Advanced Search (OLGA)

Gene: Fosb (FosB proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus

Analyze

Symbol:

Fosb

Name:

FosB proto-oncogene, AP-1 transcription factor subunit

RGD ID:

1308198

Description:

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including behavioral response to cocaine; response to corticosterone; and response to progesterone. Located in cytosol and nucleus. Used to study heroin dependence and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; cocaine abuse; and drug dependence (multiple). Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; fra-2; LOC100360880; transcription factor AP-1 subunit FosB

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	88,082,324 - 88,089,506 (-)	NCBI		GRCr8
mRatBN7.2	1	78,954,312 - 78,961,492 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	78,954,115 - 78,961,465 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	84,343,248 - 84,350,106 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	92,900,923 - 92,907,784 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	86,098,337 - 86,105,195 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	80,214,691 - 80,221,417 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	80,214,494 - 80,221,710 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	81,480,955 - 81,510,687 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,668,497 - 78,673,330 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	73,416,543 - 73,423,390 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	alcohol dependence		IEP		401901600	protein:increased expression:nucleus accumbens (rat)	RGD
Fosb	Rat	alcohol dependence		IEP		401900733	associated with Sleep Deprivation;protein:increased expression:brain	RGD
Fosb	Rat	alcohol dependence	treatment	IEP		401851075		RGD
Fosb	Rat	alcohol use disorder		ISO	RGD:1317838	401901184	protein:increased expression:brain (mouse)	RGD
Fosb	Rat	alcohol use disorder		ISO	RGD:1317838	401901287	protein:increased expression:dorsal striatum (mouse)	RGD
Fosb	Rat	alcohol use disorder	treatment	IEP		401851082		RGD
Fosb	Rat	alcohol withdrawal syndrome	disease_progression	ISO	RGD:1317838	401851085	protein:increased expression:primary motor cortex, secondary motor cortex, ventral tegmental area (mouse)	RGD
Fosb	Rat	amphetamine abuse		IEP		401900735	protein:increased expression:brain (rat)	RGD
Fosb	Rat	amphetamine abuse		IEP		401901183	associated with stress related disorder;protein:increased expression:brain (rat)	RGD
Fosb	Rat	amphetamine abuse		ISO	RGD:1317838	401900303	protein:increased expression:ventral tegmental area, nucleus accumbens (mouse)	RGD
Fosb	Rat	cocaine abuse		IEP		401900302	associated with alcohol dependence;protein:increased expression: caudate-putamen (rat)	RGD
Fosb	Rat	cocaine abuse		ISO	RGD:1317838	407446380		RGD
Fosb	Rat	cocaine dependence		ISO	RGD:1317838	401901287	protein:increased expression:dorsal striatum, nucelus accumbens (mouse)	RGD
Fosb	Rat	cocaine dependence		IEP		401851078	protein:increased expression:Brain (rat)	RGD
Fosb	Rat	cocaine dependence		IEP		401851063	protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)	RGD
Fosb	Rat	cocaine dependence	treatment	IEP		401900166		RGD
Fosb	Rat	cocaine dependence	ameliorates	IEP		401851084		RGD
Fosb	Rat	cocaine dependence		IEP		401900126	mRNA,protein:increased expression:Nucleus Accumbens, Caudate Putamen (rat)	RGD
Fosb	Rat	COVID-19		ISO	RGD:1317837	9068941	mRNA:increased expression:CD14++ monocytes (human)	RGD	PMID:32377375\|REF_RGD_ID:32716422
Fosb	Rat	depressive disorder		ISO	RGD:1317837	401851061	protein:decreased expression: hippocampus (human)	RGD
Fosb	Rat	heroin dependence	treatment	IEP		407571685		RGD
Fosb	Rat	heroin dependence	ameliorates	IDA		401901182		RGD
Fosb	Rat	heroin dependence	ameliorates	IDA		401901181		RGD
Fosb	Rat	morphine dependence	treatment	ISO	RGD:1317838	407571675		RGD
Fosb	Rat	morphine dependence		IEP		401901600	associated with alcohol dependence; protein:increased expression:nucleus accumbens, caudate-putamen (rat)	RGD
Fosb	Rat	morphine dependence	ameliorates	IEP		401851068	protein:increased expression:brain (rat)	RGD
Fosb	Rat	morphine dependence	treatment	ISO	RGD:1317838	401901284		RGD
Fosb	Rat	morphine dependence		IEP		401901281	associated with pregnancy complications; protein:increased expression:brain (rat)	RGD
Fosb	Rat	morphine dependence	treatment	IDA		401851072	associated with acute stress disorder	RGD
Fosb	Rat	nicotine dependence		IEP		407571683	protein:increased expression:nucleus accumbens, dentate gyrus of hippocampal formation (rat)	RGD
Fosb	Rat	nicotine dependence		ISO	RGD:1317838	401900124		RGD
Fosb	Rat	opioid abuse		IEP		401901180	protein:increased expression:Prefrontal Cortex, nucleus accumbens (rat)	RGD
Fosb	Rat	substance dependence		ISO	RGD:1317837	401851061	protein:decreased expression: hippocampus (human)	RGD
Fosb	Rat	Tendon Injuries	treatment	IDA		10395300		RGD
Fosb	Rat	tongue squamous cell carcinoma		ISO	RGD:1317837	11535375	protein:increased expression:tongue (human)	RGD
Fosb	Rat	withdrawal disorder		IEP		401900159	associated with morphine dependence;protein:increased expression:Brainstem (rat)	RGD

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	Cocaine-Related Disorders		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism\|therapeutic	CTD	PMID:12657709\|PMID:17898221\|PMID:18539927\|PMID:19331462
Fosb	Rat	cognitive disorder		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:24067299
Fosb	Rat	Drug-Induced Dyskinesia		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17219962
Fosb	Rat	epilepsy		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:16391389
Fosb	Rat	hepatocellular carcinoma		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28284560
Fosb	Rat	impulse control disorder		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:18539927
Fosb	Rat	juvenile rheumatoid arthritis		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19565504
Fosb	Rat	Liver Neoplasms		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:26411935
Fosb	Rat	Lung Neoplasms		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:27935865
Fosb	Rat	movement disease		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:10600402
Fosb	Rat	Prenatal Exposure Delayed Effects		ISO	RGD:1317837	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:26411935

