of cholesterol efflux  (IEA,ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of DNA repair  (IMP)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IDA,IEA,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of histone deacetylation  (IMP)
positive regulation of histone H3-K9 methylation  (IMP)
positive regulation of histone methylation  (IMP)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (IDA,IEA)
positive regulation of macrophage apoptotic process  (IEA,ISS)
positive regulation of macrophage cytokine production  (IEA,ISS)
positive regulation of MHC class II biosynthetic process  (IDA)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISS)
positive regulation of protein deacetylation  (ISO)
positive regulation of protein phosphorylation  (IEA,ISS)
positive regulation of skeletal muscle cell proliferation  (ISO)
positive regulation of smooth muscle cell differentiation  (IEA)
positive regulation of thyroid-stimulating hormone secretion  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IMP)
protein deacetylation  (IDA,IEA,IMP,ISO,TAS)
protein depropionylation  (IEA,ISS)
protein destabilization  (IDA,IEA,ISS)
protein ubiquitination  (IDA,IMP)
pyrimidine dimer repair by nucleotide-excision repair  (IEA,IMP)
rDNA heterochromatin formation  (IDA,IMP,TAS)
regulation of apoptotic process  (IMP)
regulation of bile acid biosynthetic process  (IEA,ISS)
regulation of brown fat cell differentiation  (IEA,ISS)
regulation of cell population proliferation  (IMP)
regulation of cellular response to heat  (TAS)
regulation of centrosome duplication  (IDA)
regulation of endodeoxyribonuclease activity  (IMP)
regulation of glucose metabolic process  (IEA,ISS)
regulation of lipid storage  (IEA,ISS)
regulation of mitotic cell cycle  (IDA)
regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISS)
regulation of protein serine/threonine kinase activity  (IMP)
regulation of smooth muscle cell apoptotic process  (IEA,ISS)
regulation of transcription by glucose  (IMP)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (IDA)
response to insulin  (IEA,ISS)
response to kainic acid  (ISO)
response to leptin  (IEA,ISS)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (IDA)
response to resveratrol  (ISO)
rhythmic process  (IEA)
single strand break repair  (IMP)
spermatogenesis  (IEA,ISO)
stress-induced premature senescence  (IMP)
transforming growth factor beta receptor signaling pathway  (IDA)
triglyceride mobilization  (IEA,ISS)
UV-damage excision repair  (IMP)
vasodilation  (ISO)
white fat cell differentiation  (IEA,ISS)

Cellular Component
axon  (ISO)
chromatin  (IDA,IEA)
chromatin silencing complex  (IDA)
cytoplasm  (IDA,IEA)
cytosol  (IDA,ISO)
eNoSc complex  (IPI)
ESC/E(Z) complex  (IDA)
euchromatin  (IDA)
fibrillar center  (IDA)
growth cone  (ISO)
heterochromatin  (IDA,IEA)
mitochondrion  (IDA,IEA)
nuclear envelope  (IDA)
nuclear inner membrane  (IBA,IDA)
nucleolus  (IDA)
nucleoplasm  (IBA,IDA,TAS)
nucleus  (IBA,IDA,IEA,ISO)
PML body  (IDA,IEA)
protein-containing complex  (IEA)
rDNA heterochromatin  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Alcendor RR, etal., Circ Res. 2004 Nov 12;95(10):971-80. Epub 2004 Oct 14.
2. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. Castro RE, etal., J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15.
3. [SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models]. Chen Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Apr;33(4):528-32.
4. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Choi J, etal., Ann Clin Transl Neurol. 2014 Aug;1(8):589-604. doi: 10.1002/acn3.86. Epub 2014 Aug 19.
5. SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. Costa Cdos S, etal., Obes Surg. 2010 May;20(5):633-9. doi: 10.1007/s11695-009-0052-z. Epub 2009 Dec 22.
6. Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide alpha-MSH and the processing enzyme CPE production in diet-induced obese male rats. Cyr NE, etal., Endocrinology. 2014 Jul;155(7):2423-35. doi: 10.1210/en.2013-1998. Epub 2014 Apr 28.
7. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. Deng XQ, etal., Liver Int. 2007 Jun;27(5):708-15.
8. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Erion DM, etal., Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. doi: 10.1073/pnas.0812931106. Epub 2009 Jun 22.
9. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kappaB signaling pathway. Feng J, etal., Acta Biochim Biophys Sin (Shanghai). 2014 Dec;46(12):1024-33. doi: 10.1093/abbs/gmu103. Epub 2014 Nov 6.
10. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. Gao Z, etal., J Biol Chem. 2011 Jun 24;286(25):22227-34. doi: 10.1074/jbc.M111.228874. Epub 2011 May 3.
11. Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Gorenne I, etal., Circulation. 2013 Jan 22;127(3):386-96. doi: 10.1161/CIRCULATIONAHA.112.124404. Epub 2012 Dec 7.
12. The nucleolus-guardian of cellular homeostasis and genome integrity. Grummt I Chromosoma. 2013 Dec;122(6):487-97.
13. Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. Hurtado O, etal., J Neurochem. 2013 Sep;126(6):819-26. doi: 10.1111/jnc.12269. Epub 2013 May 13.
14. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Jeong H, etal., Nat Med. 2011 Dec 18;18(1):159-65. doi: 10.1038/nm.2559.
15. Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Jian B, etal., Biochim Biophys Acta. 2011 Nov;1812(11):1446-51. doi: 10.1016/j.bbadis.2011.04.010. Epub 2011 Apr 30.
16. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Jian B, etal., Mol Med. 2012 Mar 27;18:209-14. doi: 10.2119/molmed.2011.00365.
17. Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors. Kataoka T, etal., J Sex Med. 2014 Apr;11(4):920-9. doi: 10.1111/jsm.12447. Epub 2014 Jan 28.
18. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. Kim D, etal., EMBO J. 2007 Jul 11;26(13):3169-79. Epub 2007 Jun 21.
19. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
20. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Lempiainen J, etal., Br J Pharmacol. 2012 Jul;166(6):1905-15. doi: 10.1111/j.1476-5381.2012.01895.x.
21. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy. Li L, etal., Can J Physiol Pharmacol. 2009 Jan;87(1):56-62. doi: 10.1139/Y08-099.
22. SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. Lovaas JD, etal., Prostate. 2013 Apr;73(5):522-30. doi: 10.1002/pros.22592. Epub 2012 Oct 4.
23. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Milne JC, etal., Nature. 2007 Nov 29;450(7170):712-6.
24. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies. Pallas M, etal., Neuroscience. 2008 Jul 17;154(4):1388-97. doi: 10.1016/j.neuroscience.2008.04.065. Epub 2008 May 3.
25. Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. Peng CH, etal., Biomaterials. 2011 Dec;32(34):9077-88. doi: 10.1016/j.biomaterials.2011.08.008. Epub 2011 Sep 3.
26. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. Prins SA, etal., PLoS One. 2014 Jan 8;9(1):e83166. doi: 10.1371/journal.pone.0083166. eCollection 2014.
29. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Qin W, etal., J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Sakao Y, etal., Clin Exp Nephrol. 2011 Jun;15(3):363-72. doi: 10.1007/s10157-011-0421-5. Epub 2011 Mar 18.
33. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Schilling G, etal., Hum Mol Genet. 1999 Mar;8(3):397-407.
34. Food restriction improves glucose and lipid metabolism through Sirt1 expression: a study using a new rat model with obesity and severe hypertension. Takemori K, etal., Life Sci. 2011 Jun 20;88(25-26):1088-94. doi: 10.1016/j.lfs.2011.04.002. Epub 2011 Apr 14.
35. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. Tanno M, etal., J Biol Chem. 2010 Jan 20.
36. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
37. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
38. Obesity accelerates ovarian follicle development and follicle loss in rats. Wang N, etal., Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.
39. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. Wu A, etal., J Neurotrauma. 2007 Oct;24(10):1587-95.
40. Novel Role of Resveratrol: Suppression of HMGB1 Nucleocytoplasmic Translocation by the Up-Regulation of SIRT1 in Sepsis-Induced Liver Injury. Xu W, etal., Shock. 2014 Jul 4.
41. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury. Yan H, etal., Crit Care Med. 2014 May;42(5):e373-81. doi: 10.1097/CCM.0000000000000246.
42. Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis. Yang J, etal., Arch Med Res. 2011 Jul;42(5):354-60. doi: 10.1016/j.arcmed.2011.07.005. Epub 2011 Jul 31.
43. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats. Yar AS, etal., Genet Mol Res. 2011 Nov 29;10(4):2962-75. doi: 10.4238/2011.November.29.7.
44. Resveratrol ameliorates experimental autoimmune myocarditis. Yoshida Y, etal., Circ J. 2007 Mar;71(3):397-404.
45. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Yoshizaki T, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8.
46. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Zhang J, etal., Age (Dordr). 2013 Jun;35(3):807-20. doi: 10.1007/s11357-012-9412-z. Epub 2012 May 4.
47. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.
48. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Zheng T and Lu Y, Curr Eye Res. 2011 May;36(5):449-55. doi: 10.3109/02713683.2011.559301.
Additional References at PubMed
PMID:10381378   PMID:10873683   PMID:11230166   PMID:11672522   PMID:11672523   PMID:12006491   PMID:12297502   PMID:12413881   PMID:12477932   PMID:12535671   PMID:12837246   PMID:12930829  
PMID:12939617   PMID:14702039   PMID:14976264   PMID:14980222   PMID:15126506   PMID:15152190   PMID:15164054   PMID:15175761   PMID:15205477   PMID:15220471   PMID:15302935   PMID:15469825  
PMID:15489334   PMID:15632193   PMID:15639232   PMID:15640142   PMID:15684044   PMID:15692560   PMID:15716268   PMID:15719057   PMID:15744310   PMID:15749705   PMID:15780941   PMID:16079181  
PMID:16154098   PMID:16166628   PMID:16183991   PMID:16207712   PMID:16257164   PMID:16269335   PMID:16288004   PMID:16328012   PMID:16344560   PMID:16354677   PMID:16385451   PMID:16628003  
PMID:16892051   PMID:16923962   PMID:16959573   PMID:16964243   PMID:16998474   PMID:16998810   PMID:17041012   PMID:17081983   PMID:17098745   PMID:17099246   PMID:17112576   PMID:17172643  
PMID:17180656   PMID:17283066   PMID:17317627   PMID:17334224   PMID:17373700   PMID:17456799   PMID:17487425   PMID:17505061   PMID:17516504   PMID:17601350   PMID:17612497   PMID:17624472  
PMID:17638871   PMID:17680780   PMID:17785417   PMID:17806102   PMID:17895433   PMID:17901049   PMID:17916362   PMID:17934453   PMID:17936707   PMID:17937892   PMID:17964266   PMID:17996922  
PMID:18004385   PMID:18029348   PMID:18174544   PMID:18184747   PMID:18193082   PMID:18203716   PMID:18230337   PMID:18235501   PMID:18235502   PMID:18296641   PMID:18329615   PMID:18342601  
