Sirt1 (sirtuin 1) - Rat Genome Database

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Gene: Sirt1 (sirtuin 1) Mus musculus
Symbol: Sirt1
Name: sirtuin 1
RGD ID: 1318375
Description: Enables several functions, including NAD-dependent histone H3K9 deacetylase activity; p53 binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including regulation of cellular biosynthetic process; regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and ovulation from ovarian follicle. Located in heterochromatin; mitochondrion; and nucleus. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; nervous system; and sensory organ. Used to study Alzheimer's disease; fatty liver disease; and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AA673258; MGC150273; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; regulatory protein SIR2 homolog 1; S; Si; Sir2; sir2-like 1; SIR2-like protein 1; Sir2a; Sir2alpha; SIR2L1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391063,154,784 - 63,174,814 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,154,784 - 63,217,483 (-)EnsemblGRCm39 Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,319,005 - 63,381,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBIMGSCv36mm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (IDA,IEP)
amyotrophic lateral sclerosis  (IEP)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autoimmune disease  (ISO)
Binge Drinking  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (IAGP,IEP,ISO)
Fibrosis  (ISO)
Genomic Instability  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (IMP,ISO)
Hypertrophy  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IMP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrogenic diabetes insipidus  (IAGP)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Paralysis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
retinal disease  (ISO)
senile cataract  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-nitropropanoic acid  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
4-phenylbutyric acid  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetic acid  (ISO)
acetylcholine  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allethrin  (ISO)
alpha-D-galactose  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony trichloride  (ISO)
apocynin  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bafilomycin A1  (ISO)
benzamide  (ISO)
benzophenanthridine  (ISO)
berberine  (ISO)
Betanin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
butein  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcium oxalate  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
Carbaprostacyclin  (EXP)
carbon nanotube  (EXP)
carnosic acid  (ISO)
CAY10591  (ISO)
CDP-choline  (ISO)
CGS-21680  (ISO)
Chikusetsusaponin-V  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dihydrogen  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
diprotium  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ergosterol  (ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
everolimus  (ISO)
excitatory amino acid agonist  (ISO)
fenbendazole  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
fisetin  (EXP)
folic acid  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
galactose  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Genipin  (EXP)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (EXP)
Goe 6976  (ISO)
GW 501516  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP,ISO)
imidacloprid  (EXP)
inositol  (ISO)
ionomycin  (ISO)
iprodione  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
isonicotinamide  (ISO)
isoquinoline-1,5-diol  (ISO)
kainic acid  (EXP,ISO)
KT 5720  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
Licarin A  (EXP)
linagliptin  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylglyoxal  (ISO)
metiram  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monooxygen  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N,N-dimethylglycine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (EXP,ISO)
naringin  (ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
nitrites  (ISO)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
octreotide  (EXP)
olaparib  (ISO)
oleic acid  (ISO)
organoselenium compound  (ISO)
oxaloacetic acid  (ISO)
oxidopamine  (ISO)
P(1),P(5)-bis(5'-adenosyl) pentaphosphate  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
prasugrel hydrochloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propionic acid  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyruvic acid  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
ramipril  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rutin  (ISO)
S-nitroso-L-cysteine  (ISO)
salicylic acid  (ISO)
Salidroside  (ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
splitomicin  (ISO)
staurosporine  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
suramin  (EXP,ISO)
taurine  (EXP,ISO)
temozolomide  (ISO)
tert-butanol  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
trans-piceid  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
umbelliferone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
wortmannin  (EXP,ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP,ISO)
apoptotic process  (IEA)
behavioral response to starvation  (IMP)
cell differentiation  (IEA)
cellular glucose homeostasis  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to antibiotic  (ISO)
cellular response to curcumin  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (IMP)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to organic cyclic compound  (ISO)
cellular response to rotenone  (ISO)
cellular response to starvation  (IMP)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin B3  (ISO)
cellular triglyceride homeostasis  (IMP)
cholesterol homeostasis  (IMP)
chromatin organization  (ISO)
circadian regulation of gene expression  (IMP,ISO)
circadian rhythm  (IEP)
DNA synthesis involved in DNA repair  (IMP)
energy homeostasis  (ISO)
fatty acid homeostasis  (IMP)
heterochromatin formation  (ISO)
histone deacetylation  (IDA,IGI,ISO)
histone H3 deacetylation  (IBA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IDA)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
leptin-mediated signaling pathway  (IMP)
macrophage differentiation  (IMP)
mitochondrion organization  (ISO)
muscle organ development  (IEA)
negative regulation of adipose tissue development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cAMP-dependent protein kinase activity  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cellular response to testosterone stimulus  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (IMP,ISO)
negative regulation of DNA-templated transcription  (IBA,IDA,ISO)
negative regulation of fat cell differentiation  (IMP)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of growth hormone secretion  (ISO)
negative regulation of helicase activity  (ISO)
negative regulation of histone H3-K14 acetylation  (ISO)
negative regulation of histone H3-K9 trimethylation  (IDA)