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	(+)-pilocarpine	increases expression	EXP		6480464	Pilocarpine results in increased expression of FOSB protein	CTD	PMID:16391389
Fosb	Rat	(-)-anisomycin	increases expression	ISO	RGD:1317837	6480464	Anisomycin results in increased expression of FOSB mRNA	CTD	PMID:18241849
Fosb	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	RGD:1317837	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOSB mRNA	CTD	PMID:22079256
Fosb	Rat	(R)-noradrenaline	increases expression	EXP		6480464	Norepinephrine results in increased expression of FOSB	CTD	PMID:7905536
Fosb	Rat	(S)-amphetamine	increases expression	EXP		6480464	Dextroamphetamine results in increased expression of FOSB mRNA; Dextroamphetamine results in increased expression of FOSB more ...	CTD	PMID:1347779\|PMID:16678866
Fosb	Rat	(S)-amphetamine	multiple interactions	EXP		6480464	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein; Dextroamphetamine deficiency affects the more ...	CTD	PMID:12726824\|PMID:16678866
Fosb	Rat	(S)-amphetamine	affects expression	EXP		6480464	Dextroamphetamine affects the expression of FOSB protein	CTD	PMID:12726824
Fosb	Rat	(S)-amphetamine	increases expression	ISO	RGD:1317838	6480464	Dextroamphetamine results in increased expression of FOSB mRNA	CTD	PMID:12558987
Fosb	Rat	(S)-nicotine	increases expression	ISO	RGD:1317838	6480464	Nicotine results in increased expression of FOSB mRNA	CTD	PMID:17456735
Fosb	Rat	(S)-nicotine	increases expression	ISO	RGD:1317837	6480464	Nicotine results in increased expression of FOSB mRNA	CTD	PMID:16949557
Fosb	Rat	(S)-nicotine	increases expression	EXP		6480464	Nicotine results in increased expression of FOSB protein	CTD	PMID:17324382
Fosb	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1317838	6480464	1,2-Dimethylhydrazine results in decreased expression of FOSB mRNA	CTD	PMID:22206623
Fosb	Rat	1-fluoro-2,4-dinitrobenzene	increases expression	ISO	RGD:1317837	6480464	Dinitrofluorobenzene results in increased expression of FOSB mRNA	CTD	PMID:23999411
Fosb	Rat	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	increases expression	ISO	RGD:1317838	6480464	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB more ...	CTD	PMID:27566062
Fosb	Rat	17beta-estradiol	increases expression	ISO	RGD:1317838	6480464	Estradiol results in increased expression of FOSB mRNA	CTD	PMID:25210133
Fosb	Rat	17beta-estradiol	multiple interactions	ISO	RGD:1317837	6480464	[Estradiol co-treated with Progesterone] results in decreased expression of FOSB mRNA	CTD	PMID:20660070
Fosb	Rat	17beta-estradiol	affects expression	ISO	RGD:1317838	6480464	Estradiol affects the expression of FOSB mRNA	CTD	PMID:15598610
Fosb	Rat	17beta-estradiol	increases expression	ISO	RGD:1317837	6480464	Estradiol results in increased expression of FOSB mRNA	CTD	PMID:19153601
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1317838	6480464	Tetrachlorodibenzodioxin affects the expression of FOSB mRNA	CTD	PMID:16962184\|PMID:21570461\|PMID:24058054
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA	CTD	PMID:33387578
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of FOSB mRNA	CTD	PMID:34747641
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1317837	6480464	Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA	CTD	PMID:27913140
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1317837	6480464	Tetrachlorodibenzodioxin affects the expression of FOSB protein	CTD	PMID:16985168
Fosb	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1317837	6480464	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]	CTD	PMID:20064835
Fosb	Rat	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	RGD:1317838	6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of FOSB mRNA	CTD	PMID:38648751
Fosb	Rat	2-hydroxypropanoic acid	increases expression	ISO	RGD:1317837	6480464	Lactic Acid results in increased expression of FOSB mRNA	CTD	PMID:30851411
Fosb	Rat	2-methyl-6-(phenylethynyl)pyridine	multiple interactions	EXP		6480464	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]; more ...	CTD	PMID:17933546\|PMID:19636538
Fosb	Rat	2-palmitoylglycerol	increases expression	ISO	RGD:1317837	6480464	2-palmitoylglycerol results in increased expression of FOSB mRNA	CTD	PMID:37199045
Fosb	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	RGD:1317838	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FOSB mRNA	CTD	PMID:20188158
Fosb	Rat	3,4-methylenedioxymethamphetamine	increases expression	EXP		401900735	3,4-methylenedioxymethamphetamine increases expression of Fosb protein in brain	RGD
Fosb	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	RGD:1317838	6480464	bisphenol S affects the methylation of FOSB gene	CTD	PMID:31683443
Fosb	Rat	4-(ethoxymethylene)-2-phenyloxazol-5-one	increases expression	ISO	RGD:1317837	6480464	Oxazolone results in increased expression of FOSB mRNA	CTD	PMID:23999411
Fosb	Rat	4-hydroxynon-2-enal	multiple interactions	EXP		6480464	4-hydroxy-2-nonenal promotes the reaction [FOSB protein binds to GGT1 promoter]	CTD	PMID:16195535
Fosb	Rat	8-OH-DPAT	multiple interactions	EXP		6480464	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]	CTD	PMID:19695244
Fosb	Rat	acetylsalicylic acid	decreases expression	ISO	RGD:1317837	6480464	Aspirin results in decreased expression of FOSB mRNA	CTD	PMID:15928584
Fosb	Rat	acrolein	increases expression	EXP		6480464	Acrolein results in increased expression of FOSB mRNA	CTD	PMID:38090360
Fosb	Rat	acrylamide	decreases expression	ISO	RGD:1317838	6480464	Acrylamide results in decreased expression of FOSB mRNA	CTD	PMID:30807115
Fosb	Rat	afimoxifene	increases expression	ISO	RGD:1317837	6480464	afimoxifene results in increased expression of FOSB mRNA	CTD	PMID:19153601
Fosb	Rat	afimoxifene	multiple interactions	ISO	RGD:1317837	6480464	GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]	CTD	PMID:19153601
Fosb	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of FOSB mRNA	CTD	PMID:33354967
Fosb	Rat	aflatoxin B1	increases expression	ISO	RGD:1317837	6480464	Aflatoxin B1 results in increased expression of FOSB mRNA	CTD	PMID:32234424
Fosb	Rat	agmatine	multiple interactions	EXP		6480464	Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]	CTD	PMID:15899480
Fosb	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1317837	6480464	Tretinoin results in increased expression of FOSB mRNA	CTD	PMID:15498508
Fosb	Rat	all-trans-retinoic acid	multiple interactions	ISO	RGD:1317838	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of FOSB mRNA	CTD	PMID:36189433
Fosb	Rat	AM-251	multiple interactions	ISO	RGD:1317837	6480464	AM 251 inhibits the reaction [TGFB1 protein results in increased expression of FOSB mRNA]	CTD	PMID:27936102
Fosb	Rat	AM-251	increases expression	ISO	RGD:1317837	6480464	AM 251 results in increased expression of FOSB mRNA	CTD	PMID:27936102
Fosb	Rat	amiodarone	increases expression	ISO	RGD:1317837	6480464	Amiodarone results in increased expression of FOSB mRNA	CTD	PMID:19774075
Fosb	Rat	amphetamine	multiple interactions	ISO	RGD:1317837	6480464	Amphetamine promotes the reaction [JUN protein binds to FOSB protein]; Amphetamine results in increased activity more ...	CTD	PMID:15814102
Fosb	Rat	amphetamine	increases expression	EXP		401901183	Amphetamine increases expression of Fosb protein in stress induced brain	RGD
Fosb	Rat	amphetamine	increases expression	EXP		6480464	Amphetamine results in increased expression of FOSB mRNA; Amphetamine results in increased expression of FOSB more ...	CTD	PMID:15926929\|PMID:17324382
Fosb	Rat	amphetamine	multiple interactions	ISO	RGD:1317838	6480464	SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]	CTD	PMID:19710318
Fosb	Rat	amphetamine	increases expression	ISO	RGD:1317838	6480464	Amphetamine results in increased expression of FOSB mRNA; Amphetamine results in increased expression of FOSB more ...	CTD	PMID:12417638\|PMID:19710318
Fosb	Rat	amphetamine	multiple interactions	EXP		6480464	Amphetamine promotes the reaction [FOSB protein alternative form binds to FOS promoter]; FOSB protein alternative more ...	CTD	PMID:18632938
Fosb	Rat	amphetamine	increases expression	ISO	RGD:1317837	6480464	Amphetamine results in increased expression of FOSB protein	CTD	PMID:15814102
Fosb	Rat	amphotericin B	increases expression	ISO	RGD:1317837	6480464	Amphotericin B analog results in increased expression of FOSB mRNA	CTD	PMID:28534445
Fosb	Rat	antimycin A	increases expression	ISO	RGD:1317837	6480464	Antimycin A results in increased expression of FOSB mRNA	CTD	PMID:33512557
Fosb	Rat	aristolochic acid A	increases expression	ISO	RGD:1317837	6480464	aristolochic acid I results in increased expression of FOSB mRNA	CTD	PMID:33212167
Fosb	Rat	arsane	affects methylation	ISO	RGD:1317838	6480464	Arsenic affects the methylation of FOSB gene	CTD	PMID:26411935
Fosb	Rat	arsane	increases expression	ISO	RGD:1317838	6480464	Arsenic results in increased expression of FOSB	CTD	PMID:26411935
Fosb	Rat	arsenic atom	increases expression	ISO	RGD:1317838	6480464	Arsenic results in increased expression of FOSB	CTD	PMID:26411935
Fosb	Rat	arsenic atom	affects methylation	ISO	RGD:1317838	6480464	Arsenic affects the methylation of FOSB gene	CTD	PMID:26411935
Fosb	Rat	arsenite(3-)	affects expression	ISO	RGD:1317837	6480464	arsenite affects the expression of FOSB mRNA	CTD	PMID:22959463
Fosb	Rat	arsenous acid	decreases expression	ISO	RGD:1317838	6480464	Arsenic Trioxide results in decreased expression of FOSB mRNA	CTD	PMID:19410645
Fosb	Rat	asbestos	decreases expression	ISO	RGD:1317837	6480464	Asbestos results in decreased expression of FOSB mRNA	CTD	PMID:21563230
Fosb	Rat	benzene	decreases expression	ISO	RGD:1317837	6480464	Benzene results in decreased expression of FOSB mRNA	CTD	PMID:16188089\|PMID:19162166\|PMID:20036648
Fosb	Rat	benzene-1,2,4-triol	increases expression	ISO	RGD:1317837	6480464	hydroxyhydroquinone results in increased expression of FOSB mRNA	CTD	PMID:39245080
Fosb	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1317837	6480464	Benzo(a)pyrene results in increased expression of FOSB mRNA	CTD	PMID:20064835\|PMID:32234424
Fosb	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1317837	6480464	Benzo(a)pyrene affects the methylation of FOSB intron	CTD	PMID:30157460
Fosb	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1317837	6480464	Benzo(a)pyrene results in increased methylation of FOSB 3' UTR	CTD	PMID:27901495
Fosb	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1317838	6480464	Benzo(a)pyrene results in decreased expression of FOSB mRNA	CTD	PMID:27195522
Fosb	Rat	benzo[a]pyrene diol epoxide I	increases expression	ISO	RGD:1317837	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FOSB mRNA	CTD	PMID:19150397
Fosb	Rat	benzo[a]pyrene diol epoxide I	affects expression	ISO	RGD:1317837	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FOSB mRNA	CTD	PMID:20382639
Fosb	Rat	beta-lapachone	increases expression	ISO	RGD:1317837	6480464	beta-lapachone results in increased expression of FOSB mRNA	CTD	PMID:38218311
Fosb	Rat	beta-naphthoflavone	increases expression	ISO	RGD:1317837	6480464	beta-Naphthoflavone results in increased expression of FOSB mRNA	CTD	PMID:32151702
Fosb	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1317838	6480464	Diethylhexyl Phthalate results in increased expression of FOSB mRNA	CTD	PMID:33484791
Fosb	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1317838	6480464	Diethylhexyl Phthalate results in decreased expression of FOSB mRNA	CTD	PMID:28085963\|PMID:33754040\|PMID:34319233
Fosb	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:33484791\|PMID:39150890
Fosb	Rat	bisphenol A	increases expression	ISO	RGD:1317838	6480464	bisphenol A results in increased expression of FOSB mRNA	CTD	PMID:25270620
Fosb	Rat	bisphenol A	decreases expression	ISO	RGD:1317838	6480464	bisphenol A results in decreased expression of FOSB mRNA	CTD	PMID:30951980
Fosb	Rat	bisphenol A	affects methylation	ISO	RGD:1317838	6480464	bisphenol A affects the methylation of FOSB promoter	CTD	PMID:27334623
Fosb	Rat	bisphenol F	increases expression	ISO	RGD:1317837	6480464	bisphenol F results in increased expression of FOSB mRNA	CTD	PMID:33476716
Fosb	Rat	bisphenol F	increases expression	ISO	RGD:1317838	6480464	bisphenol F results in increased expression of FOSB mRNA	CTD	PMID:38685157
Fosb	Rat	buta-1,3-diene	decreases expression	ISO	RGD:1317838	6480464	1,3-butadiene results in decreased expression of FOSB mRNA	CTD	PMID:29038090
Fosb	Rat	butanal	increases expression	ISO	RGD:1317837	6480464	butyraldehyde results in increased expression of FOSB mRNA	CTD	PMID:26079696
Fosb	Rat	Butylbenzyl phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Fosb	Rat	C.I. Natural Red 20	multiple interactions	ISO	RGD:1317838	6480464	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits more ...	CTD	PMID:25451590
Fosb	Rat	cadmium acetate	increases expression	ISO	RGD:1317837	6480464	cadmium acetate results in increased expression of FOSB mRNA	CTD	PMID:18155341
Fosb	Rat	cadmium atom	decreases expression	ISO	RGD:1317837	6480464	Cadmium results in decreased expression of FOSB mRNA	CTD	PMID:16439709
Fosb	Rat	cadmium atom	multiple interactions	ISO	RGD:1317838	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FOSB more ...	CTD	PMID:31904401\|PMID:37325564
Fosb	Rat	cadmium atom	increases expression	ISO	RGD:1317837	6480464	Cadmium results in increased expression of FOSB mRNA	CTD	PMID:21694771\|PMID:33559965
Fosb	Rat	cadmium dichloride	increases expression	ISO	RGD:1317837	6480464	Cadmium Chloride results in increased expression of FOSB mRNA; Cadmium Chloride results in increased expression more ...	CTD	PMID:21219922\|PMID:38382870\|PMID:38568856
Fosb	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1317837	6480464	[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of FOSB mRNA	CTD	PMID:33309878
Fosb	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1317838	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FOSB more ...	CTD	PMID:31904401\|PMID:37325564
Fosb	Rat	caffeine	increases expression	ISO	RGD:1317838	401901287	Caffeine increases expression of Fosb protein in dorsal striatum	RGD
Fosb	Rat	Calcimycin	multiple interactions	ISO	RGD:1317838	6480464	shikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA]	CTD	PMID:25451590
Fosb	Rat	Calcimycin	increases expression	ISO	RGD:1317838	6480464	Calcimycin results in increased expression of FOSB mRNA	CTD	PMID:25451590\|PMID:8764118
Fosb	Rat	calciol	increases expression	ISO	RGD:1317838	6480464	Cholecalciferol results in increased expression of FOSB mRNA	CTD	PMID:17170073
Fosb	Rat	cannabidiol	increases expression	ISO	RGD:1317837	6480464	Cannabidiol results in increased expression of FOSB mRNA	CTD	PMID:26504004
Fosb	Rat	carbon nanotube	increases expression	ISO	RGD:1317837	6480464	Nanotubes, Carbon analog results in increased expression of FOSB mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25102311
Fosb	Rat	chlorpromazine	affects expression	ISO	RGD:1317838	6480464	Chlorpromazine affects the expression of FOSB mRNA	CTD	PMID:20843724
Fosb	Rat	chlorpyrifos	increases expression	ISO	RGD:1317838	6480464	Chlorpyrifos results in increased expression of FOSB mRNA	CTD	PMID:32715474\|PMID:34289071
Fosb	Rat	choline	multiple interactions	ISO	RGD:1317838	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Fosb	Rat	cisplatin	multiple interactions	ISO	RGD:1317837	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of FOSB mRNA	CTD	PMID:27392435
Fosb	Rat	clofibrate	increases expression	ISO	RGD:1317838	6480464	Clofibrate analog results in increased expression of FOSB mRNA	CTD	PMID:8764118
Fosb	Rat	clozapine	increases expression	ISO	RGD:1317838	6480464	Clozapine results in increased expression of FOSB protein alternative form	CTD	PMID:15579174
Fosb	Rat	clozapine	increases expression	EXP		6480464	Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB more ...	CTD	PMID:11259127\|PMID:12093589\|PMID:12243769\|PMID:19695244
Fosb	Rat	clozapine	multiple interactions	ISO	RGD:1317838	6480464	DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]	CTD	PMID:15579174
Fosb	Rat	clozapine	decreases expression	EXP		6480464	Clozapine results in decreased expression of FOSB mRNA	CTD	PMID:12093589
Fosb	Rat	cocaine	increases expression	ISO	RGD:1317837	6480464	Cocaine results in increased expression of FOSB protein	CTD	PMID:15814102
Fosb	Rat	cocaine	increases expression	EXP		401851084	Cocaine increases expression of Fosb protein in brain	RGD
Fosb	Rat	cocaine	increases expression	EXP		401851078	cocaine increases expression of Fosb protein in Brain	RGD
Fosb	Rat	cocaine	increases expression	EXP		401851063	cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate Putamen	RGD
Fosb	Rat	cocaine	increases expression	EXP		401900166	Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamen	RGD
Fosb	Rat	cocaine	increases expression	ISO	RGD:1317838	401901287	cocaine increases expression of Fosb protein in dorsal striatum and nucelus accumbens	RGD
Fosb	Rat	cocaine	increases expression	EXP		401900126	Cocaine increases expression of Fosb mRNA and protein in Nucleus Accumbens and Caudate Putamen	RGD
Fosb	Rat	cocaine	increases expression	EXP		401900302	Cocaine increases expression of Fosb protein in caudate��putamen	RGD
Fosb	Rat	cocaine	multiple interactions	EXP		6480464	DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; more ...	CTD	PMID:16674926\|PMID:18822274
Fosb	Rat	cocaine	increases expression	EXP		6480464	Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB more ...	CTD	PMID:11391778\|PMID:11739600\|PMID:15926929\|PMID:16674926\|PMID:17898221\|PMID:18293355\|PMID:18822274\|PMID:27899881
Fosb	Rat	cocaine	affects expression	EXP		6480464	Cocaine affects the expression of FOSB mRNA; Cocaine affects the expression of FOSB protein	CTD	PMID:20633205
Fosb	Rat	cocaine	increases expression	ISO	RGD:1317838	6480464	Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB more ...	CTD	PMID:10103106\|PMID:12417638\|PMID:16710312\|PMID:20056891
Fosb	Rat	cocaine	affects expression	ISO	RGD:1317838	6480464	Cocaine affects the expression of FOSB mRNA	CTD	PMID:18355967
Fosb	Rat	cocaine	multiple interactions	ISO	RGD:1317838	6480464	[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which more ...	CTD	PMID:10103106\|PMID:15056714\|PMID:16263220\|PMID:16710312\|PMID:20056891
Fosb	Rat	colforsin daropate hydrochloride	increases expression	EXP		6480464	Colforsin results in increased expression of FOSB mRNA; Colforsin results in increased expression of FOSB more ...	CTD	PMID:11113530\|PMID:17324382
Fosb	Rat	copper atom	multiple interactions	ISO	RGD:1317837	6480464	[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA	CTD	PMID:24690739
Fosb	Rat	copper(0)	multiple interactions	ISO	RGD:1317837	6480464	[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA	CTD	PMID:24690739
Fosb	Rat	copper(II) sulfate	increases expression	ISO	RGD:1317837	6480464	Copper Sulfate results in increased expression of FOSB mRNA	CTD	PMID:19549813
Fosb	Rat	crocidolite asbestos	affects expression	ISO	RGD:1317837	6480464	Asbestos, Crocidolite affects the expression of FOSB mRNA	CTD	PMID:25757056
Fosb	Rat	crocidolite asbestos	increases expression	ISO	RGD:1317837	6480464	Asbestos, Crocidolite results in increased expression of FOSB mRNA	CTD	PMID:18687144\|PMID:25351596
Fosb	Rat	CU-O LINKAGE	increases expression	ISO	RGD:1317837	6480464	cupric oxide results in increased expression of FOSB mRNA	CTD	PMID:22077320
Fosb	Rat	cylindrospermopsin	increases expression	ISO	RGD:1317837	6480464	cylindrospermopsin results in increased expression of FOSB mRNA	CTD	PMID:23726867\|PMID:24921660
Fosb	Rat	DDE	decreases expression	ISO	RGD:1317837	6480464	Dichlorodiphenyl Dichloroethylene results in decreased expression of FOSB mRNA	CTD	PMID:38568856
Fosb	Rat	DDT	increases expression	EXP		6480464	DDT results in increased expression of FOSB mRNA	CTD	PMID:30207508
Fosb	Rat	Delta(9)-tetrahydrocannabinolic acid	increases expression	EXP		6480464	delta(9)-tetrahydrocannabinolic acid results in increased expression of FOSB protein alternative form	CTD	PMID:18293355
Fosb	Rat	deoxynivalenol	affects activity	ISO	RGD:1317838	6480464	deoxynivalenol affects the activity of FOSB protein	CTD	PMID:10662601
Fosb	Rat	deoxynivalenol	multiple interactions	ISO	RGD:1317837	6480464	[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of FOSB mRNA	CTD	PMID:33309878
Fosb	Rat	deoxynivalenol	increases expression	ISO	RGD:1317837	6480464	deoxynivalenol results in increased expression of FOSB mRNA	CTD	PMID:33309878
Fosb	Rat	dexamethasone	increases expression	ISO	RGD:1317837	6480464	Dexamethasone results in increased expression of FOSB mRNA	CTD	PMID:25047013
Fosb	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1317838	6480464	Arsenic Trioxide results in decreased expression of FOSB mRNA	CTD	PMID:19410645
Fosb	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1317837	6480464	di-n-butylphosphoric acid affects the expression of FOSB mRNA	CTD	PMID:37042841
Fosb	Rat	dibutyl phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Fosb	Rat	dibutyl phthalate	affects expression	ISO	RGD:1317837	6480464	Dibutyl Phthalate affects the expression of FOSB mRNA	CTD	PMID:36375677
Fosb	Rat	dieldrin	increases expression	ISO	RGD:1317837	6480464	Dieldrin results in increased expression of FOSB mRNA	CTD	PMID:31068361
Fosb	Rat	diethyl phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Fosb	Rat	diisobutyl phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Fosb	Rat	diisononyl phthalate	multiple interactions	ISO	RGD:1317838	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Fosb	Rat	diisopropyl fluorophosphate	increases expression	EXP		6480464	Isoflurophate results in increased expression of FOSB mRNA; Isoflurophate results in increased expression of FOSB more ...	CTD	PMID:35500718
Fosb	Rat	dimethylarsinous acid	increases expression	ISO	RGD:1317837	6480464	dimethylarsinous acid results in increased expression of FOSB mRNA	CTD	PMID:23487506
Fosb	Rat	dioxygen	multiple interactions	EXP		6480464	[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression more ...	CTD	PMID:33729688
Fosb	Rat	disulfiram	multiple interactions	ISO	RGD:1317837	6480464	[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA	CTD	PMID:24690739
Fosb	Rat	dizocilpine maleate	increases response to substance	EXP		6480464	FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate	CTD	PMID:24067299
Fosb	Rat	endosulfan	affects expression	EXP		6480464	Endosulfan affects the expression of FOSB mRNA	CTD	PMID:29391264
Fosb	Rat	epoxiconazole	increases expression	ISO	RGD:1317838	6480464	epoxiconazole results in increased expression of FOSB mRNA	CTD	PMID:35436446
Fosb	Rat	ethanol	increases expression	EXP		6480464	Ethanol results in increased expression of FOSB protein alternative form	CTD	PMID:18293355
Fosb	Rat	ethanol	increases expression	EXP		401851082	Ethanol increases expression of Fosb protein in nucleus accumbens shell and dorsal striatum lateral	RGD
Fosb	Rat	ethanol	increases expression	EXP		401851075	Ethanol increases expression of Fosb protein in nucleus accumbens, dorsolateral striatum and orbitofrontal cortex	RGD
Fosb	Rat	ethanol	increases expression	EXP		401900733	ethanol increases expression of Fosb protein in brain	RGD
Fosb	Rat	ethanol	multiple interactions	EXP		401851075	naltrexone inhibits the reaction [Ethanol increases expression of Fosb protein in nucleus accumbens, dorsolateral striatum more ...	RGD
Fosb	Rat	ethanol	multiple interactions	ISO	RGD:1317838	401901287	ethanol cotreated with caffeine increases expression of Fosb protein in dorsal striatum and nucelus more ...	RGD
Fosb	Rat	ethanol	increases expression	ISO	RGD:1317838	401901287	ethanol increases expression of Fosb protein in dorsal striatum	RGD
Fosb	Rat	ethanol	disease_progression	ISO	RGD:1317838	401851085	ethanol increases expression of Fosb protein in primary motor cortex, secondary motor cortex, ventral tegmental more ...	RGD
Fosb	Rat	ethanol	affects expression	ISO	RGD:1317838	6480464	Ethanol affects the expression of FOSB mRNA	CTD	PMID:30319688
Fosb	Rat	ferric oxide	increases expression	EXP		6480464	ferric oxide analog results in increased expression of FOSB mRNA	CTD	PMID:38615722
Fosb	Rat	fluoxetine	increases expression	ISO	RGD:1317838	6480464	Fluoxetine results in increased expression of FOSB mRNA; Fluoxetine results in increased expression of FOSB more ...	CTD	PMID:18758753
Fosb	Rat	fluoxetine	multiple interactions	ISO	RGD:1317838	6480464	N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits more ...	CTD	PMID:18758753
Fosb	Rat	folic acid	multiple interactions	ISO	RGD:1317838	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Fosb	Rat	folic acid	decreases expression	ISO	RGD:1317838	6480464	Folic Acid results in decreased expression of FOSB mRNA	CTD	PMID:25629700
Fosb	Rat	folic acid	multiple interactions	ISO	RGD:1317837	6480464	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of FOSB mRNA	CTD	PMID:24657277
Fosb	Rat	formaldehyde	increases expression	ISO	RGD:1317837	6480464	Formaldehyde results in increased expression of FOSB mRNA	CTD	PMID:17938736\|PMID:20655997\|PMID:28937961
Fosb	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of FOSB mRNA	CTD	PMID:33387578
Fosb	Rat	haloperidol	increases expression	ISO	RGD:1317838	6480464	Haloperidol results in increased expression of FOSB protein alternative form	CTD	PMID:15579174
Fosb	Rat	haloperidol	increases expression	EXP		6480464	Haloperidol results in increased expression of FOSB modified form; Haloperidol results in increased expression of more ...	CTD	PMID:11180499\|PMID:12243769\|PMID:19695244\|PMID:24067299\|PMID:8714707
Fosb	Rat	haloperidol	multiple interactions	EXP		6480464	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]	CTD	PMID:19695244
Fosb	Rat	heroin	decreases expression	EXP		401901181	heroin decreases expression of Fosb protein in brain	RGD
Fosb	Rat	hydrogen peroxide	affects expression	ISO	RGD:1317837	6480464	Hydrogen Peroxide affects the expression of FOSB mRNA	CTD	PMID:20044591
Fosb	Rat	hydrogen peroxide	increases expression	ISO	RGD:1317837	6480464	Hydrogen Peroxide results in increased expression of FOSB mRNA	CTD	PMID:37149095
Fosb	Rat	hydrogen sulfide	increases expression	ISO	RGD:1317838	6480464	Hydrogen Sulfide results in increased expression of FOSB mRNA	CTD	PMID:31843631
Fosb	Rat	ibuprofen	increases expression	ISO	RGD:1317837	6480464	Ibuprofen results in increased expression of FOSB mRNA	CTD	PMID:17070997
Fosb	Rat	irinotecan	increases expression	ISO	RGD:1317837	6480464	Irinotecan metabolite results in increased expression of FOSB mRNA; Irinotecan results in increased expression of more ...	CTD	PMID:15956246
Fosb	Rat	isoprenaline	increases expression	EXP		6480464	Isoproterenol results in increased expression of FOSB	CTD	PMID:7905536
Fosb	Rat	isotretinoin	decreases expression	ISO	RGD:1317837	6480464	Isotretinoin results in decreased expression of FOSB mRNA	CTD	PMID:20436886
Fosb	Rat	kenpaullone	increases expression	EXP		6480464	kenpaullone results in increased expression of FOSB mRNA	CTD	PMID:17993264
Fosb	Rat	L-methionine	multiple interactions	ISO	RGD:1317838	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Fosb	Rat	Licochalcone B	increases expression	ISO	RGD:1317837	6480464	licochalcone B results in increased expression of FOSB mRNA	CTD	PMID:33647349
Fosb	Rat	lipopolysaccharide	increases expression	ISO	RGD:1317838	6480464	Lipopolysaccharides results in increased expression of FOSB mRNA	CTD	PMID:12057914
Fosb	Rat	lithium atom	increases expression	ISO	RGD:1317837	6480464	Lithium results in increased expression of FOSB mRNA	CTD	PMID:21092101
Fosb	Rat	lithium hydride	increases expression	ISO	RGD:1317837	6480464	Lithium results in increased expression of FOSB mRNA	CTD	PMID:21092101
Fosb	Rat	lovastatin	multiple interactions	EXP		6480464	Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein]	CTD	PMID:18434508
Fosb	Rat	luteolin	decreases activity	ISO	RGD:1317837	6480464	Luteolin results in decreased activity of FOSB protein	CTD	PMID:16343431
Fosb	Rat	mechlorethamine	multiple interactions	ISO	RGD:1317837	6480464	FOSB protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; FOSL1 protein more ...	CTD	PMID:31639410
Fosb	Rat	mechlorethamine	multiple interactions	ISO	RGD:1317838	6480464	Mechlorethamine results in increased expression of and affects the localization of FOSB protein	CTD	PMID:31639410
Fosb	Rat	melphalan	increases expression	ISO	RGD:1317837	6480464	Melphalan results in increased expression of FOSB mRNA	CTD	PMID:22363485
Fosb	Rat	methamphetamine	increases expression	ISO	RGD:1317838	401900303	methamphetamine increases expression of Fosb protein in the ventral tegmental area and nucleus accumbens	RGD
Fosb	Rat	methotrexate	multiple interactions	ISO	RGD:1317837	6480464	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of FOSB mRNA	CTD	PMID:24657277
Fosb	Rat	methylisothiazolinone	increases expression	ISO	RGD:1317837	6480464	2-methyl-4-isothiazolin-3-one results in increased expression of FOSB mRNA	CTD	PMID:31629900
Fosb	Rat	methylmercury chloride	increases expression	ISO	RGD:1317837	6480464	methylmercuric chloride results in increased expression of FOSB mRNA	CTD	PMID:28001369
Fosb	Rat	methylphenidate	increases expression	EXP		6480464	Methylphenidate results in increased expression of FOSB protein	CTD	PMID:15916815
Fosb	Rat	mono(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1317838	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of FOSB mRNA	CTD	PMID:36189433
Fosb	Rat	morphine	multiple interactions	EXP		6480464	Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]	CTD	PMID:15899480
Fosb	Rat	morphine	increases expression	EXP		401900159	morphine increases expression of Fosb protein in the Brainstem	RGD
Fosb	Rat	morphine	increases expression	EXP		401851068	morphine increases expression of Fosb protein in brain	RGD
Fosb	Rat	morphine	increases expression	EXP		401901600	morphine increases expression of Fosb protein in nucleus accumbens and caudate-putamen	RGD
Fosb	Rat	morphine	increases expression	ISO	RGD:1317838	401901284	morphine increases expression of Fosb protein in nucleus accumbens	RGD
Fosb	Rat	morphine	increases expression	EXP		401851072	morphine increases expression of FosB mRNA in striatum	RGD
Fosb	Rat	morphine	increases expression	ISO	RGD:1317838	6480464	Morphine results in increased expression of FOSB mRNA	CTD	PMID:22454534
Fosb	Rat	morphine	increases expression	EXP		6480464	Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB more ...	CTD	PMID:15899480\|PMID:18293355\|PMID:22454534\|PMID:23185589
Fosb	Rat	N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide	multiple interactions	EXP		6480464	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine results in increased expression of FOSB mRNA]	CTD	PMID:19695244
Fosb	Rat	naloxone	multiple interactions	EXP		401900159	Naloxene co-treated with morphine increases expression of Fosb protein in the Brainstem	RGD
Fosb	Rat	nickel atom	increases expression	ISO	RGD:1317837	6480464	Nickel results in increased expression of FOSB mRNA	CTD	PMID:23195993\|PMID:24768652\|PMID:25583101
Fosb	Rat	nickel dichloride	multiple interactions	ISO	RGD:1317838	6480464	[nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of more ...	CTD	PMID:23536762
Fosb	Rat	niclosamide	increases expression	ISO	RGD:1317837	6480464	Niclosamide results in increased expression of FOSB mRNA	CTD	PMID:28284560
Fosb	Rat	nicotine	increases expression	ISO	RGD:1317838	6480464	Nicotine results in increased expression of FOSB mRNA	CTD	PMID:17456735
Fosb	Rat	nicotine	increases expression	ISO	RGD:1317838	401900124	nicotine increases expression of FosB protein in nucleus accumbens and caudate-putamen	RGD
Fosb	Rat	nicotine	increases expression	EXP		407571683	nicotine increases expression of Fosb protein in nucleus accumbens and dentate gyrus of hippocampal formation	RGD
Fosb	Rat	nicotine	increases expression	ISO	RGD:1317837	6480464	Nicotine results in increased expression of FOSB mRNA	CTD	PMID:16949557
Fosb	Rat	nicotine	increases expression	EXP		6480464	Nicotine results in increased expression of FOSB protein	CTD	PMID:17324382
Fosb	Rat	nitric oxide	increases activity	EXP		6480464	Nitric Oxide results in increased activity of FOSB protein	CTD	PMID:15949472
Fosb	Rat	okadaic acid	increases expression	ISO	RGD:1317837	6480464	Okadaic Acid results in increased expression of FOSB mRNA	CTD	PMID:38832940
Fosb	Rat	oxidopamine	multiple interactions	ISO	RGD:1317838	6480464	[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein; [Oxidopamine co-treated with Levodopa] more ...	CTD	PMID:15207268\|PMID:16139809\|PMID:19520364
Fosb	Rat	oxidopamine	multiple interactions	EXP		6480464	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]; more ...	CTD	PMID:15659429\|PMID:16095907\|PMID:17933546
Fosb	Rat	oxidopamine	increases expression	EXP		6480464	Oxidopamine results in increased expression of FOSB protein	CTD	PMID:12127155\|PMID:16095907
Fosb	Rat	ozone	multiple interactions	ISO	RGD:1317837	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of FOSB mRNA	CTD	PMID:35430440
Fosb	Rat	paclitaxel	increases expression	EXP		6480464	Paclitaxel results in increased expression of FOSB protein alternative form	CTD	PMID:30414958
Fosb	Rat	paclitaxel	multiple interactions	EXP		6480464	1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of FOSB protein alternative form]	CTD	PMID:30414958
Fosb	Rat	paracetamol	affects expression	ISO	RGD:1317838	6480464	Acetaminophen affects the expression of FOSB mRNA	CTD	PMID:17562736
Fosb	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of FOSB mRNA	CTD	PMID:33387578
Fosb	Rat	paracetamol	increases expression	ISO	RGD:1317837	6480464	Acetaminophen results in increased expression of FOSB mRNA	CTD	PMID:21420995
Fosb	Rat	paracetamol	increases expression	ISO	RGD:1317838	6480464	Acetaminophen results in increased expression of FOSB mRNA	CTD	PMID:11264010
Fosb	Rat	phencyclidine	multiple interactions	EXP		6480464	[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein	CTD	PMID:16678866
Fosb	Rat	phencyclidine	increases expression	EXP		6480464	Phencyclidine results in increased expression of FOSB protein	CTD	PMID:16678866
Fosb	Rat	phenylephrine	increases activity	EXP		6480464	Phenylephrine results in increased activity of FOSB protein	CTD	PMID:15949472
Fosb	Rat	phenylephrine	increases expression	EXP		6480464	Phenylephrine results in increased expression of FOSB	CTD	PMID:7905536
Fosb	Rat	phorbol 13-acetate 12-myristate	increases expression	ISO	RGD:1317837	6480464	Tetradecanoylphorbol Acetate results in increased expression of FOSB mRNA; Tetradecanoylphorbol Acetate results in increased expression more ...	CTD	PMID:17148446\|PMID:31068361
Fosb	Rat	phorbol 13-acetate 12-myristate	multiple interactions	ISO	RGD:1317838	6480464	[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression more ...	CTD	PMID:31904401
Fosb	Rat	phorbol 13-acetate 12-myristate	increases expression	EXP		6480464	Tetradecanoylphorbol Acetate results in increased expression of FOSB protein	CTD	PMID:11113530
Fosb	Rat	pifithrin-alpha hydrobromide	multiple interactions	ISO	RGD:1317837	6480464	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]	CTD	PMID:20064835
Fosb	Rat	pioglitazone	multiple interactions	ISO	RGD:1317838	6480464	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of FOSB mRNA	CTD	PMID:27935865
Fosb	Rat	pirinixic acid	increases expression	ISO	RGD:1317838	6480464	pirinixic acid results in increased expression of FOSB mRNA	CTD	PMID:8764118
Fosb	Rat	potassium chloride	multiple interactions	ISO	RGD:1317837	6480464	Dronabinol inhibits the reaction [Potassium Chloride results in increased expression of FOSB mRNA]	CTD	PMID:29691375
Fosb	Rat	potassium chloride	increases expression	ISO	RGD:1317837	6480464	Potassium Chloride results in increased expression of FOSB mRNA	CTD	PMID:29691375
Fosb	Rat	potassium chromate	increases expression	ISO	RGD:1317837	6480464	potassium chromate(VI) results in increased expression of FOSB mRNA	CTD	PMID:22079256
Fosb	Rat	potassium chromate	multiple interactions	ISO	RGD:1317837	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOSB mRNA	CTD	PMID:22079256
Fosb	Rat	progesterone	multiple interactions	ISO	RGD:1317837	6480464	[Estradiol co-treated with Progesterone] results in decreased expression of FOSB mRNA	CTD	PMID:20660070
Fosb	Rat	rac-lactic acid	increases expression	ISO	RGD:1317837	6480464	Lactic Acid results in increased expression of FOSB mRNA	CTD	PMID:30851411
Fosb	Rat	rimonabant	multiple interactions	EXP		6480464	Rimonabant inhibits the reaction [Dronabinol results in increased expression of FOSB protein]	CTD	PMID:9751146
Fosb	Rat	SCH 23390	multiple interactions	EXP		6480464	SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; more ...	CTD	PMID:16674926\|PMID:18822274
Fosb	Rat	SCH 23390	multiple interactions	ISO	RGD:1317838	6480464	SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]	CTD	PMID:19710318
Fosb	Rat	Shikonin	multiple interactions	ISO	RGD:1317838	6480464	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]; shikonin inhibits more ...	CTD	PMID:25451590
Fosb	Rat	silicon dioxide	increases expression	ISO	RGD:1317837	6480464	Silicon Dioxide analog results in increased expression of FOSB mRNA; Silicon Dioxide results in increased more ...	CTD	PMID:22300531\|PMID:23806026\|PMID:25351596\|PMID:25895662
Fosb	Rat	silicon dioxide	decreases expression	ISO	RGD:1317838	6480464	Silicon Dioxide results in decreased expression of FOSB mRNA	CTD	PMID:29341224
Fosb	Rat	silicon dioxide	increases expression	ISO	RGD:1317838	6480464	Silicon Dioxide results in increased expression of FOSB mRNA	CTD	PMID:19073995
Fosb	Rat	silver atom	decreases expression	ISO	RGD:1317837	6480464	Silver analog results in decreased expression of FOSB mRNA	CTD	PMID:27180073
Fosb	Rat	silver atom	increases expression	ISO	RGD:1317837	6480464	Silver results in increased expression of FOSB mRNA	CTD	PMID:26014281
Fosb	Rat	silver atom	increases expression	ISO	RGD:1317838	6480464	Silver results in increased expression of FOSB mRNA	CTD	PMID:27131904
Fosb	Rat	silver(0)	decreases expression	ISO	RGD:1317837	6480464	Silver analog results in decreased expression of FOSB mRNA	CTD	PMID:27180073
Fosb	Rat	silver(0)	increases expression	ISO	RGD:1317837	6480464	Silver results in increased expression of FOSB mRNA	CTD	PMID:26014281
Fosb	Rat	silver(0)	increases expression	ISO	RGD:1317838	6480464	Silver results in increased expression of FOSB mRNA	CTD	PMID:27131904
Fosb	Rat	silver(1+) nitrate	decreases expression	ISO	RGD:1317837	6480464	Silver Nitrate results in decreased expression of FOSB mRNA	CTD	PMID:27180073
Fosb	Rat	simvastatin	multiple interactions	ISO	RGD:1317838	6480464	Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to more ...	CTD	PMID:15187114
Fosb	Rat	SL-327	multiple interactions	ISO	RGD:1317838	6480464	SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased more ...	CTD	PMID:15056714\|PMID:16263220
Fosb	Rat	sodium arsenate	increases expression	ISO	RGD:1317838	6480464	sodium arsenate results in increased expression of FOSB mRNA	CTD	PMID:11353140
Fosb	Rat	sodium arsenite	increases activity	ISO	RGD:1317837	6480464	sodium arsenite results in increased activity of FOSB protein	CTD	PMID:12220541
Fosb	Rat	sodium arsenite	decreases expression	ISO	RGD:1317837	6480464	sodium arsenite results in decreased expression of FOSB mRNA	CTD	PMID:34032870\|PMID:38568856
Fosb	Rat	sodium arsenite	decreases methylation	ISO	RGD:1317837	6480464	sodium arsenite results in decreased methylation of FOSB exon	CTD	PMID:32844245
Fosb	Rat	sodium arsenite	increases expression	ISO	RGD:1317837	6480464	sodium arsenite results in increased expression of FOSB mRNA	CTD	PMID:29301061\|PMID:32844245\|PMID:38568856
Fosb	Rat	sodium arsenite	increases methylation	ISO	RGD:1317838	6480464	sodium arsenite results in increased methylation of FOSB gene	CTD	PMID:24118411
Fosb	Rat	sodium arsenite	increases expression	ISO	RGD:1317838	6480464	sodium arsenite results in increased expression of FOSB mRNA	CTD	PMID:11353140\|PMID:16014739\|PMID:24118411\|PMID:36209798
Fosb	Rat	sodium dichromate	increases expression	ISO	RGD:1317838	6480464	sodium bichromate results in increased expression of FOSB mRNA	CTD	PMID:27859739
Fosb	Rat	sodium hypochlorite	increases expression	ISO	RGD:1317837	6480464	Sodium Hypochlorite results in increased expression of FOSB mRNA	CTD	PMID:37149095
Fosb	Rat	streptozocin	multiple interactions	ISO	RGD:1317838	6480464	[Streptozocin co-treated with Dietary Fats] results in decreased expression of FOSB mRNA; Diethylhexyl Phthalate inhibits more ...	CTD	PMID:33484791
Fosb	Rat	sunitinib	decreases expression	ISO	RGD:1317837	6480464	Sunitinib results in decreased expression of FOSB mRNA	CTD	PMID:31533062
Fosb	Rat	tamibarotene	increases expression	ISO	RGD:1317837	6480464	tamibarotene results in increased expression of FOSB mRNA	CTD	PMID:15498508
Fosb	Rat	tebufenpyrad	increases expression	ISO	RGD:1317837	6480464	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of FOSB mRNA	CTD	PMID:33512557
Fosb	Rat	temozolomide	increases expression	ISO	RGD:1317837	6480464	Temozolomide results in increased expression of FOSB mRNA	CTD	PMID:31758290
Fosb	Rat	thalidomide	increases expression	ISO	RGD:1317837	6480464	Thalidomide analog results in increased expression of FOSB mRNA	CTD	PMID:20525221
Fosb	Rat	thapsigargin	increases expression	ISO	RGD:1317837	6480464	Thapsigargin results in increased expression of FOSB mRNA	CTD	PMID:21694771\|PMID:29453283
Fosb	Rat	thimerosal	increases expression	ISO	RGD:1317837	6480464	Thimerosal results in increased expression of FOSB mRNA	CTD	PMID:16870260
Fosb	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of FOSB mRNA	CTD	PMID:34492290
Fosb	Rat	thiram	increases expression	ISO	RGD:1317837	6480464	Thiram results in increased expression of FOSB mRNA	CTD	PMID:38568856
Fosb	Rat	titanium dioxide	decreases methylation	ISO	RGD:1317838	6480464	titanium dioxide results in decreased methylation of FOSB gene; titanium dioxide results in decreased methylation more ...	CTD	PMID:35295148
Fosb	Rat	toluene	increases expression	ISO	RGD:1317838	6480464	Toluene results in increased expression of FOSB mRNA	CTD	PMID:16737738
Fosb	Rat	tramadol	increases expression	EXP		401901180	Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens	RGD
Fosb	Rat	trichloroethene	increases expression	ISO	RGD:1317838	6480464	Trichloroethylene results in increased expression of FOSB mRNA	CTD	PMID:25549359
Fosb	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of FOSB mRNA	CTD	PMID:33387578
Fosb	Rat	triphenyl phosphate	affects expression	ISO	RGD:1317837	6480464	triphenyl phosphate affects the expression of FOSB mRNA	CTD	PMID:37042841
Fosb	Rat	triptonide	increases expression	ISO	RGD:1317838	6480464	triptonide results in increased expression of FOSB mRNA	CTD	PMID:33045310
Fosb	Rat	tungsten	decreases expression	ISO	RGD:1317838	6480464	Tungsten results in decreased expression of FOSB mRNA	CTD	PMID:30912803
Fosb	Rat	tunicamycin	increases expression	ISO	RGD:1317837	6480464	Tunicamycin results in increased expression of FOSB mRNA	CTD	PMID:33545341
Fosb	Rat	tyrphostin AG 1478	multiple interactions	ISO	RGD:1317838	6480464	RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd more ...	CTD	PMID:18758753
Fosb	Rat	urethane	increases expression	ISO	RGD:1317837	6480464	Urethane results in increased expression of FOSB mRNA	CTD	PMID:28818685
Fosb	Rat	valproic acid	increases expression	ISO	RGD:1317837	6480464	Valproic Acid results in increased expression of FOSB mRNA	CTD	PMID:24383497
Fosb	Rat	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of FOSB mRNA	CTD	PMID:29427782
Fosb	Rat	vinclozolin	increases expression	EXP		6480464	vinclozolin results in increased expression of FOSB mRNA	CTD	PMID:30207508
Fosb	Rat	zinc atom	multiple interactions	ISO	RGD:1317837	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of FOSB mRNA	CTD	PMID:18593933
Fosb	Rat	zinc(0)	multiple interactions	ISO	RGD:1317837	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of FOSB mRNA	CTD	PMID:18593933