PMID:18344999   PMID:18414679   PMID:18438697   PMID:18482975   PMID:18485871   PMID:18485895   PMID:18556572   PMID:18563176   PMID:18573234   PMID:18636124   PMID:18660489   PMID:18662546  
PMID:18662547   PMID:18681908   PMID:18687677   PMID:18689793   PMID:18704159   PMID:18723829   PMID:18724249   PMID:18753379   PMID:18755897   PMID:18774777   PMID:18800364   PMID:18820948  
PMID:18821472   PMID:18823944   PMID:18829436   PMID:18829956   PMID:18834855   PMID:18835033   PMID:18838864   PMID:18850005   PMID:18922603   PMID:18957417   PMID:18977241   PMID:19008647  
PMID:19014491   PMID:19017485   PMID:19047049   PMID:19060927   PMID:19071085   PMID:19075016   PMID:19104446   PMID:19107194   PMID:19132007   PMID:19149601   PMID:19166820   PMID:19167483  
PMID:19173742   PMID:19188449   PMID:19218236   PMID:19220062   PMID:19229036   PMID:19236849   PMID:19244234   PMID:19267881   PMID:19270680   PMID:19285077   PMID:19286634   PMID:19289152  
PMID:19322201   PMID:19343720   PMID:19356714   PMID:19364925   PMID:19376817   PMID:19377286   PMID:19404850   PMID:19430421   PMID:19433578   PMID:19470756   PMID:19478080   PMID:19491102  
PMID:19498162   PMID:19509139   PMID:19553684   PMID:19555662   PMID:19568959   PMID:19578370   PMID:19581416   PMID:19615732   PMID:19643082   PMID:19649206   PMID:19664641   PMID:19680552  
PMID:19680556   PMID:19690166   PMID:19713122   PMID:19714620   PMID:19716821   PMID:19720090   PMID:19741164   PMID:19786632   PMID:19819989   PMID:19883617   PMID:19887452   PMID:19895790  
PMID:19923004   PMID:19934257   PMID:19934264   PMID:19995796   PMID:19996091   PMID:20027304   PMID:20041875   PMID:20042607   PMID:20060806   PMID:20068143   PMID:20071779   PMID:20074560  
PMID:20097625   PMID:20100829   PMID:20102704   PMID:20103737   PMID:20107110   PMID:20131294   PMID:20157519   PMID:20160399   PMID:20167603   PMID:20169165   PMID:20203304   PMID:20217115  
PMID:20225204   PMID:20335544   PMID:20360068   PMID:20375098   PMID:20379614   PMID:20412117   PMID:20421294   PMID:20424141   PMID:20426787   PMID:20431927   PMID:20439735   PMID:20448046  
PMID:20451257   PMID:20463039   PMID:20479254   PMID:20484414   PMID:20488443   PMID:20493163   PMID:20503258   PMID:20506278   PMID:20555380   PMID:20595232   PMID:20617556   PMID:20620956  
PMID:20627091   PMID:20631301   PMID:20633545   PMID:20660480   PMID:20668205   PMID:20668706   PMID:20670893   PMID:20689156   PMID:20693263   PMID:20702418   PMID:20733005   PMID:20803525  
PMID:20812964   PMID:20813124   PMID:20817729   PMID:20819794   PMID:20844277   PMID:20869593   PMID:20941378   PMID:20955178   PMID:20956937   PMID:20966076   PMID:20972425   PMID:20977650  
PMID:20978007   PMID:21030595   PMID:21056897   PMID:21067862   PMID:21074897   PMID:21081649   PMID:21098725   PMID:21108727   PMID:21118843   PMID:21130087   PMID:21144831   PMID:21149449  
PMID:21149730   PMID:21163946   PMID:21176092   PMID:21212262   PMID:21241768   PMID:21245135   PMID:21245319   PMID:21277951   PMID:21289058   PMID:21329659   PMID:21331741   PMID:21337390  
PMID:21345792   PMID:21349544   PMID:21390332   PMID:21414717   PMID:21454709   PMID:21471201   PMID:21474819   PMID:21502801   PMID:21502975   PMID:21504832   PMID:21505241   PMID:21527554  
