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Gene: Sirt1 (sirtuin 1) Mus musculus
Symbol: Sirt1
Name: sirtuin 1
Description: This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA673258; MGC150273; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; regulatory protein SIR2 homolog 1; Sir2; sir2-like 1; SIR2-like protein 1; Sir2a; Sir2alpha; SIR2L1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1
Homo sapiens (human) : SIRT1 (sirtuin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sirt1 (sirtuin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt1 (sirtuin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT1 (sirtuin 1)
Canis lupus familiaris (dog) : SIRT1 (sirtuin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt1 (sirtuin 1)
Sus scrofa (pig) : SIRT1 (sirtuin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBImm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10 B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Sirt1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318375
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.