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	behavioral response to cocaine		IEP		401900126		RGD
Fosb	Rat	behavioral response to cocaine		IEP		401851063		RGD
Fosb	Rat	cellular response to calcium ion	acts_upstream_of_or_within	IEA	UniProtKB:P13346\|ensembl:ENSMUSP00000003640	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	cellular response to calcium ion	acts_upstream_of_or_within	ISO	RGD:1317838	1624291	PMID:19303854	RGD	PMID:19303854
Fosb	Rat	cellular response to hormone stimulus		IEP		2293788		RGD
Fosb	Rat	female pregnancy		IEP		2293785		RGD
Fosb	Rat	positive regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:P13346\|ensembl:ENSMUSP00000003640	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	positive regulation of transcription by RNA polymerase II	involved_in	ISO	RGD:1317838	1624291	PMID:12525489	RGD	PMID:12525489
Fosb	Rat	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR004827\|InterPro:IPR046347	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR046347	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	regulation of transcription by RNA polymerase II	involved_in	IEA	InterPro:IPR000837	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	regulation of transcription by RNA polymerase II	involved_in	IBA	FB:FBgn0001297\|MGI:102858\|MGI:109384\|MGI:1859147\|MGI:1932093\|MGI:95574\|MGI:95575\|PANTHER:PTN001156258\|RGD:2165\|RGD:2627\|RGD:621611\|UniProtKB:P01100\|UniProtKB:P15408\|UniProtKB:P18847\|UniProtKB:Q8WYK2\|UniProtKB:Q9NR55\|WB:WBGene00001345	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fosb	Rat	response to amphetamine		IEP		401900735		RGD
Fosb	Rat	response to cAMP		IEP		2293796		RGD
Fosb	Rat	response to cocaine		IEP		401900302		RGD
Fosb	Rat	response to cocaine		IEP		401851084		RGD
Fosb	Rat	response to cocaine		IEP		401851078		RGD
Fosb	Rat	response to cocaine		IEP		401900166		RGD
Fosb	Rat	response to corticosterone		IEP		2293759		RGD
Fosb	Rat	response to ethanol		IEP		401851075		RGD
Fosb	Rat	response to ethanol		IEP		401851082		RGD
Fosb	Rat	response to ethanol		IEP		401901600		RGD
Fosb	Rat	response to ethanol		IEP		401900733		RGD
Fosb	Rat	response to mechanical stimulus		IEP		2293778		RGD
Fosb	Rat	response to morphine		IEP		401851072		RGD
Fosb	Rat	response to morphine		IEP		401900159		RGD
Fosb	Rat	response to morphine		IEP		401851068		RGD
Fosb	Rat	response to nicotine		IEP		407571683		RGD
Fosb	Rat	response to progesterone		IEP		2293785		RGD
Fosb	Rat	response to progesterone		IEP		2293786		RGD
Fosb	Rat	response to xenobiotic stimulus		IEP		2293784		RGD
Fosb	Rat	transcription by RNA polymerase II		IMP		1626699		RGD