PMID:21533107   PMID:21543634   PMID:21555002   PMID:21555454   PMID:21556116   PMID:21567102   PMID:21596753   PMID:21604001   PMID:21636977   PMID:21697093   PMID:21698133   PMID:21700104  
PMID:21701047   PMID:21703114   PMID:21713995   PMID:21719763   PMID:21720722   PMID:21745208   PMID:21746786   PMID:21760635   PMID:21775285   PMID:21778425   PMID:21789216   PMID:21807113  
PMID:21813271   PMID:21832856   PMID:21841822   PMID:21852339   PMID:21865267   PMID:21871827   PMID:21873635   PMID:21882241   PMID:21890893   PMID:21909281   PMID:21915620   PMID:21920899  
PMID:21947282   PMID:21956116   PMID:21968188   PMID:21972126   PMID:21987377   PMID:22000456   PMID:22013015   PMID:22017869   PMID:22038097   PMID:22050448   PMID:22073865   PMID:22084251  
PMID:22094255   PMID:22094256   PMID:22121772   PMID:22124156   PMID:22133824   PMID:22137654   PMID:22146883   PMID:22149272   PMID:22152608   PMID:22157007   PMID:22157016   PMID:22159506  
PMID:22169038   PMID:22178470   PMID:22190034   PMID:22190494   PMID:22197555   PMID:22198152   PMID:22200427   PMID:22207735   PMID:22219708   PMID:22228742   PMID:22230810   PMID:22245592  
PMID:22249256   PMID:22266962   PMID:22272724   PMID:22302044   PMID:22306819   PMID:22308024   PMID:22312127   PMID:22322739   PMID:22328728   PMID:22330808   PMID:22333659   PMID:22340598  
PMID:22355666   PMID:22363646   PMID:22364258   PMID:22370592   PMID:22378745   PMID:22385246   PMID:22389628   PMID:22406815   PMID:22410779   PMID:22446626   PMID:22448750   PMID:22465953  
PMID:22479397   PMID:22493485   PMID:22510409   PMID:22510882   PMID:22537175   PMID:22542455   PMID:22544055   PMID:22552445   PMID:22553202   PMID:22554968   PMID:22564731   PMID:22584570  
PMID:22586264   PMID:22590959   PMID:22613205   PMID:22623155   PMID:22628222   PMID:22640743   PMID:22661383   PMID:22674476   PMID:22683003   PMID:22683888   PMID:22689577   PMID:22696478  
PMID:22700961   PMID:22703651   PMID:22728651   PMID:22732402   PMID:22735644   PMID:22740055   PMID:22773876   PMID:22780949   PMID:22789853   PMID:22792074   PMID:22796962   PMID:22807441  
PMID:22824213   PMID:22833338   PMID:22836009   PMID:22863012   PMID:22863883   PMID:22867969   PMID:22885181   PMID:22893703   PMID:22902626   PMID:22934845   PMID:22935421   PMID:22939629  
PMID:22956909   PMID:22980663   PMID:22986535   PMID:22986747   PMID:22990118   PMID:22990594   PMID:22995302   PMID:23024800   PMID:23045412   PMID:23050959   PMID:23056314   PMID:23070058  
PMID:23075334   PMID:23075766   PMID:23079621   PMID:23103739   PMID:23133645   PMID:23135526   PMID:23137540   PMID:23143889   PMID:23153509   PMID:23169992   PMID:23178529   PMID:23209300  
PMID:23224434   PMID:23229445   PMID:23238746   PMID:23247197   PMID:23247634   PMID:23248098   PMID:23255128   PMID:23257246   PMID:23262029   PMID:23267107   PMID:23276927   PMID:23305113  
PMID:23332867   PMID:23340254   PMID:23349863   PMID:23354305   PMID:23357110   PMID:23361587   PMID:23363613   PMID:23365135   PMID:23370328   PMID:23382074   PMID:23382833   PMID:23390957  