negative regulation of histone H4-K16 acetylation  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (IGI)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of phosphorylation  (IMP,ISO)
negative regulation of prostaglandin biosynthetic process  (IMP)
negative regulation of protein acetylation  (ISO)
negative regulation of protein kinase B signaling  (IMP,ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TOR signaling  (IMP,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA)
negative regulation of tumor necrosis factor production  (ISO)
ovulation from ovarian follicle  (IMP)
peptidyl-lysine acetylation  (ISO)
peptidyl-lysine deacetylation  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of adipose tissue development  (IMP)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cAMP-dependent protein kinase activity  (IDA,ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of cholesterol efflux  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA repair  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IMP)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (IMP,ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of histone deacetylation  (ISO)
positive regulation of histone H3-K9 methylation  (ISO)
positive regulation of histone methylation  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of macroautophagy  (IDA,ISO)
positive regulation of macrophage apoptotic process  (IMP)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IMP)
positive regulation of protein deacetylation  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of skeletal muscle cell proliferation  (ISO)
positive regulation of smooth muscle cell differentiation  (IMP)
positive regulation of thyroid-stimulating hormone secretion  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of triglyceride catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein deacetylation  (IDA,IMP,ISO)
protein depropionylation  (IDA)
protein destabilization  (IDA)
protein ubiquitination  (ISO)
pyrimidine dimer repair by nucleotide-excision repair  (IMP,ISO)
rDNA heterochromatin formation  (ISO)
regulation of apoptotic process  (ISO)
regulation of bile acid biosynthetic process  (IMP)
regulation of brown fat cell differentiation  (IMP)
regulation of cell population proliferation  (ISO)
regulation of centrosome duplication  (ISO)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of glucose metabolic process  (IMP)
regulation of lipid storage  (IMP)
regulation of mitotic cell cycle  (ISO)
regulation of peroxisome proliferator activated receptor signaling pathway  (IMP)
regulation of protein serine/threonine kinase activity  (ISO)
regulation of smooth muscle cell apoptotic process  (IDA)
regulation of transcription by glucose  (ISO)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (IDA)
response to kainic acid  (ISO)
response to leptin  (IMP)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to resveratrol  (ISO)
rhythmic process  (IEA)
single strand break repair  (ISO)
spermatogenesis  (IMP)
stress-induced premature senescence  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride mobilization  (IMP)
UV-damage excision repair  (ISO)
vasodilation  (ISO)
white fat cell differentiation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adult Leydig cell differentiation  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell death  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal DNA repair  (IAGP)
abnormal DNA replication  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal eye development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IEA)
abnormal inguinal fat pad morphology  (IAGP)
abnormal iris morphology  (IEA)
abnormal lacrimal gland morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal maxilla morphology  (IEA)
abnormal nursing  (IAGP)
abnormal palatal rugae morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal pituitary gland physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal scapula morphology  (IEA)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell development  (IAGP)
abnormal sinus arrhythmia  (IEA)
abnormal snout morphology  (IEA)
abnormal sperm flagellum morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testes secretion  (IAGP)
abnormal tooth morphology  (IEA)
abnormal tumor morphology  (IAGP)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent hindlimb buds  (IAGP)
aneuploidy  (IAGP)
anovulation  (IAGP)
arrest of male meiosis  (IAGP)
arrest of spermatogenesis  (IAGP)
atrial septal defect  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased embryo size  (IAGP)
decreased Leydig cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased pituitary gland weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased testis weight  (IAGP)
decreased urine osmolality  (IAGP)
decreased white adipose tissue amount  (IAGP)
disorganized retina inner nuclear layer  (IAGP)
disorganized retina outer nuclear layer  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged pancreas  (IAGP)
enlarged spleen  (IAGP)
exencephaly  (IAGP)
exocrine pancreas atrophy  (IAGP)
eyelids fail to open  (IAGP)
female infertility  (IAGP)
globozoospermia  (IAGP)
glomerulonephritis  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IAGP)
hyperpnea  (IAGP)
hypoactivity in response to feed restriction  (IAGP)
hypolactation  (IAGP)
immotile sperm  (IAGP)
impaired glucose tolerance  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased basophil cell number  (IEA)
increased brain size  (IAGP)
increased carcinoma incidence  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased cellular sensitivity to ultraviolet irradiation  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating prolactin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased food intake  (IAGP)
increased immunoglobulin level  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver triglyceride level  (IAGP)
increased lymphoma incidence  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased mitotic index  (IAGP)
increased oxygen consumption  (IAGP)
increased sarcoma incidence  (IAGP)
increased teratoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased urine antidiuretic hormone level  (IAGP)
interstitial pneumonia  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethargy  (IAGP)
lung inflammation  (IAGP)
male infertility  (IAGP)
microphthalmia  (IAGP)
multinucleated giant male germ cells  (IAGP)
narrow eye opening  (IEA)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypotelorism  (IAGP)
oligozoospermia  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polydipsia  (IAGP)
polyphagia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
pulmonary edema  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
short snout  (IAGP)
slow postnatal weight gain  (IAGP)
small ovary  (IAGP)
small pituitary gland  (IAGP)
small seminiferous tubules  (IAGP)
teratozoospermia  (IAGP)
thin uterus  (IAGP)
ventricular septal defect  (IAGP)

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Additional References at PubMed
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