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	cytosol		IDA		401900159	ex vivo light microscopy with histochemistry and digital image analysis	RGD
Fosb	Rat	nucleoplasm	located_in	TAS		1600115	Reactome:R-RNO-9620373	Reactome	Reactome:R-RNO-9620373
Fosb	Rat	nucleoplasm	located_in	IEA	UniProtKB:P53539\|ensembl:ENSP00000245919	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	nucleoplasm	located_in	ISO	RGD:1317837\|UniProtKB:P53539-1\|UniProtKB:P53539-10\|UniProtKB:P53539-2\|UniProtKB:P53539-3\|UniProtKB:P53539-5\|UniProtKB:P53539-8	1624291		RGD	GO_REF:0000052
Fosb	Rat	nucleus	is_active_in	IBA	FB:FBgn0001297\|FB:FBgn0028550\|MGI:102858\|MGI:109384\|MGI:1859147\|MGI:1932093\|MGI:95574\|PANTHER:PTN001156258\|RGD:1308198\|RGD:2626\|UniProtKB:P01100\|UniProtKB:P15407\|UniProtKB:P15408\|UniProtKB:P18847\|UniProtKB:P53539\|UniProtKB:Q16520\|UniProtKB:Q8N1L9\|UniProtKB:Q8WYK2\|UniProtKB:Q9NR55\|WB:WBGene00001345\|WB:WBGene00021082	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fosb	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Fosb	Rat	nucleus	located_in	IEA	UniProtKB:P53539\|ensembl:ENSP00000245919	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	nucleus	located_in	ISO	RGD:1317837	1624291	PMID:22387553	RGD	PMID:22387553
Fosb	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fosb	Rat	nucleus		IDA		401900733	MMO:0000220	RGD
Fosb	Rat	nucleus		IDA		401901600	MMO:0000498	RGD
Fosb	Rat	nucleus		IDA		401900159	ex vivo light microscopy with histochemistry and digital image analysis	RGD
Fosb	Rat	nucleus		IDA		401900302	MMO:0000422	RGD