PMID:23394938   PMID:23395904   PMID:23417673   PMID:23449222   PMID:23450480   PMID:23453030   PMID:23473037   PMID:23474493   PMID:23475622   PMID:23477488   PMID:23483263   PMID:23505545  
PMID:23542177   PMID:23547809   PMID:23548308   PMID:23561972   PMID:23583951   PMID:23602568   PMID:23612972   PMID:23613875   PMID:23636469   PMID:23661372   PMID:23673452   PMID:23702379  
PMID:23704280   PMID:23725046   PMID:23728341   PMID:23754392   PMID:23760629   PMID:23768087   PMID:23770291   PMID:23793837   PMID:23797802   PMID:23800577   PMID:23814050   PMID:23827175  
PMID:23855981   PMID:23868084   PMID:23873758   PMID:23876548   PMID:23892437   PMID:23897426   PMID:23900402   PMID:23922917   PMID:23928404   PMID:23933590   PMID:23950036   PMID:23952905  
PMID:23960241   PMID:23977047   PMID:23993977   PMID:24018803   PMID:24019980   PMID:24035280   PMID:24038750   PMID:24039251   PMID:24043310   PMID:24048733   PMID:24064760   PMID:24088390  
PMID:24100623   PMID:24107295   PMID:24112038   PMID:24126058   PMID:24127549   PMID:24141423   PMID:24147777   PMID:24184155   PMID:24184811   PMID:24211209   PMID:24211575   PMID:24218438  
PMID:24223900   PMID:24228097   PMID:24244526   PMID:24247792   PMID:24258275   PMID:24270983   PMID:24297698   PMID:24320086   PMID:24335313   PMID:24343700   PMID:24349441   PMID:24356447  
PMID:24362520   PMID:24376725   PMID:24378473   PMID:24383118   PMID:24386389   PMID:24397908   PMID:24410795   PMID:24414799   PMID:24416313   PMID:24419059   PMID:24423936   PMID:24434080  
PMID:24449278   PMID:24451382   PMID:24464653   PMID:24471483   PMID:24473773   PMID:24484175   PMID:24486147   PMID:24486702   PMID:24488909   PMID:24489003   PMID:24504520   PMID:24507186  
PMID:24518759   PMID:24548601   PMID:24549598   PMID:24570024   PMID:24570140   PMID:24587358   PMID:24652283   PMID:24672028   PMID:24681097   PMID:24681949   PMID:24702436   PMID:24726431  
PMID:24726500   PMID:24729176   PMID:24742694   PMID:24743044   PMID:24751483   PMID:24778252   PMID:24816737   PMID:24824780   PMID:24850427   PMID:24855208   PMID:24862934   PMID:24875183  
PMID:24875419   PMID:24877878   PMID:24880091   PMID:24890145   PMID:24892674   PMID:24894820   PMID:24897117   PMID:24913149   PMID:24924687   PMID:24962570   PMID:24969755   PMID:24973384  
PMID:24981860   PMID:24997996   PMID:24999758   PMID:25024332   PMID:25032863   PMID:25040736   PMID:25047736   PMID:25063737   PMID:25070626   PMID:25085245   PMID:25086746   PMID:25096191  
PMID:25109285   PMID:25116588   PMID:25119660   PMID:25131770   PMID:25132403   PMID:25136908   PMID:25143434   PMID:25165029   PMID:25172416   PMID:25180292   PMID:25189993   PMID:25193706  
PMID:25199460   PMID:25213338   PMID:25216517   PMID:25217442   PMID:25228047   PMID:25233986   PMID:25243179   PMID:25252293   PMID:25270091   PMID:25273948   PMID:25280219   PMID:25281719  
PMID:25304127   PMID:25305471   PMID:25323003   PMID:25323555   PMID:25341037   PMID:25342474   PMID:25347121   PMID:25348016   PMID:25352462   PMID:25358448   PMID:25360511   PMID:25361925  
PMID:25361978   PMID:25369635   PMID:25389371   PMID:25404446   PMID:25420528   PMID:25444742   PMID:25445714   PMID:25454945   PMID:25463605