Fosb (FosB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosb (FosB proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
Symbol: Fosb
Name: FosB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 1308198
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including response to alkaloid; response to amphetamine; and response to steroid hormone. Located in cytosol and nucleus. Used to study heroin dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; cocaine abuse; and drug dependence (multiple). Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
Previously known as: FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; fra-2; LOC100360880; transcription factor AP-1 subunit FosB
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amphetamine  (EXP,ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cylindrospermopsin  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
dizocilpine maleate  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
haloperidol  (EXP,ISO)
heroin  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
kenpaullone  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
mechlorethamine  (ISO)
melphalan  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
morphine  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
naloxone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
phencyclidine  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
rimonabant  (EXP)
SCH 23390  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
toluene  (ISO)
tramadol  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)


References - curated
# Reference Title Reference Citation
1. Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens. Carneiro de Oliveira PE, etal., Front Behav Neurosci. 2016 Sep 12;10:173. doi: 10.3389/fnbeh.2016.00173. eCollection 2016.
2. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. El Rawas R, etal., Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.
3. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
4. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. Gajewski PA, etal., PLoS One. 2016 Aug 5;11(8):e0160355. doi: 10.1371/journal.pone.0160355. eCollection 2016.
5. Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. García-Pérez D, etal., PLoS One. 2012;7(11):e50264. doi: 10.1371/journal.pone.0050264. Epub 2012 Nov 21.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats. Guo L, etal., Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi: 10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.
9. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
10. Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge. Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
11. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
12. Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex. Kontkanen O, etal., Neuropsychopharmacology. 2002 Aug;27(2):152-62.
13. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Larson EB, etal., J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3.
14. Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Li J, etal., Alcohol Clin Exp Res. 2010 Oct;34(10):1742-50. doi: 10.1111/j.1530-0277.2010.01261.x. Epub 2010 Jul 9.
15. Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions. Li J, etal., PLoS One. 2012;7(7):e40347. doi: 10.1371/journal.pone.0040347. Epub 2012 Jul 9.
16. Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats. Liu H, etal., Neurosci Lett. 2011 Apr 20;494(1):70-4. doi: 10.1016/j.neulet.2011.02.059. Epub 2011 Mar 6.
17. Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine. Marttila K, etal., Brain Res. 2007 Jul 30;1160:82-90. doi: 10.1016/j.brainres.2007.05.036. Epub 2007 May 31.
18. Early activation of transcription factor expression in Schwann cells by progesterone. Mercier G, etal., Brain Res Mol Brain Res. 2001 Dec 30;97(2):137-48.
19. Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells. Mercier G, etal., Glia. 2001 Aug;35(2):81-9.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
22. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Mitchell JA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E439-45. Epub 2004 May 4.
23. D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration. Muller DL and Unterwald EM, J Pharmacol Exp Ther. 2005 Jul;314(1):148-54. Epub 2005 Mar 16.
24. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
25. Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
26. Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
27. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. Núñez C, etal., J Neurochem. 2010 Jul;114(2):475-87. doi: 10.1111/j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice. Robins MT, etal., PLoS One. 2016 Jul 5;11(7):e0158189. doi: 10.1371/journal.pone.0158189. eCollection 2016.
31. Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Ryabinin AE and Wang YM, Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54.
32. Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
33. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
34. Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA. van de Wetering R and Schenk S, Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.
35. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
36. Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway. Yazdanfar N, etal., Brain Res Bull. 2021 May;170:98-105. doi: 10.1016/j.brainresbull.2021.02.005. Epub 2021 Feb 13.
Additional References at PubMed
PMID:7790908   PMID:12220541   PMID:12371906   PMID:12525489   PMID:15081600   PMID:15458969   PMID:15564575   PMID:15632090   PMID:15802201   PMID:15828020   PMID:15926929   PMID:16303124  
PMID:16373449   PMID:16633904   PMID:16687504   PMID:17561814   PMID:17640529   PMID:17898221   PMID:17936518   PMID:18280640   PMID:18320311   PMID:18377962   PMID:18842886   PMID:19135469  
PMID:19303854   PMID:19560520   PMID:20513656   PMID:20618447   PMID:21507338   PMID:21820506   PMID:22286499   PMID:22387553   PMID:22521816   PMID:22621966   PMID:22689746   PMID:23022956  
PMID:23426671   PMID:23585124   PMID:23895375   PMID:24026072   PMID:24090157   PMID:24246425   PMID:25721540   PMID:26164345   PMID:27530066   PMID:27542594   PMID:28003214   PMID:29101166  
PMID:30503921   PMID:31442272   PMID:33677486   PMID:34699790   PMID:37642495  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2178,954,312 - 78,961,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,343,248 - 84,350,106 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,900,923 - 92,907,784 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,098,337 - 86,105,195 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,214,691 - 80,221,417 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,480,955 - 81,510,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,668,497 - 78,673,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,416,543 - 73,423,390 (-)NCBICelera