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fosb	Rat	DNA binding	enables	IEA	ARBA:ARBA00029224	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Fosb	Rat	DNA binding	enables	IEA	UniProtKB:P13346\|ensembl:ENSMUSP00000003640	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	DNA binding	enables	ISO	RGD:1317838	1624291	PMID:12220541	RGD	PMID:12220541
Fosb	Rat	DNA binding	enables	IEA	InterPro:IPR000837	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	DNA-binding transcription activator activity, RNA polymerase II-specific	enables	ISO	RGD:1317838	1624291	PMID:12525489	RGD	PMID:12525489
Fosb	Rat	DNA-binding transcription activator activity, RNA polymerase II-specific	enables	IEA	UniProtKB:P13346\|ensembl:ENSMUSP00000003640	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	DNA-binding transcription factor activity		IMP		1626699		RGD
Fosb	Rat	DNA-binding transcription factor activity	enables	IEA	InterPro:IPR000837\|InterPro:IPR046347	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	DNA-binding transcription factor activity	enables	IEA	InterPro:IPR000837\|InterPro:IPR004827\|InterPro:IPR046347	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fosb	Rat	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IBA	FB:FBgn0001297\|MGI:109384\|MGI:1859147\|MGI:1932093\|MGI:95574\|MGI:95575\|PANTHER:PTN001156258\|RGD:2165\|RGD:2627\|UniProtKB:P01100\|UniProtKB:P15408\|UniProtKB:P18847\|UniProtKB:Q8WYK2\|UniProtKB:Q9NR55	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fosb	Rat	double-stranded DNA binding		IDA		1626699		RGD
Fosb	Rat	protein binding	enables	ISO	RGD:1317837	1624291	UniProtKB:B7ZLY0\|UniProtKB:O43189\|UniProtKB:O43639\|UniProtKB:O43711\|UniProtKB:P15336\|UniProtKB:P17275\|UniProtKB:P21549\|UniProtKB:P78424\|UniProtKB:Q01974\|UniProtKB:Q02930-3\|UniProtKB:Q08117-2\|UniProtKB:Q14119\|UniProtKB:Q14511-2\|UniProtKB:Q16236\|UniProtKB:Q7Z3K3\|UniProtKB:Q86YD7\|UniProtKB:Q8WU58\|UniProtKB:Q96A09\|UniProtKB:Q96K80\|UniProtKB:Q9BU64\|UniProtKB:Q9BZE0\|UniProtKB:Q9BZS1\|UniProtKB:Q9H0I2\|UniProtKB:Q9UIA0 PMID:28514442, PMID:32296183, PMID:32911434, PMID:33961781	RGD	PMID:28514442\|PMID:32296183\|PMID:32911434\|PMID:33961781
Fosb	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	ISO	RGD:1317838	1624291	PMID:12525489	RGD	PMID:12525489
Fosb	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:P13346\|ensembl:ENSMUSP00000003640	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fosb	Rat	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IBA	FB:FBgn0001297\|MGI:102858\|MGI:109384\|MGI:1859147\|MGI:1932093\|MGI:95574\|MGI:95575\|PANTHER:PTN001156258\|RGD:2165\|RGD:2627\|UniProtKB:P01100\|UniProtKB:P15407\|UniProtKB:Q9NR55	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fosb	Rat	sequence-specific DNA binding		IDA		1626699		RGD
Fosb	Rat	sequence-specific double-stranded DNA binding	enables	ISO	RGD:1317837	1624291	PMID:28473536	RGD	PMID:28473536
Fosb	Rat	sequence-specific double-stranded DNA binding	enables	IEA	UniProtKB:P53539\|ensembl:ENSP00000245919	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Disease Annotations Click to see Annotation Detail View

alcohol dependence (IEP)

alcohol use disorder (IEP,ISO)

alcohol withdrawal syndrome (ISO)

amphetamine abuse (IEP,ISO)

cocaine abuse (IEP,ISO)

cocaine dependence (IEP,ISO)

Cocaine-Related Disorders (ISO)

cognitive disorder (ISO)

COVID-19 (ISO)

depressive disorder (ISO)

Drug-Induced Dyskinesia (ISO)

epilepsy (ISO)

hepatocellular carcinoma (ISO)

heroin dependence (IDA,IEP)

impulse control disorder (ISO)

juvenile rheumatoid arthritis (ISO)

Liver Neoplasms (ISO)

Lung Neoplasms (ISO)

morphine dependence (IDA,IEP,ISO)

movement disease (ISO)

nicotine dependence (IEP,ISO)

opioid abuse (IEP)

Prenatal Exposure Delayed Effects (ISO)

substance dependence (ISO)

Tendon Injuries (IDA)

tongue squamous cell carcinoma (ISO)

withdrawal disorder (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

(-)-anisomycin (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(R)-noradrenaline (EXP)

(S)-amphetamine (EXP,ISO)

(S)-nicotine (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1-fluoro-2,4-dinitrobenzene (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

2-methyl-6-(phenylethynyl)pyridine (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (EXP)

8-OH-DPAT (EXP)

acetylsalicylic acid (ISO)

acrolein (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (EXP,ISO)

agmatine (EXP)

all-trans-retinoic acid (ISO)

AM-251 (ISO)

amiodarone (ISO)

amphetamine (EXP,ISO)

amphotericin B (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

asbestos (ISO)

benzene (ISO)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

C.I. Natural Red 20 (ISO)

cadmium acetate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

Calcimycin (ISO)

calciol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chlorpromazine (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

clozapine (EXP,ISO)

cocaine (EXP,ISO)

colforsin daropate hydrochloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

DDT (EXP)

Delta(9)-tetrahydrocannabinolic acid (EXP)

deoxynivalenol (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dieldrin (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

diisopropyl fluorophosphate (EXP)

dimethylarsinous acid (ISO)

dioxygen (EXP)

disulfiram (ISO)

dizocilpine maleate (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (EXP,ISO)

ferric oxide (EXP)

fluoxetine (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

haloperidol (EXP,ISO)

heroin (EXP)

hydrogen peroxide (ISO)

hydrogen sulfide (ISO)

ibuprofen (ISO)

irinotecan (ISO)

isoprenaline (EXP)

isotretinoin (ISO)

kenpaullone (EXP)

L-methionine (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

lithium atom (ISO)

lithium hydride (ISO)

lovastatin (EXP)

luteolin (ISO)

mechlorethamine (ISO)

melphalan (ISO)

methamphetamine (ISO)

methotrexate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

methylphenidate (EXP)

mono(2-ethylhexyl) phthalate (ISO)

morphine (EXP,ISO)

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide (EXP)

naloxone (EXP)

nickel atom (ISO)

nickel dichloride (ISO)

niclosamide (ISO)

nicotine (EXP,ISO)

nitric oxide (EXP)

okadaic acid (ISO)

oxidopamine (EXP,ISO)

ozone (ISO)

paclitaxel (EXP)

paracetamol (EXP,ISO)

phencyclidine (EXP)

phenylephrine (EXP)

phorbol 13-acetate 12-myristate (EXP,ISO)

pifithrin-alpha hydrobromide (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

potassium chloride (ISO)

potassium chromate (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

rimonabant (EXP)

SCH 23390 (EXP,ISO)

Shikonin (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

silver(1+) nitrate (ISO)

simvastatin (ISO)

SL-327 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium hypochlorite (ISO)

streptozocin (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

thalidomide (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

toluene (ISO)

tramadol (EXP)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

tunicamycin (ISO)

tyrphostin AG 1478 (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to cocaine (IEP)

cellular response to calcium ion (IEA,ISO)

cellular response to hormone stimulus (IEP)

female pregnancy (IEP)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA,IEA)

response to amphetamine (IEP)

response to cAMP (IEP)

response to cocaine (IEP)

response to corticosterone (IEP)

response to ethanol (IEP)

response to mechanical stimulus (IEP)

response to morphine (IEP)

response to nicotine (IEP)

response to progesterone (IEP)

response to xenobiotic stimulus (IEP)

transcription by RNA polymerase II (IMP)