Cytogenetic Map1q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381945,467,996 - 45,475,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,467,995 - 45,475,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,971,254 - 45,978,437 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,663,093 - 50,670,276 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,663,092 - 50,670,276NCBI
Celera1942,777,353 - 42,784,537 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,400,874 - 42,408,060 (+)NCBIHuRef
CHM1_11945,974,496 - 45,981,682 (+)NCBICHM1_1
T2T-CHM13v2.01948,295,244 - 48,302,427 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39719,036,621 - 19,043,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,036,621 - 19,043,976 (-)EnsemblGRCm39 Ensembl
GRCm38719,302,696 - 19,310,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,302,696 - 19,310,051 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,888,045 - 19,895,394 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,461,436 - 18,468,273 (-)NCBIMGSCv36mm8
Celera716,719,831 - 16,727,180 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.56NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555552,438,864 - 2,445,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,438,864 - 2,445,846 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11953,500,106 - 53,507,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,416,781 - 42,424,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,013,350 - 51,020,570 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,013,350 - 51,020,570 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11110,088,686 - 110,092,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,087,036 - 110,092,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,572,939 - 109,577,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,619,054 - 110,625,469 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,619,068 - 110,625,971 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,297,099 - 110,301,231 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,931,231 - 109,935,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,800,596 - 110,804,728 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934917,553,572 - 17,560,226 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,900,931 - 1,906,772 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,900,954 - 1,907,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl651,837,719 - 51,844,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,836,780 - 51,844,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1638,916,039 - 38,924,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,534,366 - 18,539,824 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249072,328,691 - 2,339,099 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,332,746 - 2,338,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fosb
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:217
Interacting mature miRNAs:266
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,954,237 - 78,954,423 (+)MAPPERmRatBN7.2
Rnor_6.0180,214,617 - 80,214,802NCBIRnor6.0
Rnor_5.0181,481,100 - 81,481,285UniSTSRnor5.0
RGSC_v3.4178,666,557 - 78,666,742UniSTSRGSC3.4
Celera173,416,469 - 73,416,654UniSTS
RH 3.4 Map1787.5UniSTS
Cytogenetic Map1q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1
Low 3 18 2 4 3 23 4 21 10
Below cutoff 25 36 22 15 22 7 7 47 31 20 7


RefSeq Acc Id: ENSRNOT00000072149   ⟹   ENSRNOP00000065427
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,954,312 - 78,961,172 (-)Ensembl
Rnor_6.0 Ensembl180,214,691 - 80,221,417 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091687   ⟹   ENSRNOP00000073814
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,954,115 - 78,961,465 (-)Ensembl
Rnor_6.0 Ensembl180,214,494 - 80,221,710 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109325   ⟹   ENSRNOP00000091996
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,955,918 - 78,961,465 (-)Ensembl
RefSeq Acc Id: NM_001256509   ⟹   NP_001243438
Rat AssemblyChrPosition (strand)Source
mRatBN7.2178,954,312 - 78,961,172 (-)NCBI
Rnor_6.0180,214,691 - 80,221,417 (-)NCBI
Rnor_5.0181,480,955 - 81,510,687 (-)NCBI
Celera173,416,543 - 73,423,390 (-)NCBI
RefSeq Acc Id: XM_039101873   ⟹   XP_038957801
Rat AssemblyChrPosition (strand)Source
mRatBN7.2178,956,246 - 78,961,492 (-)NCBI
RefSeq Acc Id: NP_001243438   ⟸   NM_001256509
- UniProtKB: D3ZLB7 (UniProtKB/TrEMBL),   S5NB67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065427   ⟸   ENSRNOT00000072149
RefSeq Acc Id: ENSRNOP00000073814   ⟸   ENSRNOT00000091687
RefSeq Acc Id: XP_038957801   ⟸   XM_039101873
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091996   ⟸   ENSRNOT00000109325
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLB7-F1-model_v2 AlphaFold D3ZLB7 1-338 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689774
Promoter ID:EPDNEW_R291
Type:initiation region
Description:FosB proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,221,674 - 80,221,734EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308198 AgrOrtholog
BioCyc Gene G2FUF-60514 BioCyc
Ensembl Genes ENSRNOG00000046667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032941 UniProtKB/Swiss-Prot
  ENSRNOG00060032929 UniProtKB/Swiss-Prot
  ENSRNOG00065031402 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072149 ENTREZGENE
  ENSRNOT00000072149.2 UniProtKB/Swiss-Prot
  ENSRNOT00000091687.2 UniProtKB/TrEMBL
  ENSRNOT00000109325.1 UniProtKB/TrEMBL
  ENSRNOT00055056986 UniProtKB/Swiss-Prot
  ENSRNOT00060057100 UniProtKB/Swiss-Prot
  ENSRNOT00065054191 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Fos UniProtKB/TrEMBL
KEGG Report rno:100360880 UniProtKB/Swiss-Prot
NCBI Gene 100360880 ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fosb PhenoGen
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046667 RatGTEx
  ENSRNOG00055032941 RatGTEx
  ENSRNOG00060032929 RatGTEx
  ENSRNOG00065031402 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D3ZLB7 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-11 Fosb  FosB proto-oncogene, AP-1 transcription factor subunit  Fosb  FBJ osteosarcoma oncogene B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-19 Fosb  FBJ osteosarcoma oncogene B  LOC100360880  FBJ osteosarcoma oncogene B  Data merged from RGD:2321278 737654 APPROVED
2010-05-05 LOC100360880  FBJ osteosarcoma oncogene B      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Fosb  FBJ osteosarcoma oncogene B  Fosb_predicted  FBJ osteosarcoma oncogene B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fosb_predicted  FBJ osteosarcoma oncogene B (predicted)      Symbol and Name status set to approved 70820 APPROVED