Cellular Component

cytosol (IDA)

nucleoplasm (IEA,ISO,TAS)

nucleus (IBA,IDA,IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA,IMP)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

double-stranded DNA binding (IDA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific DNA binding (IDA)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens.	Carneiro de Oliveira PE, etal., Front Behav Neurosci. 2016 Sep 12;10:173. doi: 10.3389/fnbeh.2016.00173. eCollection 2016.
2.	H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference.	Chen M, etal., PLoS One. 2019 Aug 23;14(8):e0221506. doi: 10.1371/journal.pone.0221506. eCollection 2019.
3.	Withdrawal induces distinct patterns of FosB/∆FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization.	De Pauli RF, etal., Pharmacol Biochem Behav. 2014 Feb;117:70-8. doi: 10.1016/j.pbb.2013.12.007. Epub 2013 Dec 16.
4.	Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas.	El Rawas R, etal., Front Behav Neurosci. 2012 Mar 2;6:8. doi: 10.3389/fnbeh.2012.00008. eCollection 2012.
5.	Primary gene response to mechanical loading in healing rat Achilles tendons.	Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
6.	Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients.	Gajewski PA, etal., PLoS One. 2016 Aug 5;11(8):e0160355. doi: 10.1371/journal.pone.0160355. eCollection 2016.
7.	Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction.	García-García F, etal., Alcohol. 2021 Jun;93:63-70. doi: 10.1016/j.alcohol.2021.02.004. Epub 2021 Mar 1.
8.	Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system.	García-Pérez D, etal., PLoS One. 2012;7(11):e50264. doi: 10.1371/journal.pone.0050264. Epub 2012 Nov 21.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
11.	DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats.	Guo L, etal., Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi: 10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.
12.	Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer.	Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
13.	Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.	Hansson AC and Fuxe K, Brain Res. 2008 Jun 18;1215:1-10. Epub 2008 Apr 10.
14.	FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects.	Hiroi N, etal., Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10397-402. doi: 10.1073/pnas.94.19.10397.
15.	The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect.	Huang M, etal., Behav Brain Res. 2018 Jan 30;337:280-286. doi: 10.1016/j.bbr.2017.07.047. Epub 2017 Aug 4.
16.	Differences in basal and morphine-induced FosB/DeltaFosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats.	Kaste K, etal., Pharmacol Biochem Behav. 2009 Jun;92(4):655-62. doi: 10.1016/j.pbb.2009.03.004. Epub 2009 Mar 24.
17.	Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex.	Kontkanen O, etal., Neuropsychopharmacology. 2002 Aug;27(2):152-62.
18.	Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal.	Larson EB, etal., J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3.
19.	Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone.	Li J, etal., Alcohol Clin Exp Res. 2010 Oct;34(10):1742-50. doi: 10.1111/j.1530-0277.2010.01261.x. Epub 2010 Jul 9.
20.	Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions.	Li J, etal., PLoS One. 2012;7(7):e40347. doi: 10.1371/journal.pone.0040347. Epub 2012 Jul 9.
21.	Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats.	Liu H, etal., Neurosci Lett. 2011 Apr 20;494(1):70-4. doi: 10.1016/j.neulet.2011.02.059. Epub 2011 Mar 6.
22.	Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine.	Marttila K, etal., Brain Res. 2007 Jul 30;1160:82-90. doi: 10.1016/j.brainres.2007.05.036. Epub 2007 May 31.
23.	Early activation of transcription factor expression in Schwann cells by progesterone.	Mercier G, etal., Brain Res Mol Brain Res. 2001 Dec 30;97(2):137-48.
24.	Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells.	Mercier G, etal., Glia. 2001 Aug;35(2):81-9.
25.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
26.	Differential expression of activator protein-1 transcription factors in pregnant rat myometrium.	Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
27.	Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells.	Mitchell JA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E439-45. Epub 2004 May 4.
28.	Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats.	Moon S, etal., Neurochem Res. 2019 Apr;44(4):874-883. doi: 10.1007/s11064-019-02720-9. Epub 2019 Jan 10.
29.	D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration.	Muller DL and Unterwald EM, J Pharmacol Exp Ther. 2005 Jul;314(1):148-54. Epub 2005 Mar 16.
30.	NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior.	Nygard SK, etal., Behav Brain Res. 2017 Jan 15;317:218-225. doi: 10.1016/j.bbr.2016.09.047. Epub 2016 Sep 21.
31.	Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression.	Nygard SK, etal., Brain Res. 2013 Jul 3;1520:121-33. doi: 10.1016/j.brainres.2013.04.060. Epub 2013 May 9.
32.	Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression.	Nygard SK, etal., Neuroscience. 2015 Feb 26;287:1-8. doi: 10.1016/j.neuroscience.2014.12.010. Epub 2014 Dec 15.
33.	Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal.	Núñez C, etal., J Neurochem. 2010 Jul;114(2):475-87. doi: 10.1111/j.1471-4159.2010.06765.x. Epub 2010 Apr 23.
34.	GOA pipeline	RGD automated data pipeline
35.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
36.	Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice.	Robins MT, etal., PLoS One. 2016 Jul 5;11(7):e0158189. doi: 10.1371/journal.pone.0158189. eCollection 2016.
37.	Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice.	Ryabinin AE and Wang YM, Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54.
38.	Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat.	Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
39.	Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.	Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
40.	Nicotine increases FosB expression within a subset of reward- and memory-related brain regions during both peri- and post-adolescence.	Soderstrom K, etal., Psychopharmacology (Berl). 2007 May;191(4):891-7. doi: 10.1007/s00213-007-0744-9. Epub 2007 Feb 27.
41.	[Effects of electroacupuncture of low frequency on heroin-seeking behavior and FosB protein expression in relative brain regions].	Sun LM, etal., Zhongguo Zhen Jiu. 2006 Nov;26(11):833-7.
42.	Regional changes in ∆FosB expression in rat brain following MDMA self-administration predict increased sensitivity to effects of locally infused MDMA.	van de Wetering R and Schenk S, Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.
43.	Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site.	Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
44.	Effects of enriched environment on morphine-induced reward in mice.	Xu Z, etal., Exp Neurol. 2007 Apr;204(2):714-9. doi: 10.1016/j.expneurol.2006.12.027. Epub 2007 Jan 27.
45.	Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.	Yazdanfar N, etal., Brain Res Bull. 2021 May;170:98-105. doi: 10.1016/j.brainresbull.2021.02.005. Epub 2021 Feb 13.
46.	Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice.	Zhu H, etal., Hum Mol Genet. 2007 Apr 1;16(7):820-36. doi: 10.1093/hmg/ddm027.

Additional References at PubMed

PMID:7790908	PMID:12220541	PMID:12371906	PMID:12525489	PMID:15081600	PMID:15458969	PMID:15564575	PMID:15632090	PMID:15802201	PMID:15828020	PMID:15926929	PMID:16303124
PMID:16373449	PMID:16633904	PMID:16687504	PMID:17561814	PMID:17640529	PMID:17898221	PMID:17936518	PMID:18280640	PMID:18320311	PMID:18377962	PMID:18842886	PMID:19135469
PMID:19303854	PMID:19560520	PMID:20513656	PMID:20618447	PMID:21507338	PMID:21820506	PMID:22286499	PMID:22387553	PMID:22521816	PMID:22621966	PMID:22689746	PMID:23022956
PMID:23426671	PMID:23585124	PMID:23895375	PMID:24026072	PMID:24090157	PMID:24246425	PMID:25721540	PMID:26164345	PMID:27530066	PMID:27542594	PMID:28003214	PMID:29101166
PMID:30503921	PMID:33677486	PMID:34699790	PMID:37642495

Genomics

Comparative Map Data

Fosb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	88,082,324 - 88,089,506 (-)	NCBI		GRCr8
mRatBN7.2	1	78,954,312 - 78,961,492 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	78,954,115 - 78,961,465 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	84,343,248 - 84,350,106 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	92,900,923 - 92,907,784 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	86,098,337 - 86,105,195 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	80,214,691 - 80,221,417 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	80,214,494 - 80,221,710 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	81,480,955 - 81,510,687 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,668,497 - 78,673,330 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	73,416,543 - 73,423,390 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

FOSB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	45,467,996 - 45,475,179 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	45,467,995 - 45,475,179 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	45,971,254 - 45,978,437 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	50,663,093 - 50,670,276 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	50,663,092 - 50,670,276	NCBI
Celera	19	42,777,353 - 42,784,537 (+)	NCBI		Celera
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	42,400,874 - 42,408,060 (+)	NCBI		HuRef
CHM1_1	19	45,974,496 - 45,981,682 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	48,295,244 - 48,302,427 (+)	NCBI		T2T-CHM13v2.0

Fosb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	19,036,621 - 19,043,970 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	19,036,621 - 19,043,976 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	19,302,696 - 19,310,118 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	19,302,696 - 19,310,051 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	19,888,045 - 19,895,394 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	18,461,436 - 18,468,273 (-)	NCBI		MGSCv36	mm8
Celera	7	16,719,831 - 16,727,180 (-)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	9.56	NCBI

Fosb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	2,438,864 - 2,445,846 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	2,438,864 - 2,445,846 (+)	NCBI	ChiLan1.0	ChiLan1.0

FOSB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	51,628,596 - 51,636,058 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	53,500,106 - 53,507,556 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	42,416,781 - 42,424,003 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	51,013,350 - 51,020,570 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	51,013,350 - 51,020,570 (+)	Ensembl	panpan1.1		panPan2

FOSB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	110,088,686 - 110,092,818 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	110,087,036 - 110,092,818 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	109,572,939 - 109,577,071 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	110,619,054 - 110,625,469 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	110,619,068 - 110,625,971 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	110,297,099 - 110,301,231 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	109,931,231 - 109,935,353 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	110,800,596 - 110,804,728 (-)	NCBI		UU_Cfam_GSD_1.0

Fosb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	17,553,572 - 17,560,226 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	1,900,931 - 1,906,772 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	1,900,954 - 1,907,567 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOSB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	51,837,719 - 51,844,529 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	51,836,780 - 51,844,531 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FOSB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	38,916,039 - 38,924,129 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666073	18,534,366 - 18,539,824 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fosb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	2,328,691 - 2,339,099 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624907	2,332,746 - 2,338,825 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fosb
6 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	393
Count of miRNA genes:	217
Interacting mature miRNAs:	266
Transcripts:	ENSRNOT00000072149
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	53895117	82174945	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49361465	82174945	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	34836858	79836858	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	50343510	99980958	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	53895117	82174945	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	78430754	91209302	Rat

Markers in Region

RH135266

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	78,954,237 - 78,954,423 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	80,214,617 - 80,214,802	NCBI	Rnor6.0
Rnor_5.0	1	81,481,100 - 81,481,285	UniSTS	Rnor5.0
RGSC_v3.4	1	78,666,557 - 78,666,742	UniSTS	RGSC3.4
Celera	1	73,416,469 - 73,416,654	UniSTS
RH 3.4 Map	1	787.5	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	49	109	71	70	39	25	39	6	197	97	89	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001256509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KC847115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072149 ⟹ ENSRNOP00000065427

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,954,312 - 78,961,172 (-)	Ensembl
Rnor_6.0 Ensembl	1	80,214,691 - 80,221,417 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091687 ⟹ ENSRNOP00000073814

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,954,115 - 78,961,465 (-)	Ensembl
Rnor_6.0 Ensembl	1	80,214,494 - 80,221,710 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109325 ⟹ ENSRNOP00000091996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	78,955,918 - 78,961,465 (-)	Ensembl

RefSeq Acc Id:

NM_001256509 ⟹ NP_001243438

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	88,082,324 - 88,089,184 (-)	NCBI
mRatBN7.2	1	78,954,312 - 78,961,172 (-)	NCBI
Rnor_6.0	1	80,214,691 - 80,221,417 (-)	NCBI
Rnor_5.0	1	81,480,955 - 81,510,687 (-)	NCBI
Celera	1	73,416,543 - 73,423,390 (-)	NCBI

Sequence:

show sequence

GGTATCTGAATCGCACGCTGCACCGCGGCACTGCCCGGCGGGTTTCTGGGCGGGGAGCGATCCC
CGCGTCGCCCCCCGTGAAACCGACAGAGCCTGGACTTTCAGGAGGTACAGCGGAGGTCTGAAGG
GGACCTGGGAGCGCAACAGAGGGAACTTGCATCGAAACTTGGGCAGTTCTCCGAACCGGAGACT
AAGCTTCCCCGAGCAGCGCACTTTGGAGACGTGTCCGGTCTACTCCGGACTCGCATCTCATCCC
ACTCGGCCATAGCCTTGGCTTCCAGAAGACCTCAGCGTGGTCACAGGGGCCCCCCTGTGCCCAG
GGAAATGTTTCAAGCTTTCCCCGGAGACTACGACTCCGGCTCCCGGTGTAGCTCATCACCCTCC
GCCGAGTCTCAGTACCTGTCTTCGGTGGACTCCTTCGGCAGTCCACCCACCGCCGCCGCCTCCC
AGGAGTGCGCCGGTCTCGGGGAAATGCCCGGCTCCTTCGTGCCAACGGTCACCGCAATCACAAC
CAGCCAGGACCTTCAGTGGCTCGTGCAGCCCACCCTCATCTCTTCCATGGCCCAGTCCCAGGGG
CAGCCACTGGCCTCCCAGCCTCCAGCTGTTGACCCTTATGACATGCCTGGAACCAGCTACTCAA
CCCCGGGCCTGAGTGCCTACAGCACTGGTGGGGCAAGCGGAAGTGGTGGGCCTTCAACTAGCAC
AAGCACCAGTGGACCCGTGTCTGCCCGCCCAGCCAGAGCCAGGCCTAGAAGACCCCGAGAAGAA
ACACTTACCCCAGAAGAAGAAGAAAAACGAAGGGTTCGCAGAGAGCGGAACAAGCTGGCTGCAG
CTAAATGCAGAAACCGTCGGAGGGAGCTGACAGACCGACTCCAGGCGGAAACGGATCAGCTCGA
AGAGGAAAAGGCAGAGCTGGAGTCGGAGATCGCCGAGCTGCAAAAAGAGAAGGAACGCCTGGAG
TTTGTCCTGGTGGCCCACAAACCGGGCTGCAAGATCCCTTACGAAGAGGGGCCGGGGCCAGGCC
CGCTGGCCGAGGTGAGAGATTTGCCAGGGTCAACATCCGCTAAGGAAGACGGCTTCGGCTGGCT
GCTGCCGCCCCCTCCACCACCGCCCCTGCCCTTCCAGAGCAGCCGAGACGCACCCCCCAACCTG
ACGGCTTCTCTCTTTACACACAGTGAAGTTCAAGTCCTCGGCGACCCCTTCCCCGTTGTTAGCC
CTTCGTACACTTCCTCGTTTGTCCTCACCTGCCCGGAGGTCTCCGCGTTCGCCGGCTCCCAACG
CACCAGCGGCAGCGAGCAGCCGTCCGACCCCCTGAACTCGCCCTCCCTTCTTGCTCTGTAAACT
CTTTAAACAAACAAAACAAACAAAACCGCAAGGAACGAGGAGGAGGAAGAGGAGGAGAGGGGAG
GAAGCGGTCCGGGGTGTGTGTGAGGACCCCTTGACTCTTCTGTCTGACCGCCTGTCGCCTCTGC
CATCGGACTTGACGGAAGGACCTCCTTTGTGTTTTGTGCTCCGCCTCTGGTTTTCTGCGCCCCG
GCGAGGCCGGAGAGCTGGTGACTTTGGGGACGGGGTGGGGCGGGTGCACCCTTCCTGCAGATAA
CTTTGTCCTGTTACTTCAACCCACCTTCTGGGGATAGATGCTGGCTGGCTGGGTGGGTGGGGTG
GGATGCGACGCCCACCTTTGGCGTCCTGCGTGAGGCTGGAGGGGAAAGGGTGCTGGGTGTGGGG
TACAGGGTGGGTTGAGGTCGAGCTGGCATGCACCCCCAGAGAGACCCAACGAGGAAATGACAGC
ACTGTCCTTCTCTTCCCTACCCACCCATCCACCCTCCAGGGTGCAGGGTGACCAAGATAGCTCT
GTTTTGCTCCCTCGGGCCTTAGCTGATTAACCTAACATTTCCAGGAGGTTACAACCTCCTCCGG
GACGAATTGAACCCCCGACTGAGGGAAGTCGATGGCCGCTTTGGGAGTCTGCTAACCCTAATTC
CCCGCTGATTCCAAAATGTGAACCCCTATCTGACTGTTCAGTCTTTCCCTCCTGGGAAAACTGA
CTCAGGTTGGATTTTTTTCTCATCTGCTACGGAGCCCCCTTCCAACTCAGGCCCGCTCCCACCC
CTGTGCAGTATTATGCCATGTCCCTCTCACCCCCACGGGCAACCCAGGCGCCCTTGGCCGTCCT
CGTTGGGCCTTTCTGGTTTTGGGCAGCAGGGGGCGCTGCGACGCCCGTCTTGCTGGAGCGCTTT
ATACTGTGAATGAATGGCCAGATTGCTGGGTGCGCCGGATGGGATTGACCCCCAACCCTCCAAA
GCCTTCCCTGGGCCTCTCCTTCTTCCACTTGCCCCCTTCCAACCCTTGACAGGGAGTTAGACCC
GAAAGGAGTGACTGCGATGCATCCCGGTGGCCTTCTTGCTCAGGCCCCAGACATTTTCTCTAAG
TCCTTCGCCTTCCCCAGCCTAGGACGCCAACTTCTCCCCATCCTGGGAGCCCCGCATCCTCTCA
CAGAGGTCGTCGAGGCAATTTCCAGAGAAGTTTTCAGGGCTGAGGCTTTGGCTCCCCTACCCTC
GATATTTGAACCCCCAAATATTTTTGGACTGGCATACTTCAGAGGGGGCTGAGTTCCCACTATC
CTAATCCATCCAATTCCTCCAGCCCCGAATATGGGTTCTGGCTTTTCCCTCCAGCTTTCACCTC
GTGAGAATTCCACGAGTCAGATTTCTATTTTTTAATATTGGGGAGATGGGCCCTACCGCCCCCC
CCCGTGCTGCATGGAACATTCCATACTCTGTCCTGGGTCCTCGGTTCCAAGCCTAATCCCAACC
CCCAACCCTCAGCTATTTATCCCTTTCCTGGTTCCCAAAAAGCACTTATATCTATTATGTATAA
ATAAATATATTATATATGGGTGTGCGTGTGTGTGCGTGCGTGCGTGCGAGCTTCCTCGTTTGCA
AGTGTGCTGTGGAATTCAAAATCGCTTTTGGGGATTTGAGTCAGACTTTCTGGCTGTCCCTTTC
CTAACTTGTCACTTTTTTTGTTGTTGTCTCAGCCCCTCTGGCTGTTGGAAACAGCCTCTTCCTT
TCCTTTTATCTTTTTTCAACTCTGTCTCGCTCAGACCACTTCCAACATGTCTCCTCTCTCAATG
GCCCTGACCTCCCGTCTGTCTGTTAATTCCGGATTTGTCGGGGACATGCAATTTTACTTTTGTA
AGTAAGTGTGACTGGGTGGTAGATTTTTACAATCTATATCGTTGAGAATTC

hide sequence

RefSeq Acc Id:

XM_039101873 ⟹ XP_038957801

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	88,083,291 - 88,089,506 (-)	NCBI
mRatBN7.2	1	78,956,246 - 78,961,492 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001243438	(Get FASTA)	NCBI Sequence Viewer
	XP_038957801	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AGR67147	(Get FASTA)	NCBI Sequence Viewer
	D3ZLB7	(Get FASTA)	NCBI Sequence Viewer
	EDM08212	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000065427
	ENSRNOP00000065427.1
	ENSRNOP00000091996

RefSeq Acc Id:

NP_001243438 ⟸ NM_001256509

- UniProtKB:

D3ZLB7 (UniProtKB/Swiss-Prot), S5NB67 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTS
QDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGSGGPSTSTS
TSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEE
EKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLL
PPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGSQRT
SGSEQPSDPLNSPSLLAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000065427 ⟸ ENSRNOT00000072149

Ensembl Acc Id:

ENSRNOP00000073814 ⟸ ENSRNOT00000091687

RefSeq Acc Id:	XP_038957801 ⟸ XM_039101873
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AEQ0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091996 ⟸ ENSRNOT00000109325

Protein Domains

bZIP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZLB7-F1-model_v2	AlphaFold	D3ZLB7	1-338	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689774

Promoter ID:

EPDNEW_R291

Type:

initiation region

Name:

Fosb_1

Description:

FosB proto-oncogene, AP-1 transcription factor subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	80,221,674 - 80,221,734	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308198	AgrOrtholog
BioCyc Gene	G2FUF-60514	BioCyc
Ensembl Genes	ENSRNOG00000046667	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000072149	ENTREZGENE
	ENSRNOT00000072149.2	UniProtKB/Swiss-Prot
	ENSRNOT00000109325	ENTREZGENE
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot
InterPro	AP-1	UniProtKB/Swiss-Prot
	bZIP	UniProtKB/Swiss-Prot
	bZIP_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:100360880	UniProtKB/Swiss-Prot
NCBI Gene	Fosb	ENTREZGENE
PANTHER	PTHR23351	UniProtKB/Swiss-Prot
	PTHR23351:SF3	UniProtKB/Swiss-Prot
Pfam	bZIP_1	UniProtKB/Swiss-Prot
PhenoGen	Fosb	PhenoGen
PRINTS	LEUZIPPRFOS	UniProtKB/Swiss-Prot
PROSITE	BZIP	UniProtKB/Swiss-Prot
	BZIP_BASIC	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000046667	RatGTEx
SMART	BRLZ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57959	UniProtKB/Swiss-Prot
UniProt	A0A8I6AEQ0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZLB7	ENTREZGENE, UniProtKB/Swiss-Prot
	S5NB67	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-11	Fosb	FosB proto-oncogene, AP-1 transcription factor subunit	Fosb	FBJ osteosarcoma oncogene B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-03-19	Fosb	FBJ osteosarcoma oncogene B	LOC100360880	FBJ osteosarcoma oncogene B	Data merged from RGD:2321278	737654	APPROVED
2010-05-05	LOC100360880	FBJ osteosarcoma oncogene B			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Fosb	FBJ osteosarcoma oncogene B	Fosb_predicted	FBJ osteosarcoma oncogene B (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Fosb_predicted	FBJ osteosarcoma oncogene B (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD